PT1578741E - Compostos aromáticos como agentes antiinflamatórios, imunoreguladores e antiproliferativos - Google Patents

Compostos aromáticos como agentes antiinflamatórios, imunoreguladores e antiproliferativos Download PDF

Info

Publication number
PT1578741E
PT1578741E PT03789317T PT03789317T PT1578741E PT 1578741 E PT1578741 E PT 1578741E PT 03789317 T PT03789317 T PT 03789317T PT 03789317 T PT03789317 T PT 03789317T PT 1578741 E PT1578741 E PT 1578741E
Authority
PT
Portugal
Prior art keywords
immunomodulatory
inflammatory
aromatic compounds
proliferatory
agents
Prior art date
Application number
PT03789317T
Other languages
English (en)
Inventor
Johann Leban
Stefan Tasler
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Publication of PT1578741E publication Critical patent/PT1578741E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PT03789317T 2002-12-23 2003-12-17 Compostos aromáticos como agentes antiinflamatórios, imunoreguladores e antiproliferativos PT1578741E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10260800 2002-12-23

Publications (1)

Publication Number Publication Date
PT1578741E true PT1578741E (pt) 2011-10-17

Family

ID=32667540

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03789317T PT1578741E (pt) 2002-12-23 2003-12-17 Compostos aromáticos como agentes antiinflamatórios, imunoreguladores e antiproliferativos

Country Status (22)

Country Link
EP (3) EP1578741B1 (pt)
JP (3) JP2006511564A (pt)
KR (1) KR101107456B1 (pt)
CN (3) CN1732147A (pt)
AT (2) ATE516284T1 (pt)
AU (2) AU2003299316A1 (pt)
BR (2) BR0317687A (pt)
CA (2) CA2509138A1 (pt)
CY (1) CY1111851T1 (pt)
DE (1) DE60330391D1 (pt)
DK (1) DK1578741T3 (pt)
ES (1) ES2368735T3 (pt)
IL (2) IL169184A (pt)
MX (2) MXPA05006890A (pt)
NO (2) NO335748B1 (pt)
NZ (1) NZ541382A (pt)
PL (2) PL377478A1 (pt)
PT (1) PT1578741E (pt)
RU (2) RU2367650C2 (pt)
SI (1) SI1578741T1 (pt)
WO (1) WO2004056797A1 (pt)
ZA (1) ZA200504387B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2742910A1 (en) * 2008-11-07 2010-05-14 4Sc Ag Combinational therapy comprising dhodh inhibitor and methotrexate for treating autoimmune disease
TWI530286B (zh) * 2009-05-04 2016-04-21 帕納特斯製藥格斯有限公司 作為抑制病毒化合物之抗發炎劑
US8686048B2 (en) 2010-05-06 2014-04-01 Rhizen Pharmaceuticals Sa Immunomodulator and anti-inflammatory compounds
EP2672963A4 (en) 2011-02-08 2015-06-24 Childrens Medical Center METHOD FOR THE TREATMENT OF MELANOMA
RU2485112C1 (ru) * 2012-04-26 2013-06-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" 4-(4-бромфенил)-4-оксо-2-{[3-(этоксикарбонил)-4,5-диметилтиен-2-ил]амино}-2-бутеновая кислота, обладающая противовоспалительной и анальгетической активностью
US9795590B2 (en) 2014-04-11 2017-10-24 Panoptes Pharma Gmbh Anti-inflammatory agents as virostatic compounds
KR102312186B1 (ko) 2014-05-08 2021-10-14 판옵테스 파르마 게스.엠.베.하. 안 질환 및 장애 치료용 화합물
CA3043938A1 (en) 2016-12-21 2018-06-28 Biotheryx, Inc. Thienopyrrole derivatives for use in targeting proteins, compositions, methods, and uses thereof
WO2022167402A1 (en) 2021-02-02 2022-08-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of therapy comprising administering a therapeutically effective combination comprising a dhodh inhibitor and an idh inhibitor
AU2022253683A1 (en) 2021-04-09 2023-10-26 Immunic Ag Deuterated dhodh inhibitors
CA3240950A1 (en) 2021-12-23 2023-06-29 Christian Gege Dhodh inhibitors containing a carboxylic acid bioisostere

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL186239B (nl) 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
AU1526483A (en) * 1982-06-14 1983-12-22 Nippon Kayaku Kabushiki Kaisha N-substituted-3,4,5,6-tetrahydrophthalamic acids
ZA839187B (en) * 1982-12-10 1984-07-25 Ciba Geigy Ag Amide compounds
GB8311519D0 (en) * 1983-04-27 1983-06-02 Fisons Plc Nitrogen heterocycles
GB8323293D0 (en) * 1983-08-31 1983-10-05 Zyma Sa Substituted flavene and thioflavene derivatives
DE3402026A1 (de) 1984-01-21 1985-07-25 Basf Ag, 6700 Ludwigshafen Neue 2-aminothiophenderivate
DE3534440A1 (de) 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
DE3812225A1 (de) * 1988-04-13 1989-10-26 Basf Ag Isoxazol(isothiazol)-5-carbonsaeureamide
EP0418667B1 (de) * 1989-09-22 1995-08-16 BASF Aktiengesellschaft Carbonsäureamide
DE3932052A1 (de) * 1989-09-26 1991-04-04 Basf Ag Oxazol- bzw. thiazolcarbonsaeureamide
DE3933573A1 (de) * 1989-10-07 1991-04-18 Basf Ag Carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
ATE127122T1 (de) * 1990-06-23 1995-09-15 Basf Ag Dicarbonsäureimide als herbizide.
DE4023048A1 (de) * 1990-07-20 1992-01-23 Basf Ag Dicarbonsaeureimide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
DE4108181A1 (de) * 1991-03-14 1992-09-17 Basf Ag Isoxazol- und isothiazol-5-carbonsaeureamide
EP0633771A4 (en) * 1992-04-02 1995-02-22 Smithkline Beecham Corporation Compounds.
JP3055365B2 (ja) * 1993-06-30 2000-06-26 東洋インキ製造株式会社 ２，５−ジ（アリールアミノ）−３，６−ジヒドロテレフタル酸ジアルキルエステル類の製造法およびこれを中間体とするキナクリドン類の製造法
GB9320299D0 (en) 1993-10-01 1993-11-17 Roussel Lab Ltd Isoxazole derivatives
DE19547648A1 (de) 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
DE19610955A1 (de) 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
CN1234029A (zh) * 1996-08-27 1999-11-03 盐野义制药株式会社 色烯－3－羚酸衍生物
US6020357A (en) * 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
US6187797B1 (en) * 1996-12-23 2001-02-13 Dupont Pharmaceuticals Company Phenyl-isoxazoles as factor XA Inhibitors
WO1998028282A2 (en) * 1996-12-23 1998-07-02 Du Pont Pharmaceuticals Company OXYGEN OR SULFUR CONTAINING 5-MEMBERED HETEROAROMATICS AS FACTOR Xa INHIBITORS
EA003056B1 (ru) * 1996-12-23 2002-12-26 Дюпон Фармасьютикалз Компани АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ
ES2239806T3 (es) * 1997-06-19 2005-10-01 Bristol-Myers Squibb Pharma Company Inhibidores del factor xa con un grupo de especificidad neutro p1.
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
WO1999038846A1 (en) 1998-01-30 1999-08-05 Procept, Inc. Immunosuppressive agents
GB9804343D0 (en) 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
AU1707700A (en) * 1998-10-29 2000-05-22 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
US6747041B1 (en) * 1999-06-24 2004-06-08 Nihon Nohyaku Co., Ltd. Heterocyclic dicarboxylic acid diamide derivatives, agricultural/horticultural insecticides and method of using the same
JP4706810B2 (ja) * 1999-06-24 2011-06-22 日本農薬株式会社 ピリジン環ジカルボン酸ジアミド誘導体及び農園芸用殺虫剤並びにその使用方法
WO2001021160A2 (en) * 1999-09-23 2001-03-29 Axxima Pharmaceuticals Aktiengesellschaft Carboxymide and aniline derivatives as selective inhibitors of pathogens
JP2003510352A (ja) 1999-10-01 2003-03-18 インスティチュート オブ モレキュラー アンド セル バイオロジー ウイルス媒介性疾病の治療用化合物
DE60024861T2 (de) * 1999-10-28 2006-07-06 Trine Pharmaceuticals, Inc., Waltham Pumpeninhibitoren zur freisetzung von medikamenten
EP1226123A1 (en) * 1999-11-03 2002-07-31 Du Pont Pharmaceuticals Company Cyano compounds as factor xa inhibitors
US6599926B2 (en) * 2000-06-23 2003-07-29 Bristol-Myers Squibb Company Heteroaryl-phenyl substituted factor Xa inhibitors
RU2181270C1 (ru) 2000-07-21 2002-04-20 Общество с ограниченной ответственностью "Медицинское предприятие "ХИТ плюс" Способ повреждения термонетолерантных патологических биоструктур организма теплокровных
JP2002128768A (ja) * 2000-10-26 2002-05-09 Dai Ichi Seiyaku Co Ltd 薬剤排出ポンプ阻害作用を有する化合物
JP2002322054A (ja) * 2001-04-26 2002-11-08 Dai Ichi Seiyaku Co Ltd 薬剤排出ポンプ阻害薬
ATE438637T1 (de) * 2001-06-11 2009-08-15 Virochem Pharma Inc Thiophenderivate als antivirale mittel gegen flavivirus-infektion
MXPA04000224A (es) * 2001-07-10 2005-07-25 4Sc Ag Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos.
DE10133665A1 (de) * 2001-07-11 2003-01-30 Boehringer Ingelheim Pharma Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung
GB0219896D0 (en) * 2002-08-27 2002-10-02 Bayer Ag Dihydropyridine derivatives
JP4093023B2 (ja) * 2002-11-15 2008-05-28 コニカミノルタビジネステクノロジーズ株式会社 非磁性一成分現像用トナーおよび画像形成方法

Also Published As

Publication number Publication date
RU2386625C2 (ru) 2010-04-20
EP1578741A1 (en) 2005-09-28
BR0317731A (pt) 2005-11-22
EP2283898A1 (en) 2011-02-16
EP1581477A1 (en) 2005-10-05
JP2010215655A (ja) 2010-09-30
AU2003299316A1 (en) 2004-07-14
CN1732163A (zh) 2006-02-08
AU2003293914B2 (en) 2010-09-23
NO20052907L (no) 2005-09-12
CA2509139A1 (en) 2004-07-08
PL377467A1 (pl) 2006-02-06
NO20052907D0 (no) 2005-06-15
DE60330391D1 (de) 2010-01-14
ATE450498T1 (de) 2009-12-15
PL377478A1 (pl) 2006-02-06
WO2004056797A1 (en) 2004-07-08
RU2005123401A (ru) 2006-01-20
ES2368735T3 (es) 2011-11-21
SI1578741T1 (sl) 2011-11-30
CA2509139C (en) 2012-03-20
IL169184A (en) 2012-08-30
CA2509138A1 (en) 2004-07-08
IL169184A0 (en) 2009-02-11
MXPA05006890A (es) 2006-04-07
EP1581477B1 (en) 2009-12-02
JP2006514023A (ja) 2006-04-27
BR0317687A (pt) 2005-11-22
ATE516284T1 (de) 2011-07-15
NO20052908D0 (no) 2005-06-15
RU2005123402A (ru) 2006-01-20
CN1939896A (zh) 2007-04-04
ZA200504387B (en) 2006-02-22
IL169257A (en) 2012-02-29
KR101107456B1 (ko) 2012-01-19
KR20050089843A (ko) 2005-09-08
PL209303B1 (pl) 2011-08-31
JP2006511564A (ja) 2006-04-06
DK1578741T3 (da) 2011-09-26
CN1732147A (zh) 2006-02-08
NZ541382A (en) 2009-04-30
JP5300789B2 (ja) 2013-09-25
NO20052908L (no) 2005-09-12
IL169257A0 (en) 2007-07-04
NO335748B1 (no) 2015-02-02
RU2367650C2 (ru) 2009-09-20
EP1578741B1 (en) 2011-07-13
CY1111851T1 (el) 2015-11-04
MXPA05006889A (es) 2006-04-07
CN1732163B (zh) 2012-07-18
AU2003293914A1 (en) 2004-07-14

Similar Documents

Publication Publication Date Title
IL169184A0 (en) Aromatic compounds as anti-inflammatory, immunomdulatory and anti-proliferatory agents
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
HRP20090281T1 (en) 1,2,3,4-tetrasubstituted indole for the treatment of respiratory diseases
WO2006005609A3 (de) Substituierte oxindol-derivate und diese enthaltende arzneimittel
IL159418A0 (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
AUPR213700A0 (en) Antiviral agents
WO2006067165A3 (en) Indolidone derivatives for the treatment or prevention of fibrotic diseases
BR0312729A (pt) Novos derivados de indol-3-enxofre
NO20020968D0 (no) Glukopyranosyloksypyrazolderivater, medisinske sammensetninger inneholdende det samme og intermediater forfremstillingen derav
JO2354B1 (en) New derivatives of aromatic fluoroglycosides and drugs containing these compounds and their use
RS20050432A (en) Novel aromatic fluoroglycoside derivatives,pharmaceutical products containing said compounds and the use thereof
WO2002055496A8 (en) Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression
HK1155146A1 (zh) 作為藥物活性劑的茚衍生物
IT1311922B1 (it) Composti farmaceutici.
WO2004048381A3 (en) Pyrazoloazepine compounds as pharmaceutical agents
SI1924255T1 (sl) Uporaba n-(dibenz(b,f)oksepin-10-ilmetil)-n-metil-n-prop-2-inilamina(omigapil), za profilakso in/ali zdravljenje miĺ iäśne distrofije
HK1083839A1 (en) Indoline compound and medicinal use thereof
WO2003004019A8 (en) Use of heterocyclic and benzoheterocyclic polyamides structurally related to the natural antibiotic distamycin a for the treatment of beta-thalassaemia