BR0210179A - Compostos analgésicos de liberação sustentada - Google Patents
Compostos analgésicos de liberação sustentadaInfo
- Publication number
- BR0210179A BR0210179A BR0210179-3A BR0210179A BR0210179A BR 0210179 A BR0210179 A BR 0210179A BR 0210179 A BR0210179 A BR 0210179A BR 0210179 A BR0210179 A BR 0210179A
- Authority
- BR
- Brazil
- Prior art keywords
- analgesic
- opioid
- moieties
- sulfonamide
- analgesic compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"COMPOSTOS ANALGéSICOS DE LIBERAçãO SUSTENTADA". Um composto inventivo farmaceuticamente ativo compreende duas porções analgésicas independentemente analgésicas covalentemente cojuntadas através de um ligante fisiologicamente eficaz. Uma modalidade preferida compreende um opióide, tal como morfina, covalentemente ligado a pelo menos um composto analgésico selecionado do grupo consistindo em um composto opióide ou um não opióide através de um ligante fisiologicamente fraco. Ligantes covalente adequados são covalentemente ligados a dois compostos analgésicos independentemente ativos através de um ou mais lactona, lactama, ou ligações sulfonamido. Ligantes adequados incluem carboxilato endógeno, amido, e porções sulfonamido, e porções exógenas, que formam as ligações lactona, lactama ou sulfonamido acima mencionadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29555601P | 2001-06-05 | 2001-06-05 | |
PCT/US2002/017613 WO2002098427A2 (en) | 2001-06-05 | 2002-06-05 | Sustained-release analgesic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0210179A true BR0210179A (pt) | 2004-04-27 |
Family
ID=23138201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0210179-3A BR0210179A (pt) | 2001-06-05 | 2002-06-05 | Compostos analgésicos de liberação sustentada |
Country Status (15)
Country | Link |
---|---|
US (1) | US20030022876A1 (pt) |
EP (2) | EP1399161B1 (pt) |
JP (2) | JP4814486B2 (pt) |
KR (1) | KR20040014544A (pt) |
CN (1) | CN1514729B (pt) |
AR (1) | AR034362A1 (pt) |
AT (1) | ATE506064T1 (pt) |
AU (1) | AU2002305816B2 (pt) |
BR (1) | BR0210179A (pt) |
CA (1) | CA2448665C (pt) |
DE (1) | DE60239801D1 (pt) |
IL (1) | IL158882A0 (pt) |
NZ (1) | NZ529661A (pt) |
TW (1) | TWI255186B (pt) |
WO (1) | WO2002098427A2 (pt) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040022853A1 (en) * | 2001-04-26 | 2004-02-05 | Control Delivery Systems, Inc. | Polymer-based, sustained release drug delivery system |
CA2444894C (en) * | 2001-04-26 | 2013-06-25 | Control Delivery Systems, Inc. | Sustained release drug delivery system containing codrugs |
IN2014DN10834A (pt) * | 2001-09-17 | 2015-09-04 | Psivida Inc | |
TW200500067A (en) * | 2003-01-21 | 2005-01-01 | Control Delivery Sys Inc | Salts of codrugs and uses related thereto |
ATE454169T1 (de) * | 2003-03-13 | 2010-01-15 | Controlled Chemicals Inc | Oxycodon- konjugate mit niedrigerem missbrauch- potential und ausgedehnter tätigkeitsdauer |
US20050008695A1 (en) * | 2003-05-21 | 2005-01-13 | Control Delivery Systems, Inc. | Compositions and methods for delivering a biologically active agent |
TWI365880B (en) * | 2004-03-30 | 2012-06-11 | Euro Celtique Sa | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp |
US20060105941A1 (en) * | 2004-11-12 | 2006-05-18 | Allergan, Inc. | Mixed antibiotic codrugs |
AU2005323534A1 (en) * | 2005-01-05 | 2006-07-13 | Philip S. Portoghese | Analgesic conjugates |
US20060281775A1 (en) * | 2005-06-14 | 2006-12-14 | Applied Pharmacy Services, Inc. | Two-component pharmaceutical composition for the treatment of pain |
EP1829878A1 (de) | 2006-03-02 | 2007-09-05 | Universitätsklinikum Freiburg | Neue Morphinverbindungen für pharmazeutische Zusammensetzungen |
US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US20090082314A1 (en) * | 2007-06-29 | 2009-03-26 | The Provost Fellows And Scholars Of The College Of The | Targeting Prodrugs for the Treatment of Gastrointestinal Diseases |
EP2067858A1 (en) | 2007-12-07 | 2009-06-10 | Universidad de Sevilla | Animal models for neurodegenerative diseases |
CA2724788C (en) | 2008-05-20 | 2016-12-06 | Neurogesx, Inc. | Hepatoprotectant acetaminophen mutual prodrugs |
JP5757864B2 (ja) | 2008-05-20 | 2015-08-05 | ニューロジェシックス, インコーポレイテッド | 水溶性アセトアミノフェン類似体 |
MX2010012649A (es) | 2008-05-20 | 2010-12-21 | Neurogesx Inc | Profarmacos de carbonato y metodos para usar los mismos. |
WO2010033195A1 (en) * | 2008-09-16 | 2010-03-25 | Nektar Therapeutics | Pegylated opioids with low potential for abuse |
EP2344447B1 (en) * | 2008-10-08 | 2016-06-08 | Xgene Pharmaceutical Inc | Gaba conjugates and methods of use thereof |
FR2939436B1 (fr) * | 2008-12-10 | 2010-12-17 | Sanofi Aventis | Synthese de morphine-6-glucuronide ou de l'un de ses derives |
UA102916C2 (uk) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань |
WO2011002995A1 (en) | 2009-07-02 | 2011-01-06 | Kempharm, Inc. | Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof |
US10849981B2 (en) | 2009-07-02 | 2020-12-01 | KemPham, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
CA2856608C (en) | 2011-10-26 | 2017-05-16 | Travis Mickle | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof |
US9295731B2 (en) * | 2013-04-01 | 2016-03-29 | Mark Quang Nguyen | Cleavable drug conjugates, compositions thereof and methods of use |
KR101616998B1 (ko) * | 2014-03-18 | 2016-04-29 | 전남대학교병원 | 오피오이드 진통제 및 p7c3를 포함하는 진통제 조성물 |
KR101976101B1 (ko) | 2014-11-25 | 2019-05-09 | 켐팜 인코포레이티드 | 옥시코돈의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트 |
RU2683274C2 (ru) | 2014-12-02 | 2019-03-27 | Кемфарм, Инк. | Бензойная кислота, производные бензойной кислоты и конъюгаты гетероарилкарбоновой кислоты и оксиморфона, их пролекарства, способы получения и применение |
GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
CN107033154B (zh) * | 2016-02-02 | 2020-02-04 | 上海瀚迈生物医药科技有限公司 | 阿片受体拮抗剂缀合物及其应用 |
CN107778187A (zh) * | 2016-08-26 | 2018-03-09 | 江苏恩华药业股份有限公司 | 一种地佐辛晶型a及其制备方法 |
WO2019071246A2 (en) | 2017-10-06 | 2019-04-11 | Foundry Therapeutics, Inc. | IMPLANTABLE DEPOSITS FOR CONTROLLED RELEASE OF ANALGESICS TO TREAT POSTOPERATIVE PAIN, AND DEVICES, SYSTEMS, AND RELATED METHODS |
US10807995B2 (en) | 2018-07-13 | 2020-10-20 | Alkermes Pharma Ireland Limited | Thienothiophene compounds for long-acting injectable compositions and related methods |
US10799496B2 (en) | 2018-07-13 | 2020-10-13 | Alkermes Pharma Ireland Limited | Naphthylenyl compounds for long-acting injectable compositions and related methods |
CN109096191B (zh) * | 2018-10-25 | 2022-03-08 | 西北工业大学 | 氟比洛芬美普他酚酯药用化合物及其制备方法 |
WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
KR102665346B1 (ko) * | 2022-01-04 | 2024-05-13 | 한국생명공학연구원 | 신규한 디클로로페녹시아세트산 유도체 및 이의 용도 |
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US2999102A (en) * | 1959-10-14 | 1961-09-05 | Thomae Gmbh Dr K | Bis-(steroid-21)-dicarboxylic acid esters |
US3147183A (en) * | 1962-04-16 | 1964-09-01 | Boehringer Sohn Ingelheim | Bis-(steroid-21)-dicarboxylic acid esters |
FR2576213B1 (fr) * | 1985-01-21 | 1989-02-24 | Cortial | Nouveau procede d'obtention de formes pharmaceutiques a liberation prolongee |
JPH0232027A (ja) * | 1988-07-19 | 1990-02-01 | Rooman Kogyo:Kk | 鎮痛剤 |
TW225536B (pt) * | 1990-08-23 | 1994-06-21 | Ciba Geigy Ag | |
US5681964A (en) * | 1990-10-23 | 1997-10-28 | University Of Kentucky Research Foundation | Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents |
SE9003665D0 (sv) * | 1990-11-16 | 1990-11-16 | Kabivitrum Ab | Morphine prodrugs |
GB9116909D0 (en) * | 1991-08-06 | 1991-09-18 | Salford Ultrafine Chem & Res | Morphine derivatives |
CA2132342A1 (en) * | 1992-04-06 | 1993-10-14 | Kenneth F. Buechler | Novel opiate derivatives and protein and polypeptide opiate derivative conjugates and labels |
JPH06271578A (ja) * | 1993-03-15 | 1994-09-27 | Natl Sci Council | 鎮痛剤ナルブフィン前薬の誘導体 |
FR2708611B1 (fr) * | 1993-07-29 | 1995-10-27 | Meram Lab | Sel de codéine de l'acide 2-(3-benzoylphényl)propionique, procédé d'obtention et compositions pharmaceutiques le contenant. |
DK0712389T3 (da) * | 1993-08-02 | 2001-06-05 | Commw Scient Ind Res Org | Terapeutisk forbindelse - fedtsyrekonjugater |
US6051576A (en) * | 1994-01-28 | 2000-04-18 | University Of Kentucky Research Foundation | Means to achieve sustained release of synergistic drugs by conjugation |
WO1996022303A1 (en) * | 1995-01-16 | 1996-07-25 | Commonwealth Scientific And Industrial Research Organisation | Therapeutic compound - fatty acid conjugates |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
US5840731A (en) * | 1995-08-02 | 1998-11-24 | Virginia Commonwealth University | Pain-alleviating drug composition and method for alleviating pain |
DE19607395C2 (de) * | 1996-02-28 | 2002-11-21 | Lohmann Therapie Syst Lts | Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate |
ZA979404B (en) * | 1996-10-21 | 1998-06-01 | Cal Internat Ltd | Aspirinate compounds. |
US6225321B1 (en) * | 1997-06-05 | 2001-05-01 | Oliver Yoa-Pu Hu | Long analgesic acting nalbuphine polyester derivative and method of use |
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-
2002
- 2002-06-05 AR ARP020102088A patent/AR034362A1/es unknown
- 2002-06-05 BR BR0210179-3A patent/BR0210179A/pt not_active Application Discontinuation
- 2002-06-05 NZ NZ529661A patent/NZ529661A/xx not_active IP Right Cessation
- 2002-06-05 CA CA2448665A patent/CA2448665C/en not_active Expired - Fee Related
- 2002-06-05 EP EP02734669A patent/EP1399161B1/en not_active Expired - Lifetime
- 2002-06-05 AT AT02734669T patent/ATE506064T1/de not_active IP Right Cessation
- 2002-06-05 EP EP06006592A patent/EP1709957A3/en not_active Ceased
- 2002-06-05 TW TW091112133A patent/TWI255186B/zh not_active IP Right Cessation
- 2002-06-05 IL IL15888202A patent/IL158882A0/xx unknown
- 2002-06-05 KR KR10-2003-7015769A patent/KR20040014544A/ko not_active Application Discontinuation
- 2002-06-05 JP JP2003501466A patent/JP4814486B2/ja not_active Expired - Fee Related
- 2002-06-05 DE DE60239801T patent/DE60239801D1/de not_active Expired - Lifetime
- 2002-06-05 CN CN028114205A patent/CN1514729B/zh not_active Expired - Fee Related
- 2002-06-05 WO PCT/US2002/017613 patent/WO2002098427A2/en active Application Filing
- 2002-06-05 AU AU2002305816A patent/AU2002305816B2/en not_active Ceased
- 2002-06-05 US US10/162,216 patent/US20030022876A1/en not_active Abandoned
-
2010
- 2010-04-08 JP JP2010089721A patent/JP2010155869A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CN1514729B (zh) | 2012-09-05 |
TWI255186B (en) | 2006-05-21 |
JP2004536811A (ja) | 2004-12-09 |
DE60239801D1 (de) | 2011-06-01 |
JP4814486B2 (ja) | 2011-11-16 |
US20030022876A1 (en) | 2003-01-30 |
KR20040014544A (ko) | 2004-02-14 |
CA2448665C (en) | 2013-01-29 |
NZ529661A (en) | 2006-03-31 |
AR034362A1 (es) | 2004-02-18 |
EP1399161A2 (en) | 2004-03-24 |
WO2002098427A3 (en) | 2003-02-20 |
ATE506064T1 (de) | 2011-05-15 |
CA2448665A1 (en) | 2002-12-12 |
CN1514729A (zh) | 2004-07-21 |
IL158882A0 (en) | 2004-05-12 |
EP1709957A3 (en) | 2007-02-14 |
EP1399161B1 (en) | 2011-04-20 |
WO2002098427A2 (en) | 2002-12-12 |
EP1709957A2 (en) | 2006-10-11 |
JP2010155869A (ja) | 2010-07-15 |
AU2002305816B2 (en) | 2008-04-10 |
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