JP2005533804A5 - - Google Patents

Download PDF

Info

Publication number
JP2005533804A5
JP2005533804A5 JP2004515329A JP2004515329A JP2005533804A5 JP 2005533804 A5 JP2005533804 A5 JP 2005533804A5 JP 2004515329 A JP2004515329 A JP 2004515329A JP 2004515329 A JP2004515329 A JP 2004515329A JP 2005533804 A5 JP2005533804 A5 JP 2005533804A5
Authority
JP
Japan
Prior art keywords
formula
compounds
iii
prepared
phosgene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004515329A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005533804A (ja
Filing date
Publication date
Priority claimed from SE0201980A external-priority patent/SE0201980D0/xx
Application filed filed Critical
Publication of JP2005533804A publication Critical patent/JP2005533804A/ja
Publication of JP2005533804A5 publication Critical patent/JP2005533804A5/ja
Pending legal-status Critical Current

Links

JP2004515329A 2002-06-24 2003-06-23 システイン・プロテアーゼ活性に関係する疾患を処置するための新規プリン−もしくはピロール−[2,3−d]ピリミジン−2−カルボニトリル Pending JP2005533804A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0201980A SE0201980D0 (sv) 2002-06-24 2002-06-24 Novel compounds
PCT/SE2003/001079 WO2004000843A1 (en) 2002-06-24 2003-06-23 NOVEL PURINE- OR PYRROLOL[2,3-d]PYRIMIDINE-2-CARBONITILES FOR TREATING DISEASES ASSOCIATED WITH CYSTEINE PROTEASE ACTIVITY

Publications (2)

Publication Number Publication Date
JP2005533804A JP2005533804A (ja) 2005-11-10
JP2005533804A5 true JP2005533804A5 (enExample) 2006-08-10

Family

ID=20288336

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004515329A Pending JP2005533804A (ja) 2002-06-24 2003-06-23 システイン・プロテアーゼ活性に関係する疾患を処置するための新規プリン−もしくはピロール−[2,3−d]ピリミジン−2−カルボニトリル

Country Status (8)

Country Link
US (3) US7439240B2 (enExample)
EP (1) EP1532148B1 (enExample)
JP (1) JP2005533804A (enExample)
AU (1) AU2003243096A1 (enExample)
DE (1) DE60311272T2 (enExample)
ES (1) ES2279162T3 (enExample)
SE (1) SE0201980D0 (enExample)
WO (1) WO2004000843A1 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
AR036375A1 (es) 2001-08-30 2004-09-01 Novartis Ag Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos
SE0201980D0 (sv) * 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
EP1927594A1 (en) 2003-01-14 2008-06-04 Arena Pharmaceuticals, Inc. 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
BRPI0406761A (pt) * 2003-01-14 2005-12-20 Arena Pharm Inc Derivados de arila e heteroarila 1,2,3-trissubstituìdos como moduladores do metabolismo e a profilaxia e tratamento de distúrbios relacionados a estes tais como diabetes e hiper-glicemia
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
AR045697A1 (es) 2003-07-14 2005-11-09 Arena Pharm Inc Aril y heteroaril derivados fusionados como moduladores del metabolismo y la prevencion y tratamiento de trastornos relacionados con el mismo
EP1724264A1 (en) * 2004-03-10 2006-11-22 Ono Pharmaceutical Co., Ltd. Nitriles and medicinal compositions containing the same as the active ingredient
TW200614993A (en) 2004-06-11 2006-05-16 Akzo Nobel Nv 4-phenyl-pyrimidine-2-carbonitrile derivatives
US7326715B2 (en) 2005-09-23 2008-02-05 N.V. Organon 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
TW200745055A (en) * 2005-09-23 2007-12-16 Organon Nv 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
TW200734338A (en) * 2006-01-16 2007-09-16 Organon Nv 6-Phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives
US7687515B2 (en) 2006-01-17 2010-03-30 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
EP2035422A1 (en) * 2006-06-23 2009-03-18 AstraZeneca AB Pteridine derivatives and their use as cathespin inhibitors
US20080269241A1 (en) * 2007-02-15 2008-10-30 Darin Allen Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20090118274A1 (en) * 2007-02-15 2009-05-07 Darin Allen Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20090099157A1 (en) * 2007-02-15 2009-04-16 Ameriks Michael K Tetrahydro-pyrazolo-pyridine thioether modulators of cathepsin s
US20080200454A1 (en) * 2007-02-15 2008-08-21 Ameriks Michael K Carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20080207683A1 (en) * 2007-02-15 2008-08-28 Darin Allen Biaryl-substituted tetrahydro-pyrazolo-pyridine modulators of cathepsin s
EP1972630A1 (en) * 2007-03-02 2008-09-24 Glaxo Group Limited Purines as cysteine protease inhibitors
EP2118106A1 (en) * 2007-03-02 2009-11-18 Glaxo Group Limited Purines as cysteine protease inhibitors
TW200911803A (en) * 2007-07-16 2009-03-16 Organon Nv 6-phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives
US7932251B2 (en) 2007-07-16 2011-04-26 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
WO2009107767A1 (ja) * 2008-02-29 2009-09-03 大日本住友製薬株式会社 H4受容体アンタゴニスト作用を有する新規2環性ピリミジン誘導体
JP5575110B2 (ja) 2008-04-21 2014-08-20 レクシコン ファーマシューティカルズ インコーポレイテッド Limk2阻害剤、それらを含む組成物、及びそれらの使用の方法
WO2010059418A1 (en) * 2008-11-19 2010-05-27 The Government Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health & Human Services Substituted triazine and purine compounds, methods of inhibiting cruzain and rhodesain and methods of treating chagas disease and african trypanosomiasis
US8026236B2 (en) 2009-01-16 2011-09-27 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
TW201035094A (en) 2009-01-16 2010-10-01 Organon Nv 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
GB0917934D0 (en) 2009-10-13 2009-11-25 Syngenta Ltd Herbicidal compounds
US9115126B2 (en) 2010-01-15 2015-08-25 Merck Sharp & Dohme B.V. 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derivatives
SG188548A1 (en) 2010-09-22 2013-04-30 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
EP3091085B1 (en) 2010-10-06 2019-02-27 Institució Catalana de Recerca I Estudis Avançats Method of designing a therapy for breast cancer metastasis
EP2650682A1 (en) 2012-04-09 2013-10-16 Fundació Privada Institut de Recerca Biomèdica Method for the prognosis and treatment of cancer metastasis
MX355055B (es) 2012-04-17 2018-04-03 Astellas Pharma Inc Compuesto heterociclico aromatico biciclico nitrogenado.
CA2875918A1 (en) 2012-06-06 2013-12-12 Fundacio Institut De Recerca Biomedica (Irb Barcelona) Method for the diagnosis, prognosis and treatment of lung cancer metastasis
US10119171B2 (en) 2012-10-12 2018-11-06 Inbiomotion S.L. Method for the diagnosis, prognosis and treatment of prostate cancer metastasis
HK1213946A1 (zh) 2012-10-12 2016-07-15 Inbiomotion S.L. 用於使用c-maf对前列腺癌转移进行诊断、预後和治疗的方法
ES2652514T3 (es) 2012-11-08 2018-02-02 Pfizer Inc. Compuestos heteroaromáticos como ligandos de dopamina D1
US20160032399A1 (en) 2013-03-15 2016-02-04 Inbiomotion S.L. Method for the Prognosis and Treatment of Renal Cell Carcinoma Metastasis
BR112015023783A2 (pt) 2013-03-15 2017-10-24 Fundacio Inst De Recerca Biomedica Irb Barcelona método para diagnóstico e tratamento de metastase no câncer
JP6550045B2 (ja) 2013-10-09 2019-07-24 フンダシオ、インスティトゥト、デ、レセルカ、ビオメディカ(イエレベ、バルセロナ)Fundacio Institut De Recerca Biomedica (Irb Barcelona) 乳がんに由来する骨の転移がんの予後診断および処置のための方法
EP3137469B1 (en) 2014-04-28 2019-10-09 Pfizer Inc Heterocyclic compounds and their use as dopamine d1 ligands
SG11201700777VA (en) 2014-08-04 2017-02-27 Nuevolution As Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
AU2015358868A1 (en) 2014-12-11 2017-06-01 Inbiomotion S.L. Binding members for human C-Maf
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
CA3002551A1 (en) 2015-06-22 2016-12-29 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(com pound 1)for use in s1p1 receptor-associated disorders
PL3458610T3 (pl) 2016-05-25 2021-11-22 Inbiomotion S.L. Leczenie raka piersi w oparciu o status c-MAF
CA3053418A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
US11654153B2 (en) 2017-11-22 2023-05-23 Inbiomotion S.L. Therapeutic treatment of breast cancer based on c-MAF status
KR102054910B1 (ko) * 2017-12-19 2019-12-12 한림제약(주) 피롤로[2,3-d]피리미딘 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
CA3102136A1 (en) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
US12350260B2 (en) 2019-04-05 2025-07-08 Universite De Bretagne Occidentale Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning
TWI872177B (zh) 2019-12-20 2025-02-11 丹麥商紐韋盧森公司 對核受體具有活性之化合物
US11447479B2 (en) 2019-12-20 2022-09-20 Nuevolution A/S Compounds active towards nuclear receptors
CA3174176A1 (en) 2020-03-31 2021-10-07 Sanne Schroder Glad Compounds active towards nuclear receptors
JP7713953B2 (ja) 2020-03-31 2025-07-28 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性な化合物
WO2024105159A1 (en) * 2022-11-16 2024-05-23 University Of Zurich Ligands of the m6a-rna readers

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1362947A (zh) * 1999-03-15 2002-08-07 Axys药物公司 用作蛋白酶抑制剂的n-氰基甲基酰胺
JP2001011037A (ja) * 1999-07-01 2001-01-16 Kissei Pharmaceut Co Ltd シクロアルカンカルボン酸アミド誘導体
WO2001044257A1 (en) * 1999-12-17 2001-06-21 Ariad Pharmaceuticals, Inc. Proton pump inhibitors
SK10882002A3 (sk) * 2000-02-04 2003-10-07 Pfizer Products Inc. Heterocyklické amidové deriváty
US6921753B2 (en) * 2000-06-27 2005-07-26 Pfizer Inc Purine derivatives
GB0015727D0 (en) * 2000-06-27 2000-08-16 Pfizer Ltd Purine derivatives
WO2002032879A1 (en) * 2000-10-19 2002-04-25 Naeja Pharmaceutical Inc. Dihydropyrimidine derivatives as cysteine protease inhibitors
GB0121033D0 (en) 2001-08-30 2001-10-24 Novartis Ag Organic compounds
AR036375A1 (es) 2001-08-30 2004-09-01 Novartis Ag Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos
SE0201976D0 (sv) * 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
SE0201980D0 (sv) * 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
GB0220187D0 (en) * 2002-08-30 2002-10-09 Novartis Ag Organic compounds
AR043692A1 (es) 2003-02-06 2005-08-10 Novartis Ag 2-cianopirrolopirimidinas y sus usos farmaceuticos
GB0304640D0 (en) 2003-02-28 2003-04-02 Novartis Ag Organic compounds
EP1724264A1 (en) 2004-03-10 2006-11-22 Ono Pharmaceutical Co., Ltd. Nitriles and medicinal compositions containing the same as the active ingredient
WO2006040300A1 (en) 2004-10-12 2006-04-20 N.V. Organon 4-cycloalkyl-pyrimidine-2-carbonitrile derivatives

Similar Documents

Publication Publication Date Title
JP2005533804A5 (enExample)
JP2009538336A5 (enExample)
JP2005523310A5 (enExample)
JP2005502658A5 (enExample)
JP2009537469A5 (enExample)
JP2007523139A5 (enExample)
JP2005053931A5 (enExample)
EP2261218A3 (en) Process for preparing phenyl-, pyridinyl- or pyrimidinyl-substituted imidazoles
EP1241528A3 (en) Radical polymerizable compounds for image forming materials
CA2454306A1 (en) Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates their preparation and use
JP2004536811A5 (enExample)
JP2011519910A5 (enExample)
EP2308828A3 (en) CaSR antagonist
WO2004020430A3 (fr) Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
EP1591832A3 (en) Photosensitive composition, compound used in the same, and patterning method using the same
JP2006520417A5 (enExample)
JP2006508979A5 (enExample)
EP1849788A8 (en) Organosilicon compound
JP2005517008A5 (enExample)
JP2005538088A5 (enExample)
JP2004531527A5 (enExample)
EP2088142A3 (en) Dihydropyrimidines, process for their preparation and use thereof.
CA2461060A1 (en) Method for preparing pyrimidinone compound and pharmaceutically acceptable salts thereof
JP2004524408A5 (enExample)
JP2005514512A5 (enExample)