JP2004131511A5 - - Google Patents
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- Publication number
- JP2004131511A5 JP2004131511A5 JP2004017703A JP2004017703A JP2004131511A5 JP 2004131511 A5 JP2004131511 A5 JP 2004131511A5 JP 2004017703 A JP2004017703 A JP 2004017703A JP 2004017703 A JP2004017703 A JP 2004017703A JP 2004131511 A5 JP2004131511 A5 JP 2004131511A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- following structure
- compound according
- alkyl
- halide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000004820 halides Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41051895A | 1995-03-24 | 1995-03-24 | |
| US54900695A | 1995-10-27 | 1995-10-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000079170A Division JP2000319295A (ja) | 1995-03-24 | 2000-03-21 | βシート模倣物およびプロテアーゼインヒビターとしてのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004131511A JP2004131511A (ja) | 2004-04-30 |
| JP2004131511A5 true JP2004131511A5 (enExample) | 2007-01-18 |
| JP4152900B2 JP4152900B2 (ja) | 2008-09-17 |
Family
ID=27021026
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8529594A Withdrawn JPH10508035A (ja) | 1995-03-24 | 1996-03-25 | βシート模倣物およびプロテアーゼインヒビターとしてのその使用 |
| JP8529567A Pending JPH10508034A (ja) | 1995-03-24 | 1996-03-25 | βシート模倣物および生物学的に活性なペプチドまたはタンパク質のインヒビターとしてのその使用 |
| JP2000079170A Withdrawn JP2000319295A (ja) | 1995-03-24 | 2000-03-21 | βシート模倣物およびプロテアーゼインヒビターとしてのその使用 |
| JP2004017703A Expired - Lifetime JP4152900B2 (ja) | 1995-03-24 | 2004-01-26 | βシート模倣物およびプロテアーゼインヒビターとしてのその使用 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8529594A Withdrawn JPH10508035A (ja) | 1995-03-24 | 1996-03-25 | βシート模倣物およびプロテアーゼインヒビターとしてのその使用 |
| JP8529567A Pending JPH10508034A (ja) | 1995-03-24 | 1996-03-25 | βシート模倣物および生物学的に活性なペプチドまたはタンパク質のインヒビターとしてのその使用 |
| JP2000079170A Withdrawn JP2000319295A (ja) | 1995-03-24 | 2000-03-21 | βシート模倣物およびプロテアーゼインヒビターとしてのその使用 |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP0817642A1 (enExample) |
| JP (4) | JPH10508035A (enExample) |
| AT (1) | ATE206433T1 (enExample) |
| AU (2) | AU713530B2 (enExample) |
| CA (2) | CA2215695C (enExample) |
| DE (1) | DE69615671T2 (enExample) |
| ES (1) | ES2161354T3 (enExample) |
| WO (1) | WO1996030035A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7604196A (en) * | 1995-10-30 | 1997-05-22 | Merck & Co., Inc. | Novel inhibitors of peptide binding to mhc class ii proteins |
| US5817757A (en) * | 1995-10-30 | 1998-10-06 | Merck & Co., Inc. | Inhibitors of peptide binding to MHO class II proteins |
| US5840835A (en) * | 1995-10-30 | 1998-11-24 | Merck & Co., Inc. | Inhibitors of peptide binding to MHC class II proteins |
| US5719296A (en) * | 1995-10-30 | 1998-02-17 | Merck & Co., Inc. | Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins |
| GB9702377D0 (en) * | 1996-02-23 | 1997-03-26 | Zeneca Ltd | Peptide derivatives |
| ATE283278T1 (de) | 1996-06-07 | 2004-12-15 | Astrazeneca Ab | Peptid derivate |
| AU733562B2 (en) * | 1996-06-18 | 2001-05-17 | Warner-Lambert Company | Process for the preparation of chiral keto-heterocycles of basic amino acids |
| EP1661566A3 (en) * | 1996-08-05 | 2008-04-16 | Myriad Genetics, Inc. | Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors |
| ATE320811T1 (de) * | 1996-08-05 | 2006-04-15 | Myriad Genetics Inc | Verwendung von beta-blatt mimetika als protease und kinase hemmer und alshemmer eines transkriptionsfaktors |
| GB9621836D0 (en) | 1996-10-19 | 1996-12-11 | Zeneca Ltd | Peptide compounds |
| GB9624562D0 (en) | 1996-11-27 | 1997-01-15 | Zeneca Ltd | Peptide derivatives |
| GB9625865D0 (en) * | 1996-12-12 | 1997-01-29 | Zeneca Ltd | Peptides |
| ATE230414T1 (de) * | 1998-02-12 | 2003-01-15 | Molecumetics Ltd | Mimetika von beta-faltblatt und verfahren zur verwendung davon |
| US6323219B1 (en) | 1998-04-02 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for treating immunomediated inflammatory disorders |
| US8106094B2 (en) | 1998-07-06 | 2012-01-31 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for treating skin conditions |
| US8093293B2 (en) | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
| BR0007778A (pt) | 1999-01-27 | 2002-06-04 | Ortho Mcneil Pharm Inc | Peptidila cetonas heterocìclicas úteis como inibidores de triptase |
| US7309688B2 (en) | 2000-10-27 | 2007-12-18 | Johnson & Johnson Consumer Companies | Topical anti-cancer compositions and methods of use thereof |
| JP2003525294A (ja) * | 2000-02-29 | 2003-08-26 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Ｃ型肝炎ウイルスｎｓ３プロテアーゼの阻害剤 |
| US8431550B2 (en) | 2000-10-27 | 2013-04-30 | Johnson & Johnson Consumer Companies, Inc. | Topical anti-cancer compositions and methods of use thereof |
| US7192615B2 (en) | 2001-02-28 | 2007-03-20 | J&J Consumer Companies, Inc. | Compositions containing legume products |
| US20120296067A1 (en) | 2010-02-03 | 2012-11-22 | Prism BioLab Co., Ltd. | Compound capable of binding to naturally occurring denatured protein, and method for screening for the compound |
| KR20170068521A (ko) | 2014-10-06 | 2017-06-19 | 코텍자임, 인코포레이티드 | 리신 진지페인의 억제제 |
| CA3004095A1 (en) | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
| WO2018053353A1 (en) | 2016-09-16 | 2018-03-22 | Cortexyme, Inc. | Ketone inhibitors of lysine gingipain |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA896851B (en) * | 1988-09-14 | 1990-06-27 | Hoffmann La Roche | Use of ace-inhibitors |
-
1996
- 1996-03-25 JP JP8529594A patent/JPH10508035A/ja not_active Withdrawn
- 1996-03-25 WO PCT/US1996/004044 patent/WO1996030035A1/en not_active Ceased
- 1996-03-25 JP JP8529567A patent/JPH10508034A/ja active Pending
- 1996-03-25 AU AU53729/96A patent/AU713530B2/en not_active Ceased
- 1996-03-25 CA CA002215695A patent/CA2215695C/en not_active Expired - Fee Related
- 1996-03-25 EP EP96910547A patent/EP0817642A1/en not_active Withdrawn
- 1996-03-25 ES ES96910566T patent/ES2161354T3/es not_active Expired - Lifetime
- 1996-03-25 AU AU53714/96A patent/AU712581B2/en not_active Ceased
- 1996-03-25 CA CA002215720A patent/CA2215720A1/en not_active Abandoned
- 1996-03-25 EP EP96910566A patent/EP0815123B1/en not_active Expired - Lifetime
- 1996-03-25 AT AT96910566T patent/ATE206433T1/de not_active IP Right Cessation
- 1996-03-25 DE DE69615671T patent/DE69615671T2/de not_active Expired - Fee Related
-
2000
- 2000-03-21 JP JP2000079170A patent/JP2000319295A/ja not_active Withdrawn
-
2004
- 2004-01-26 JP JP2004017703A patent/JP4152900B2/ja not_active Expired - Lifetime
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