ATE206433T1 - Beta-schleifenähnliche verbindungen und deren verwendung als protease-inhibitoren - Google Patents

Beta-schleifenähnliche verbindungen und deren verwendung als protease-inhibitoren

Info

Publication number
ATE206433T1
ATE206433T1 AT96910566T AT96910566T ATE206433T1 AT E206433 T1 ATE206433 T1 AT E206433T1 AT 96910566 T AT96910566 T AT 96910566T AT 96910566 T AT96910566 T AT 96910566T AT E206433 T1 ATE206433 T1 AT E206433T1
Authority
AT
Austria
Prior art keywords
beta
compounds
protease inhibitors
sheet
mhc
Prior art date
Application number
AT96910566T
Other languages
English (en)
Inventor
Michael Kahn
Original Assignee
Molecumetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecumetics Ltd filed Critical Molecumetics Ltd
Priority claimed from PCT/US1996/004115 external-priority patent/WO1996030396A1/en
Application granted granted Critical
Publication of ATE206433T1 publication Critical patent/ATE206433T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT96910566T 1995-03-24 1996-03-25 Beta-schleifenähnliche verbindungen und deren verwendung als protease-inhibitoren ATE206433T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41051895A 1995-03-24 1995-03-24
US54900695A 1995-10-27 1995-10-27
PCT/US1996/004115 WO1996030396A1 (en) 1995-03-24 1996-03-25 β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS

Publications (1)

Publication Number Publication Date
ATE206433T1 true ATE206433T1 (de) 2001-10-15

Family

ID=27021026

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96910566T ATE206433T1 (de) 1995-03-24 1996-03-25 Beta-schleifenähnliche verbindungen und deren verwendung als protease-inhibitoren

Country Status (8)

Country Link
EP (2) EP0815123B1 (de)
JP (4) JPH10508034A (de)
AT (1) ATE206433T1 (de)
AU (2) AU713530B2 (de)
CA (2) CA2215695C (de)
DE (1) DE69615671T2 (de)
ES (1) ES2161354T3 (de)
WO (1) WO1996030035A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817757A (en) * 1995-10-30 1998-10-06 Merck & Co., Inc. Inhibitors of peptide binding to MHO class II proteins
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
AU7604196A (en) * 1995-10-30 1997-05-22 Merck & Co., Inc. Novel inhibitors of peptide binding to mhc class ii proteins
US5840835A (en) * 1995-10-30 1998-11-24 Merck & Co., Inc. Inhibitors of peptide binding to MHC class II proteins
GB9702377D0 (en) * 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives
US6541453B2 (en) 1996-06-07 2003-04-01 Syngenta Limited Peptide derivatives
NZ332740A (en) 1996-06-18 2000-05-26 Warner Lambert Co heterocyclically substituted carbamate or sulphonamide derivatives
DE69735545T2 (de) * 1996-08-05 2006-08-10 Myriad Genetics, Inc., Salt Lake City Verwendung von beta-blatt mimetika als protease und kinase hemmer und alshemmer eines transkriptionsfaktors
EP1661566A3 (de) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Verwendung von Beta-Blatt Mimetika als Protease und Kinase Hemmer sowie als Hemmer eines Transkriptionsfaktors
GB9621836D0 (en) 1996-10-19 1996-12-11 Zeneca Ltd Peptide compounds
GB9624562D0 (en) 1996-11-27 1997-01-15 Zeneca Ltd Peptide derivatives
GB9625865D0 (en) * 1996-12-12 1997-01-29 Zeneca Ltd Peptides
ATE230414T1 (de) * 1998-02-12 2003-01-15 Molecumetics Ltd Mimetika von beta-faltblatt und verfahren zur verwendung davon
US6323219B1 (en) 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
HUP0201295A3 (en) 1999-01-27 2002-10-28 Ortho Mcneil Pharm Inc Peptidyl heterocyclic ketones useful as tryptase inhibitors
WO2001064678A2 (en) * 2000-02-29 2001-09-07 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US7192615B2 (en) 2001-02-28 2007-03-20 J&J Consumer Companies, Inc. Compositions containing legume products
US20120296067A1 (en) 2010-02-03 2012-11-22 Prism BioLab Co., Ltd. Compound capable of binding to naturally occurring denatured protein, and method for screening for the compound
PT3204352T (pt) 2014-10-06 2020-09-23 Cortexyme Inc Inibidores de lisina-gingipaína
JP6877424B2 (ja) 2015-11-09 2021-05-26 コーテクシーミー， インコーポレイテッド アルギニンジンジパインの阻害剤
TWI787202B (zh) 2016-09-16 2022-12-21 美商昆斯治療公司 離胺酸牙齦蛋白酶（gingipain）之酮抑制劑

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA896851B (en) * 1988-09-14 1990-06-27 Hoffmann La Roche Use of ace-inhibitors

Also Published As

Publication number Publication date
EP0815123B1 (de) 2001-10-04
AU712581B2 (en) 1999-11-11
CA2215695C (en) 2003-09-16
EP0815123A1 (de) 1998-01-07
JP4152900B2 (ja) 2008-09-17
JPH10508035A (ja) 1998-08-04
WO1996030035A1 (en) 1996-10-03
JPH10508034A (ja) 1998-08-04
JP2000319295A (ja) 2000-11-21
JP2004131511A (ja) 2004-04-30
EP0817642A1 (de) 1998-01-14
DE69615671D1 (de) 2001-11-08
DE69615671T2 (de) 2002-08-08
AU5371496A (en) 1996-10-16
CA2215720A1 (en) 1996-10-03
ES2161354T3 (es) 2001-12-01
CA2215695A1 (en) 1996-10-03
AU713530B2 (en) 1999-12-02
AU5372996A (en) 1996-10-16

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Legal Events

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