JPH10508034A - βシート模倣物および生物学的に活性なペプチドまたはタンパク質のインヒビターとしてのその使用 - Google Patents

βシート模倣物および生物学的に活性なペプチドまたはタンパク質のインヒビターとしてのその使用

Info

Publication number
JPH10508034A
JPH10508034A JP8529567A JP52956796A JPH10508034A JP H10508034 A JPH10508034 A JP H10508034A JP 8529567 A JP8529567 A JP 8529567A JP 52956796 A JP52956796 A JP 52956796A JP H10508034 A JPH10508034 A JP H10508034A
Authority
JP
Japan
Prior art keywords
sheet
solution
mmol
synthesis
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8529567A
Other languages
English (en)
Japanese (ja)
Inventor
マイケル カーン，
Original Assignee
モレキュメティックス リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by モレキュメティックス リミテッド filed Critical モレキュメティックス リミテッド
Publication of JPH10508034A publication Critical patent/JPH10508034A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Paper (AREA)
JP8529567A 1995-03-24 1996-03-25 βシート模倣物および生物学的に活性なペプチドまたはタンパク質のインヒビターとしてのその使用 Pending JPH10508034A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41051895A 1995-03-24 1995-03-24
US54900695A 1995-10-27 1995-10-27
US08/549,006 1995-10-27
US08/410,518 1995-10-27
PCT/US1996/004044 WO1996030035A1 (en) 1995-03-24 1996-03-25 β-SHEET MIMETICS AND USE THEREOF AS INHIBITORS OF BIOLOGICALLY ACTIVE PEPTIDES OR PROTEINS

Publications (1)

Publication Number Publication Date
JPH10508034A true JPH10508034A (ja) 1998-08-04

Family

ID=27021026

Family Applications (4)

Application Number Title Priority Date Filing Date
JP8529567A Pending JPH10508034A (ja) 1995-03-24 1996-03-25 βシート模倣物および生物学的に活性なペプチドまたはタンパク質のインヒビターとしてのその使用
JP8529594A Withdrawn JPH10508035A (ja) 1995-03-24 1996-03-25 βシート模倣物およびプロテアーゼインヒビターとしてのその使用
JP2000079170A Withdrawn JP2000319295A (ja) 1995-03-24 2000-03-21 βシート模倣物およびプロテアーゼインヒビターとしてのその使用
JP2004017703A Expired - Lifetime JP4152900B2 (ja) 1995-03-24 2004-01-26 βシート模倣物およびプロテアーゼインヒビターとしてのその使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP8529594A Withdrawn JPH10508035A (ja) 1995-03-24 1996-03-25 βシート模倣物およびプロテアーゼインヒビターとしてのその使用
JP2000079170A Withdrawn JP2000319295A (ja) 1995-03-24 2000-03-21 βシート模倣物およびプロテアーゼインヒビターとしてのその使用
JP2004017703A Expired - Lifetime JP4152900B2 (ja) 1995-03-24 2004-01-26 βシート模倣物およびプロテアーゼインヒビターとしてのその使用

Country Status (8)

Country Link
EP (2) EP0815123B1 (enExample)
JP (4) JPH10508034A (enExample)
AT (1) ATE206433T1 (enExample)
AU (2) AU712581B2 (enExample)
CA (2) CA2215695C (enExample)
DE (1) DE69615671T2 (enExample)
ES (1) ES2161354T3 (enExample)
WO (1) WO1996030035A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840835A (en) * 1995-10-30 1998-11-24 Merck & Co., Inc. Inhibitors of peptide binding to MHC class II proteins
US5817757A (en) * 1995-10-30 1998-10-06 Merck & Co., Inc. Inhibitors of peptide binding to MHO class II proteins
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
WO1997016425A1 (en) * 1995-10-30 1997-05-09 Merck & Co., Inc. Novel inhibitors of peptide binding to mhc class ii proteins
GB9702377D0 (en) * 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives
NZ332347A (en) 1996-06-07 2000-05-26 Zeneca Ltd Peptide derivatives containing a hydrophobic group, L-amino acid residues and modified L-amino acid residues
JP2000513354A (ja) 1996-06-18 2000-10-10 ワーナー―ランバート・コンパニー キラルな塩基性アミノ酸ケト―複素環化合物の製造方法
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
ATE320811T1 (de) * 1996-08-05 2006-04-15 Myriad Genetics Inc Verwendung von beta-blatt mimetika als protease und kinase hemmer und alshemmer eines transkriptionsfaktors
GB9621836D0 (en) 1996-10-19 1996-12-11 Zeneca Ltd Peptide compounds
GB9624562D0 (en) * 1996-11-27 1997-01-15 Zeneca Ltd Peptide derivatives
GB9625865D0 (en) * 1996-12-12 1997-01-29 Zeneca Ltd Peptides
EP1053246B1 (en) * 1998-02-12 2003-01-02 Molecumetics, Ltd. Beta-sheet mimetics and methods relating to the use thereof
US6323219B1 (en) 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
CA2361479A1 (en) 1999-01-27 2000-08-03 Ortho-Mcneil Pharmaceutical, Inc. Peptidyl heterocyclic ketones useful as tryptase inhibitors
US7309688B2 (en) 2000-10-27 2007-12-18 Johnson & Johnson Consumer Companies Topical anti-cancer compositions and methods of use thereof
AU2001245356A1 (en) * 2000-02-29 2001-09-12 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US7192615B2 (en) 2001-02-28 2007-03-20 J&J Consumer Companies, Inc. Compositions containing legume products
JPWO2011096440A1 (ja) 2010-02-03 2013-06-10 株式会社 ＰＲＩＳＭ ＢｉｏＬａｂ 天然変性タンパク質に結合する化合物およびそのスクリーニング方法
CA2963305A1 (en) 2014-10-06 2016-04-14 Cortexyme, Inc. Inhibitors of lysine gingipain
CA3004095A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
CA3036862A1 (en) 2016-09-16 2018-03-22 Cortexyme, Inc. Ketone inhibitors of lysine gingipain

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA896851B (en) * 1988-09-14 1990-06-27 Hoffmann La Roche Use of ace-inhibitors

Also Published As

Publication number Publication date
AU5372996A (en) 1996-10-16
ATE206433T1 (de) 2001-10-15
JP4152900B2 (ja) 2008-09-17
DE69615671T2 (de) 2002-08-08
CA2215720A1 (en) 1996-10-03
AU712581B2 (en) 1999-11-11
CA2215695C (en) 2003-09-16
AU5371496A (en) 1996-10-16
AU713530B2 (en) 1999-12-02
JPH10508035A (ja) 1998-08-04
ES2161354T3 (es) 2001-12-01
EP0815123B1 (en) 2001-10-04
EP0817642A1 (en) 1998-01-14
JP2004131511A (ja) 2004-04-30
WO1996030035A1 (en) 1996-10-03
CA2215695A1 (en) 1996-10-03
JP2000319295A (ja) 2000-11-21
DE69615671D1 (de) 2001-11-08
EP0815123A1 (en) 1998-01-07

Similar Documents

Publication Publication Date Title
JPH10508034A (ja) βシート模倣物および生物学的に活性なペプチドまたはタンパク質のインヒビターとしてのその使用
AU732174B2 (en) Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
US6245764B1 (en) β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6372744B1 (en) β-sheet mimetics and methods relating to the use thereof
WO1996030396A1 (en) β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
US6586426B1 (en) β-sheet mimetics and use thereof as protease inhibitors
AU748887B2 (en) Beta-sheet mimetics and methods relating to the use thereof
US6699869B1 (en) β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US20030191109A1 (en) Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
AU733205B2 (en) Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
EP1661566A2 (en) Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
AU5421301A (en) Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors