CN102272101A - 用于癌症治疗和成像的ca-ix特异性放射性药物 - Google Patents

用于癌症治疗和成像的ca-ix特异性放射性药物 Download PDF

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CN102272101A
CN102272101A CN2009801538771A CN200980153877A CN102272101A CN 102272101 A CN102272101 A CN 102272101A CN 2009801538771 A CN2009801538771 A CN 2009801538771A CN 200980153877 A CN200980153877 A CN 200980153877A CN 102272101 A CN102272101 A CN 102272101A
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alkyl
amino
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J·W·巴比克
C·齐默曼
J·乔亚尔
K·P·玛勒斯卡
G·陆
S·希利尔
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Molecular Insight Pharmaceuticals Inc
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Molecular Insight Pharmaceuticals Inc
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
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    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN2009801538771A 2008-12-05 2009-12-04 用于癌症治疗和成像的ca-ix特异性放射性药物 Pending CN102272101A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12022608P 2008-12-05 2008-12-05
US61/120,226 2008-12-05
US18034109P 2009-05-21 2009-05-21
US61/180,341 2009-05-21
PCT/US2009/066842 WO2010065906A2 (en) 2008-12-05 2009-12-04 Ca-ix specific radiopharmaceuticals for the treatment and imaging of cancer

Publications (1)

Publication Number Publication Date
CN102272101A true CN102272101A (zh) 2011-12-07

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Application Number Title Priority Date Filing Date
CN2009801538771A Pending CN102272101A (zh) 2008-12-05 2009-12-04 用于癌症治疗和成像的ca-ix特异性放射性药物
CN2009801538786A Pending CN102272102A (zh) 2008-12-05 2009-12-04 锝-和铼-双(杂芳基)络合物及其使用方法
CN200980153722.8A Active CN102272100B (zh) 2008-12-05 2009-12-04 用于抑制psma的锝-和铼-双(杂芳基)络合物及其使用方法

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CN2009801538786A Pending CN102272102A (zh) 2008-12-05 2009-12-04 锝-和铼-双(杂芳基)络合物及其使用方法
CN200980153722.8A Active CN102272100B (zh) 2008-12-05 2009-12-04 用于抑制psma的锝-和铼-双(杂芳基)络合物及其使用方法

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US (1) US8211401B2 (enExample)
EP (4) EP2373622A2 (enExample)
JP (4) JP5220203B2 (enExample)
CN (3) CN102272101A (enExample)
AU (3) AU2009322171A1 (enExample)
BR (3) BRPI0922839A2 (enExample)
CA (3) CA2745955C (enExample)
ES (2) ES2595128T3 (enExample)
HU (2) HUE029940T2 (enExample)
PL (2) PL2389361T3 (enExample)
RU (3) RU2539584C2 (enExample)
TW (3) TW201034690A (enExample)
WO (1) WO2010065902A2 (enExample)

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