JP5220203B2 - テクネチウム−及びレニウム−ビス（ヘテロアリール）錯体及びｐｓｍａを阻害するその使用方法 - Google Patents

テクネチウム−及びレニウム−ビス（ヘテロアリール）錯体及びｐｓｍａを阻害するその使用方法 Download PDF

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JP5220203B2
JP5220203B2 JP2011539755A JP2011539755A JP5220203B2 JP 5220203 B2 JP5220203 B2 JP 5220203B2 JP 2011539755 A JP2011539755 A JP 2011539755A JP 2011539755 A JP2011539755 A JP 2011539755A JP 5220203 B2 JP5220203 B2 JP 5220203B2
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compound
tert
amino
integer
oxoethyl
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JP2012511023A5 (enExample
JP2012511023A (ja
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バビッチ，ジョン，ダブリュ．
ツィマーマン，クレイグ
ジョヤル，ジョン
マレスカ，ケヴィン，ピー．
ルー，ジャンリン
ヒリアー，ショーン
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モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
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    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
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    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P35/00—Antineoplastic agents
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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2011539755A 2008-12-05 2009-12-04 テクネチウム−及びレニウム−ビス（ヘテロアリール）錯体及びｐｓｍａを阻害するその使用方法 Active JP5220203B2 (ja)

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US12022608P 2008-12-05 2008-12-05
US61/120,226 2008-12-05
US18034109P 2009-05-21 2009-05-21
US61/180,341 2009-05-21
PCT/US2009/066836 WO2010065902A2 (en) 2008-12-05 2009-12-04 Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting psma

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JP2012511023A JP2012511023A (ja) 2012-05-17
JP2012511023A5 JP2012511023A5 (enExample) 2012-11-01
JP5220203B2 true JP5220203B2 (ja) 2013-06-26

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JP2011539755A Active JP5220203B2 (ja) 2008-12-05 2009-12-04 テクネチウム−及びレニウム−ビス（ヘテロアリール）錯体及びｐｓｍａを阻害するその使用方法
JP2011539752A Pending JP2012511022A (ja) 2008-12-05 2009-12-04 テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法
JP2011539757A Ceased JP2012511024A (ja) 2008-12-05 2009-12-04 癌の治療及び撮像用のｃａ−ｉｘ特異性放射性医薬品
JP2014145241A Active JP5856247B2 (ja) 2008-12-05 2014-07-15 テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法

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JP2011539757A Ceased JP2012511024A (ja) 2008-12-05 2009-12-04 癌の治療及び撮像用のｃａ−ｉｘ特異性放射性医薬品
JP2014145241A Active JP5856247B2 (ja) 2008-12-05 2014-07-15 テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法

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US (1) US8211401B2 (enExample)
EP (4) EP2389361B1 (enExample)
JP (4) JP5220203B2 (enExample)
CN (3) CN102272101A (enExample)
AU (3) AU2009322167B2 (enExample)
BR (3) BRPI0922779A8 (enExample)
CA (3) CA2745918C (enExample)
ES (2) ES2574514T3 (enExample)
HU (2) HUE029940T2 (enExample)
PL (2) PL2706057T3 (enExample)
RU (3) RU2539565C2 (enExample)
TW (3) TW201034689A (enExample)
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JP2014240394A (ja) * 2008-12-05 2014-12-25 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法
US9422251B2 (en) 2012-01-06 2016-08-23 Molecular Insight Pharmaceuticals, Inc. Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX
US9433594B2 (en) 2008-01-09 2016-09-06 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
US9447121B2 (en) 2013-01-14 2016-09-20 Molecular Insight Pharmaceuticals, Inc. Triazine based radiopharmaceuticals and radioimaging agents

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US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
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JP5843338B2 (ja) * 2011-08-05 2016-01-13 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 放射標識された前立腺特異的膜抗原阻害剤
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FR2989085A1 (fr) * 2012-04-05 2013-10-11 Commissariat Energie Atomique Radiotraceurs, procedes de preparation et applications
KR102318999B1 (ko) 2012-11-15 2021-10-29 엔도사이트, 인코포레이티드 Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트
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JP2017530109A (ja) 2014-09-08 2017-10-12 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 前立腺癌についてのｐｓｍａを標的とした放射性核種治療中の臓器の保護
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PL3356385T3 (pl) 2015-09-30 2021-06-28 Deutsches Krebsforschungszentrum Tagowane 18F inhibitory antygenu błonowego specyficznego dla gruczołu krokowego (PSMA) i ich zastosowanie jako środków do obrazowania w nowotworze gruczołu krokowego
KR101639599B1 (ko) * 2015-11-09 2016-07-14 서울대학교산학협력단 펩타이드 싸이오우레아 유도체, 이를 포함하는 방사성 동위원소 표지 화합물 및 이를 유효 성분으로 함유하는 전립선암 치료 또는 진단용 약학적 조성물
EP3192810A1 (en) * 2016-01-14 2017-07-19 Deutsches Krebsforschungszentrum Psma binding antibody and uses thereof
CN105510511B (zh) * 2016-01-23 2017-04-12 河北科技大学 一种2‑氨基丁醇对映异构体的hplc分离检测方法
KR20250057132A (ko) * 2016-03-22 2025-04-28 더 존스 홉킨스 유니버시티 전립선 암의 내부방사선요법을 위한 전립선-특이적 막 항원 표적화된 고-친화성 제제
US10806806B2 (en) 2016-06-23 2020-10-20 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
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US11478558B2 (en) * 2017-05-30 2022-10-25 The Johns Hopkins University Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
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