RU2539584C2 - Комплексы технеция и рения с бис(гетероарилами) и способы их применения - Google Patents

Комплексы технеция и рения с бис(гетероарилами) и способы их применения Download PDF

Info

Publication number
RU2539584C2
RU2539584C2 RU2011127462/04A RU2011127462A RU2539584C2 RU 2539584 C2 RU2539584 C2 RU 2539584C2 RU 2011127462/04 A RU2011127462/04 A RU 2011127462/04A RU 2011127462 A RU2011127462 A RU 2011127462A RU 2539584 C2 RU2539584 C2 RU 2539584C2
Authority
RU
Russia
Prior art keywords
compound
amino
tert
mmol
acid
Prior art date
Application number
RU2011127462/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2011127462A (ru
Inventor
Джон У. БАБИЧ
Крейг ЦИММЕРМАН
Джон ДЖОЯЛ
Кевин П. МАРЕСКА
Генлианг ЛУ
Цзянь-Чэн ВАН
Шон ХИЛЬЕР
Джон МАРКИС
Original Assignee
Моликьюлар Инсайт Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/350,894 external-priority patent/US8877970B2/en
Application filed by Моликьюлар Инсайт Фармасьютикалз, Инк. filed Critical Моликьюлар Инсайт Фармасьютикалз, Инк.
Priority claimed from PCT/US2009/066832 external-priority patent/WO2010065899A2/en
Publication of RU2011127462A publication Critical patent/RU2011127462A/ru
Application granted granted Critical
Publication of RU2539584C2 publication Critical patent/RU2539584C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
RU2011127462/04A 2008-12-05 2009-12-04 Комплексы технеция и рения с бис(гетероарилами) и способы их применения RU2539584C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12022608P 2008-12-05 2008-12-05
US61/120,226 2008-12-05
US12/350,894 US8877970B2 (en) 2008-01-09 2009-01-08 Inhibitors of carbonic anhydrase IX
US12/350,894 2009-01-08
US18034109P 2009-05-21 2009-05-21
US61/180,341 2009-05-21
PCT/US2009/066832 WO2010065899A2 (en) 2008-12-05 2009-12-04 Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof

Publications (2)

Publication Number Publication Date
RU2011127462A RU2011127462A (ru) 2013-01-10
RU2539584C2 true RU2539584C2 (ru) 2015-01-20

Family

ID=42076951

Family Applications (3)

Application Number Title Priority Date Filing Date
RU2011127462/04A RU2539584C2 (ru) 2008-12-05 2009-12-04 Комплексы технеция и рения с бис(гетероарилами) и способы их применения
RU2011127468/04A RU2532912C2 (ru) 2008-12-05 2009-12-04 Технеций- и рений-бис(гетероарильные) комплексы и методы их применения для ингибирования psma
RU2011127467/04A RU2539565C2 (ru) 2008-12-05 2009-12-04 Са-ix специфические радиофармпрепараты для лечения и визуалазиции злокачественных опухолей

Family Applications After (2)

Application Number Title Priority Date Filing Date
RU2011127468/04A RU2532912C2 (ru) 2008-12-05 2009-12-04 Технеций- и рений-бис(гетероарильные) комплексы и методы их применения для ингибирования psma
RU2011127467/04A RU2539565C2 (ru) 2008-12-05 2009-12-04 Са-ix специфические радиофармпрепараты для лечения и визуалазиции злокачественных опухолей

Country Status (13)

Country Link
US (1) US8211401B2 (enExample)
EP (4) EP2373622A2 (enExample)
JP (4) JP2012511024A (enExample)
CN (3) CN102272102A (enExample)
AU (3) AU2009322171A1 (enExample)
BR (3) BRPI0922840A2 (enExample)
CA (3) CA2745918C (enExample)
ES (2) ES2574514T3 (enExample)
HU (2) HUE030681T2 (enExample)
PL (2) PL2389361T3 (enExample)
RU (3) RU2539584C2 (enExample)
TW (3) TW201034689A (enExample)
WO (1) WO2010065902A2 (enExample)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2696627C (en) 2007-08-17 2016-09-27 Purdue Research Foundation Psma binding ligand-linker conjugates and methods for using
WO2009084995A1 (en) 2007-12-28 2009-07-09 Exini Diagnostics Ab System for detecting bone cancer metastases
EP2823826A3 (en) * 2008-01-09 2015-03-25 Molecular Insight Pharmaceuticals, Inc. Inhibitors of carbonic anhydrase IX
WO2010065899A2 (en) 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof
WO2010065906A2 (en) 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Ca-ix specific radiopharmaceuticals for the treatment and imaging of cancer
CA2745918C (en) * 2008-12-05 2017-10-10 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
US8465725B2 (en) 2009-06-15 2013-06-18 Molecular Insight Pharmaceuticlas, Inc. Process for production of heterodimers of glutamic acid
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
JP6275484B2 (ja) * 2010-12-06 2018-02-07 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド Ｐｓｍａ標的化デンドリマー
EP2739316B1 (en) 2011-08-05 2019-04-10 Molecular Insight Pharmaceuticals, Inc. Radiolabeled prostate specific membrane antigen inhibitors
US10011632B2 (en) * 2011-08-22 2018-07-03 Siemens Medical Solutions Usa, Inc. PSMA imaging agents
US9371360B2 (en) 2011-11-30 2016-06-21 The Johns Hopkins University Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (PSMA) and uses thereof
EP2800471A4 (en) 2012-01-06 2015-11-04 Molecular Insight Pharm Inc METAL COMPLEX OF POLY (CARBOXYL) AMINE CONTAINING LIGANDS HAVING AFFINITY FOR CARBON IX ANHYDRASE
FR2989085A1 (fr) * 2012-04-05 2013-10-11 Commissariat Energie Atomique Radiotraceurs, procedes de preparation et applications
KR102354613B1 (ko) * 2012-11-15 2022-01-21 엔도사이트, 인코포레이티드 Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트
JP6468602B2 (ja) * 2013-01-14 2019-02-13 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド トリアジン系放射性医薬品及び放射線造影剤
EP2988742A4 (en) * 2013-04-22 2016-10-19 Abbvie Inc THIAZOLES AND USES THEREOF
CN105792855A (zh) * 2013-10-18 2016-07-20 分子制药洞察公司 使用spect/ct分析进行癌症分期的方法
HUE066137T2 (hu) 2013-10-18 2024-07-28 Novartis Ag A prosztata-specifikus membrán antigén (PSMA) jelzett inhibitorai, alkalmazásuk képalkotásban és gyógyszerkészítmények prosztatarák kezelésére
JP6464166B2 (ja) 2013-11-14 2019-02-06 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． 陽電子放出断層撮影用の化合物
EP2993171A1 (en) * 2014-09-04 2016-03-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the production of 18F-labeled PSMA-specific PET-tracers
JP2017530109A (ja) 2014-09-08 2017-10-12 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 前立腺癌についてのｐｓｍａを標的とした放射性核種治療中の臓器の保護
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
PL3356385T3 (pl) 2015-09-30 2021-06-28 Deutsches Krebsforschungszentrum Tagowane 18F inhibitory antygenu błonowego specyficznego dla gruczołu krokowego (PSMA) i ich zastosowanie jako środków do obrazowania w nowotworze gruczołu krokowego
KR101639599B1 (ko) * 2015-11-09 2016-07-14 서울대학교산학협력단 펩타이드 싸이오우레아 유도체, 이를 포함하는 방사성 동위원소 표지 화합물 및 이를 유효 성분으로 함유하는 전립선암 치료 또는 진단용 약학적 조성물
EP3192810A1 (en) * 2016-01-14 2017-07-19 Deutsches Krebsforschungszentrum Psma binding antibody and uses thereof
CN105510511B (zh) * 2016-01-23 2017-04-12 河北科技大学 一种2‑氨基丁醇对映异构体的hplc分离检测方法
SI3925952T1 (sl) * 2016-03-22 2024-03-29 The Johns Hopkins University Za prostato specifična, na membranski antigen usmerjena visoko afinitetna sredstva za endoradioterapijo raka prostate
US10806806B2 (en) 2016-06-23 2020-10-20 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
WO2018187631A1 (en) 2017-04-05 2018-10-11 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
US10179117B2 (en) * 2016-06-23 2019-01-15 Cornell University Double targeted constructs to affect tumor kill
JP7390188B2 (ja) 2016-10-27 2023-12-01 プロジェニクス ファーマシューティカルズ， インコーポレイテッド 医用画像分析、決定サポートシステム、および関連するグラフィカルユーザインタフェース（ｇｕｉ）アプリケーションのためのネットワーク
CN118146170A (zh) * 2017-05-30 2024-06-07 约翰霍普金斯大学 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂
CN116023429A (zh) 2017-12-13 2023-04-28 塞控斯公司 一种含有与铅或钍放射性核素连接的psma靶向化合物的络合物
US10973486B2 (en) 2018-01-08 2021-04-13 Progenics Pharmaceuticals, Inc. Systems and methods for rapid neural network-based image segmentation and radiopharmaceutical uptake determination
CA3085441A1 (en) 2018-01-08 2019-07-11 Progenics Pharmaceuticals, Inc. Systems and methods for rapid neural network-based image segmentation and radiopharmaceutical uptake determination
CN120172924A (zh) * 2018-02-06 2025-06-20 约翰霍普金斯大学 用于癌症放射治疗的psma靶向的放射性卤化尿素-聚氨基羧酸盐
RU2692126C1 (ru) * 2018-02-13 2019-06-21 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) Способ получения производного мочевины с хелатным центром, тропного к простат-специфичному мембранному антигену для связывания технеция-99м/рения для диагностики/лечения рака предстательной железы
CA3097381A1 (en) 2018-04-17 2019-10-24 Endocyte, Inc. Methods of treating cancer
US20210276971A1 (en) * 2018-06-20 2021-09-09 The Research Foundation For The State University Of New York Triazamacrocycle-derived chelator compositions for coordination of imaging and therapy metal ions and methods of using same
WO2020045638A1 (ja) * 2018-08-30 2020-03-05 日本メジフィジックス株式会社 放射性イミダゾチアジアゾール誘導体化合物
CA3122540A1 (en) 2019-01-07 2020-07-16 Exini Diagnostics Ab Systems and methods for platform agnostic whole body image segmentation
WO2020219619A1 (en) 2019-04-24 2020-10-29 Progenics Pharmaceuticals, Inc. Systems and methods for interactive adjustment of intensity windowing in nuclear medicine images
AU2020261370B2 (en) 2019-04-24 2025-04-10 Exini Diagnostics Ab Systems and methods for automated and interactive analysis of bone scan images for detection of metastases
CN120097930A (zh) 2019-05-20 2025-06-06 因多塞特股份有限公司 制备psma缀合物的方法
US12417533B2 (en) 2019-09-27 2025-09-16 Progenics Pharmaceuticals, Inc. Systems and methods for artificial intelligence-based image analysis for cancer assessment
US11900597B2 (en) 2019-09-27 2024-02-13 Progenics Pharmaceuticals, Inc. Systems and methods for artificial intelligence-based image analysis for cancer assessment
US11564621B2 (en) 2019-09-27 2023-01-31 Progenies Pharmacenticals, Inc. Systems and methods for artificial intelligence-based image analysis for cancer assessment
US11544407B1 (en) 2019-09-27 2023-01-03 Progenics Pharmaceuticals, Inc. Systems and methods for secure cloud-based medical image upload and processing
US11386988B2 (en) 2020-04-23 2022-07-12 Exini Diagnostics Ab Systems and methods for deep-learning-based segmentation of composite images
US11321844B2 (en) 2020-04-23 2022-05-03 Exini Diagnostics Ab Systems and methods for deep-learning-based segmentation of composite images
US11721428B2 (en) 2020-07-06 2023-08-08 Exini Diagnostics Ab Systems and methods for artificial intelligence-based image analysis for detection and characterization of lesions
MX2022016373A (es) 2020-07-06 2023-03-06 Exini Diagnostics Ab Sistemas y metodos para analisis de imagenes basado en inteligencia artificial para deteccion y caracterizacion de lesiones.
CA3212963A1 (en) * 2021-04-23 2022-10-27 Reinier HERNANDEZ Psma-targeting ligands with optimal properties for imaging and therapy
TW202324443A (zh) 2021-10-08 2023-06-16 瑞典商艾西尼診斷公司 用於自動鑑別及分類局部淋巴及遠處轉移中之病變的系統和方法
WO2023121390A1 (ko) * 2021-12-24 2023-06-29 주식회사 엘지에너지솔루션 양극 활물질, 이를 포함하는 양극 및 리튬 이차 전지
JP2025521179A (ja) 2022-06-08 2025-07-08 プロジェニクス ファーマシューティカルズ， インコーポレイテッド 疾患負荷および進行度を査定するためのシステムおよび方法
US20240285248A1 (en) 2023-02-13 2024-08-29 Progenics Pharmaceuticals, Inc. Systems and methods for predicting biochemical progression free survival in prostate cancer patients
WO2024211651A1 (en) 2023-04-07 2024-10-10 Progenics Pharmaceuticals, Inc. Systems and methods for facilitating lesion inspection and analysis
WO2025072177A1 (en) 2023-09-25 2025-04-03 Progenics Pharmaceuticals, Inc. Systems and methods for automated cancer staging and risk prediction

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2114115C1 (ru) * 1991-12-10 1998-06-27 Дзе Дау Кемикал Компани Производные бициклополиазамакроциклофосфоновых кислот или их фармацевтически приемлемые соли и способ их получения
EP1389460A1 (en) * 2001-05-24 2004-02-18 Kureha Chemical Industry Co., Ltd. Cxcr4-antagonistic drugs comprising nitrogen-containing compound
US20040209921A1 (en) * 2003-04-11 2004-10-21 Gary Bridger CXCR4 chemokine receptor binding comounds
US20050038258A1 (en) * 2001-12-21 2005-02-17 Tohru Koike Zinc complexes capable of capturing substances having anionic substituents
UA78208C2 (en) * 2001-05-29 2007-03-15 Schering Ag Cdk inhibiting pyrimidines, production thereof and their use as medicaments
EP1961744A1 (en) * 2005-11-18 2008-08-27 Ono Pharmaceutical Co., Ltd. Basic group-containing compound and use thereof
US20080227962A1 (en) * 2005-09-15 2008-09-18 Commissariat A L'energie Atomique Method for Obtaining Highly Luminescent Lanthanide Complexes

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2800457A (en) * 1953-06-30 1957-07-23 Ncr Co Oil-containing microscopic capsules and method of making them
US2730456A (en) * 1953-06-30 1956-01-10 Ncr Co Manifold record material
US2730457A (en) * 1953-06-30 1956-01-10 Ncr Co Pressure responsive record materials
US3625214A (en) * 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US4272398A (en) * 1978-08-17 1981-06-09 The United States Of America As Represented By The Secretary Of Agriculture Microencapsulation process
US4906474A (en) * 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
JPS6131056A (ja) * 1984-07-25 1986-02-13 K Baiorojikaru Sci Lab:Kk ホイッピングクリームの製造方法
US4925673A (en) * 1986-08-18 1990-05-15 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
JP3051497B2 (ja) * 1991-05-17 2000-06-12 株式会社第一ラジオアイソトープ研究所 スルファニルアミド誘導体のテクネチウム錯体をもちいる放射性診断剤
US6359120B1 (en) * 1991-10-29 2002-03-19 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia-localizing moiety
ES2200617B1 (es) * 2001-01-19 2005-05-01 Almirall Prodesfarma, S.A. Derivados de urea como antagonistas de integrinas alfa 4.
DE10135355C1 (de) * 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
US20030100594A1 (en) 2001-08-10 2003-05-29 Pharmacia Corporation Carbonic anhydrase inhibitor
CA2372731A1 (en) * 2002-02-22 2003-08-22 Claudiu T. Supuran Oligo-amine/oligo-carboxy sulfonamides
JP4846199B2 (ja) * 2002-03-11 2011-12-28 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド テクネチウム−ジビリジン複合体、およびその使用法
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
KR100863667B1 (ko) * 2002-09-11 2008-10-15 가부시끼가이샤 구레하 아민 화합물 및 그 용도
US7833734B2 (en) * 2002-11-26 2010-11-16 Institute Of Virology Of The Slovak Academy Of Sciences CA IX-specific inhibitors
US7550424B2 (en) 2002-11-26 2009-06-23 Institute Of Virology Slovak Academy Of Sciences CA IX-specific inhibitors
WO2005056520A1 (en) 2003-12-12 2005-06-23 Oy Juvantia Pharma Ltd Somatostatin receptor subtype 1 (sstr1) active compounds and their use in therapy
EP1713515A4 (en) * 2004-02-12 2009-07-22 Molecular Insight Pharm Inc TECHNETIUM AND RHENIUM-TO (HETEROARYL) COMPLEXES AND METHOD OF USE THEREOF
KR101149124B1 (ko) * 2004-03-10 2012-05-25 가부시끼가이샤 구레하 아민계 염기성 화합물과 그의 용도
WO2006080993A1 (en) 2004-12-08 2006-08-03 Purdue Research Foundation Novel cationic metal complex radiopharmaceuticals
WO2006137092A1 (en) * 2005-06-23 2006-12-28 Supuran Claudiu T Fluorescent sulfonamide derivatives having carbonic anhydrase inhibiting activity and their use as theapeutic and diagnostic agents
WO2007090461A1 (en) 2006-02-06 2007-08-16 Ciba Holding Inc. Use of metal complex compounds as oxidation catalysts
EP2030971B1 (en) 2006-06-20 2011-10-12 Ishihara Sangyo Kaisha, Ltd. Pest control agent containing novel pyridyl-methanamine derivative or salt thereof
EP2055705A4 (en) * 2006-07-31 2014-08-20 Ono Pharmaceutical Co COMPOUND WITH A CYCLIC GROUP BOUND BY A SPIRO BINDING THEREOF AND APPLY THEREOF
US20080213172A1 (en) * 2006-08-29 2008-09-04 Molecular Insight Pharmaceuticals, Inc. Radioimaging moieties coupled to peptidease-binding moieties for imaging tissues and organs that express peptidases
PT3699162T (pt) * 2006-11-08 2022-10-11 Molecular Insight Pharm Inc Heterodímeros de ácido glutâmico
CN101626787A (zh) * 2007-01-19 2010-01-13 马林克罗特公司 诊断的和治疗的环氧合酶-2结合配体
WO2008098056A2 (en) * 2007-02-06 2008-08-14 Epix Pharmaceuticals, Inc. High relaxivity chelates
WO2009076434A1 (en) 2007-12-12 2009-06-18 Molecular Insight Pharmaceuticals, Inc. Inhibitors of integrin vla-4
EP2823826A3 (en) * 2008-01-09 2015-03-25 Molecular Insight Pharmaceuticals, Inc. Inhibitors of carbonic anhydrase IX
RU2011116223A (ru) 2008-09-25 2012-10-27 Моликьюлар Инсайт Фармасьютикалз, Инк. (Us) Селективные ингибиторы сепразы
CA2745918C (en) * 2008-12-05 2017-10-10 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
WO2010065906A2 (en) 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Ca-ix specific radiopharmaceuticals for the treatment and imaging of cancer
WO2010065899A2 (en) * 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2114115C1 (ru) * 1991-12-10 1998-06-27 Дзе Дау Кемикал Компани Производные бициклополиазамакроциклофосфоновых кислот или их фармацевтически приемлемые соли и способ их получения
EP1389460A1 (en) * 2001-05-24 2004-02-18 Kureha Chemical Industry Co., Ltd. Cxcr4-antagonistic drugs comprising nitrogen-containing compound
UA78208C2 (en) * 2001-05-29 2007-03-15 Schering Ag Cdk inhibiting pyrimidines, production thereof and their use as medicaments
US20050038258A1 (en) * 2001-12-21 2005-02-17 Tohru Koike Zinc complexes capable of capturing substances having anionic substituents
US20040209921A1 (en) * 2003-04-11 2004-10-21 Gary Bridger CXCR4 chemokine receptor binding comounds
US20080227962A1 (en) * 2005-09-15 2008-09-18 Commissariat A L'energie Atomique Method for Obtaining Highly Luminescent Lanthanide Complexes
EP1961744A1 (en) * 2005-11-18 2008-08-27 Ono Pharmaceutical Co., Ltd. Basic group-containing compound and use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BANERJEE S.R. et al, { Re III Cl 3 } Core Complexes with Bifunctional Single Amino Acid Chelates, Inorg. Chem., 2002, v.41, p.5795-5802 . *
BANERJEE S.R. et al, Bifunctional Single Amino Acid Chelates for Labeling of Biomolecules with the { Tc(CO) 3 } + and { Re(CO) 3 } + Cores. Crystal and Molecular Structures of [ReBr(CO) 3 (H 2 NCH 2 C 5 H 4 N)], [Re(CO) 3 { (C 5 H 4 NCH 2 ) 2 NH} ]Br, [Re(CO) 3 { (C 5 H 4 NCH 2 ) 2 NCH 2 CO 2 H} ]Br, [Re(CO) 3 { X(Y)NCH 2 CO 2 CH 2 CH 3 } ]Br (X=Y=2-pyridylmethyl; X=2-pyridylmethyl, Y=2-(1-methylimidazolyl)methyl; X=Y=2-(1-methylimidazolyl)methyl, [ReBr(CO) 3 { (C 5 H 4 NCH 2 )NH(CH 2 C 4 H 3 S)} ], and [Re(CO) 3 { (C 5 H 4 NCH 2 )N(CH 2 C 4 H 3 S)(CH 2 CO 2 )} ], Inorg. Chem., 2002, v.41, p.6417-6425 . *
TAKAHIKO Kojima et al, Synthesis and Characterization of Mononuclear Ruthenium (III) Pyridylamine Complexes and Mechanistic Insights into Their Catalytic Alkane Functionalization with m-Chloroperbenzoic Acid, Chem. Eur. J., 2007, v.13, p. 8212-8222 . Bonomi R. et al, Phosphate Diester and DNA Hydrolysis by a Multivalent, Nanoparticle-Based Catalyst, J. Am. Chem. Soc., 2008, v.130, p. 15744-15745 . HENSON M. J. et al, Resonance Raman Investigation of Equatorial Ligand Donor Effects on the Cu 2 O 2 2+ Core in End-On and Side-On µ-Peroxo-Dicopper(II) and Bis-µ-oxo-Dicopper(III) Complexes, J. Am. Chem. Soc., 2003, v.125, p. 5186-5192 . FENG G. et al, Comparing a mononuclear Zn(II) complex with hydrogen bond donors with a dinuclear Zn(II) complex for catalysing phosphate ester cleavage, Chem. Commun., 2006, p. 1845-1847 . NONAT A. et al, Structure, Stability, Dynamics, High-Field Relaxivity and Yernary-Complex Formation of a New Tris(aquo) Gadolinium Complex, Chem. Eur. J., 2007, v.13, p. 8 *
THALLAJ Nasser K. et al, A Ferrous Center as Reaction Site for Hydration of a Nitrile Group into a Carboxamide in Mild Conditions, J. Am. Chem. Soc., 2008, v.130, 2414-2415. *

Also Published As

Publication number Publication date
CA2745955C (en) 2017-05-23
BRPI0922779A8 (pt) 2018-06-19
EP2389361A2 (en) 2011-11-30
BRPI0922840A2 (pt) 2015-12-29
US8211401B2 (en) 2012-07-03
JP2012511023A (ja) 2012-05-17
AU2009322164B2 (en) 2014-12-18
CN102272102A (zh) 2011-12-07
TW201034689A (en) 2010-10-01
EP2373621A2 (en) 2011-10-12
JP5856247B2 (ja) 2016-02-09
CA2745918C (en) 2017-10-10
JP2012511024A (ja) 2012-05-17
HUE030681T2 (en) 2017-05-29
WO2010065902A3 (en) 2011-02-17
EP2389361B1 (en) 2016-08-24
CN102272100A (zh) 2011-12-07
JP5220203B2 (ja) 2013-06-26
CN102272101A (zh) 2011-12-07
AU2009322167A1 (en) 2011-07-07
TW201034691A (en) 2010-10-01
EP2373622A2 (en) 2011-10-12
ES2574514T3 (es) 2016-06-20
BRPI0922839A2 (pt) 2019-09-03
AU2009322167B2 (en) 2014-11-20
JP2012511022A (ja) 2012-05-17
CA2745955A1 (en) 2010-06-10
PL2706057T3 (pl) 2016-10-31
RU2539565C2 (ru) 2015-01-20
EP2759535A1 (en) 2014-07-30
BRPI0922779A2 (pt) 2017-07-11
JP2014240394A (ja) 2014-12-25
HUE029940T2 (en) 2017-04-28
RU2532912C2 (ru) 2014-11-20
US20100178246A1 (en) 2010-07-15
WO2010065902A2 (en) 2010-06-10
CA2745918A1 (en) 2010-06-10
CA2745958A1 (en) 2010-06-10
CN102272100B (zh) 2016-08-17
TW201034690A (en) 2010-10-01
AU2009322171A1 (en) 2011-06-30
ES2595128T3 (es) 2016-12-27
AU2009322164A1 (en) 2011-06-30
PL2389361T3 (pl) 2017-02-28

Similar Documents

Publication Publication Date Title
RU2539584C2 (ru) Комплексы технеция и рения с бис(гетероарилами) и способы их применения
EP2706057B1 (en) Bis(imidazolyl)compounds and radionuclide complexes
US8211402B2 (en) CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer
JP4846199B2 (ja) テクネチウム−ジビリジン複合体、およびその使用法
HUE035739T2 (en) Triazine-based radiopharmaceuticals and radiological imaging agents
CA2969551A1 (en) Bifunctional do2pa derivatives, chelates with metallic cations and use thereof
KR20070028333A (ko) 테크네튬- 및 레늄-비스(헤테로아릴) 착체 및 그의 사용방법
CN1972718B (zh) 锝-和铼-双（杂芳基）络合物，及其使用方法
BRPI0922840B1 (pt) Compostos e complexos de tecnécio e rênio-bis(heteroarila)
JP2025540658A (ja) 神経ペプチドｙ１受容体（ｎｐｙ１ｒ）を標的とした治療薬およびその使用