CN102272102A - 锝-和铼-双(杂芳基)络合物及其使用方法 - Google Patents

锝-和铼-双(杂芳基)络合物及其使用方法 Download PDF

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Publication number
CN102272102A
CN102272102A CN2009801538786A CN200980153878A CN102272102A CN 102272102 A CN102272102 A CN 102272102A CN 2009801538786 A CN2009801538786 A CN 2009801538786A CN 200980153878 A CN200980153878 A CN 200980153878A CN 102272102 A CN102272102 A CN 102272102A
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compound
receptors
amino
aryl
formula
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Chinese (zh)
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J·W·巴比奇
C·齐默曼
J·乔亚尔
K·P·玛勒斯卡
J·马奎斯
G·陆
J·王
S·希利尔
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Molecular Insight Pharmaceuticals Inc
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Molecular Insight Pharmaceuticals Inc
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Priority claimed from US12/350,894 external-priority patent/US8877970B2/en
Application filed by Molecular Insight Pharmaceuticals Inc filed Critical Molecular Insight Pharmaceuticals Inc
Priority claimed from PCT/US2009/066832 external-priority patent/WO2010065899A2/en
Publication of CN102272102A publication Critical patent/CN102272102A/zh
Pending legal-status Critical Current

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
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    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
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  • Animal Behavior & Ethology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CN2009801538786A 2008-12-05 2009-12-04 锝-和铼-双(杂芳基)络合物及其使用方法 Pending CN102272102A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12022608P 2008-12-05 2008-12-05
US61/120,226 2008-12-05
US12/350,894 2009-01-08
US12/350,894 US8877970B2 (en) 2008-01-09 2009-01-08 Inhibitors of carbonic anhydrase IX
US18034109P 2009-05-21 2009-05-21
US61/180,341 2009-05-21
PCT/US2009/066832 WO2010065899A2 (en) 2008-12-05 2009-12-04 Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof

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Publication Number Publication Date
CN102272102A true CN102272102A (zh) 2011-12-07

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CN2009801538786A Pending CN102272102A (zh) 2008-12-05 2009-12-04 锝-和铼-双(杂芳基)络合物及其使用方法
CN2009801538771A Pending CN102272101A (zh) 2008-12-05 2009-12-04 用于癌症治疗和成像的ca-ix特异性放射性药物
CN200980153722.8A Active CN102272100B (zh) 2008-12-05 2009-12-04 用于抑制psma的锝-和铼-双(杂芳基)络合物及其使用方法

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CN2009801538771A Pending CN102272101A (zh) 2008-12-05 2009-12-04 用于癌症治疗和成像的ca-ix特异性放射性药物
CN200980153722.8A Active CN102272100B (zh) 2008-12-05 2009-12-04 用于抑制psma的锝-和铼-双(杂芳基)络合物及其使用方法

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US (1) US8211401B2 (enExample)
EP (4) EP2389361B1 (enExample)
JP (4) JP2012511024A (enExample)
CN (3) CN102272102A (enExample)
AU (3) AU2009322171A1 (enExample)
BR (3) BRPI0922779A8 (enExample)
CA (3) CA2745958A1 (enExample)
ES (2) ES2574514T3 (enExample)
HU (2) HUE030681T2 (enExample)
PL (2) PL2389361T3 (enExample)
RU (3) RU2532912C2 (enExample)
TW (3) TW201034690A (enExample)
WO (1) WO2010065902A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102272101A (zh) * 2008-12-05 2011-12-07 分子制药洞察公司 用于癌症治疗和成像的ca-ix特异性放射性药物
US8840865B2 (en) 2008-01-09 2014-09-23 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
US8877970B2 (en) 2008-01-09 2014-11-04 Molecular Insight Pharmaceuticals, Inc. Inhibitors of carbonic anhydrase IX
US9120837B2 (en) 2012-01-06 2015-09-01 Molecular Insight Pharmaceuticals Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX
US9149547B2 (en) 2009-06-15 2015-10-06 Molecular Insight Pharmaceuticals, Inc. Process for production of heterodimers of glutamic acid
US9447121B2 (en) 2013-01-14 2016-09-20 Molecular Insight Pharmaceuticals, Inc. Triazine based radiopharmaceuticals and radioimaging agents

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US8855387B2 (en) 2007-12-28 2014-10-07 Exini Diagnostics Ab System for detecting bone cancer metastases
WO2010065906A2 (en) 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Ca-ix specific radiopharmaceuticals for the treatment and imaging of cancer
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
WO2012078534A1 (en) * 2010-12-06 2012-06-14 Molecular Insight Pharmaceuticals Psma-targeted dendrimers
JP5843338B2 (ja) * 2011-08-05 2016-01-13 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 放射標識された前立腺特異的膜抗原阻害剤
WO2013028664A1 (en) 2011-08-22 2013-02-28 Siemens Medical Solutions Usa, Inc. Psma imaging agents
US9371360B2 (en) 2011-11-30 2016-06-21 The Johns Hopkins University Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (PSMA) and uses thereof
FR2989085A1 (fr) * 2012-04-05 2013-10-11 Commissariat Energie Atomique Radiotraceurs, procedes de preparation et applications
KR102575825B1 (ko) 2012-11-15 2023-09-06 엔도사이트, 인코포레이티드 Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트
CN105307651A (zh) * 2013-04-22 2016-02-03 艾伯维公司 噻唑类化合物及其用途
EP3057620A4 (en) * 2013-10-18 2017-05-24 Molecular Insight Pharmaceuticals, Inc. Methods of using spect/ct analysis for staging cancer
SG11201602249RA (en) 2013-10-18 2016-05-30 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
EA035171B1 (ru) 2013-11-14 2020-05-08 Эндосайт, Инк. Конъюгаты на основе связывающихся с psma лигандов или ингибиторов psma для позитронно-эмиссионной томографии
EP2993171A1 (en) * 2014-09-04 2016-03-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the production of 18F-labeled PSMA-specific PET-tracers
AU2015315465B2 (en) 2014-09-08 2019-08-29 Molecular Insight Pharmaceuticals, Inc. Organ protection in PSMA-targeted radionuclide therapy of prostate cancer
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
HRP20210183T1 (hr) 2015-09-30 2021-04-30 Deutsches Krebsforschungszentrum 18f-obilježeni inhibitori specifičnog membranskog antigena prostate (psma) i njihova uporaba kao sredstava za vizualizaciju raka prostate
KR101639599B1 (ko) * 2015-11-09 2016-07-14 서울대학교산학협력단 펩타이드 싸이오우레아 유도체, 이를 포함하는 방사성 동위원소 표지 화합물 및 이를 유효 성분으로 함유하는 전립선암 치료 또는 진단용 약학적 조성물
EP3192810A1 (en) * 2016-01-14 2017-07-19 Deutsches Krebsforschungszentrum Psma binding antibody and uses thereof
CN105510511B (zh) * 2016-01-23 2017-04-12 河北科技大学 一种2‑氨基丁醇对映异构体的hplc分离检测方法
KR20220063298A (ko) * 2016-03-22 2022-05-17 더 존스 홉킨스 유니버시티 전립선 암의 내부방사선요법을 위한 전립선-특이적 막 항원 표적화된 고-친화성 제제
US10806806B2 (en) 2016-06-23 2020-10-20 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
WO2017223357A1 (en) * 2016-06-23 2017-12-28 Cornell University Double targeted constructs to affect tumor kill
AU2017348111B2 (en) 2016-10-27 2023-04-06 Progenics Pharmaceuticals, Inc. Network for medical image analysis, decision support system, and related graphical user interface (GUI) applications
KR102724812B1 (ko) 2017-04-05 2024-11-01 코넬 유니버시티 영상화 및 항종양 치료요법에 유용한 조정 가능한 약동학을 갖는 삼작용성 작제물
JP2020522506A (ja) * 2017-05-30 2020-07-30 ザ・ジョンズ・ホプキンス・ユニバーシティ 前立腺がんの内部放射線療法のための前立腺特異的膜抗原をターゲットとした高親和性薬剤
MX2020006112A (es) 2017-12-13 2020-08-24 Sciencons AS Complejo que comprende un compuesto orientado a psma vinculado a un radionucleido de plomo o torio.
US10973486B2 (en) 2018-01-08 2021-04-13 Progenics Pharmaceuticals, Inc. Systems and methods for rapid neural network-based image segmentation and radiopharmaceutical uptake determination
ES3026214T3 (en) 2018-01-08 2025-06-10 Progenics Pharm Inc System and method for rapid neural network-based image segmentation
IL276528B2 (en) * 2018-02-06 2024-11-01 Univ Johns Hopkins PSMA Targeted Radiohalogenated Urea-Polyaminocarboxylates For Cancer Radiotherapy
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