JP2016193934A5 - - Google Patents
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- Publication number
- JP2016193934A5 JP2016193934A5 JP2016137224A JP2016137224A JP2016193934A5 JP 2016193934 A5 JP2016193934 A5 JP 2016193934A5 JP 2016137224 A JP2016137224 A JP 2016137224A JP 2016137224 A JP2016137224 A JP 2016137224A JP 2016193934 A5 JP2016193934 A5 JP 2016193934A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- independently
- group
- probe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 62
- 125000003118 aryl group Chemical group 0.000 claims 51
- 239000000523 sample Substances 0.000 claims 19
- 229910052757 nitrogen Inorganic materials 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000012636 effector Substances 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 150000001993 dienes Chemical class 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- -1 N 3 Inorganic materials 0.000 claims 3
- 150000001721 carbon Chemical class 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 238000002059 diagnostic imaging Methods 0.000 claims 2
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 238000006742 Retro-Diels-Alder reaction Methods 0.000 claims 1
- 125000004432 carbon atom Chemical class C* 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10187619 | 2010-10-14 | ||
| EP10187619.1 | 2010-10-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013533311A Division JP6063384B2 (ja) | 2010-10-14 | 2011-10-11 | プレターゲットキット、プレターゲット方法及びその使用試薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016193934A JP2016193934A (ja) | 2016-11-17 |
| JP2016193934A5 true JP2016193934A5 (enExample) | 2017-03-30 |
| JP6368745B2 JP6368745B2 (ja) | 2018-08-01 |
Family
ID=43736149
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013533311A Active JP6063384B2 (ja) | 2010-10-14 | 2011-10-11 | プレターゲットキット、プレターゲット方法及びその使用試薬 |
| JP2016137224A Active JP6368745B2 (ja) | 2010-10-14 | 2016-07-12 | プレターゲットキット、プレターゲット方法及びその使用試薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013533311A Active JP6063384B2 (ja) | 2010-10-14 | 2011-10-11 | プレターゲットキット、プレターゲット方法及びその使用試薬 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9463256B2 (enExample) |
| EP (1) | EP2627358B1 (enExample) |
| JP (2) | JP6063384B2 (enExample) |
| RU (1) | RU2013121799A (enExample) |
| WO (1) | WO2012049624A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012049624A1 (en) * | 2010-10-14 | 2012-04-19 | Koninklijke Philips Electronics N.V. | Pretargeting kit, method and agents used therein |
| EP2522369A1 (en) * | 2011-05-09 | 2012-11-14 | Koninklijke Philips Electronics N.V. | Pretargeting kit, method and agents used therein |
| EP2709666B1 (en) * | 2011-05-16 | 2021-07-14 | Koninklijke Philips N.V. | Bio-orthogonal drug activation |
| US20150166596A1 (en) * | 2012-05-21 | 2015-06-18 | Agilent Technologies, Inc. | Retro Diels Alder Reaction as a Cleavable Linker in DNA/RNA Applications |
| US10927139B2 (en) | 2012-11-22 | 2021-02-23 | Tagworks Pharmaceuticals B.V. | Chemically cleavable group |
| WO2014081299A1 (en) * | 2012-11-22 | 2014-05-30 | Tagworks Pharmaceuticals B.V. | Activatable liposomes |
| WO2014081300A1 (en) * | 2012-11-22 | 2014-05-30 | Tagworks Pharmaceuticals B.V. | Channel protein activatable liposomes |
| US20150297741A1 (en) * | 2012-11-22 | 2015-10-22 | Tagworks Pharmaceuticals B.V. | Bio-orthogonal drug activation |
| US20150359913A1 (en) * | 2013-01-25 | 2015-12-17 | Memorial Sloan-Kettering Cancer Center | Tetrazines/trans-cyclooctenes in solid phase synthesis of labeled peptides |
| US9110230B2 (en) | 2013-05-07 | 2015-08-18 | Corning Incorporated | Scratch-resistant articles with retained optical properties |
| US9366784B2 (en) | 2013-05-07 | 2016-06-14 | Corning Incorporated | Low-color scratch-resistant articles with a multilayer optical film |
| EP3010486B1 (en) | 2013-06-19 | 2023-11-22 | The Regents of The University of California | Chemical structures for localized delivery of therapeutic agents |
| ES2694723T3 (es) | 2014-01-04 | 2018-12-26 | Craniovation, Inc. | Dispositivo para su uso en terapia fotodinámica |
| WO2015117235A1 (en) * | 2014-02-10 | 2015-08-13 | Mcmaster University | Targeted molecular imaging contrast agents |
| AU2015229014B2 (en) | 2014-03-14 | 2019-07-25 | The Regents Of The University Of California | TCO conjugates and methods for delivery of therapeutic agents |
| JP6787789B2 (ja) * | 2014-04-04 | 2020-11-18 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 詰め替え可能な薬物送達デバイスおよびその使用方法 |
| US11267973B2 (en) | 2014-05-12 | 2022-03-08 | Corning Incorporated | Durable anti-reflective articles |
| US9790593B2 (en) | 2014-08-01 | 2017-10-17 | Corning Incorporated | Scratch-resistant materials and articles including the same |
| WO2016025480A1 (en) | 2014-08-11 | 2016-02-18 | The General Hospital Corporation | Cyclooctenes for bioorthogonol reactions |
| CN108135857A (zh) | 2015-09-10 | 2018-06-08 | 沙思奇公司 | 生物正交组合物 |
| EP3770649A1 (en) | 2015-09-14 | 2021-01-27 | Corning Incorporated | High light transmission and scratch-resistant anti-reflective articles |
| EP3153155B1 (en) * | 2015-10-08 | 2021-03-03 | President and Fellows of Harvard College | Refillable drug delivery devices and methods of use thereof |
| US11617799B2 (en) * | 2016-06-27 | 2023-04-04 | Tagworks Pharmaceuticals B.V. | Cleavable tetrazine used in bio-orthogonal drug activation |
| AU2018250312C1 (en) | 2017-04-07 | 2024-08-22 | Tambo, Inc. | Bioorthogonal compositions |
| US11560384B2 (en) | 2017-05-04 | 2023-01-24 | University Of Utah Research Foundation | Benzonorbornadiene derivatives and reactions thereof |
| WO2018204872A2 (en) * | 2017-05-05 | 2018-11-08 | Fusion Pharmaceuticals Inc. | Igf-1r monoclonal antibodies and uses thereof |
| EP3651741A4 (en) | 2017-07-14 | 2021-04-21 | The Penn State Research Foundation | COMPOSITIONS AND METHODS OF TARGETED DELIVERY OF A THERAPEUTIC AND / OR DIAGNOSTIC SPECIES |
| GB201720769D0 (en) | 2017-12-13 | 2018-01-24 | Univ Of Northumbria At Newcastle | Pericyclic reactions |
| JP2021506842A (ja) | 2017-12-18 | 2021-02-22 | ヤンセン バイオテツク，インコーポレーテツド | ポリペプチドの放射性標識 |
| CA3099419A1 (en) | 2018-05-04 | 2019-11-07 | Tagworks Pharmaceuticals B.V. | Tetrazines for high click conjugation yield in vivo and high click release yield |
| AU2019262521B2 (en) | 2018-05-04 | 2024-04-18 | Tagworks Pharmaceuticals B.V. | Compounds comprising a linker for increasing transcyclooctene stability |
| KR102591065B1 (ko) | 2018-08-17 | 2023-10-19 | 코닝 인코포레이티드 | 얇고, 내구성 있는 반사-방지 구조를 갖는 무기산화물 물품 |
| JP7337174B2 (ja) | 2018-09-18 | 2023-09-01 | ニカング セラピューティクス， インコーポレイテッド | Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての三置換ヘテロアリール誘導体 |
| CN113677397A (zh) | 2019-02-13 | 2021-11-19 | 阿尔菲斯医疗股份有限公司 | 无创声动力学治疗 |
| AU2020282737A1 (en) | 2019-05-29 | 2021-12-16 | Sonalasense, Inc. | Sonosensitization |
| WO2020256546A1 (en) | 2019-06-17 | 2020-12-24 | Tagworks Pharmaceuticals B.V. | Compounds for fast and efficient click release |
| CA3143924C (en) | 2019-06-17 | 2025-06-03 | Tagworks Pharmaceuticals B.V. | Agents that allow in vivo cleavage of markers linked to biomolecules |
| US12386101B2 (en) | 2020-07-09 | 2025-08-12 | Corning Incorporated | Textured region of a substrate to reduce specular reflectance incorporating surface features with an elliptical perimeter or segments thereof, and method of making the same |
| CA3185803A1 (en) | 2020-08-07 | 2022-02-10 | Vijay Agarwal | Ultrasound arrays for enhanced sonodynamic therapy for treating cancer |
| JP2023537066A (ja) | 2020-08-07 | 2023-08-30 | タンボ・インコーポレイテッド | トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 |
| KR20230173150A (ko) | 2021-04-20 | 2023-12-26 | 테라파워, 엘엘씨 | Ac-225 생성용 티타니아 기반 발생기 |
| EP4108669A1 (en) * | 2021-06-24 | 2022-12-28 | Institute Of Organic Chemistry And Biochemistry As CR, V.V.I. | Carbohydrate derivatives and kits for cell surface labeling |
| WO2023244185A1 (en) * | 2022-06-13 | 2023-12-21 | Fikrettin Sahin | Use of lutetium salt compounds for antiviral effect |
| CN122138843A (zh) * | 2023-09-15 | 2026-06-02 | 坦博公司 | 用于有效载荷的体内靶向递送的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| US5326856A (en) | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
| EP2026840A2 (en) * | 2005-10-04 | 2009-02-25 | Koninklijke Philips Electronics N.V. | Targeted imaging and/or therapy using the [3+2]-azide-alkyne cycloaddition |
| CN102271712B (zh) * | 2008-10-31 | 2015-11-25 | 通用医疗公司 | 用于将物质递送至生物靶标的组合物和方法 |
| WO2010119389A2 (en) | 2009-04-16 | 2010-10-21 | Koninklijke Philips Electronics N.V. | Pretargeting kit, method and agents used therein |
| WO2012049624A1 (en) * | 2010-10-14 | 2012-04-19 | Koninklijke Philips Electronics N.V. | Pretargeting kit, method and agents used therein |
| US10927139B2 (en) * | 2012-11-22 | 2021-02-23 | Tagworks Pharmaceuticals B.V. | Chemically cleavable group |
-
2011
- 2011-10-11 WO PCT/IB2011/054481 patent/WO2012049624A1/en not_active Ceased
- 2011-10-11 US US13/877,725 patent/US9463256B2/en active Active
- 2011-10-11 EP EP11776566.9A patent/EP2627358B1/en active Active
- 2011-10-11 RU RU2013121799/15A patent/RU2013121799A/ru unknown
- 2011-10-11 JP JP2013533311A patent/JP6063384B2/ja active Active
-
2016
- 2016-07-12 JP JP2016137224A patent/JP6368745B2/ja active Active
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