JP2011521635A5 - - Google Patents

Download PDF

Info

Publication number
JP2011521635A5
JP2011521635A5 JP2011511111A JP2011511111A JP2011521635A5 JP 2011521635 A5 JP2011521635 A5 JP 2011521635A5 JP 2011511111 A JP2011511111 A JP 2011511111A JP 2011511111 A JP2011511111 A JP 2011511111A JP 2011521635 A5 JP2011521635 A5 JP 2011521635A5
Authority
JP
Japan
Prior art keywords
hybridization composition
hybridization
composition according
polar aprotic
aprotic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011511111A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011521635A (ja
JP5592357B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2009/006548 external-priority patent/WO2009147537A2/en
Publication of JP2011521635A publication Critical patent/JP2011521635A/ja
Publication of JP2011521635A5 publication Critical patent/JP2011521635A5/ja
Application granted granted Critical
Publication of JP5592357B2 publication Critical patent/JP5592357B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011511111A 2008-05-27 2009-05-27 新規なハイブリダイゼーションバッファーを用いた染色体異常の検出のための組成物及び方法 Expired - Fee Related JP5592357B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US5608908P 2008-05-27 2008-05-27
US61/056,089 2008-05-27
DKPA200800727 2008-05-27
DKPA200800727 2008-05-27
US15568309P 2009-02-26 2009-02-26
US61/155,683 2009-02-26
DKPA200900278 2009-02-27
DKPA200900278 2009-02-27
PCT/IB2009/006548 WO2009147537A2 (en) 2008-05-27 2009-05-27 Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers

Publications (3)

Publication Number Publication Date
JP2011521635A JP2011521635A (ja) 2011-07-28
JP2011521635A5 true JP2011521635A5 (enExample) 2014-07-24
JP5592357B2 JP5592357B2 (ja) 2014-09-17

Family

ID=58714504

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011511111A Expired - Fee Related JP5592357B2 (ja) 2008-05-27 2009-05-27 新規なハイブリダイゼーションバッファーを用いた染色体異常の検出のための組成物及び方法
JP2011511105A Expired - Fee Related JP5588970B2 (ja) 2008-05-27 2009-05-27 ハイブリダイゼーション組成物及び方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011511105A Expired - Fee Related JP5588970B2 (ja) 2008-05-27 2009-05-27 ハイブリダイゼーション組成物及び方法

Country Status (9)

Country Link
US (5) US9297035B2 (enExample)
EP (8) EP2636756B2 (enExample)
JP (2) JP5592357B2 (enExample)
CN (3) CN102084004B (enExample)
BR (1) BRPI0912046B1 (enExample)
CA (2) CA2724552C (enExample)
ES (4) ES2610588T3 (enExample)
RU (2) RU2618868C2 (enExample)
WO (2) WO2009144581A1 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009144581A1 (en) 2008-05-27 2009-12-03 Dako Denmark A/S Hybridization compositions and methods
WO2010097655A1 (en) 2009-02-26 2010-09-02 Dako Denmark A/S Compositions and methods for rna hybridization applications
CA2781907C (en) * 2009-12-02 2019-07-16 Dako Denmark A/S Compositions and methods for performing hybridizations with no denaturation
ES2621812T3 (es) * 2010-05-10 2017-07-05 Mayo Foundation For Medical Education And Research Detección de anomalías cromosómicas asociadas con el cáncer endometrial
CN105223357A (zh) * 2010-09-16 2016-01-06 Cbs生物科学有限公司 预测肝癌预后的组合物或试剂盒
EA201391074A1 (ru) * 2011-01-25 2013-12-30 Олмак Дайэгностикс Лимитед Профили экспрессии генов рака толстой кишки и способы применения
CN104845992B (zh) * 2011-09-16 2018-09-14 上海长海医院 前列腺癌的生物学标志物、治疗靶点及其用途
WO2013046033A1 (en) * 2011-09-30 2013-04-04 Dako Denmark A/S Hybridization compositions and methods using formamide
EP3252173A1 (en) * 2011-10-21 2017-12-06 Dako Denmark A/S Hybridization compositions and methods
US20130171622A1 (en) * 2011-12-30 2013-07-04 Abbott Laboratories Compositions and methods for detecting viral infection using direct-label fluorescence in situ hybridization
KR101938699B1 (ko) 2012-07-23 2019-01-16 삼성전자주식회사 Ｌｒｉｇ１의 항 ｃ―ｍｅｔ 항체 적용 대상 환자 선별을 위한 용도
JP6656733B2 (ja) 2013-08-05 2020-03-04 ツイスト バイオサイエンス コーポレーション 新規合成した遺伝子ライブラリ
GB201319180D0 (en) * 2013-10-30 2013-12-11 Mast Group Ltd Nucleic acid probe
US10253353B2 (en) * 2013-12-06 2019-04-09 The Broad Institute, Inc. Enhanced methods of ribonucleic acid hybridization
US9587268B2 (en) * 2014-01-29 2017-03-07 Agilent Technologies Inc. Fast hybridization for next generation sequencing target enrichment
US9994912B2 (en) 2014-07-03 2018-06-12 Abbott Molecular Inc. Materials and methods for assessing progression of prostate cancer
WO2016050681A1 (en) * 2014-09-29 2016-04-07 Ventana Medical Systems, Inc. MULTIPLEX TP53/CEN17/B CELL GENE-PROTEIN CO-DETECTION ASSAY AND UNIQUELY SPECIFIC PROBES FOR 19q12, INSR, ATM, DLEU2, TP53, and 13q12
US10669304B2 (en) 2015-02-04 2020-06-02 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
JP6675758B2 (ja) * 2015-02-20 2020-04-01 国立大学法人名古屋大学 ホスファフルオレセイン化合物若しくはその塩、又はそれを用いた蛍光色素
WO2016172377A1 (en) 2015-04-21 2016-10-27 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
ES2753274T5 (es) * 2015-08-21 2023-05-26 42 Life Sciences Gmbh & Co Kg Composición y procedimiento de hibridación
US10844373B2 (en) 2015-09-18 2020-11-24 Twist Bioscience Corporation Oligonucleic acid variant libraries and synthesis thereof
CN108698012A (zh) 2015-09-22 2018-10-23 特韦斯特生物科学公司 用于核酸合成的柔性基底
US10457981B2 (en) * 2016-01-08 2019-10-29 Abbott Molecular Inc. Hybridization buffers
CN105755136B (zh) * 2016-04-13 2017-08-25 武汉康录生物技术有限公司 一种人12号染色体着丝粒探针试剂盒及其制备方法和应用
CN107419001A (zh) * 2016-05-23 2017-12-01 益善生物技术股份有限公司 Brca1、pten基因异常检测试剂盒及检测方法
CN107058565A (zh) * 2016-08-31 2017-08-18 郭军 肢端型黑色素瘤的诊断和治疗
KR102217487B1 (ko) 2016-09-21 2021-02-23 트위스트 바이오사이언스 코포레이션 핵산 기반 데이터 저장
WO2018093777A1 (en) * 2016-11-15 2018-05-24 The Regents Of The University Of Michigan Centromere analysis
EP4556433A3 (en) 2017-02-22 2025-08-06 Twist Bioscience Corporation Nucleic acid based data storage
CN107227359A (zh) * 2017-06-19 2017-10-03 福建万科药业有限公司 一种亚型Ph‑likeALL的检测试剂盒及其检测方法
CN107312838A (zh) * 2017-06-28 2017-11-03 广西大学 细胞荧光原位杂交方法
SG11202002043YA (en) 2017-09-05 2020-04-29 Agency Science Tech & Res Clear cell renal cell carcinoma biomarkers
GB2583590A (en) 2017-10-20 2020-11-04 Twist Bioscience Corp Heated nanowells for polynucleotide synthesis
JP2021526366A (ja) 2018-05-18 2021-10-07 ツイスト バイオサイエンス コーポレーション 核酸ハイブリダイゼーションのためのポリヌクレオチド、試薬、および方法
WO2020021084A1 (en) * 2018-07-27 2020-01-30 F. Hoffmann-La Roche Ag Formamide free target enrichment compositions for next-generation sequencing applications
CN108998531B (zh) * 2018-08-31 2021-10-01 昆明医科大学第一附属医院 肺癌下调长链非编码rna标志物及其应用
CN113166800A (zh) * 2018-11-01 2021-07-23 领先细胞医疗诊断有限公司 用于原位核酸数字多路复用的方法
US10768173B1 (en) 2019-09-06 2020-09-08 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
US10704094B1 (en) 2018-11-14 2020-07-07 Element Biosciences, Inc. Multipart reagents having increased avidity for polymerase binding
GB2613480B (en) 2018-11-15 2023-11-22 Element Biosciences Inc Methods for generating circular nucleic acid molecules
EP3902816A4 (en) 2018-12-26 2022-09-14 Twist Bioscience Corporation HIGHLY ACCURATE POLYNUCLEOTIDE DE NOVO SYNTHESIS
EP3930753A4 (en) 2019-02-26 2023-03-29 Twist Bioscience Corporation VARIANT NUCLEIC ACID LIBRARIES FOR GLP1 RECEPTOR
CN111781356A (zh) * 2019-04-04 2020-10-16 清华大学 一种胃癌极早期细胞标志和胃癌前病变早期细胞标志及其在诊断试剂盒中的应用
EP4674979A2 (en) 2019-04-25 2026-01-07 Agilent Technologies, Inc. Hybridization compositions and methods for making and using compositions
US12313627B2 (en) 2019-05-01 2025-05-27 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
CN110172511A (zh) * 2019-05-10 2019-08-27 广州安必平医药科技股份有限公司 用于检测her-2基因扩增水平的探针组、试剂盒及其应用
CN110257483B (zh) * 2019-07-10 2022-08-05 厦门通灵生物医药科技有限公司 用于原位杂交的杂交液、其制备方法及检测试剂盒
EP4464827A3 (en) 2019-09-23 2025-02-26 Twist Bioscience Corporation Variant nucleic acid libraries for crth2
US12173282B2 (en) 2019-09-23 2024-12-24 Twist Bioscience, Inc. Antibodies that bind CD3 epsilon
US11287422B2 (en) 2019-09-23 2022-03-29 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
EP4237581A4 (en) 2020-10-30 2025-03-26 Element Biosciences, Inc. REAGENTS FOR MASSIVELY PARALLEL NUCLEIC ACID SEQUENCED ANALYSIS
CN112626180A (zh) * 2020-12-30 2021-04-09 北京思尔成生物技术有限公司 一种dna杂交增强液及其制备方法与应用
CA3205524A1 (en) * 2021-02-26 2022-09-01 Elips Diagnostics Inc. Novel electrochemiluminescence co-reactant, and electrochemiluminescence system comprising same
CN114561449B (zh) * 2022-02-28 2022-10-14 深圳大学 一种免预杂交的Northern blot杂交液及其应用
CN116144780A (zh) * 2023-03-17 2023-05-23 重庆医科大学 一种慢性淋巴细胞白血病的细胞的遗传学检测方法
WO2025046314A1 (en) 2023-08-30 2025-03-06 Foss Analytical A/S Improved hybridization assay with stringency buffer dilution
WO2025046313A1 (en) 2023-08-30 2025-03-06 Foss Analytical A/S Combined pre-treatment and hybridization of nucleic acids
CN117247995A (zh) * 2023-09-12 2023-12-19 上海新培晶医学检验所有限公司 一种在g-显带的玻片上进行分子荧光原位杂交处理方法
CN117887813B (zh) * 2023-11-28 2024-07-12 首都医科大学附属北京口腔医院 一种杂交缓冲液与应用
CN118454487B (zh) * 2024-05-20 2024-11-08 上海乐纯生物技术股份有限公司 一种亲水改性聚偏氟乙烯过滤膜的制备方法

Family Cites Families (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3151405A (en) 1960-12-15 1964-10-06 Ludwig Herbert Ladies' slipper having a plastic bead construction
US4652517A (en) 1984-06-11 1987-03-24 Diagnostic Research Limited Partnership Methods for the in vitro detection and identification of unknown pathogens or genetic entities
US5132207A (en) 1984-07-05 1992-07-21 Gen-Probe Incorporated Accelerated nucleic acid reassociation method
US4888278A (en) 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US6475720B1 (en) 1986-01-16 2002-11-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US6344315B1 (en) 1986-01-16 2002-02-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
EP0261955A3 (en) 1986-09-26 1989-06-07 E.I. Du Pont De Nemours And Company Process for immobilization of dna
US4886741A (en) 1987-12-09 1989-12-12 Microprobe Corporation Use of volume exclusion agents for the enhancement of in situ hybridization
US4996359A (en) 1988-03-14 1991-02-26 Arco Chemical Technology, Inc. Process for the preparation of aromatic bis dialkyl ureas
US6203977B1 (en) 1988-11-15 2001-03-20 Yale University Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization
US5869237A (en) 1988-11-15 1999-02-09 Yale University Amplification karyotyping
US5650148A (en) 1988-12-15 1997-07-22 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5633129A (en) 1989-07-13 1997-05-27 Massachusetts Institute Of Technology Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices
WO1992004341A1 (en) 1990-08-30 1992-03-19 Tropix, Inc. Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes
AU6144590A (en) * 1989-07-24 1991-03-11 Microprobe Corporation Lactam-containing compositions and methods useful for the hybridization of nucleic acids
US5106730A (en) * 1989-07-24 1992-04-21 Microprobe Corporation Lactam-containing compositions and methods useful for the hybridization of nucleic acids
WO1992007959A1 (en) 1990-11-05 1992-05-14 Biowhittaker Inc. Homogeneous membrane lytic immunoassay method utilizing contact sensitive liposome formulations
GB9024005D0 (en) * 1990-11-05 1990-12-19 British Bio Technology Process for amplifying nucleic acid
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5766855A (en) 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US6228982B1 (en) 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5641625A (en) 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
GB9211979D0 (en) 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
WO1994002638A1 (en) 1992-07-17 1994-02-03 Aprogenex, Inc. Free radical scavengers useful for reducing autofluorescence in fixed cells
US5521061A (en) * 1992-07-17 1996-05-28 Aprogenex, Inc. Enhancement of probe signal in nucleic acid-mediated in-situ hybridization studies
AU5355594A (en) 1992-10-09 1994-05-09 Oncor, Inc. Methods for the detection of chromosome structural abnormalities by (in situ) hybridization to fixed tissue
US5432065A (en) 1993-03-30 1995-07-11 United States Biochemical Corporation Cycle sequencing with non-thermostable DNA polymerases
US5382285A (en) 1993-04-06 1995-01-17 Regents Of The University Of California Biofoam
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
US5582985A (en) 1994-08-05 1996-12-10 The Regents Of The University Of California Detection of mycobacteria
US5705333A (en) 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
CA2197788A1 (en) 1994-09-02 1996-03-14 Robert Haner Functional terpyridine metal complexes, methods for their preparation and oligonucleotide conjugates with terpyridine metal complexes
US5718915A (en) 1994-10-31 1998-02-17 Burstein Laboratories, Inc. Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme
US20010011131A1 (en) 1997-07-28 2001-08-02 Luyten Frank P. DNA molecules encoding cartilage-derived morphogenetic proteins
US5750340A (en) * 1995-04-07 1998-05-12 University Of New Mexico In situ hybridization solution and process
DE19516399A1 (de) 1995-05-04 1996-11-07 Bayer Ag Verfahren zur Herstellung von Polymeren mit wiederkehrenden Succinyleinheiten
EP0952767A4 (en) 1995-11-13 2001-10-24 Univ Rochester PRODUCTION OF A SOMATIC MOSAICISM IN MAMMALS USING A RECOMBINATORY SUBSTRATE
US5962227A (en) 1996-07-26 1999-10-05 The Regents Of The University Of California DNA-based diagnostic test for detecting myxobolus, the cause of salmonid whirling disease
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6361940B1 (en) * 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
AU4549997A (en) 1996-10-04 1998-05-05 Dako A/S Novel probes for the detection of mycobacteria
US6329197B2 (en) 1996-10-09 2001-12-11 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR3 receptors and uses thereof
US5858671A (en) 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
CA2284211A1 (en) 1997-03-20 1998-09-24 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
US6716625B1 (en) 1997-04-16 2004-04-06 Claude Selitrennikoff Histidine kinases of Aspergillus and other fungal species, related compositions, and methods of use
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
EP0878552A1 (en) 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molecular detection of chromosome aberrations
US6107470A (en) 1997-05-29 2000-08-22 Nielsen; Peter E. Histidine-containing peptide nucleic acids
CA2242035C (en) * 1997-07-01 2004-11-23 Transgene S.A. Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy
CA2301924C (en) 1997-08-20 2008-12-09 The University Of Miami A high quality, continuous throughput, tissue fixation-dehydration-fat removal-impregnation method
DE69829760T3 (de) 1997-09-12 2016-04-14 Exiqon A/S Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US20020192659A1 (en) 1997-09-17 2002-12-19 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP0905123B1 (de) 1997-09-24 2001-12-12 Infineon Technologies AG o-Amino(thio)phenol-carbonsäuren und deren Herstellung
WO1999027103A1 (en) * 1997-11-26 1999-06-03 Zymogenetics, Inc. Mammalian cytokine-like polypeptide-10
US5972615A (en) 1998-01-21 1999-10-26 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6043039A (en) 1998-02-17 2000-03-28 Applied Spectral Imaging Method of and composite for in situ fluorescent hybridization
US7396508B1 (en) 2000-07-12 2008-07-08 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6405609B1 (en) 1998-02-27 2002-06-18 Ventana Medical Systems, Inc. System and method of aspirating and dispensing reagent
US6265168B1 (en) 1998-10-06 2001-07-24 Transgenomic, Inc. Apparatus and method for separating and purifying polynucleotides
US6287772B1 (en) 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
AU3516899A (en) 1998-05-04 1999-11-23 Dako A/S Method and probes for the detection of chromosome aberrations
ATE327345T1 (de) 1998-08-07 2006-06-15 Cellay Llc Gel mikrotropfen für die genetische analyse
KR100633221B1 (ko) 1998-08-24 2006-10-11 후소 야쿠힝 고교 가부시끼가이샤 신규 콜렉틴
US20080050393A1 (en) 1998-12-03 2008-02-28 Tang Y Tom Novel nucleic acids and polypeptides
EP1013772A1 (en) 1998-12-21 2000-06-28 Transgene S.A. Method for preparing suspension of stable posiplexes
US6331618B1 (en) 1999-05-13 2001-12-18 Pe Corporation (Ny) Compositions of solvents and high concentrations of nucleic acid analogs
US6300073B1 (en) 1999-10-01 2001-10-09 Clontech Laboratories, Inc. One step RT-PCR methods, enzyme mixes and kits for use in practicing the same
WO2001029265A1 (en) 1999-10-15 2001-04-26 Ventana Medical Systems, Inc. Method of detecting single gene copies in-situ
US8012471B2 (en) 1999-11-19 2011-09-06 Abbott Healthcare Products B.V. Screening and treatment methods using IGS5 enzymes of the metalloprotease family
US20010031468A1 (en) 2000-02-08 2001-10-18 Alex Chenchik Analyte assays employing universal arrays
AU2001243573A1 (en) 2000-03-09 2001-09-17 Protogene Laboratories, Inc. Methods for optimizing hybridization performance of polynucleotide probes and localizing and detecting sequence variations
US6617131B2 (en) 2000-03-21 2003-09-09 Aventis Pharma Deutschland Gmbh Nucleic acid molecule encoding the potassium channel protein, KCNQ5
US6969587B2 (en) 2000-04-04 2005-11-29 Taylor Paul D Detection of nucleic acid heteroduplex molecules by anion-exchange chromatography
US20040048376A1 (en) 2000-04-10 2004-03-11 Benoit Chabot Methods for modulating splicing and/or alternative splicing, and for identifying alternatively spliced units in genes
AU2001248284A1 (en) 2000-04-14 2001-10-30 Maxygen, Inc. Nucleic acids encoding polypeptides having haloperoxidase activity
US7482151B2 (en) 2000-05-19 2009-01-27 Aquaria, Inc. Method of using ammonia-oxidizing bacteria
DE60125243T2 (de) 2000-07-03 2007-05-31 Applera Corp., Foster City Polynukleotid-sequenzassay
US6716829B2 (en) 2000-07-27 2004-04-06 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
US6942970B2 (en) 2000-09-14 2005-09-13 Zymed Laboratories, Inc. Identifying subjects suitable for topoisomerase II inhibitor treatment
EP1325300A1 (en) 2000-09-15 2003-07-09 Biogenex Laboratories ENHANCEMENT OF i IN SITU /i HYBRIDIZATION
CA2703141C (en) 2000-09-15 2014-10-21 Ventana Medical Systems, Inc. Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in situ analysis
EP1340780B1 (en) 2000-09-28 2010-07-21 Sanyo Chemical Industries, Ltd. Use of selected metal catalysts for ring-opening polymerization of epoxides
JP2002112777A (ja) 2000-10-03 2002-04-16 Livestock Improvement Association Of Japan Inc 新規精巣特異的遺伝子
DE10053047A1 (de) 2000-10-13 2002-06-06 Univ Lausanne Epalinges Verwendung von Caveolin-1 oder des Gens desselben zur Behandlung von nichtsteroidabhängigem Karzinom
US7309573B2 (en) 2000-11-21 2007-12-18 Stratagene California Methods for detection of a nucleic acid by sequential amplification
WO2002048404A2 (en) * 2000-12-14 2002-06-20 Gen-Probe Incorporated Method and kit for enhancing the association rates of polynucleotides
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
WO2003014398A2 (en) * 2001-01-03 2003-02-20 Transgenomic, Inc. Methods and compositions for mutation detection by liquid chromatography
US6656685B2 (en) 2001-01-29 2003-12-02 Ventana Medical Systems, Inc. Hybridization buffers using low molecular weight dextran sulfate and methods for their use
US6949368B2 (en) 2001-01-30 2005-09-27 The Trustees Of Princeton University Compositions and methods for enhancing polynucleotide amplification reactions
WO2002088389A1 (fr) 2001-04-26 2002-11-07 Nof Corporation Inhibiteurs d'hybridation non specifiques, reactifs d'examen clinique et procede d'examen clinique
CN1384203A (zh) 2001-04-30 2002-12-11 香港科技创业股份有限公司 具有高度延伸专一性的dna低温循环延伸反应方法
WO2002088396A2 (en) 2001-04-30 2002-11-07 Ventana Medical Systems, Inc. Reagents and methods for automated in situ or microarray hybridization
US7297494B2 (en) 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US20030108903A1 (en) 2001-07-19 2003-06-12 Liman Wang Multiple word DNA computing on surfaces
WO2003020932A1 (en) 2001-09-03 2003-03-13 Takeda Chemical Industries, Ltd. Novel secretory proteins and dna thereof
WO2003027328A2 (en) 2001-09-24 2003-04-03 Boston Probes, Inc. Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid
US20040106109A1 (en) 2001-10-02 2004-06-03 Belly Robert T Detection of ras mutations
US7132236B2 (en) 2001-10-25 2006-11-07 Agilent Technologies, Inc. Composition and method for optimized hybridization using modified solutions
US6783940B2 (en) 2001-10-31 2004-08-31 Applera Corporation Method of reducing non-specific amplification in PCR
DE10154291B4 (de) 2001-11-05 2005-05-19 Hain Lifescience Gmbh Verfahren zum Nachweis von Nukleinsäuren in Form eines Trockenschnelltestes
US20060270595A1 (en) 2001-12-18 2006-11-30 Denis Jullien Nucleic acids encoding compositions of THAP-family chemokine binding domains
US7153390B2 (en) 2001-12-31 2006-12-26 Kimberly-Clark Wordwide, Inc. Process for manufacturing a cellulosic paper product exhibiting reduced malodor
ES2310660T3 (es) 2002-01-18 2009-01-16 Zymogenetics, Inc. Citoquina (ligando zcytor17).
US7772383B2 (en) 2002-01-25 2010-08-10 The Trustees Of Princeton University Chemical PCR: Compositions for enhancing polynucleotide amplification reactions
US7456219B2 (en) 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
US20060030541A1 (en) 2002-04-05 2006-02-09 Proskelia Genes involved in osteogenesis, and methods of use
WO2004004647A2 (en) 2002-07-02 2004-01-15 Nanosphere Inc. Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
US20040029184A1 (en) 2002-08-09 2004-02-12 Pickcell Laboratories B.V. Method for antigen retrieval and submersion fluid compositions for use therein
TWI228511B (en) 2002-10-25 2005-03-01 Univ Nat Cheng Kung Genes controlling floral development in orchid
WO2004039966A1 (en) 2002-10-31 2004-05-13 Pfizer Products Inc. Suspension method for producing embryoid bodies, and compositions and methods related thereto
US7517697B2 (en) * 2003-02-05 2009-04-14 Applied Biosystems, Llc Compositions and methods for preserving RNA in biological samples
US7601491B2 (en) 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
US20040224343A1 (en) 2003-05-06 2004-11-11 Biochain Inc. Methods and products to enhance interactions among molecules
US7064196B2 (en) 2003-05-20 2006-06-20 E. I. Du Pont De Nemours And Company Genes encoding carotenoid compounds
US20040241666A1 (en) 2003-05-30 2004-12-02 Amorese Douglas A. Ligand array assays that include an organic fluid wash step and compositions for practicing the same
US20050250094A1 (en) 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US20050064472A1 (en) 2003-07-23 2005-03-24 Affymetrix, Inc. Methods of monitoring gene expression
WO2005033333A2 (en) 2003-10-07 2005-04-14 Dako Denmark A/S Methods and compositions for the diagnosis of cancer
CA2482097C (en) † 2003-10-13 2012-02-21 F. Hoffmann-La Roche Ag Methods for isolating nucleic acids
US20050191657A1 (en) 2003-11-18 2005-09-01 Demorest David M. Stringency modifiers in hybridization assays
EP1711590B1 (en) 2004-01-08 2016-12-14 Dako Denmark A/S Apparatus and methods for processing biological samples and a reservoir therefore
JP2005300998A (ja) 2004-04-13 2005-10-27 Tokyo Ohka Kogyo Co Ltd ポジ型レジスト組成物及びレジストパターン形成方法
WO2005100323A1 (en) 2004-04-15 2005-10-27 F. Hoffmann-La Roche Ag Process for preparing pyridazinone compounds
US7306916B2 (en) * 2004-05-04 2007-12-11 Dako Denmark A/S Methods for detecting chromosome aberrations
US20060024751A1 (en) 2004-06-03 2006-02-02 Fluidigm Corporation Scale-up methods and systems for performing the same
CN1989245A (zh) 2004-06-14 2007-06-27 株式会社嘉尔药物 新型半乳凝素8变体蛋白质以及其用途
EP1774029B1 (en) 2004-07-16 2013-04-24 DSM IP Assets B.V. Method for detecting the risk of type 2 diabetes
US7867443B2 (en) 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
WO2006073504A2 (en) 2004-08-04 2006-07-13 President And Fellows Of Harvard College Wobble sequencing
WO2006023919A2 (en) * 2004-08-24 2006-03-02 Cornell Research Foundation, Inc. Detection of nucleic acid differences using endonuclease cleavage/ligas releasing reactions and capillary electrophoresis or microarrays
US20060147957A1 (en) 2004-11-12 2006-07-06 Affymetrix, Inc. Methods for high throughput sample preparation for microarray analysis
WO2006065853A2 (en) 2004-12-15 2006-06-22 Bristol-Myers Squibb Company Crystalline forms of a factor xa inhibitor
WO2006066039A2 (en) 2004-12-17 2006-06-22 Kram Brian H High temperature tissue conditioning with low volatility solutions and applications
WO2006073892A2 (en) * 2004-12-30 2006-07-13 Ge Healthcare Bio-Sciences Corp. Phi 15 dna polymerase
JPWO2006093150A1 (ja) 2005-02-28 2008-08-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 シグナル増幅方法
PT103257B (pt) 2005-04-05 2007-05-31 Inst Superior Tecnico Método de produção subcrítica de xerogéis e aerogéis monolíticos híbridos de sílica e látex modificado com grupos alcoxissilano
AU2006244394B2 (en) * 2005-05-06 2010-10-21 Gen-Probe Incorporated Methods of nucleic acid target capture
CA2618060A1 (en) 2005-08-05 2007-02-15 Xm Satellite Radio Inc. Broadcast signal interface device and method thereof
JP5088134B2 (ja) 2005-09-28 2012-12-05 日本電気株式会社 信号測定装置
WO2007037341A1 (ja) 2005-09-29 2007-04-05 Toto Ltd. 光電流を用いた被検物質の特異的検出方法、それに用いられる電極、測定用セルおよび測定装置
JP4712814B2 (ja) 2005-11-17 2011-06-29 独立行政法人科学技術振興機構 特定の塩基配列の標的核酸類を検出する方法、及び検出のための核酸類セット
US20070141583A1 (en) 2005-12-20 2007-06-21 Weiwei Li Methods of rapid chromatin immunoprecipitation
US7807354B2 (en) 2005-12-28 2010-10-05 Agilent Technologies, Inc. Low volume hybridization
US7660454B2 (en) * 2006-03-13 2010-02-09 Ikonisys, Inc. Process for identifying FISH signals
RU2338787C2 (ru) * 2006-03-15 2008-11-20 Институт белка Российской академии наук Обнаружение молекулярных колоний посредством гибридизации на мембранах с флуоресцентными зондами
US7820883B2 (en) 2006-03-15 2010-10-26 Dow Agrosciences Llc Resistance to auxinic herbicides
CN101454444A (zh) 2006-03-20 2009-06-10 诺维信股份有限公司 具有内切葡聚糖酶活性的多肽和编码该多肽的多核苷酸
WO2007109941A1 (en) 2006-03-29 2007-10-04 Huawei Technologies Co., Ltd. Method and application of reducing traffic interrupt of a terminal during ps handover procedure of mobile communication
EP1870411B1 (en) 2006-06-21 2016-03-16 Fidia Farmaceutici S.p.A. Process for the preparation and purification of valgancyclovir
WO2008018839A1 (en) 2006-08-09 2008-02-14 National University Of Singapore Method for molecular biology applications
US7846703B2 (en) 2006-10-02 2010-12-07 Takara Bio Inc. Method for enhancing polymerase activity
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
US8686129B2 (en) 2007-03-20 2014-04-01 Agilent Technologies, Inc. Methods for the separation of biological molecules using sulfolane
AU2008240834B2 (en) 2007-04-24 2012-08-23 F. Hoffmann-La Roche Ag Process for HCV protease inhibitor intermediate
US8841437B2 (en) 2008-06-20 2014-09-23 The Board Of Trustees Of The Leland Stanford Junior University Precursor miRNA loop-modulated target regulation
WO2009036427A2 (en) 2007-09-14 2009-03-19 Ventana Medical Systems, Inc. Prostate cancer biomarkers
US9409166B2 (en) 2007-12-10 2016-08-09 The Trustees Of The University Of Pennsylvania Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications
US8877144B2 (en) 2007-12-10 2014-11-04 Dako Denmark A/S Tissue processing apparatus
US9261508B2 (en) 2008-04-25 2016-02-16 Istituto Superiore Di Sanita Antisense RNA for treating cancer and inhibition of metastasis and vectors for antisense sequestration
WO2009144581A1 (en) 2008-05-27 2009-12-03 Dako Denmark A/S Hybridization compositions and methods
ITMI20081002A1 (it) 2008-05-30 2009-11-30 Kardia S R L Dispositivo per il trattamento di occlusioni arteriose degli arti inferiori
US8193161B2 (en) 2008-06-09 2012-06-05 New York Medical College Compositions comprising cardiac stem cells overexpressing specific micrornas and methods of their use in repairing damaged myocardium
CA2727399C (en) 2008-06-12 2017-11-07 Massachusetts Institute Of Technology High energy density redox flow device
US7750208B2 (en) 2008-07-09 2010-07-06 National Taiwan University Anther-specific expression promoter in plant and application thereof
WO2010088517A1 (en) 2009-01-30 2010-08-05 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Methods and systems for purifying transferring and/or manipulating nucleic acids
WO2010097655A1 (en) 2009-02-26 2010-09-02 Dako Denmark A/S Compositions and methods for rna hybridization applications
CN105296474B (zh) 2009-03-24 2020-05-12 奥斯瑞根公司 对fmr1和fmr2基因5’非翻译区进行表征的pcr方法
CA2781907C (en) 2009-12-02 2019-07-16 Dako Denmark A/S Compositions and methods for performing hybridizations with no denaturation
WO2011147690A1 (en) 2010-05-28 2011-12-01 Syngenta Participations Ag Pyrazolecarboxamide derivatives and their use as microbiocides
BR112012030813A2 (pt) 2010-06-03 2017-06-20 Cellay Inc "métodos e kits para detecção in situ de sequências de nucleotídeo"
JP6013376B2 (ja) 2011-02-28 2016-10-25 ダコ・デンマーク・エー／エス 包埋生体試料の前処置のための２相非混和系
WO2013046033A1 (en) 2011-09-30 2013-04-04 Dako Denmark A/S Hybridization compositions and methods using formamide
EP3252173A1 (en) 2011-10-21 2017-12-06 Dako Denmark A/S Hybridization compositions and methods
US9651549B2 (en) 2012-07-13 2017-05-16 Genisphere, Llc Lateral flow assays using DNA dendrimers
EP2914737B1 (en) 2012-10-31 2017-12-06 Cellay, Inc. Methods and kits for performing in situ hybridization
GB201303666D0 (en) 2013-03-01 2013-04-17 Goldsborough Andrew S Sample fixation and stabilisation
WO2014138688A1 (en) 2013-03-07 2014-09-12 Bio-Rad Laboratories, Inc. Repetitive reverse transcription partition assay
SG10201805453XA (en) 2013-04-25 2018-08-30 Firefly Bioworks Inc Multiplexed analysis of target nucleic acids
AU2014373792A1 (en) 2013-12-30 2016-07-07 Genomatix Genomic rearrangements associated with prostate cancer and methods of using the same
CN103966321A (zh) 2014-04-24 2014-08-06 哈尔滨工业大学（威海） 一种区域选择性抗生物污染阵列芯片的制备方法
WO2015184144A1 (en) 2014-05-28 2015-12-03 Siemens Healthcare Diagnostics Inc. Rare molecule signal amplification
CN104032033B (zh) 2014-07-07 2015-09-23 玉峰惠仁生物医药科技（北京）有限公司 用于荧光原位杂交检测粪肠球菌和/或其他肠球菌的肽核酸探针组及其试剂盒、使用方法、用途
WO2016125091A1 (en) 2015-02-04 2016-08-11 Alma Mater Studiorum Universita Di Bologna Additive for accelerating hybridization

Similar Documents

Publication Publication Date Title
JP2011521635A5 (enExample)
Salk et al. Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations
RU2010151495A (ru) Композиции и способы определения хромосомных аберраций с новыми буферами для гибридизации
RU2688435C2 (ru) Набор для получения реакционной смеси для синтеза 3′-o-пропаргил-модифицированной нуклеиновой кислоты
ES2685465T3 (es) Sistemas de ensayo para la determinación de la contribución de fuente en una muestra
CA3214947A1 (en) Libraries for mutational analysis
JP2013531983A (ja) 多重生物検出のための核酸ならびにその使用および製造方法
JP6860662B2 (ja) キメラ生成物の同定のためのバーコードを付けられた環状ライブラリーの構築
KR20130113476A (ko) 인터칼레이터 （ｉｎｔｅｒｃａｌａｔｏｒ） 분자를 포함하는 프로브에 의한 표적 ＤＮＡ 및 ＲＮＡ의 캡쳐
US10131944B2 (en) Molecular adapter for capture and manipulation of transfer RNA
No et al. Comparison of targeted next-generation sequencing for whole-genome sequencing of Hantaan orthohantavirus in Apodemus agrarius lung tissues
US20230134138A1 (en) Methods for detecting cystic fibrosis mutations using mitra tip extraction
JP2023519919A (ja) 病原体を検出するためのアッセイ
EP2707486A1 (en) Diagnosis and treatment of friedreich's ataxia
US11866765B2 (en) Composition for improving molecular barcoding efficiency and use thereof
JP2025133754A (ja) 核酸ハイブリダイゼーションのためのエンハンサーオリゴヌクレオチド
US20160002740A1 (en) Detection of nucleic acids in urine
JP5834413B2 (ja) エネルギー移動を用いた蛍光物質による核酸検出法
JP5322141B2 (ja) ５’領域ディファレンシャルディスプレー法
CN108753949A (zh) 血清中circ_0082660作为URSA诊断及妊娠结局评估标志物的应用
Zhang et al. Cost-effective and Flexible Preimplantation Genetic Testing (PGT) Using Adaptive Sampling-based Targeted Nanopore Sequencing (ASTN-seq)
CN117431309A (zh) circRNA_03628在制备动眼神经麻痹特异性辅助诊断试剂中的应用
CN110846396A (zh) 一种检测肺动脉高压病的eng基因探针组及其应用
CN110846397A (zh) 一种检测肺动脉高压病的smad9基因探针组及其应用
CN110669837A (zh) 一种检测肺动脉高压病的Caveolin-1基因探针组及其应用