DE69130668T2 - Chemolumineszente 3-(substituierte adamant-2'-ylidene)1,2-dioxetane - Google Patents
Chemolumineszente 3-(substituierte adamant-2'-ylidene)1,2-dioxetaneInfo
- Publication number
- DE69130668T2 DE69130668T2 DE69130668T DE69130668T DE69130668T2 DE 69130668 T2 DE69130668 T2 DE 69130668T2 DE 69130668 T DE69130668 T DE 69130668T DE 69130668 T DE69130668 T DE 69130668T DE 69130668 T2 DE69130668 T2 DE 69130668T2
- Authority
- DE
- Germany
- Prior art keywords
- group
- substituent
- substituted
- enzymatically cleavable
- dioxetane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BVTJGGGYKAMDBN-UHFFFAOYSA-N Dioxetane Chemical compound C1COO1 BVTJGGGYKAMDBN-UHFFFAOYSA-N 0.000 title abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- -1 dioxetane compound Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1788—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
- C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Luminescent Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Fats And Perfumes (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Polyesters Or Polycarbonates (AREA)
- Polyethers (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/574,786 US5112960A (en) | 1989-07-17 | 1990-08-30 | Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes |
| US07/574,787 US5220005A (en) | 1986-07-24 | 1990-08-30 | Substituted adamantyl dioxetanes |
| PCT/US1991/006096 WO1992004341A1 (en) | 1990-08-30 | 1991-08-30 | Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69130668D1 DE69130668D1 (de) | 1999-02-04 |
| DE69130668T2 true DE69130668T2 (de) | 1999-05-20 |
Family
ID=27076500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69130668T Expired - Lifetime DE69130668T2 (de) | 1990-08-30 | 1991-08-30 | Chemolumineszente 3-(substituierte adamant-2'-ylidene)1,2-dioxetane |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0497972B1 (de) |
| JP (1) | JP2552413B2 (de) |
| AT (1) | ATE174914T1 (de) |
| AU (1) | AU656927B2 (de) |
| BR (1) | BR9105888A (de) |
| CA (1) | CA2069957C (de) |
| DE (1) | DE69130668T2 (de) |
| DK (1) | DK0497972T3 (de) |
| ES (1) | ES2128326T3 (de) |
| FI (1) | FI102751B (de) |
| NO (1) | NO302120B1 (de) |
| OA (1) | OA09659A (de) |
| WO (1) | WO1992004341A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538847A (en) * | 1989-07-17 | 1996-07-23 | Tropix, Inc. | Chemiluminescent 1,2-dioxetanes |
| US5582980A (en) * | 1989-07-17 | 1996-12-10 | Tropix, Inc. | Chemiluminescent 1,2-dioxetanes |
| US6022964A (en) | 1989-07-17 | 2000-02-08 | Tropix, Inc. | Chemiluminescent 1,2-dioxetanes |
| US5783381A (en) * | 1995-10-19 | 1998-07-21 | Tropix, Inc. | Chemiluminescent 1,2-dioxetanes |
| US6068979A (en) * | 1998-04-22 | 2000-05-30 | Lumigen, Inc. | Simplified sequential chemiluminescent detection |
| ATE441725T1 (de) * | 1998-12-15 | 2009-09-15 | Applera Corp | Multienzym-nachweisverfahren |
| CA2370520A1 (en) * | 1999-04-16 | 2000-10-26 | Komandoor Elayavalli Achyuthan | Viral detection method using viral encoded enzymes and chemiluminescent substrates |
| US7276343B2 (en) * | 2002-06-24 | 2007-10-02 | Fujirebio Inc. | Chemiluminescence enhancer |
| RU2618868C2 (ru) | 2008-05-27 | 2017-05-11 | Дако Денмарк А/С | Композиции и способы определения хромосомных аберраций с новыми буферами для гибридизации |
| US9303287B2 (en) | 2009-02-26 | 2016-04-05 | Dako Denmark A/S | Compositions and methods for RNA hybridization applications |
| US10662465B2 (en) | 2011-09-30 | 2020-05-26 | Agilent Technologies, Inc. | Hybridization compositions and methods using formamide |
| EP3252173A1 (de) | 2011-10-21 | 2017-12-06 | Dako Denmark A/S | Hybridisierungszusammensetzungen und -verfahren |
| DE102016119810A1 (de) | 2016-10-18 | 2018-04-19 | Hamilton Bonaduz Ag | Schichten zum Nachweis von Sauerstoff |
| CN113203728B (zh) * | 2021-03-19 | 2022-07-19 | 四川轻化工大学 | 一种臭氧检测装置及其检测方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4983779A (en) * | 1986-07-17 | 1991-01-08 | The Board Of Governors Of Wayne State University | Process for the preparation of vinyl ethers |
-
1991
- 1991-08-30 BR BR919105888A patent/BR9105888A/pt unknown
- 1991-08-30 AT AT91919701T patent/ATE174914T1/de not_active IP Right Cessation
- 1991-08-30 DK DK91919701T patent/DK0497972T3/da active
- 1991-08-30 DE DE69130668T patent/DE69130668T2/de not_active Expired - Lifetime
- 1991-08-30 ES ES91919701T patent/ES2128326T3/es not_active Expired - Lifetime
- 1991-08-30 CA CA002069957A patent/CA2069957C/en not_active Expired - Lifetime
- 1991-08-30 WO PCT/US1991/006096 patent/WO1992004341A1/en active IP Right Grant
- 1991-08-30 AU AU88714/91A patent/AU656927B2/en not_active Expired
- 1991-08-30 JP JP3518245A patent/JP2552413B2/ja not_active Expired - Lifetime
- 1991-08-30 EP EP91919701A patent/EP0497972B1/de not_active Expired - Lifetime
-
1992
- 1992-04-20 OA OA60193A patent/OA09659A/en unknown
- 1992-04-29 NO NO921682A patent/NO302120B1/no not_active IP Right Cessation
- 1992-04-29 FI FI921925A patent/FI102751B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| FI921925A0 (fi) | 1992-04-29 |
| ATE174914T1 (de) | 1999-01-15 |
| AU656927B2 (en) | 1995-02-23 |
| AU8871491A (en) | 1992-03-30 |
| EP0497972A1 (de) | 1992-08-12 |
| WO1992004341A1 (en) | 1992-03-19 |
| DE69130668D1 (de) | 1999-02-04 |
| CA2069957C (en) | 2000-07-18 |
| FI921925A (fi) | 1992-04-29 |
| ES2128326T3 (es) | 1999-05-16 |
| FI102751B1 (fi) | 1999-02-15 |
| OA09659A (en) | 1993-05-15 |
| NO302120B1 (no) | 1998-01-26 |
| NO921682L (no) | 1992-04-29 |
| JPH05503714A (ja) | 1993-06-17 |
| CA2069957A1 (en) | 1992-03-01 |
| FI102751B (fi) | 1999-02-15 |
| BR9105888A (pt) | 1992-11-10 |
| EP0497972B1 (de) | 1998-12-23 |
| DK0497972T3 (da) | 1999-08-23 |
| NO921682D0 (no) | 1992-04-29 |
| JP2552413B2 (ja) | 1996-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: APPLERA CORP. (N.D.GES.D.STAATES DELAWARE), BEDFOR |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US |