JP2011519561A5 - - Google Patents
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- JP2011519561A5 JP2011519561A5 JP2011507667A JP2011507667A JP2011519561A5 JP 2011519561 A5 JP2011519561 A5 JP 2011519561A5 JP 2011507667 A JP2011507667 A JP 2011507667A JP 2011507667 A JP2011507667 A JP 2011507667A JP 2011519561 A5 JP2011519561 A5 JP 2011519561A5
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- Japan
- Prior art keywords
- coa
- item
- naturally occurring
- microbial organism
- exogenous nucleic
- Prior art date
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- 102000039446 nucleic acids Human genes 0.000 claims description 219
- 108020004707 nucleic acids Proteins 0.000 claims description 219
- 150000007523 nucleic acids Chemical class 0.000 claims description 219
- 230000000813 microbial effect Effects 0.000 claims description 216
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 160
- 230000037361 pathway Effects 0.000 claims description 143
- 102000004190 Enzymes Human genes 0.000 claims description 121
- 108090000790 Enzymes Proteins 0.000 claims description 121
- 238000000034 method Methods 0.000 claims description 118
- 102000004867 Hydro-Lyases Human genes 0.000 claims description 68
- 108090001042 Hydro-Lyases Proteins 0.000 claims description 68
- BWLBGMIXKSTLSX-UHFFFAOYSA-N 2-hydroxyisobutyric acid Chemical compound CC(C)(O)C(O)=O BWLBGMIXKSTLSX-UHFFFAOYSA-N 0.000 claims description 62
- DBXBTMSZEOQQDU-UHFFFAOYSA-N 3-hydroxyisobutyric acid Chemical compound OCC(C)C(O)=O DBXBTMSZEOQQDU-UHFFFAOYSA-N 0.000 claims description 50
- 229920001791 ((R)-3-Hydroxybutanoyl)(n-2) Polymers 0.000 claims description 40
- QHHKKMYHDBRONY-RMNRSTNRSA-N 3-hydroxybutanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QHHKKMYHDBRONY-RMNRSTNRSA-N 0.000 claims description 40
- 102000003960 Ligases Human genes 0.000 claims description 34
- 108090000364 Ligases Proteins 0.000 claims description 34
- 102000004357 Transferases Human genes 0.000 claims description 34
- 108090000992 Transferases Proteins 0.000 claims description 34
- 108090000623 proteins and genes Proteins 0.000 claims description 32
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims description 25
- 102000005345 Acetyl-CoA C-acetyltransferase Human genes 0.000 claims description 25
- 102000011426 Enoyl-CoA hydratase Human genes 0.000 claims description 25
- 108010023922 Enoyl-CoA hydratase Proteins 0.000 claims description 25
- 108091000039 acetoacetyl-CoA reductase Proteins 0.000 claims description 25
- 244000005700 microbiome Species 0.000 claims description 25
- FFVUICCDNWZCRC-ZSJPKINUSA-N 2-hydroxyisobutanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(C)(C)O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 FFVUICCDNWZCRC-ZSJPKINUSA-N 0.000 claims description 24
- BAMBWCGEVIAQBF-CITAKDKDSA-N 4-hydroxybutyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCO)O[C@H]1N1C2=NC=NC(N)=C2N=C1 BAMBWCGEVIAQBF-CITAKDKDSA-N 0.000 claims description 24
- 102000004157 Hydrolases Human genes 0.000 claims description 22
- 108090000604 Hydrolases Proteins 0.000 claims description 22
- 102000019010 Methylmalonyl-CoA Mutase Human genes 0.000 claims description 21
- 108010051862 Methylmalonyl-CoA mutase Proteins 0.000 claims description 21
- 238000012258 culturing Methods 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 18
- 102000004316 Oxidoreductases Human genes 0.000 claims description 17
- 108090000854 Oxidoreductases Proteins 0.000 claims description 17
- 108010035023 4-hydroxybutyryl-CoA dehydratase Proteins 0.000 claims description 16
- 108010093991 Vinylacetyl-CoA Delta-isomerase Proteins 0.000 claims description 16
- 238000012239 gene modification Methods 0.000 claims description 16
- 230000005017 genetic modification Effects 0.000 claims description 16
- 235000013617 genetically modified food Nutrition 0.000 claims description 16
- 102000030503 Methylmalonyl-CoA epimerase Human genes 0.000 claims description 15
- MZFOKIKEPGUZEN-FBMOWMAESA-N methylmalonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(C(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MZFOKIKEPGUZEN-FBMOWMAESA-N 0.000 claims description 15
- 108091000124 methylmalonyl-CoA epimerase Proteins 0.000 claims description 15
- 108010077268 3-hydroxyisobutyryl-CoA hydrolase Proteins 0.000 claims description 12
- 102100034767 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Human genes 0.000 claims description 12
- QCHPKSFMDHPSNR-UHFFFAOYSA-N 3-aminoisobutyric acid Chemical compound NCC(C)C(O)=O QCHPKSFMDHPSNR-UHFFFAOYSA-N 0.000 claims description 11
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 11
- 229930029653 phosphoenolpyruvate Natural products 0.000 claims description 11
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 11
- 101710088194 Dehydrogenase Proteins 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 9
- 108010030844 2-methylcitrate synthase Proteins 0.000 claims description 8
- WWEOGFZEFHPUAM-MIZDRFBCSA-N 3-hydroxy-2-methylpropanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(CO)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 WWEOGFZEFHPUAM-MIZDRFBCSA-N 0.000 claims description 8
- 108020003281 3-hydroxyisobutyrate dehydrogenase Proteins 0.000 claims description 8
- 102000006027 3-hydroxyisobutyrate dehydrogenase Human genes 0.000 claims description 8
- 102000009836 Aconitate hydratase Human genes 0.000 claims description 8
- 108010009924 Aconitate hydratase Proteins 0.000 claims description 8
- 102100034229 Citramalyl-CoA lyase, mitochondrial Human genes 0.000 claims description 8
- 108010071536 Citrate (Si)-synthase Proteins 0.000 claims description 8
- 102000006732 Citrate synthase Human genes 0.000 claims description 8
- 108020003285 Isocitrate lyase Proteins 0.000 claims description 8
- 108020004687 Malate Synthase Proteins 0.000 claims description 8
- 108010031852 Pyruvate Synthase Proteins 0.000 claims description 8
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims description 8
- HNEGQIOMVPPMNR-NSCUHMNNSA-N mesaconic acid Chemical compound OC(=O)C(/C)=C/C(O)=O HNEGQIOMVPPMNR-NSCUHMNNSA-N 0.000 claims description 8
- HNEGQIOMVPPMNR-UHFFFAOYSA-N methylfumaric acid Natural products OC(=O)C(C)=CC(O)=O HNEGQIOMVPPMNR-UHFFFAOYSA-N 0.000 claims description 8
- VNAIXPVBNZGXNO-UHFFFAOYSA-N 3-amino-2-methylpropanoic acid azane Chemical compound N.NCC(C(=O)O)C VNAIXPVBNZGXNO-UHFFFAOYSA-N 0.000 claims description 7
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims description 7
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims description 7
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims description 7
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims description 7
- 108090000673 Ammonia-Lyases Proteins 0.000 claims description 7
- 102000004118 Ammonia-Lyases Human genes 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 102000003929 Transaminases Human genes 0.000 claims description 7
- 108090000340 Transaminases Proteins 0.000 claims description 7
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims description 6
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims description 6
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 claims description 6
- 102000016901 Glutamate dehydrogenase Human genes 0.000 claims description 6
- GXSDWXSYZHGBBO-RXMQYKEDSA-N (2r)-2-amino-2-hydroxypentanedioic acid Chemical compound OC(=O)[C@@](O)(N)CCC(O)=O GXSDWXSYZHGBBO-RXMQYKEDSA-N 0.000 claims description 4
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 claims description 4
- NPYQJIHHTGFBLN-UHFFFAOYSA-N 3-methylmalic acid Chemical compound OC(=O)C(C)C(O)C(O)=O NPYQJIHHTGFBLN-UHFFFAOYSA-N 0.000 claims description 4
- 108010003415 Aspartate Aminotransferases Proteins 0.000 claims description 4
- 102000004625 Aspartate Aminotransferases Human genes 0.000 claims description 4
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims description 4
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims description 4
- 108010065059 methylaspartate ammonia-lyase Proteins 0.000 claims description 4
- 108010009674 methylaspartate mutase Proteins 0.000 claims description 4
- 108010092060 Acetate kinase Proteins 0.000 claims description 3
- 108700016171 Aspartate ammonia-lyases Proteins 0.000 claims description 3
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims description 3
- 108010026217 Malate Dehydrogenase Proteins 0.000 claims description 3
- 102000013460 Malate Dehydrogenase Human genes 0.000 claims description 3
- 102000006746 NADH Dehydrogenase Human genes 0.000 claims description 3
- 108010086428 NADH Dehydrogenase Proteins 0.000 claims description 3
- 108700023175 Phosphate acetyltransferases Proteins 0.000 claims description 3
- 108091000080 Phosphotransferase Proteins 0.000 claims description 3
- 102000001253 Protein Kinase Human genes 0.000 claims description 3
- 108010065064 acetaldehyde dehydrogenase (acylating) Proteins 0.000 claims description 3
- 238000012217 deletion Methods 0.000 claims description 3
- 230000037430 deletion Effects 0.000 claims description 3
- 108010008221 formate C-acetyltransferase Proteins 0.000 claims description 3
- 102000020233 phosphotransferase Human genes 0.000 claims description 3
- -1 2-hydroxyisobutyryl Chemical group 0.000 claims description 2
- 108010014720 2-methylacyl-CoA dehydrogenase Proteins 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- 108090000489 Carboxy-Lyases Proteins 0.000 claims 2
- 102100021646 Isobutyryl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 2
- 108010008386 malonyl-Coa reductase Proteins 0.000 claims 2
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 1
- 102000002735 Acyl-CoA Dehydrogenase Human genes 0.000 claims 1
- 108010001058 Acyl-CoA Dehydrogenase Proteins 0.000 claims 1
- 108010068197 Butyryl-CoA Dehydrogenase Proteins 0.000 claims 1
- 102000010079 Coenzyme A-Transferases Human genes 0.000 claims 1
- 108010077385 Coenzyme A-Transferases Proteins 0.000 claims 1
- 108030005217 Isobutyryl-CoA mutases Proteins 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 108010085747 Methylmalonyl-CoA Decarboxylase Proteins 0.000 claims 1
- 102100024639 Short-chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 1
- 108010067653 lactate dehydratase Proteins 0.000 claims 1
- 108010033041 valine aminotransferase Proteins 0.000 claims 1
- 239000001963 growth medium Substances 0.000 description 22
- 239000002609 medium Substances 0.000 description 6
- BWLBGMIXKSTLSX-UHFFFAOYSA-M 2-hydroxyisobutyrate Chemical compound CC(C)(O)C([O-])=O BWLBGMIXKSTLSX-UHFFFAOYSA-M 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4973008P | 2008-05-01 | 2008-05-01 | |
| US61/049,730 | 2008-05-01 | ||
| PCT/US2009/042426 WO2009135074A2 (en) | 2008-05-01 | 2009-04-30 | Microorganisms for the production of methacrylic acid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014108853A Division JP2014147400A (ja) | 2008-05-01 | 2014-05-27 | メタクリル酸の産生のための微生物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011519561A JP2011519561A (ja) | 2011-07-14 |
| JP2011519561A5 true JP2011519561A5 (enExample) | 2012-06-07 |
Family
ID=41255834
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507667A Pending JP2011519561A (ja) | 2008-05-01 | 2009-04-30 | メタクリル酸の産生のための微生物 |
| JP2014108853A Pending JP2014147400A (ja) | 2008-05-01 | 2014-05-27 | メタクリル酸の産生のための微生物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014108853A Pending JP2014147400A (ja) | 2008-05-01 | 2014-05-27 | メタクリル酸の産生のための微生物 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US8241877B2 (enExample) |
| EP (1) | EP2285973A4 (enExample) |
| JP (2) | JP2011519561A (enExample) |
| AU (1) | AU2009242615A1 (enExample) |
| BR (1) | BRPI0911759A2 (enExample) |
| CA (1) | CA2722680A1 (enExample) |
| WO (1) | WO2009135074A2 (enExample) |
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| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
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| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| CA2735883C (en) | 2008-09-10 | 2020-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
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| US9637746B2 (en) | 2008-12-15 | 2017-05-02 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways |
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2009
- 2009-04-30 JP JP2011507667A patent/JP2011519561A/ja active Pending
- 2009-04-30 EP EP09739876A patent/EP2285973A4/en not_active Ceased
- 2009-04-30 BR BRPI0911759A patent/BRPI0911759A2/pt not_active IP Right Cessation
- 2009-04-30 AU AU2009242615A patent/AU2009242615A1/en not_active Abandoned
- 2009-04-30 CA CA2722680A patent/CA2722680A1/en not_active Abandoned
- 2009-04-30 US US12/433,829 patent/US8241877B2/en not_active Expired - Fee Related
- 2009-04-30 WO PCT/US2009/042426 patent/WO2009135074A2/en not_active Ceased
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2012
- 2012-06-22 US US13/531,377 patent/US8900837B2/en active Active
- 2012-07-10 US US13/545,880 patent/US8865439B2/en active Active
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2014
- 2014-05-27 JP JP2014108853A patent/JP2014147400A/ja active Pending
- 2014-12-01 US US14/557,188 patent/US9951355B2/en active Active
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2018
- 2018-04-23 US US15/960,252 patent/US20190376096A1/en not_active Abandoned
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2020
- 2020-08-19 US US16/997,704 patent/US20210040511A1/en not_active Abandoned
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