JP2011519561A5 - - Google Patents
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- JP2011519561A5 JP2011519561A5 JP2011507667A JP2011507667A JP2011519561A5 JP 2011519561 A5 JP2011519561 A5 JP 2011519561A5 JP 2011507667 A JP2011507667 A JP 2011507667A JP 2011507667 A JP2011507667 A JP 2011507667A JP 2011519561 A5 JP2011519561 A5 JP 2011519561A5
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- Japan
- Prior art keywords
- coa
- item
- naturally occurring
- microbial organism
- exogenous nucleic
- Prior art date
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- 102000039446 nucleic acids Human genes 0.000 claims description 219
- 108020004707 nucleic acids Proteins 0.000 claims description 219
- 150000007523 nucleic acids Chemical class 0.000 claims description 219
- 230000000813 microbial effect Effects 0.000 claims description 216
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 160
- 230000037361 pathway Effects 0.000 claims description 143
- 102000004190 Enzymes Human genes 0.000 claims description 121
- 108090000790 Enzymes Proteins 0.000 claims description 121
- 238000000034 method Methods 0.000 claims description 118
- 102000004867 Hydro-Lyases Human genes 0.000 claims description 68
- 108090001042 Hydro-Lyases Proteins 0.000 claims description 68
- BWLBGMIXKSTLSX-UHFFFAOYSA-N 2-hydroxyisobutyric acid Chemical compound CC(C)(O)C(O)=O BWLBGMIXKSTLSX-UHFFFAOYSA-N 0.000 claims description 62
- DBXBTMSZEOQQDU-UHFFFAOYSA-N 3-hydroxyisobutyric acid Chemical compound OCC(C)C(O)=O DBXBTMSZEOQQDU-UHFFFAOYSA-N 0.000 claims description 50
- 229920001791 ((R)-3-Hydroxybutanoyl)(n-2) Polymers 0.000 claims description 40
- QHHKKMYHDBRONY-RMNRSTNRSA-N 3-hydroxybutanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QHHKKMYHDBRONY-RMNRSTNRSA-N 0.000 claims description 40
- 102000003960 Ligases Human genes 0.000 claims description 34
- 108090000364 Ligases Proteins 0.000 claims description 34
- 102000004357 Transferases Human genes 0.000 claims description 34
- 108090000992 Transferases Proteins 0.000 claims description 34
- 108090000623 proteins and genes Proteins 0.000 claims description 32
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims description 25
- 102000005345 Acetyl-CoA C-acetyltransferase Human genes 0.000 claims description 25
- 102000011426 Enoyl-CoA hydratase Human genes 0.000 claims description 25
- 108010023922 Enoyl-CoA hydratase Proteins 0.000 claims description 25
- 108091000039 acetoacetyl-CoA reductase Proteins 0.000 claims description 25
- 244000005700 microbiome Species 0.000 claims description 25
- FFVUICCDNWZCRC-ZSJPKINUSA-N 2-hydroxyisobutanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(C)(C)O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 FFVUICCDNWZCRC-ZSJPKINUSA-N 0.000 claims description 24
- BAMBWCGEVIAQBF-CITAKDKDSA-N 4-hydroxybutyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCO)O[C@H]1N1C2=NC=NC(N)=C2N=C1 BAMBWCGEVIAQBF-CITAKDKDSA-N 0.000 claims description 24
- 102000004157 Hydrolases Human genes 0.000 claims description 22
- 108090000604 Hydrolases Proteins 0.000 claims description 22
- 102000019010 Methylmalonyl-CoA Mutase Human genes 0.000 claims description 21
- 108010051862 Methylmalonyl-CoA mutase Proteins 0.000 claims description 21
- 238000012258 culturing Methods 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 18
- 102000004316 Oxidoreductases Human genes 0.000 claims description 17
- 108090000854 Oxidoreductases Proteins 0.000 claims description 17
- 108010035023 4-hydroxybutyryl-CoA dehydratase Proteins 0.000 claims description 16
- 108010093991 Vinylacetyl-CoA Delta-isomerase Proteins 0.000 claims description 16
- 238000012239 gene modification Methods 0.000 claims description 16
- 230000005017 genetic modification Effects 0.000 claims description 16
- 235000013617 genetically modified food Nutrition 0.000 claims description 16
- 102000030503 Methylmalonyl-CoA epimerase Human genes 0.000 claims description 15
- MZFOKIKEPGUZEN-FBMOWMAESA-N methylmalonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(C(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MZFOKIKEPGUZEN-FBMOWMAESA-N 0.000 claims description 15
- 108091000124 methylmalonyl-CoA epimerase Proteins 0.000 claims description 15
- 108010077268 3-hydroxyisobutyryl-CoA hydrolase Proteins 0.000 claims description 12
- 102100034767 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Human genes 0.000 claims description 12
- QCHPKSFMDHPSNR-UHFFFAOYSA-N 3-aminoisobutyric acid Chemical compound NCC(C)C(O)=O QCHPKSFMDHPSNR-UHFFFAOYSA-N 0.000 claims description 11
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 11
- 229930029653 phosphoenolpyruvate Natural products 0.000 claims description 11
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 11
- 101710088194 Dehydrogenase Proteins 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 9
- 108010030844 2-methylcitrate synthase Proteins 0.000 claims description 8
- WWEOGFZEFHPUAM-MIZDRFBCSA-N 3-hydroxy-2-methylpropanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(CO)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 WWEOGFZEFHPUAM-MIZDRFBCSA-N 0.000 claims description 8
- 108020003281 3-hydroxyisobutyrate dehydrogenase Proteins 0.000 claims description 8
- 102000006027 3-hydroxyisobutyrate dehydrogenase Human genes 0.000 claims description 8
- 102000009836 Aconitate hydratase Human genes 0.000 claims description 8
- 108010009924 Aconitate hydratase Proteins 0.000 claims description 8
- 102100034229 Citramalyl-CoA lyase, mitochondrial Human genes 0.000 claims description 8
- 108010071536 Citrate (Si)-synthase Proteins 0.000 claims description 8
- 102000006732 Citrate synthase Human genes 0.000 claims description 8
- 108020003285 Isocitrate lyase Proteins 0.000 claims description 8
- 108020004687 Malate Synthase Proteins 0.000 claims description 8
- 108010031852 Pyruvate Synthase Proteins 0.000 claims description 8
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims description 8
- HNEGQIOMVPPMNR-NSCUHMNNSA-N mesaconic acid Chemical compound OC(=O)C(/C)=C/C(O)=O HNEGQIOMVPPMNR-NSCUHMNNSA-N 0.000 claims description 8
- HNEGQIOMVPPMNR-UHFFFAOYSA-N methylfumaric acid Natural products OC(=O)C(C)=CC(O)=O HNEGQIOMVPPMNR-UHFFFAOYSA-N 0.000 claims description 8
- VNAIXPVBNZGXNO-UHFFFAOYSA-N 3-amino-2-methylpropanoic acid azane Chemical compound N.NCC(C(=O)O)C VNAIXPVBNZGXNO-UHFFFAOYSA-N 0.000 claims description 7
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims description 7
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims description 7
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims description 7
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims description 7
- 108090000673 Ammonia-Lyases Proteins 0.000 claims description 7
- 102000004118 Ammonia-Lyases Human genes 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 102000003929 Transaminases Human genes 0.000 claims description 7
- 108090000340 Transaminases Proteins 0.000 claims description 7
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims description 6
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims description 6
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 claims description 6
- 102000016901 Glutamate dehydrogenase Human genes 0.000 claims description 6
- GXSDWXSYZHGBBO-RXMQYKEDSA-N (2r)-2-amino-2-hydroxypentanedioic acid Chemical compound OC(=O)[C@@](O)(N)CCC(O)=O GXSDWXSYZHGBBO-RXMQYKEDSA-N 0.000 claims description 4
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 claims description 4
- NPYQJIHHTGFBLN-UHFFFAOYSA-N 3-methylmalic acid Chemical compound OC(=O)C(C)C(O)C(O)=O NPYQJIHHTGFBLN-UHFFFAOYSA-N 0.000 claims description 4
- 108010003415 Aspartate Aminotransferases Proteins 0.000 claims description 4
- 102000004625 Aspartate Aminotransferases Human genes 0.000 claims description 4
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims description 4
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims description 4
- 108010065059 methylaspartate ammonia-lyase Proteins 0.000 claims description 4
- 108010009674 methylaspartate mutase Proteins 0.000 claims description 4
- 108010092060 Acetate kinase Proteins 0.000 claims description 3
- 108700016171 Aspartate ammonia-lyases Proteins 0.000 claims description 3
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims description 3
- 108010026217 Malate Dehydrogenase Proteins 0.000 claims description 3
- 102000013460 Malate Dehydrogenase Human genes 0.000 claims description 3
- 102000006746 NADH Dehydrogenase Human genes 0.000 claims description 3
- 108010086428 NADH Dehydrogenase Proteins 0.000 claims description 3
- 108700023175 Phosphate acetyltransferases Proteins 0.000 claims description 3
- 108091000080 Phosphotransferase Proteins 0.000 claims description 3
- 102000001253 Protein Kinase Human genes 0.000 claims description 3
- 108010065064 acetaldehyde dehydrogenase (acylating) Proteins 0.000 claims description 3
- 238000012217 deletion Methods 0.000 claims description 3
- 230000037430 deletion Effects 0.000 claims description 3
- 108010008221 formate C-acetyltransferase Proteins 0.000 claims description 3
- 102000020233 phosphotransferase Human genes 0.000 claims description 3
- -1 2-hydroxyisobutyryl Chemical group 0.000 claims description 2
- 108010014720 2-methylacyl-CoA dehydrogenase Proteins 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- 108090000489 Carboxy-Lyases Proteins 0.000 claims 2
- 102100021646 Isobutyryl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 2
- 108010008386 malonyl-Coa reductase Proteins 0.000 claims 2
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 1
- 102000002735 Acyl-CoA Dehydrogenase Human genes 0.000 claims 1
- 108010001058 Acyl-CoA Dehydrogenase Proteins 0.000 claims 1
- 108010068197 Butyryl-CoA Dehydrogenase Proteins 0.000 claims 1
- 102000010079 Coenzyme A-Transferases Human genes 0.000 claims 1
- 108010077385 Coenzyme A-Transferases Proteins 0.000 claims 1
- 108030005217 Isobutyryl-CoA mutases Proteins 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 108010085747 Methylmalonyl-CoA Decarboxylase Proteins 0.000 claims 1
- 102100024639 Short-chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 1
- 108010067653 lactate dehydratase Proteins 0.000 claims 1
- 108010033041 valine aminotransferase Proteins 0.000 claims 1
- 239000001963 growth medium Substances 0.000 description 22
- 239000002609 medium Substances 0.000 description 6
- BWLBGMIXKSTLSX-UHFFFAOYSA-M 2-hydroxyisobutyrate Chemical compound CC(C)(O)C([O-])=O BWLBGMIXKSTLSX-UHFFFAOYSA-M 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4973008P | 2008-05-01 | 2008-05-01 | |
| US61/049,730 | 2008-05-01 | ||
| PCT/US2009/042426 WO2009135074A2 (en) | 2008-05-01 | 2009-04-30 | Microorganisms for the production of methacrylic acid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014108853A Division JP2014147400A (ja) | 2008-05-01 | 2014-05-27 | メタクリル酸の産生のための微生物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011519561A JP2011519561A (ja) | 2011-07-14 |
| JP2011519561A5 true JP2011519561A5 (enExample) | 2012-06-07 |
Family
ID=41255834
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507667A Pending JP2011519561A (ja) | 2008-05-01 | 2009-04-30 | メタクリル酸の産生のための微生物 |
| JP2014108853A Pending JP2014147400A (ja) | 2008-05-01 | 2014-05-27 | メタクリル酸の産生のための微生物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014108853A Pending JP2014147400A (ja) | 2008-05-01 | 2014-05-27 | メタクリル酸の産生のための微生物 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US8241877B2 (enExample) |
| EP (1) | EP2285973A4 (enExample) |
| JP (2) | JP2011519561A (enExample) |
| AU (1) | AU2009242615A1 (enExample) |
| BR (1) | BRPI0911759A2 (enExample) |
| CA (1) | CA2722680A1 (enExample) |
| WO (1) | WO2009135074A2 (enExample) |
Families Citing this family (62)
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| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| EP2285973A4 (en) | 2008-05-01 | 2012-04-25 | Genomatica Inc | PROCESS FOR PREPARING METHACRYLIC ACID |
| EP2304039B1 (en) | 2008-06-17 | 2019-08-21 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| CA2735883C (en) | 2008-09-10 | 2020-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
| WO2010057022A1 (en) * | 2008-11-14 | 2010-05-20 | Genomatica, Inc. | Microorganisms for the production of methyl ethyl ketone and 2-butanol |
| WO2010077806A1 (en) | 2008-12-15 | 2010-07-08 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways |
| KR20110097951A (ko) | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
| CN102333878B (zh) * | 2008-12-22 | 2015-08-26 | 绿光生物科学公司 | 用于制造化合物的组合物和方法 |
| WO2010098865A1 (en) * | 2009-02-26 | 2010-09-02 | Gt Life Sciences, Inc. | Mammalian cell line models and related methods |
| US8129169B2 (en) | 2009-06-04 | 2012-03-06 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol and related methods |
| KR20180042467A (ko) | 2009-06-04 | 2018-04-25 | 게노마티카 인코포레이티드 | 발효액 성분들의 분리 방법 |
| JP2012529889A (ja) | 2009-06-10 | 2012-11-29 | ゲノマチカ， インク． | Ｍｅｋ及び２−ブタノールの炭素効率のよい生合成のための微生物及び方法 |
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| WO2011066076A1 (en) * | 2009-11-25 | 2011-06-03 | Genomatica, Inc. | Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone |
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| US8445244B2 (en) | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
| JP5911847B2 (ja) | 2010-05-05 | 2016-04-27 | ジェノマティカ， インコーポレイテッド | ブタジエンの生合成のための微生物および方法 |
| KR20130071433A (ko) | 2010-05-07 | 2013-06-28 | 그린라이트 바이오사이언시스, 아이엔씨. | 효소의 재배치를 통한 대사 경로에서의 흐름의 제어 방법 |
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| WO2012135789A2 (en) * | 2011-04-01 | 2012-10-04 | Genomatica, Inc. | Microorganisms for producing methacrylic acid and methacrylate esters and methods related thereto |
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| RU2658770C2 (ru) | 2011-07-12 | 2018-06-22 | Сайентист Оф Фортчун С.А. | Рекомбинантный микроорганизм для получения полезных метаболитов |
| US9822387B2 (en) | 2011-07-29 | 2017-11-21 | Mitsui Chemicals, Inc. | Microorganism having carbon dioxide fixation pathway introduced thereinto |
| CN104093848A (zh) | 2011-09-09 | 2014-10-08 | 绿光生物科学公司 | 碳青霉烯(carbapenem)的无细胞制备 |
| EP2773767A4 (en) * | 2011-11-02 | 2015-08-05 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PRODUCTION OF CAPROLACTONE |
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| EP2850180A1 (en) | 2012-05-18 | 2015-03-25 | Novozymes A/S | Bacterial mutants with improved transformation efficiency |
| SI2855687T1 (sl) | 2012-06-04 | 2020-09-30 | Genomatica, Inc. | Mikroorganizmi in metode za proizvodnjo 4-hidroksibutirat, 1,4-butandiola in sorodne spojine |
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| WO2014038214A1 (ja) | 2012-09-10 | 2014-03-13 | 三菱レイヨン株式会社 | メタクリル酸エステルの製造方法 |
| KR101980982B1 (ko) | 2012-09-10 | 2019-05-21 | 미쯔비시 케미컬 주식회사 | 메타크릴산 및/또는 그의 에스테르의 제조 방법 |
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| AU2013364025A1 (en) | 2012-12-21 | 2015-07-23 | Greenlight Biosciences, Inc. | Cell-free system for converting methane into fuel, pyruvate or isobutanol |
| BE1021047B1 (fr) * | 2013-01-18 | 2015-02-25 | Man To Tree S.A. | Actinobacillus succinogenes genetiquement modifiee et son utilisation pour la production d'acide succinique |
| EP2949751B1 (en) | 2013-01-24 | 2022-08-03 | Mitsui Chemicals, Inc. | Microorganism having carbon dioxide fixation cycle introduced thereinto |
| BR112015020904A2 (pt) | 2013-03-15 | 2017-10-10 | Genomatica Inc | microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato |
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| CN118879602A (zh) | 2013-12-27 | 2024-11-01 | 基因组股份公司 | 具有增加的碳通量效率的方法和生物 |
| KR20160111936A (ko) * | 2014-01-28 | 2016-09-27 | 란자테크 뉴질랜드 리미티드 | 부티르산에 대한 증가된 내성을 갖는 박테리아 |
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| BR112017005665A2 (pt) | 2014-09-18 | 2017-12-12 | Genomatica Inc | organismos microbianos não naturais com eficiência energética melhorada |
| WO2016130597A1 (en) * | 2015-02-10 | 2016-08-18 | GeneSys Consulting, LLC | Methylmalonic acid compositions, biological methods for making same, and microorganisms for making same |
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| EP3366767A4 (en) * | 2015-10-23 | 2018-10-17 | The Regents of the University of California | Biological production of methyl methacrylate |
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-
2009
- 2009-04-30 EP EP09739876A patent/EP2285973A4/en not_active Ceased
- 2009-04-30 US US12/433,829 patent/US8241877B2/en not_active Expired - Fee Related
- 2009-04-30 AU AU2009242615A patent/AU2009242615A1/en not_active Abandoned
- 2009-04-30 CA CA2722680A patent/CA2722680A1/en not_active Abandoned
- 2009-04-30 BR BRPI0911759A patent/BRPI0911759A2/pt not_active IP Right Cessation
- 2009-04-30 JP JP2011507667A patent/JP2011519561A/ja active Pending
- 2009-04-30 WO PCT/US2009/042426 patent/WO2009135074A2/en not_active Ceased
-
2012
- 2012-06-22 US US13/531,377 patent/US8900837B2/en active Active
- 2012-07-10 US US13/545,880 patent/US8865439B2/en active Active
-
2014
- 2014-05-27 JP JP2014108853A patent/JP2014147400A/ja active Pending
- 2014-12-01 US US14/557,188 patent/US9951355B2/en active Active
-
2018
- 2018-04-23 US US15/960,252 patent/US20190376096A1/en not_active Abandoned
-
2020
- 2020-08-19 US US16/997,704 patent/US20210040511A1/en not_active Abandoned
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