|
DE2330742C2
(de)
|
1973-06-16 |
1982-07-29 |
Hoechst Ag, 6000 Frankfurt |
1-(Oxoalkyl)-3-methyl-7-alkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
|
|
JPS5576876A
(en)
|
1978-12-05 |
1980-06-10 |
Grelan Pharmaceut Co Ltd |
Preparation of 1-(oxoalkyl)-3,7-dimethylxanthine derivatne
|
|
JPS55122779A
(en)
|
1979-03-13 |
1980-09-20 |
Maruko Seiyaku Kk |
Preparation of theobromine derivative
|
|
CS201558B1
(en)
|
1979-05-14 |
1980-11-28 |
Pavol Kovar |
Method of preparing 1-/5-oxohexyl/-3,7-dimethylxanthine
|
|
JPS567785A
(en)
|
1979-07-02 |
1981-01-27 |
Maruko Seiyaku Kk |
Preparation of theobromine derivative
|
|
JPS5610187A
(en)
|
1979-07-05 |
1981-02-02 |
Grelan Pharmaceut Co Ltd |
Separation and purification of 1-(5-oxohexyl)- 3,7-dimethylxanthine
|
|
JPS5610188A
(en)
|
1979-07-06 |
1981-02-02 |
Dainippon Ink & Chem Inc |
Xanthine derivative and its preparation
|
|
JPS5632477A
(en)
|
1979-08-27 |
1981-04-01 |
Nippon Iyakuhin Kaihatsu Kenkyusho:Kk |
Preparation of 1- 5-oxohexyl -3,7-dimethylxanthine
|
|
JPS5677279A
(en)
|
1979-11-28 |
1981-06-25 |
Ota Seiyaku Kk |
Preparation of xanthine derivative
|
|
JPS5711981A
(en)
|
1980-06-26 |
1982-01-21 |
Sagami Chem Res Center |
Theobromine derivative and its preparation
|
|
JPS5724386A
(en)
|
1980-07-17 |
1982-02-08 |
Nissan Chem Ind Ltd |
Preparation of xanthine derivative
|
|
JPS5724382A
(en)
|
1980-07-17 |
1982-02-08 |
Nissan Chem Ind Ltd |
Trithiane derivative and its preparation
|
|
JPS5724385A
(en)
|
1980-07-17 |
1982-02-08 |
Nissan Chem Ind Ltd |
Theobromine derivative and its preparation
|
|
JPS5756481A
(en)
|
1980-09-22 |
1982-04-05 |
Kawashima Yakuhin Kaihatsu Kk |
Production of 1-(5-oxohexyl)-3,7-dimethylxanthine
|
|
JPS5762278A
(en)
|
1980-10-01 |
1982-04-15 |
Sagami Chem Res Center |
Theobromine derivative and its preparation
|
|
JPS5780385A
(en)
|
1980-11-05 |
1982-05-19 |
Mitsubishi Petrochem Co Ltd |
Preparation of 1-((omega-1)-oxoalkyl)-3,7-dialkylxanthine
|
|
JPS5785387A
(en)
|
1980-11-14 |
1982-05-28 |
Teikoku Chem Ind Corp Ltd |
Preparation of 1-(-5'-oxohexyl)-3,7-dimethylxanthine
|
|
JPS5798284A
(en)
|
1980-12-10 |
1982-06-18 |
Kawashima Yakuhin Kaihatsu Kk |
Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine
|
|
JPS57200391A
(en)
|
1981-06-02 |
1982-12-08 |
Daito Koeki Kk |
1-(5-oxo-2-hexenyl)3,7-dimethylxanthine
|
|
JPS5838284A
(ja)
|
1981-09-01 |
1983-03-05 |
Teikoku Chem Ind Corp Ltd |
１−（５′−オキソヘキシル）−３，７−ジメチルキサンチンの製造方法
|
|
JPS58134092A
(ja)
|
1982-02-05 |
1983-08-10 |
Sagami Chem Res Center |
テオブロミン誘導体
|
|
JPS58150594A
(ja)
|
1982-03-03 |
1983-09-07 |
Daito Koeki Kk |
キサンチン誘導体の製造方法
|
|
CS237719B1
(cs)
|
1983-05-12 |
1985-10-16 |
Jan Jendrichovsky |
SpAsob přípravy dimetyl-(5-oxohexyl)-xantlnov
|
|
DE3508097A1
(de)
|
1984-07-21 |
1986-02-06 |
Hoechst Ag, 6230 Frankfurt |
Kombinationspraeparat aus xanthinderivaten und o-acetylsalicylsaeure bzw. deren pharmakologisch vertraeglichen salzen und dessen verwendung
|
|
DE3525801A1
(de)
*
|
1985-07-19 |
1987-01-22 |
Hoechst Ag |
Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
|
|
DD274334A3
(de)
|
1985-12-17 |
1989-12-20 |
Dresden Arzneimittel |
Verfahren zur herstellung von reinem 3,7-dimethyl-1-(5-oxohexyl)-xanthin
|
|
IL100535A
(en)
|
1986-12-31 |
1994-05-30 |
Hoechst Roussel Pharma |
Pharmaceutical preparations containing a history of xanthine to relieve disease states
|
|
CS263595B1
(sk)
|
1988-01-06 |
1989-04-14 |
Rybar Alfonz |
Spdsob pripravy 7-n-prnpyl-3-metyl 3,7-dihydro-lH-purín-2,6-dionu
|
|
JP2661666B2
(ja)
|
1988-02-19 |
1997-10-08 |
ヘキスト薬品工業株式会社 |
抗消化性潰瘍剤
|
|
IT1231779B
(it)
|
1989-08-09 |
1991-12-21 |
Eniricerche Spa |
Procedimento per l'ossidazione di composti paraffinici.
|
|
US5304121A
(en)
|
1990-12-28 |
1994-04-19 |
Boston Scientific Corporation |
Drug delivery system making use of a hydrogel polymer coating
|
|
DE3942872A1
(de)
|
1989-12-23 |
1991-06-27 |
Hoechst Ag |
Verfahren zur enantioselektiven darstellung von ((omega)-1)-hydroxyalkylxanthinen
|
|
US5112827A
(en)
*
|
1990-05-18 |
1992-05-12 |
Board Of Regents, The University Of Texas System |
Drug to reverse fatty liver and atheromatous lesions
|
|
WO1992007566A2
(en)
|
1990-11-01 |
1992-05-14 |
Board Of Regents, The University Of Texas System |
Antifungal activity of and prevention of drug induced nephrotoxicity by methylxanthine analogues
|
|
ATE138266T1
(de)
|
1990-11-07 |
1996-06-15 |
Hoechst Roussel Pharma |
Verwendung von xanthinen zur herstellung von arzneimitteln zur hemmung der vermehrung menschlicher retroviren
|
|
US6420374B1
(en)
|
1990-11-30 |
2002-07-16 |
Fred Hutchinson Cancer Research Center |
Use of xanthines as immunosuppressants and to inhibit allograft reactions
|
|
EP0490181A1
(en)
|
1990-11-30 |
1992-06-17 |
Hoechst-Roussel Pharmaceuticals Incorporated |
Use of xanthines for preparation of a medicament having immunosuppressing activity
|
|
EP0493682A3
(en)
*
|
1990-11-30 |
1992-11-19 |
Hoechst-Roussel Pharmaceuticals Incorporated |
Use of xanthines for the preparation of a medicament effective for inhibiting the effects of allograft reaction in humans
|
|
US5648357A
(en)
*
|
1992-03-04 |
1997-07-15 |
Cell Therapeutics, Inc. |
Enatiomerically pure hydroxylated xanthine compounds
|
|
US5763446A
(en)
|
1992-03-26 |
1998-06-09 |
University Of Southern California |
Use of pentoxifylline and other tumor necrosis factor blockers for the treatment of aids-associated optic neuropathy and other central nervous system diseases
|
|
US5780476A
(en)
*
|
1992-11-16 |
1998-07-14 |
Cell Therapeutics, Inc. |
Hydroxyl-containing xanthine compounds
|
|
US6020337A
(en)
*
|
1993-04-05 |
2000-02-01 |
Cell Therapeutics, Inc. |
Electronegative-substituted long chain xanthine compounds
|
|
US5670506A
(en)
*
|
1993-04-05 |
1997-09-23 |
Cell Therapeutics, Inc. |
Halogen, isothiocyanate or azide substituted xanthines
|
|
US5886026A
(en)
|
1993-07-19 |
1999-03-23 |
Angiotech Pharmaceuticals Inc. |
Anti-angiogenic compositions and methods of use
|
|
HUT68560A
(en)
|
1993-08-02 |
1995-04-27 |
Chinoin Gyogyszer Es Vegyeszet |
The use of xantine derivatives for promotion of healing of operative lesions
|
|
CN1087725C
(zh)
*
|
1994-03-25 |
2002-07-17 |
同位素技术有限公司 |
用氘代方法增强药物效果
|
|
US6221335B1
(en)
*
|
1994-03-25 |
2001-04-24 |
Isotechnika, Inc. |
Method of using deuterated calcium channel blockers
|
|
DE69528585D1
(de)
|
1994-05-16 |
2002-11-21 |
Cell Therapeutics Inc |
Asymmetrische synthese von chiralen sekondären alkoholen
|
|
AU3539795A
(en)
|
1994-08-25 |
1996-03-14 |
Medical University Of South Carolina |
Methods of treating cold symptoms using pentoxifylline
|
|
DE4430127A1
(de)
*
|
1994-08-25 |
1996-03-14 |
Hoechst Ag |
Kombinationspräparat, enthaltend Cyclosporin A oder FK506 und ein Xanthinderivat
|
|
DE4430128A1
(de)
|
1994-08-25 |
1996-02-29 |
Hoechst Ag |
Kombinationspräparat mit immunsuppressiven, kardiovaskulären und cerebralen Wirkungen
|
|
US6099562A
(en)
|
1996-06-13 |
2000-08-08 |
Schneider (Usa) Inc. |
Drug coating with topcoat
|
|
DE19544768C1
(de)
|
1995-11-30 |
1997-07-10 |
Rentschler Arzneimittel |
Verwendung einer Kombination aus Pentoxifyllin mit Typ-I-Interferonen zur Behandlung der Multiplen Sklerose
|
|
US6294350B1
(en)
|
1997-06-05 |
2001-09-25 |
Dalhousie University |
Methods for treating fibroproliferative diseases
|
|
US5985592A
(en)
|
1997-06-05 |
1999-11-16 |
Dalhousie University |
Uses for pentoxifylline or functional derivatives/metabolites thereof
|
|
US6248889B1
(en)
|
1998-11-20 |
2001-06-19 |
3M Innovative Properties Company |
Process for converting an alcohol to the corresponding fluoride
|
|
US6440710B1
(en)
*
|
1998-12-10 |
2002-08-27 |
The Scripps Research Institute |
Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
|
|
US6417208B1
(en)
|
1999-02-05 |
2002-07-09 |
Albert Einstein College Of Medicine Of Yeshiva University |
Method of identification of inhibitors of PDE1C
|
|
US6316458B1
(en)
*
|
1999-04-30 |
2001-11-13 |
Cell Therapeutics, Inc. |
Method of enhancing insulin action
|
|
GB9925962D0
(en)
|
1999-11-02 |
1999-12-29 |
Novartis Ag |
Organic compounds
|
|
PT1104760E
(pt)
*
|
1999-12-03 |
2003-06-30 |
Pfizer Prod Inc |
Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios
|
|
GB0102107D0
(en)
|
2001-01-26 |
2001-03-14 |
Syngenta Ltd |
Chemical process
|
|
HU229938B1
(en)
|
2001-05-03 |
2015-01-28 |
Hoffmann La Roche |
Pharmaceutical dosage form of amorphous nelfinavir mesylate
|
|
CA2446904A1
(en)
|
2001-05-24 |
2003-04-03 |
Alexza Pharmaceuticals, Inc. |
Delivery of drug esters through an inhalation route
|
|
WO2003013568A1
(en)
|
2001-08-02 |
2003-02-20 |
Ortho-Mcneil Pharmaceutical, Inc. |
Cytokine modulation therapy
|
|
EP1444009A1
(en)
|
2001-11-02 |
2004-08-11 |
Pfizer Products Inc. |
Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors
|
|
BR0308415A
(pt)
|
2002-03-14 |
2005-02-15 |
Bayer Pharmaceuticals Corp |
Métodos de tratamento de diabetes usando-se inibidores de pde11a
|
|
DE10214228A1
(de)
|
2002-03-22 |
2003-10-02 |
Bdd Group Holding Ag Zug |
Deuterierte substitutierte Indole sowie diese Verbindungen enthaltende Arzneimittel
|
|
US20050107420A1
(en)
*
|
2002-05-23 |
2005-05-19 |
Boehringe Ingelheim Pharma Gmbh & Co. Kg |
Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases
|
|
US7407955B2
(en)
*
|
2002-08-21 |
2008-08-05 |
Boehringer Ingelheim Pharma Gmbh & Co., Kg |
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
|
|
TW200413273A
(en)
*
|
2002-11-15 |
2004-08-01 |
Wako Pure Chem Ind Ltd |
Heavy hydrogenation method of heterocyclic rings
|
|
US20040220186A1
(en)
|
2003-04-30 |
2004-11-04 |
Pfizer Inc. |
PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
|
|
RS20050945A
(sr)
|
2003-06-30 |
2008-06-05 |
Altana Pharma Ag., |
Novi pirolodihidroizohinolini koji se mogu upotrebiti u tretmanu kancera
|
|
EP1651251A4
(en)
|
2003-07-31 |
2008-06-18 |
Bayer Pharmaceuticals Corp |
METHOD FOR THE TREATMENT OF DIABETES AND RELATED DISEASES USING PDE 10A INHIBITORS
|
|
WO2005023193A2
(en)
|
2003-09-04 |
2005-03-17 |
Interleukin Genetics, Inc. |
Methods of treating endometriosis
|
|
WO2005120514A1
(en)
|
2004-06-07 |
2005-12-22 |
Pfizer Products Inc. |
Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions
|
|
EP2444071A1
(en)
|
2004-09-27 |
2012-04-25 |
Sigmoid Pharma Limited |
Minicapsule formulations
|
|
US20060094744A1
(en)
|
2004-09-29 |
2006-05-04 |
Maryanoff Cynthia A |
Pharmaceutical dosage forms of stable amorphous rapamycin like compounds
|
|
CN101309917B
(zh)
*
|
2005-10-06 |
2013-09-11 |
奥斯拜客斯制药有限公司 |
具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂
|
|
US7750168B2
(en)
*
|
2006-02-10 |
2010-07-06 |
Sigma-Aldrich Co. |
Stabilized deuteroborane-tetrahydrofuran complex
|
|
JO2630B1
(en)
|
2006-04-13 |
2012-06-17 |
نوفارتيس ايه جي |
Organic compounds
|
|
WO2008030382A1
(en)
*
|
2006-09-05 |
2008-03-13 |
Schering Corporation |
Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
|
|
KR20100121527A
(ko)
|
2008-02-29 |
2010-11-17 |
콘서트 파마슈티컬즈, 인크. |
치환된 잔틴 유도체
|
|
US20110053961A1
(en)
*
|
2009-02-27 |
2011-03-03 |
Concert Pharmaceuticals, Inc. |
Substituted xanthine derivatives
|
|
US8263601B2
(en)
|
2009-02-27 |
2012-09-11 |
Concert Pharmaceuticals, Inc. |
Deuterium substituted xanthine derivatives
|
|
US8485557B2
(en)
|
2009-08-27 |
2013-07-16 |
Kermit Zarley Enterprises |
Self-supporting book
|
|
MX2012002704A
(es)
*
|
2009-09-02 |
2012-03-21 |
Concert Pharmaceuticals Inc |
Derivados de xantina sustituidos.
|