JP2013503883A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013503883A5 JP2013503883A5 JP2012528018A JP2012528018A JP2013503883A5 JP 2013503883 A5 JP2013503883 A5 JP 2013503883A5 JP 2012528018 A JP2012528018 A JP 2012528018A JP 2012528018 A JP2012528018 A JP 2012528018A JP 2013503883 A5 JP2013503883 A5 JP 2013503883A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- disease
- pharmaceutically acceptable
- pharmaceutical composition
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 229910052805 deuterium Inorganic materials 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- 208000020832 chronic kidney disease Diseases 0.000 claims description 5
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 5
- 208000017667 Chronic Disease Diseases 0.000 claims description 4
- 206010022489 Insulin Resistance Diseases 0.000 claims description 4
- 206010022562 Intermittent claudication Diseases 0.000 claims description 4
- 230000007850 degeneration Effects 0.000 claims description 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- 239000011737 fluorine Substances 0.000 claims description 4
- 125000001153 fluoro group Chemical group F* 0.000 claims description 4
- 208000021156 intermittent vascular claudication Diseases 0.000 claims description 4
- 210000004185 liver Anatomy 0.000 claims description 4
- 150000002431 hydrogen Chemical group 0.000 claims description 3
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 2
- 200000000007 Arterial disease Diseases 0.000 claims description 2
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims description 2
- 206010056340 Diabetic ulcer Diseases 0.000 claims description 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims description 2
- 208000004232 Enteritis Diseases 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 208000004930 Fatty Liver Diseases 0.000 claims description 2
- 206010016654 Fibrosis Diseases 0.000 claims description 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 2
- 208000002705 Glucose Intolerance Diseases 0.000 claims description 2
- 201000005569 Gout Diseases 0.000 claims description 2
- 208000015023 Graves' disease Diseases 0.000 claims description 2
- 206010019663 Hepatic failure Diseases 0.000 claims description 2
- 206010019708 Hepatic steatosis Diseases 0.000 claims description 2
- 206010019728 Hepatitis alcoholic Diseases 0.000 claims description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 206010055171 Hypertensive nephropathy Diseases 0.000 claims description 2
- 201000001431 Hyperuricemia Diseases 0.000 claims description 2
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims description 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims description 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims description 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 2
- 206010029164 Nephrotic syndrome Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 206010033647 Pancreatitis acute Diseases 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- 206010067362 Radiation necrosis Diseases 0.000 claims description 2
- 208000033626 Renal failure acute Diseases 0.000 claims description 2
- 201000007527 Retinal artery occlusion Diseases 0.000 claims description 2
- 208000017442 Retinal disease Diseases 0.000 claims description 2
- 206010038923 Retinopathy Diseases 0.000 claims description 2
- 208000018020 Sickle cell-beta-thalassemia disease syndrome Diseases 0.000 claims description 2
- 206010043391 Thalassaemia beta Diseases 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 208000026723 Urinary tract disease Diseases 0.000 claims description 2
- 208000012931 Urologic disease Diseases 0.000 claims description 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 2
- 201000011040 acute kidney failure Diseases 0.000 claims description 2
- 201000003229 acute pancreatitis Diseases 0.000 claims description 2
- 208000012998 acute renal failure Diseases 0.000 claims description 2
- 208000002353 alcoholic hepatitis Diseases 0.000 claims description 2
- 208000007502 anemia Diseases 0.000 claims description 2
- 201000007058 anterior ischemic optic neuropathy Diseases 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 230000007882 cirrhosis Effects 0.000 claims description 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 208000033679 diabetic kidney disease Diseases 0.000 claims description 2
- 230000037213 diet Effects 0.000 claims description 2
- 235000005911 diet Nutrition 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000010706 fatty liver disease Diseases 0.000 claims description 2
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims description 2
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 231100000268 induced nephrotoxicity Toxicity 0.000 claims description 2
- 230000000155 isotopic effect Effects 0.000 claims description 2
- 231100000835 liver failure Toxicity 0.000 claims description 2
- 208000007903 liver failure Diseases 0.000 claims description 2
- 208000002780 macular degeneration Diseases 0.000 claims description 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 208000030761 polycystic kidney disease Diseases 0.000 claims description 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 208000004644 retinal vein occlusion Diseases 0.000 claims description 2
- 208000007056 sickle cell anemia Diseases 0.000 claims description 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims description 2
- 201000005665 thrombophilia Diseases 0.000 claims description 2
- 208000014001 urinary system disease Diseases 0.000 claims description 2
- 208000003807 Graves Disease Diseases 0.000 claims 1
- 229940125782 compound 2 Drugs 0.000 claims 1
- -1 deuterium compound Chemical class 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 1
- 0 CN(c1c(C(N2CCCC(*)(*)C(*)(*)F)=O)[n](*)c(*)n1)C2=O Chemical compound CN(c1c(C(N2CCCC(*)(*)C(*)(*)F)=O)[n](*)c(*)n1)C2=O 0.000 description 45
- 238000000034 method Methods 0.000 description 14
- 239000000203 mixture Substances 0.000 description 10
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- JARVGPSQVYDXAK-UHFFFAOYSA-N CC(C)CCCCN(C(c1c(N2C)nc[n]1C)=O)C2=O Chemical compound CC(C)CCCCN(C(c1c(N2C)nc[n]1C)=O)C2=O JARVGPSQVYDXAK-UHFFFAOYSA-N 0.000 description 2
- RMGBWAPCRXWHJB-VIFPVBQESA-N C[C@@H](CCCCN(C(c1c(N2C)nc[n]1C)=O)C2=O)F Chemical compound C[C@@H](CCCCN(C(c1c(N2C)nc[n]1C)=O)C2=O)F RMGBWAPCRXWHJB-VIFPVBQESA-N 0.000 description 2
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 description 2
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 description 2
- 229960001476 pentoxifylline Drugs 0.000 description 2
- 208000023328 Basedow disease Diseases 0.000 description 1
- 229940126062 Compound A Drugs 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23933609P | 2009-09-02 | 2009-09-02 | |
| US61/239,336 | 2009-09-02 | ||
| PCT/US2010/047574 WO2011028835A1 (en) | 2009-09-02 | 2010-09-01 | Substituted xanthine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013503883A JP2013503883A (ja) | 2013-02-04 |
| JP2013503883A5 true JP2013503883A5 (https=) | 2013-10-10 |
Family
ID=43649624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528018A Pending JP2013503883A (ja) | 2009-09-02 | 2010-09-01 | 置換キサンチン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8952016B2 (https=) |
| EP (1) | EP2473052A4 (https=) |
| JP (1) | JP2013503883A (https=) |
| AU (1) | AU2010289551A1 (https=) |
| CA (1) | CA2771331A1 (https=) |
| IN (1) | IN2012DN01642A (https=) |
| MX (1) | MX2012002704A (https=) |
| WO (1) | WO2011028835A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100121527A (ko) | 2008-02-29 | 2010-11-17 | 콘서트 파마슈티컬즈, 인크. | 치환된 잔틴 유도체 |
| WO2010075086A2 (en) * | 2008-12-15 | 2010-07-01 | Auspex Pharmaceuticals, Inc. | Pyrrolidinone inhibitors of pde-4 |
| US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
| MX2012002704A (es) | 2009-09-02 | 2012-03-21 | Concert Pharmaceuticals Inc | Derivados de xantina sustituidos. |
| WO2011028820A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds |
| EP2611807A2 (en) * | 2010-09-01 | 2013-07-10 | Concert Pharmaceuticals Inc. | Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3-7-dimethyl-1h-purine-2,6(3h,7h)dione |
| WO2012031072A1 (en) | 2010-09-01 | 2012-03-08 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
| WO2012031073A1 (en) | 2010-09-01 | 2012-03-08 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
| WO2013013052A1 (en) * | 2011-07-19 | 2013-01-24 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| IN2014DN08443A (https=) | 2012-04-13 | 2015-05-08 | Concert Pharmaceuticals Inc | |
| US10954300B2 (en) | 2015-09-28 | 2021-03-23 | The Trustees Of Columbia University In The City Of New York | Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2330742C2 (de) | 1973-06-16 | 1982-07-29 | Hoechst Ag, 6000 Frankfurt | 1-(Oxoalkyl)-3-methyl-7-alkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| JPS5576876A (en) | 1978-12-05 | 1980-06-10 | Grelan Pharmaceut Co Ltd | Preparation of 1-(oxoalkyl)-3,7-dimethylxanthine derivatne |
| JPS55122779A (en) | 1979-03-13 | 1980-09-20 | Maruko Seiyaku Kk | Preparation of theobromine derivative |
| CS201558B1 (en) | 1979-05-14 | 1980-11-28 | Pavol Kovar | Method of preparing 1-/5-oxohexyl/-3,7-dimethylxanthine |
| JPS567785A (en) | 1979-07-02 | 1981-01-27 | Maruko Seiyaku Kk | Preparation of theobromine derivative |
| JPS5610187A (en) | 1979-07-05 | 1981-02-02 | Grelan Pharmaceut Co Ltd | Separation and purification of 1-(5-oxohexyl)- 3,7-dimethylxanthine |
| JPS5610188A (en) | 1979-07-06 | 1981-02-02 | Dainippon Ink & Chem Inc | Xanthine derivative and its preparation |
| JPS5632477A (en) | 1979-08-27 | 1981-04-01 | Nippon Iyakuhin Kaihatsu Kenkyusho:Kk | Preparation of 1- 5-oxohexyl -3,7-dimethylxanthine |
| JPS5677279A (en) | 1979-11-28 | 1981-06-25 | Ota Seiyaku Kk | Preparation of xanthine derivative |
| JPS5711981A (en) | 1980-06-26 | 1982-01-21 | Sagami Chem Res Center | Theobromine derivative and its preparation |
| JPS5724382A (en) | 1980-07-17 | 1982-02-08 | Nissan Chem Ind Ltd | Trithiane derivative and its preparation |
| JPS5724386A (en) | 1980-07-17 | 1982-02-08 | Nissan Chem Ind Ltd | Preparation of xanthine derivative |
| JPS5724385A (en) | 1980-07-17 | 1982-02-08 | Nissan Chem Ind Ltd | Theobromine derivative and its preparation |
| JPS5756481A (en) | 1980-09-22 | 1982-04-05 | Kawashima Yakuhin Kaihatsu Kk | Production of 1-(5-oxohexyl)-3,7-dimethylxanthine |
| JPS5762278A (en) | 1980-10-01 | 1982-04-15 | Sagami Chem Res Center | Theobromine derivative and its preparation |
| JPS5780385A (en) | 1980-11-05 | 1982-05-19 | Mitsubishi Petrochem Co Ltd | Preparation of 1-((omega-1)-oxoalkyl)-3,7-dialkylxanthine |
| JPS5785387A (en) | 1980-11-14 | 1982-05-28 | Teikoku Chem Ind Corp Ltd | Preparation of 1-(-5'-oxohexyl)-3,7-dimethylxanthine |
| JPS5798284A (en) | 1980-12-10 | 1982-06-18 | Kawashima Yakuhin Kaihatsu Kk | Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine |
| JPS57200391A (en) | 1981-06-02 | 1982-12-08 | Daito Koeki Kk | 1-(5-oxo-2-hexenyl)3,7-dimethylxanthine |
| JPS5838284A (ja) | 1981-09-01 | 1983-03-05 | Teikoku Chem Ind Corp Ltd | １−（５′−オキソヘキシル）−３，７−ジメチルキサンチンの製造方法 |
| JPS58134092A (ja) | 1982-02-05 | 1983-08-10 | Sagami Chem Res Center | テオブロミン誘導体 |
| JPS58150594A (ja) | 1982-03-03 | 1983-09-07 | Daito Koeki Kk | キサンチン誘導体の製造方法 |
| CS237719B1 (cs) | 1983-05-12 | 1985-10-16 | Jan Jendrichovsky | SpAsob přípravy dimetyl-(5-oxohexyl)-xantlnov |
| DE3508097A1 (de) | 1984-07-21 | 1986-02-06 | Hoechst Ag, 6230 Frankfurt | Kombinationspraeparat aus xanthinderivaten und o-acetylsalicylsaeure bzw. deren pharmakologisch vertraeglichen salzen und dessen verwendung |
| DE3525801A1 (de) | 1985-07-19 | 1987-01-22 | Hoechst Ag | Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
| DD274334A3 (de) | 1985-12-17 | 1989-12-20 | Dresden Arzneimittel | Verfahren zur herstellung von reinem 3,7-dimethyl-1-(5-oxohexyl)-xanthin |
| IL100535A (en) | 1986-12-31 | 1994-05-30 | Hoechst Roussel Pharma | Pharmaceutical preparations containing a history of xanthine to relieve disease states |
| DE3942872A1 (de) | 1989-12-23 | 1991-06-27 | Hoechst Ag | Verfahren zur enantioselektiven darstellung von ((omega)-1)-hydroxyalkylxanthinen |
| US5112827A (en) | 1990-05-18 | 1992-05-12 | Board Of Regents, The University Of Texas System | Drug to reverse fatty liver and atheromatous lesions |
| WO1992007566A2 (en) | 1990-11-01 | 1992-05-14 | Board Of Regents, The University Of Texas System | Antifungal activity of and prevention of drug induced nephrotoxicity by methylxanthine analogues |
| ATE138266T1 (de) | 1990-11-07 | 1996-06-15 | Hoechst Roussel Pharma | Verwendung von xanthinen zur herstellung von arzneimitteln zur hemmung der vermehrung menschlicher retroviren |
| EP0493682A3 (en) | 1990-11-30 | 1992-11-19 | Hoechst-Roussel Pharmaceuticals Incorporated | Use of xanthines for the preparation of a medicament effective for inhibiting the effects of allograft reaction in humans |
| EP0490181A1 (en) | 1990-11-30 | 1992-06-17 | Hoechst-Roussel Pharmaceuticals Incorporated | Use of xanthines for preparation of a medicament having immunosuppressing activity |
| US5648357A (en) | 1992-03-04 | 1997-07-15 | Cell Therapeutics, Inc. | Enatiomerically pure hydroxylated xanthine compounds |
| US5763446A (en) | 1992-03-26 | 1998-06-09 | University Of Southern California | Use of pentoxifylline and other tumor necrosis factor blockers for the treatment of aids-associated optic neuropathy and other central nervous system diseases |
| US5780476A (en) | 1992-11-16 | 1998-07-14 | Cell Therapeutics, Inc. | Hydroxyl-containing xanthine compounds |
| US6020337A (en) * | 1993-04-05 | 2000-02-01 | Cell Therapeutics, Inc. | Electronegative-substituted long chain xanthine compounds |
| US5670506A (en) * | 1993-04-05 | 1997-09-23 | Cell Therapeutics, Inc. | Halogen, isothiocyanate or azide substituted xanthines |
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| DE69528585D1 (de) | 1994-05-16 | 2002-11-21 | Cell Therapeutics Inc | Asymmetrische synthese von chiralen sekondären alkoholen |
| AU3539795A (en) | 1994-08-25 | 1996-03-14 | Medical University Of South Carolina | Methods of treating cold symptoms using pentoxifylline |
| DE19544768C1 (de) | 1995-11-30 | 1997-07-10 | Rentschler Arzneimittel | Verwendung einer Kombination aus Pentoxifyllin mit Typ-I-Interferonen zur Behandlung der Multiplen Sklerose |
| US6294350B1 (en) | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
| US5985592A (en) | 1997-06-05 | 1999-11-16 | Dalhousie University | Uses for pentoxifylline or functional derivatives/metabolites thereof |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| US6316458B1 (en) | 1999-04-30 | 2001-11-13 | Cell Therapeutics, Inc. | Method of enhancing insulin action |
| PT1104760E (pt) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| WO2003013568A1 (en) | 2001-08-02 | 2003-02-20 | Ortho-Mcneil Pharmaceutical, Inc. | Cytokine modulation therapy |
| US20050107420A1 (en) * | 2002-05-23 | 2005-05-19 | Boehringe Ingelheim Pharma Gmbh & Co. Kg | Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases |
| US7407955B2 (en) * | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| WO2005023193A2 (en) | 2003-09-04 | 2005-03-17 | Interleukin Genetics, Inc. | Methods of treating endometriosis |
| CN101309917B (zh) | 2005-10-06 | 2013-09-11 | 奥斯拜客斯制药有限公司 | 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂 |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| WO2008030382A1 (en) | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| KR20100121527A (ko) | 2008-02-29 | 2010-11-17 | 콘서트 파마슈티컬즈, 인크. | 치환된 잔틴 유도체 |
| US20110053961A1 (en) | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| US8263601B2 (en) * | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
| MX2012002704A (es) | 2009-09-02 | 2012-03-21 | Concert Pharmaceuticals Inc | Derivados de xantina sustituidos. |
-
2010
- 2010-09-01 MX MX2012002704A patent/MX2012002704A/es unknown
- 2010-09-01 EP EP20100814449 patent/EP2473052A4/en not_active Withdrawn
- 2010-09-01 US US12/874,049 patent/US8952016B2/en active Active
- 2010-09-01 AU AU2010289551A patent/AU2010289551A1/en not_active Abandoned
- 2010-09-01 IN IN1642DEN2012 patent/IN2012DN01642A/en unknown
- 2010-09-01 CA CA2771331A patent/CA2771331A1/en not_active Abandoned
- 2010-09-01 JP JP2012528018A patent/JP2013503883A/ja active Pending
- 2010-09-01 WO PCT/US2010/047574 patent/WO2011028835A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013503894A5 (https=) | ||
| JP2013503883A5 (https=) | ||
| JP2011513307A5 (https=) | ||
| JP2011513309A5 (https=) | ||
| JP2015512947A5 (https=) | ||
| JP2019531320A5 (https=) | ||
| JP2009531280A5 (https=) | ||
| JP2015517579A5 (https=) | ||
| JP2011527332A5 (https=) | ||
| RU2009137190A (ru) | Соединения, обладающие активностью в отношении ppar | |
| JP2013500986A5 (https=) | ||
| JP2008513358A5 (https=) | ||
| JP2010523476A5 (https=) | ||
| CA2607848A1 (en) | 3-substituted (3-phenyl)-propionic acid derivatives for the treatment of metabolic disorders | |
| JP2008518890A5 (https=) | ||
| JP2005534673A5 (https=) | ||
| JP2007517833A5 (https=) | ||
| JPWO2023106310A5 (https=) | ||
| JP2009528275A5 (https=) | ||
| CN109863152A (zh) | 3-苯基-2,3,4,8,9,10-六氢吡喃并[2,3-f]色烯衍生物以及用于合成其光学异构体的方法 | |
| JP2005529965A5 (https=) | ||
| JP2021533206A5 (https=) | ||
| CN103724339B (zh) | 二氢嘧啶衍生物的晶型 | |
| KR20130083592A (ko) | 치환된 피페리딘 유도체 및 이의 제조방법 | |
| JP6446051B2 (ja) | １−（３−メチル−２−オキソ−２，３−ジヒドロ−１，３−ベンゾキサゾール−６−イル）−２，４−ジオキソ−３−［（１ｒ）−４−（トリフルオルメチル）−２，３−ジヒドロ−１ｈ−インデン−１−イル］−１，２，３，４−テトラヒドロピリミジン−５−カルボン酸の塩 |