JP2015512947A5 - - Google Patents
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- JP2015512947A5 JP2015512947A5 JP2015505959A JP2015505959A JP2015512947A5 JP 2015512947 A5 JP2015512947 A5 JP 2015512947A5 JP 2015505959 A JP2015505959 A JP 2015505959A JP 2015505959 A JP2015505959 A JP 2015505959A JP 2015512947 A5 JP2015512947 A5 JP 2015512947A5
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- 150000001875 compounds Chemical class 0.000 claims description 65
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 25
- 229910052805 deuterium Inorganic materials 0.000 claims description 25
- 229910052739 hydrogen Inorganic materials 0.000 claims description 24
- 239000001257 hydrogen Substances 0.000 claims description 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 8
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 6
- 206010022489 Insulin Resistance Diseases 0.000 claims description 4
- 206010022562 Intermittent claudication Diseases 0.000 claims description 4
- 208000020832 chronic kidney disease Diseases 0.000 claims description 4
- 208000021156 intermittent vascular claudication Diseases 0.000 claims description 4
- 230000007850 degeneration Effects 0.000 claims description 3
- 230000000155 isotopic effect Effects 0.000 claims description 3
- 208000019423 liver disease Diseases 0.000 claims description 3
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 2
- 200000000007 Arterial disease Diseases 0.000 claims description 2
- 206010056340 Diabetic ulcer Diseases 0.000 claims description 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 208000004930 Fatty Liver Diseases 0.000 claims description 2
- 206010016654 Fibrosis Diseases 0.000 claims description 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 2
- 208000002705 Glucose Intolerance Diseases 0.000 claims description 2
- 201000005569 Gout Diseases 0.000 claims description 2
- 208000015023 Graves' disease Diseases 0.000 claims description 2
- 206010019663 Hepatic failure Diseases 0.000 claims description 2
- 206010019708 Hepatic steatosis Diseases 0.000 claims description 2
- 206010019728 Hepatitis alcoholic Diseases 0.000 claims description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 206010055171 Hypertensive nephropathy Diseases 0.000 claims description 2
- 201000001431 Hyperuricemia Diseases 0.000 claims description 2
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims description 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims description 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims description 2
- 206010028851 Necrosis Diseases 0.000 claims description 2
- 206010029164 Nephrotic syndrome Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 206010033647 Pancreatitis acute Diseases 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- 208000033626 Renal failure acute Diseases 0.000 claims description 2
- 208000017442 Retinal disease Diseases 0.000 claims description 2
- 206010038923 Retinopathy Diseases 0.000 claims description 2
- 208000018020 Sickle cell-beta-thalassemia disease syndrome Diseases 0.000 claims description 2
- 206010043391 Thalassaemia beta Diseases 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 208000026723 Urinary tract disease Diseases 0.000 claims description 2
- 208000012931 Urologic disease Diseases 0.000 claims description 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 2
- 201000011040 acute kidney failure Diseases 0.000 claims description 2
- 201000003229 acute pancreatitis Diseases 0.000 claims description 2
- 208000012998 acute renal failure Diseases 0.000 claims description 2
- 208000002353 alcoholic hepatitis Diseases 0.000 claims description 2
- 208000007502 anemia Diseases 0.000 claims description 2
- 201000007058 anterior ischemic optic neuropathy Diseases 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 230000007882 cirrhosis Effects 0.000 claims description 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 2
- 230000037213 diet Effects 0.000 claims description 2
- 235000005911 diet Nutrition 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000010706 fatty liver disease Diseases 0.000 claims description 2
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims description 2
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 claims description 2
- 231100000268 induced nephrotoxicity Toxicity 0.000 claims description 2
- 208000007903 liver failure Diseases 0.000 claims description 2
- 231100000835 liver failure Toxicity 0.000 claims description 2
- 208000002780 macular degeneration Diseases 0.000 claims description 2
- 230000017074 necrotic cell death Effects 0.000 claims description 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 208000030761 polycystic kidney disease Diseases 0.000 claims description 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 208000004644 retinal vein occlusion Diseases 0.000 claims description 2
- 208000007056 sickle cell anemia Diseases 0.000 claims description 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims description 2
- 208000014001 urinary system disease Diseases 0.000 claims description 2
- 208000017667 Chronic Disease Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-VVKOMZTBSA-N Dideuterium Chemical compound [2H][2H] UFHFLCQGNIYNRP-VVKOMZTBSA-N 0.000 claims 1
- 208000003807 Graves Disease Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 208000010227 enterocolitis Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 210000001927 retinal artery Anatomy 0.000 claims 1
- 201000005665 thrombophilia Diseases 0.000 claims 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 13
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 0 **(C(*)(*C1c2c(N3*)nc(*)[n]2*)C(*)(*)C(*)(*)C(*)(*)*)N1C3=O Chemical compound **(C(*)(*C1c2c(N3*)nc(*)[n]2*)C(*)(*)C(*)(*)C(*)(*)*)N1C3=O 0.000 description 6
- MRWQRJMESRRJJB-UHFFFAOYSA-N pentifylline Chemical compound O=C1N(CCCCCC)C(=O)N(C)C2=C1N(C)C=N2 MRWQRJMESRRJJB-UHFFFAOYSA-N 0.000 description 4
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 150000002431 hydrogen Chemical group 0.000 description 2
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 description 2
- 229960002371 pentifylline Drugs 0.000 description 2
- 208000023328 Basedow disease Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- 201000007527 Retinal artery occlusion Diseases 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261623858P | 2012-04-13 | 2012-04-13 | |
| US61/623,858 | 2012-04-13 | ||
| PCT/US2013/036454 WO2013155465A1 (en) | 2012-04-13 | 2013-04-12 | Substituted xanthine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015512947A JP2015512947A (ja) | 2015-04-30 |
| JP2015512947A5 true JP2015512947A5 (https=) | 2016-06-09 |
Family
ID=48184515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505959A Pending JP2015512947A (ja) | 2012-04-13 | 2013-04-12 | 置換キサンチン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9328113B2 (https=) |
| EP (1) | EP2836492B1 (https=) |
| JP (1) | JP2015512947A (https=) |
| KR (1) | KR20150002779A (https=) |
| CN (1) | CN104364255A (https=) |
| AU (1) | AU2013245662A1 (https=) |
| CA (1) | CA2869874A1 (https=) |
| EA (1) | EA201491878A8 (https=) |
| IN (1) | IN2014DN08443A (https=) |
| MX (1) | MX2014012384A (https=) |
| WO (1) | WO2013155465A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
| WO2017087795A1 (en) * | 2015-11-19 | 2017-05-26 | Concert Pharmaceuticals, Inc. | Deuterated epi-743 |
| WO2020210125A1 (en) | 2019-04-10 | 2020-10-15 | University Of Notre Dame Du Lac | Deuterated antimicrobial compounds |
| WO2022056190A2 (en) * | 2020-09-14 | 2022-03-17 | Lennham Pharmaceuticals, Inc. | Deuterated paraxanthine and uses thereof |
| US12194046B2 (en) | 2021-03-09 | 2025-01-14 | Lennham Pharmaceuticals, Inc. | D9-caffeine compositions and uses thereof |
Family Cites Families (72)
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|---|---|---|---|---|
| DE860217C (de) | 1950-10-28 | 1952-12-18 | Albert Ag Chem Werke | Verfahren zur Herstellung von 1-Hexyl-3, 7-dimethylxanthin |
| JPS5576876A (en) | 1978-12-05 | 1980-06-10 | Grelan Pharmaceut Co Ltd | Preparation of 1-(oxoalkyl)-3,7-dimethylxanthine derivatne |
| JPS55122779A (en) | 1979-03-13 | 1980-09-20 | Maruko Seiyaku Kk | Preparation of theobromine derivative |
| CS201558B1 (en) | 1979-05-14 | 1980-11-28 | Pavol Kovar | Method of preparing 1-/5-oxohexyl/-3,7-dimethylxanthine |
| JPS567785A (en) | 1979-07-02 | 1981-01-27 | Maruko Seiyaku Kk | Preparation of theobromine derivative |
| JPS5610187A (en) | 1979-07-05 | 1981-02-02 | Grelan Pharmaceut Co Ltd | Separation and purification of 1-(5-oxohexyl)- 3,7-dimethylxanthine |
| JPS5610188A (en) | 1979-07-06 | 1981-02-02 | Dainippon Ink & Chem Inc | Xanthine derivative and its preparation |
| JPS5632477A (en) | 1979-08-27 | 1981-04-01 | Nippon Iyakuhin Kaihatsu Kenkyusho:Kk | Preparation of 1- 5-oxohexyl -3,7-dimethylxanthine |
| JPS5677279A (en) | 1979-11-28 | 1981-06-25 | Ota Seiyaku Kk | Preparation of xanthine derivative |
| JPS5711981A (en) | 1980-06-26 | 1982-01-21 | Sagami Chem Res Center | Theobromine derivative and its preparation |
| JPS5724382A (en) | 1980-07-17 | 1982-02-08 | Nissan Chem Ind Ltd | Trithiane derivative and its preparation |
| JPS5724385A (en) | 1980-07-17 | 1982-02-08 | Nissan Chem Ind Ltd | Theobromine derivative and its preparation |
| JPS5724386A (en) | 1980-07-17 | 1982-02-08 | Nissan Chem Ind Ltd | Preparation of xanthine derivative |
| JPS5756481A (en) | 1980-09-22 | 1982-04-05 | Kawashima Yakuhin Kaihatsu Kk | Production of 1-(5-oxohexyl)-3,7-dimethylxanthine |
| JPS5762278A (en) | 1980-10-01 | 1982-04-15 | Sagami Chem Res Center | Theobromine derivative and its preparation |
| JPS5780385A (en) | 1980-11-05 | 1982-05-19 | Mitsubishi Petrochem Co Ltd | Preparation of 1-((omega-1)-oxoalkyl)-3,7-dialkylxanthine |
| JPS5785387A (en) | 1980-11-14 | 1982-05-28 | Teikoku Chem Ind Corp Ltd | Preparation of 1-(-5'-oxohexyl)-3,7-dimethylxanthine |
| JPS5798284A (en) | 1980-12-10 | 1982-06-18 | Kawashima Yakuhin Kaihatsu Kk | Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine |
| JPS57200391A (en) | 1981-06-02 | 1982-12-08 | Daito Koeki Kk | 1-(5-oxo-2-hexenyl)3,7-dimethylxanthine |
| JPS5838284A (ja) | 1981-09-01 | 1983-03-05 | Teikoku Chem Ind Corp Ltd | １−（５′−オキソヘキシル）−３，７−ジメチルキサンチンの製造方法 |
| JPS58134092A (ja) | 1982-02-05 | 1983-08-10 | Sagami Chem Res Center | テオブロミン誘導体 |
| JPS58150594A (ja) | 1982-03-03 | 1983-09-07 | Daito Koeki Kk | キサンチン誘導体の製造方法 |
| CS237719B1 (cs) | 1983-05-12 | 1985-10-16 | Jan Jendrichovsky | SpAsob přípravy dimetyl-(5-oxohexyl)-xantlnov |
| DE3508097A1 (de) | 1984-07-21 | 1986-02-06 | Hoechst Ag, 6230 Frankfurt | Kombinationspraeparat aus xanthinderivaten und o-acetylsalicylsaeure bzw. deren pharmakologisch vertraeglichen salzen und dessen verwendung |
| DE3525801A1 (de) | 1985-07-19 | 1987-01-22 | Hoechst Ag | Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
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| KR20100121527A (ko) | 2008-02-29 | 2010-11-17 | 콘서트 파마슈티컬즈, 인크. | 치환된 잔틴 유도체 |
| US20110053961A1 (en) | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
| MX2012002704A (es) | 2009-09-02 | 2012-03-21 | Concert Pharmaceuticals Inc | Derivados de xantina sustituidos. |
-
2013
- 2013-04-12 IN IN8443DEN2014 patent/IN2014DN08443A/en unknown
- 2013-04-12 KR KR1020147031315A patent/KR20150002779A/ko not_active Withdrawn
- 2013-04-12 MX MX2014012384A patent/MX2014012384A/es unknown
- 2013-04-12 JP JP2015505959A patent/JP2015512947A/ja active Pending
- 2013-04-12 WO PCT/US2013/036454 patent/WO2013155465A1/en not_active Ceased
- 2013-04-12 CA CA 2869874 patent/CA2869874A1/en not_active Abandoned
- 2013-04-12 US US14/391,443 patent/US9328113B2/en active Active
- 2013-04-12 EP EP13718735.7A patent/EP2836492B1/en active Active
- 2013-04-12 CN CN201380031266.6A patent/CN104364255A/zh active Pending
- 2013-04-12 EA EA201491878A patent/EA201491878A8/ru unknown
- 2013-04-12 AU AU2013245662A patent/AU2013245662A1/en not_active Abandoned
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