JP2009531280A5 - - Google Patents
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- Publication number
- JP2009531280A5 JP2009531280A5 JP2008552536A JP2008552536A JP2009531280A5 JP 2009531280 A5 JP2009531280 A5 JP 2009531280A5 JP 2008552536 A JP2008552536 A JP 2008552536A JP 2008552536 A JP2008552536 A JP 2008552536A JP 2009531280 A5 JP2009531280 A5 JP 2009531280A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- carbon atoms
- compound
- alkyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 36
- 229910052739 hydrogen Inorganic materials 0.000 claims 36
- 239000001257 hydrogen Substances 0.000 claims 36
- 150000001875 compounds Chemical class 0.000 claims 31
- 125000000217 alkyl group Chemical group 0.000 claims 20
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 19
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 125000005843 halogen group Chemical group 0.000 claims 12
- 150000002431 hydrogen Chemical class 0.000 claims 12
- -1 perfluoromethoxy Phenyl Chemical group 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 8
- 206010012601 diabetes mellitus Diseases 0.000 claims 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- ROSZOOKSBMWJBY-UHFFFAOYSA-N 1-[3-[(2,6-dimethylphenyl)methoxy]phenyl]-4-hydroxybutan-1-one Chemical compound CC1=CC=CC(C)=C1COC1=CC=CC(C(=O)CCCO)=C1 ROSZOOKSBMWJBY-UHFFFAOYSA-N 0.000 claims 4
- GMDLVEOKHFVEOE-UHFFFAOYSA-N 1-[3-[(2,6-dimethylphenyl)methoxy]phenyl]butane-1,4-diol Chemical compound CC1=CC=CC(C)=C1COC1=CC=CC(C(O)CCCO)=C1 GMDLVEOKHFVEOE-UHFFFAOYSA-N 0.000 claims 4
- XJQFGBILGHQHBP-UHFFFAOYSA-N 4-[3-[(2,6-dimethylphenyl)methoxy]phenyl]butan-1-ol Chemical compound CC1=CC=CC(C)=C1COC1=CC=CC(CCCCO)=C1 XJQFGBILGHQHBP-UHFFFAOYSA-N 0.000 claims 4
- 201000001320 Atherosclerosis Diseases 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 208000004930 Fatty Liver Diseases 0.000 claims 4
- 206010019708 Hepatic steatosis Diseases 0.000 claims 4
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 4
- 208000031773 Insulin resistance syndrome Diseases 0.000 claims 4
- 208000008589 Obesity Diseases 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 208000010706 fatty liver disease Diseases 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 235000020824 obesity Nutrition 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 206010003210 Arteriosclerosis Diseases 0.000 claims 3
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 3
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 3
- 206010006895 Cachexia Diseases 0.000 claims 2
- 208000002177 Cataract Diseases 0.000 claims 2
- 208000003790 Foot Ulcer Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000017442 Retinal disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- RDOXTESZEPMUJZ-UHFFFAOYSA-N COc1ccccc1 Chemical compound COc1ccccc1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76209106P | 2006-01-25 | 2006-01-25 | |
| PCT/US2007/060832 WO2007087505A2 (en) | 2006-01-25 | 2007-01-22 | Compounds for the treatment of metabolic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009531280A JP2009531280A (ja) | 2009-09-03 |
| JP2009531280A5 true JP2009531280A5 (https=) | 2011-01-20 |
Family
ID=38309905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552536A Withdrawn JP2009531280A (ja) | 2006-01-25 | 2007-01-22 | 代謝障害を処置するための化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7820721B2 (https=) |
| EP (1) | EP1976377A4 (https=) |
| JP (1) | JP2009531280A (https=) |
| CA (1) | CA2637375A1 (https=) |
| WO (1) | WO2007087505A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1750758B (zh) * | 2003-02-13 | 2012-06-20 | 维尔斯达医疗公司 | 用于治疗代谢紊乱的化合物 |
| RU2358722C2 (ru) * | 2003-04-15 | 2009-06-20 | Веллстат Терапьютикс Корпорейшн | Соединения для лечения метаболических расстройств |
| JP4837557B2 (ja) * | 2003-04-30 | 2011-12-14 | ウェルスタット セラピューティクス コーポレイション | 代謝障害の処置のための化合物 |
| JP2008507288A (ja) | 2004-07-23 | 2008-03-13 | アクセルロン ファーマ インコーポレーテッド | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| ES2649983T3 (es) | 2005-11-23 | 2018-01-16 | Acceleron Pharma, Inc. | Antagonistas de activina-ActRIIa en su uso para promover el crecimiento óseo |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US20090176885A1 (en) * | 2006-02-02 | 2009-07-09 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| KR20080106455A (ko) * | 2006-03-31 | 2008-12-05 | 웰스태트 테러퓨틱스 코포레이션 | 대사장애의 조합치료 |
| CA2651598A1 (en) * | 2006-05-18 | 2007-11-29 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| EP2026659A4 (en) * | 2006-06-09 | 2010-06-30 | Wellstat Therapeutics Corp | COMPOUNDS FOR THE TREATMENT OF METABOLISM DISORDER |
| WO2008022267A2 (en) * | 2006-08-17 | 2008-02-21 | Wellstat Therapeutics Corporation | Combination treatment for metabolic disorders |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| MX2009008222A (es) | 2007-02-01 | 2009-10-12 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama. |
| TW201803890A (zh) | 2007-02-02 | 2018-02-01 | 艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| EA018221B1 (ru) | 2007-02-09 | 2013-06-28 | Акселерон Фарма Инк. | АНТАГОНИСТЫ АКТИВИНА-ActRIIa И ПРИМЕНЕНИЕ ДЛЯ СТИМУЛЯЦИИ РОСТА КОСТИ У БОЛЬНЫХ РАКОМ |
| CN101861161B (zh) | 2007-09-18 | 2017-04-19 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途 |
| EP2240024A4 (en) * | 2008-01-15 | 2014-05-21 | Wellstat Therapeutics Corp | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS |
| TW201803586A (zh) | 2008-08-14 | 2018-02-01 | 艾瑟勒朗法瑪公司 | 使用ｇｄｆ阱以增加紅血球水平 |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| KR20120049214A (ko) | 2009-06-08 | 2012-05-16 | 악셀레론 파마 인코포레이티드 | 발열성 지방세포를 증가시키는 방법 |
| KR20180026795A (ko) | 2009-06-12 | 2018-03-13 | 악셀레론 파마 인코포레이티드 | 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질 |
| AU2010315245B2 (en) * | 2009-11-03 | 2016-11-03 | Acceleron Pharma Inc. | Methods for treating fatty liver disease |
| EP3332796A1 (en) | 2009-11-17 | 2018-06-13 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| AU2011326586A1 (en) | 2010-11-08 | 2013-05-30 | Acceleron Pharma, Inc. | ActRIIA binding agents and uses thereof |
| US10195249B2 (en) | 2012-11-02 | 2019-02-05 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
| CN114699529A (zh) | 2014-06-13 | 2022-07-05 | 阿塞勒隆制药公司 | 用于治疗溃疡的方法和组合物 |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| JP2018501307A (ja) | 2014-12-03 | 2018-01-18 | セルジーン コーポレイション | アクチビン−ＡｃｔＲＩＩアンタゴニスト及び貧血を治療するための使用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2216999B1 (https=) * | 1972-10-10 | 1977-04-15 | Serdex | |
| US4350822A (en) * | 1975-03-12 | 1982-09-21 | American Cyanamid Company | Antilipidemicpara-[aryl(alkyl or alkenyl)amino]benzoic acid derivatives |
| GB1561350A (en) | 1976-11-05 | 1980-02-20 | May & Baker Ltd | Benzamide derivatives |
| DE3575127D1 (de) | 1984-02-14 | 1990-02-08 | Hirai Hidefumi | Herstellung substituierter ungesaettigter sechsgliedriger ringverbindungen aus phenolabkoemmlingen. |
| DE3884825D1 (de) | 1987-02-16 | 1993-11-18 | Konishiroku Photo Ind | Entwickler für lichtempfindliche lithographische Druckplatte, gemeinschaftlich verarbeitungsfähig für den Negativ-Typ und den Positiv-Typ und Entwicklerzusammensetzung für lichtempfindliches Material. |
| JPH0770025B2 (ja) | 1987-09-16 | 1995-07-31 | 富士通株式会社 | 薄膜磁気ヘッドの製造方法 |
| US4923501A (en) | 1987-11-04 | 1990-05-08 | Kumiai Chemical Industry Co., Ltd. | Pyrimidine derivatives, processes for their production, and herbicidal method and compositions |
| US5108363A (en) * | 1988-02-19 | 1992-04-28 | Gensia Pharmaceuticals, Inc. | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist |
| NZ231735A (en) | 1988-12-23 | 1992-04-28 | Ici Plc | Alcohol/ether derivatives, preparation and pharmaceutical compositions thereof |
| US5089514A (en) | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| JPH04154773A (ja) | 1990-10-15 | 1992-05-27 | Green Cross Corp:The | チアゾール誘導体 |
| JPH04282345A (ja) | 1991-03-11 | 1992-10-07 | Mitsubishi Petrochem Co Ltd | 光学活性化合物 |
| WO1994005153A1 (en) | 1992-09-09 | 1994-03-17 | E.I. Du Pont De Nemours And Company | Herbicidal benzene compounds |
| US5484926A (en) | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| JPH06293700A (ja) | 1993-04-08 | 1994-10-21 | Nippon Soda Co Ltd | ６−クロロサリチル酸の製造法 |
| GB9315595D0 (en) | 1993-07-28 | 1993-09-08 | Res Inst Medicine Chem | New compounds |
| JPH07206658A (ja) | 1994-01-12 | 1995-08-08 | Shiseido Co Ltd | 尋常性座瘡治療剤 |
| JPH08119959A (ja) | 1994-10-20 | 1996-05-14 | Oyo Seikagaku Kenkyusho | キサントン誘導体及びこれを有効成分とするモノアミン酸化酵素阻害剤 |
| US5728718A (en) | 1994-12-20 | 1998-03-17 | The United States Of America As Represented By The Department Of Health And Human Services | 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same |
| FR2730731B1 (fr) | 1995-02-20 | 1997-04-04 | Rhone Poulenc Chimie | Procede de carboxylation d'un ether aromatique |
| AU4953796A (en) | 1995-03-15 | 1996-10-02 | Sanyko Company, Limited | Dipeptide compounds having ahpba structure |
| FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| US5519133A (en) | 1995-06-02 | 1996-05-21 | American Cyanamid Co. | 3-(3-aryloxyphenyl)-1-(substituted methyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents |
| US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
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| WO1997025992A1 (en) | 1996-01-16 | 1997-07-24 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| CA2255858C (en) | 1996-05-24 | 2007-09-11 | Neurosearch A/S | Phenyl derivatives containing an acidic group, their preparation and their use as chloride channel blockers |
| JPH1087489A (ja) | 1996-09-13 | 1998-04-07 | Sankyo Co Ltd | Ａｈｐｂａ構造含有ジペプチド化合物を有効成分とする医薬 |
| US20020064847A1 (en) * | 1996-10-22 | 2002-05-30 | Daicel Chemical Industries, Ltd. | Novel secondary alcohol dehydrogenase, process for preparing said enzyme, and process for preparing alcohols and ketones using said enzyme |
| JP2003517427A (ja) | 1997-09-09 | 2003-05-27 | メルク エンド カムパニー インコーポレーテッド | ３−（ヨードフェノキシメチル）カルバペネム系抗菌剤 |
| KR20010015639A (ko) | 1997-09-30 | 2001-02-26 | 스즈키 다다시 | 술포닐 유도체 |
| GB9914371D0 (en) | 1999-06-18 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
| HK1052351B (en) | 2000-06-28 | 2006-11-03 | Japan Tobacco Inc. | Benzothiazolyl ppar-gamma modulators |
| AR031126A1 (es) | 2000-08-29 | 2003-09-10 | Abbott Lab | Acidos amino(oxo)aceticos inhibidores de la proteina tirosina fosfatasa |
| AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| CN101444496B (zh) * | 2001-06-12 | 2011-04-13 | 维尔斯达医疗公司 | 用于治疗代谢失调的化合物 |
| EP1556085A4 (en) * | 2002-11-01 | 2012-08-22 | Wellstat Therapeutics Corp | COMPOUNDS FOR THE TREATMENT OF METABOLISM |
| CN1750758B (zh) * | 2003-02-13 | 2012-06-20 | 维尔斯达医疗公司 | 用于治疗代谢紊乱的化合物 |
| RU2358722C2 (ru) * | 2003-04-15 | 2009-06-20 | Веллстат Терапьютикс Корпорейшн | Соединения для лечения метаболических расстройств |
| US7361686B2 (en) * | 2003-04-22 | 2008-04-22 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| JP4837557B2 (ja) * | 2003-04-30 | 2011-12-14 | ウェルスタット セラピューティクス コーポレイション | 代謝障害の処置のための化合物 |
| EP1656127B1 (en) * | 2003-08-20 | 2011-03-23 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
-
2007
- 2007-01-22 WO PCT/US2007/060832 patent/WO2007087505A2/en not_active Ceased
- 2007-01-22 US US12/160,854 patent/US7820721B2/en not_active Expired - Fee Related
- 2007-01-22 JP JP2008552536A patent/JP2009531280A/ja not_active Withdrawn
- 2007-01-22 CA CA002637375A patent/CA2637375A1/en not_active Abandoned
- 2007-01-22 EP EP07717340A patent/EP1976377A4/en not_active Withdrawn
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