JP2007523155A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007523155A5 JP2007523155A5 JP2006553706A JP2006553706A JP2007523155A5 JP 2007523155 A5 JP2007523155 A5 JP 2007523155A5 JP 2006553706 A JP2006553706 A JP 2006553706A JP 2006553706 A JP2006553706 A JP 2006553706A JP 2007523155 A5 JP2007523155 A5 JP 2007523155A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- benzamide
- amino
- pyrrolo
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 nitro, hydroxyl Chemical group 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- KKWUYHFACPLBGF-UHFFFAOYSA-N 1-amino-n-pyridin-4-yl-2,3-dihydro-1h-indene-5-carboxamide Chemical compound C=1C=C2C(N)CCC2=CC=1C(=O)NC1=CC=NC=C1 KKWUYHFACPLBGF-UHFFFAOYSA-N 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 6
- OTGLOKZMFREKRJ-UHFFFAOYSA-N 4-(4,5-dihydro-1h-imidazol-2-yl)-n-pyridin-4-ylbenzamide Chemical compound C=1C=C(C=2NCCN=2)C=CC=1C(=O)NC1=CC=NC=C1 OTGLOKZMFREKRJ-UHFFFAOYSA-N 0.000 claims 5
- IQNKRAWRKBNOKR-UHFFFAOYSA-N 4-piperidin-2-yl-n-(1h-pyrrolo[2,3-b]pyridin-4-yl)benzamide Chemical compound C=1C=NC=2NC=CC=2C=1NC(=O)C(C=C1)=CC=C1C1CCCCN1 IQNKRAWRKBNOKR-UHFFFAOYSA-N 0.000 claims 5
- SQQWULIZIPGEIA-UHFFFAOYSA-N 5-amino-n-(1h-pyrrolo[2,3-b]pyridin-4-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide Chemical compound C=1C=C2C(N)CCCC2=CC=1C(=O)NC1=CC=NC2=C1C=CN2 SQQWULIZIPGEIA-UHFFFAOYSA-N 0.000 claims 5
- NHUPJCHRWRHUKF-UHFFFAOYSA-N n-pyridin-4-yl-4-pyrrolidin-2-ylbenzamide Chemical compound C=1C=C(C2NCCC2)C=CC=1C(=O)NC1=CC=NC=C1 NHUPJCHRWRHUKF-UHFFFAOYSA-N 0.000 claims 5
- QEMYLDYQDFRTRT-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinolin-2-ium-6-carboxylate Chemical compound C1NCCC2=CC(C(=O)O)=CC=C21 QEMYLDYQDFRTRT-UHFFFAOYSA-N 0.000 claims 4
- ZCYGCPVXXJYQDY-UHFFFAOYSA-N 4-piperidin-2-yl-n-pyridin-4-ylbenzamide Chemical compound C=1C=C(C2NCCCC2)C=CC=1C(=O)NC1=CC=NC=C1 ZCYGCPVXXJYQDY-UHFFFAOYSA-N 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 208000030159 metabolic disease Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- IIVCSIFQZZMOBI-UHFFFAOYSA-N n-pyridin-4-yl-1,2,3,4-tetrahydroisoquinoline-6-carboxamide Chemical compound C=1C=C2CNCCC2=CC=1C(=O)NC1=CC=NC=C1 IIVCSIFQZZMOBI-UHFFFAOYSA-N 0.000 claims 4
- 208000008589 Obesity Diseases 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 235000020824 obesity Nutrition 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- ZFBHHXHSPRMSQS-UHFFFAOYSA-N 1-amino-2,3-dihydro-1h-indene-5-carboxylic acid Chemical compound OC(=O)C1=CC=C2C(N)CCC2=C1 ZFBHHXHSPRMSQS-UHFFFAOYSA-N 0.000 claims 2
- ZMRMIGRTPQOGOL-UHFFFAOYSA-N 1-amino-n-(1h-pyrrolo[2,3-b]pyridin-4-yl)-2,3-dihydro-1h-indene-5-carboxamide Chemical compound C=1C=C2C(N)CCC2=CC=1C(=O)NC1=CC=NC2=C1C=CN2 ZMRMIGRTPQOGOL-UHFFFAOYSA-N 0.000 claims 2
- KRAYOARFOGSKJI-UHFFFAOYSA-N 4-(1-amino-2,2-dimethylpropyl)-n-pyridin-4-ylbenzamide Chemical compound C1=CC(C(N)C(C)(C)C)=CC=C1C(=O)NC1=CC=NC=C1 KRAYOARFOGSKJI-UHFFFAOYSA-N 0.000 claims 2
- JTVBXQAYBIJXRP-UHFFFAOYSA-N 4-(1-aminoethyl)-n-(1h-pyrrolo[2,3-b]pyridin-4-yl)benzamide Chemical compound C1=CC(C(N)C)=CC=C1C(=O)NC1=CC=NC2=C1C=CN2 JTVBXQAYBIJXRP-UHFFFAOYSA-N 0.000 claims 2
- LLSFXOUAPAZFIV-UHFFFAOYSA-N 4-(1-aminoethyl)-n-pyridin-4-ylbenzamide Chemical compound C1=CC(C(N)C)=CC=C1C(=O)NC1=CC=NC=C1 LLSFXOUAPAZFIV-UHFFFAOYSA-N 0.000 claims 2
- GMDVSDXMBONTNR-UHFFFAOYSA-N 4-(aminomethyl)-2,5-dimethyl-n-pyridin-4-ylbenzamide Chemical compound C1=C(CN)C(C)=CC(C(=O)NC=2C=CN=CC=2)=C1C GMDVSDXMBONTNR-UHFFFAOYSA-N 0.000 claims 2
- RZZGLZFZZYYVCO-UHFFFAOYSA-N 4-[2-(1-aminocyclobutyl)ethyl]-n-(1h-pyrrolo[2,3-b]pyridin-4-yl)benzamide Chemical compound C=1C=C(C(=O)NC=2C=3C=CNC=3N=CC=2)C=CC=1CCC1(N)CCC1 RZZGLZFZZYYVCO-UHFFFAOYSA-N 0.000 claims 2
- BREHCBBQUGUALM-UHFFFAOYSA-N 4-[2-(1-aminocyclopentyl)ethyl]-n-(1h-pyrrolo[2,3-b]pyridin-4-yl)benzamide Chemical compound C=1C=C(C(=O)NC=2C=3C=CNC=3N=CC=2)C=CC=1CCC1(N)CCCC1 BREHCBBQUGUALM-UHFFFAOYSA-N 0.000 claims 2
- 230000003345 hyperglycaemic effect Effects 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- RCWISWVYKNLXHC-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridin-4-amine Chemical compound NC1=CC=NC2=C1C=CN2 RCWISWVYKNLXHC-UHFFFAOYSA-N 0.000 claims 1
- HVFBLNMGJWVBOH-UHFFFAOYSA-N 4-(1-amino-2,2-dimethylbutyl)-n-(1h-pyrrolo[2,3-b]pyridin-4-yl)benzamide Chemical compound C1=CC(C(N)C(C)(C)CC)=CC=C1C(=O)NC1=CC=NC2=C1C=CN2 HVFBLNMGJWVBOH-UHFFFAOYSA-N 0.000 claims 1
- IZTDNPWBQHCWAF-UHFFFAOYSA-N 4-(1-amino-2,2-dimethylbutyl)-n-pyridin-4-ylbenzamide Chemical compound C1=CC(C(N)C(C)(C)CC)=CC=C1C(=O)NC1=CC=NC=C1 IZTDNPWBQHCWAF-UHFFFAOYSA-N 0.000 claims 1
- QRIIJGVRMJWJMC-UHFFFAOYSA-N 4-(1-amino-2,2-dimethylpropyl)-n-(1h-pyrrolo[2,3-b]pyridin-4-yl)benzamide Chemical compound C1=CC(C(N)C(C)(C)C)=CC=C1C(=O)NC1=CC=NC2=C1C=CN2 QRIIJGVRMJWJMC-UHFFFAOYSA-N 0.000 claims 1
- MFYXHARIDVVKQE-UHFFFAOYSA-N 4-(1-amino-2-methylpropyl)-n-pyridin-4-ylbenzamide Chemical compound C1=CC(C(N)C(C)C)=CC=C1C(=O)NC1=CC=NC=C1 MFYXHARIDVVKQE-UHFFFAOYSA-N 0.000 claims 1
- GUVVJWIZMJTOHB-UHFFFAOYSA-N 4-(1-amino-3,3-dimethylbutyl)-n-pyridin-4-ylbenzamide Chemical compound C1=CC(C(N)CC(C)(C)C)=CC=C1C(=O)NC1=CC=NC=C1 GUVVJWIZMJTOHB-UHFFFAOYSA-N 0.000 claims 1
- DMIYJAIUCNVDNZ-UHFFFAOYSA-N 4-(1-aminobutyl)-n-(1h-pyrrolo[2,3-b]pyridin-4-yl)benzamide Chemical compound C1=CC(C(N)CCC)=CC=C1C(=O)NC1=CC=NC2=C1C=CN2 DMIYJAIUCNVDNZ-UHFFFAOYSA-N 0.000 claims 1
- OXBJQHBEBMMYCJ-UHFFFAOYSA-N 4-(1-aminoethyl)-n-pyridin-4-ylnaphthalene-1-carboxamide Chemical compound C12=CC=CC=C2C(C(N)C)=CC=C1C(=O)NC1=CC=NC=C1 OXBJQHBEBMMYCJ-UHFFFAOYSA-N 0.000 claims 1
- AFPVZEOZNLCEFO-UHFFFAOYSA-N 4-(1-aminopentyl)-n-pyridin-4-ylbenzamide Chemical compound C1=CC(C(N)CCCC)=CC=C1C(=O)NC1=CC=NC=C1 AFPVZEOZNLCEFO-UHFFFAOYSA-N 0.000 claims 1
- ZZGFVFADCZZOTR-UHFFFAOYSA-N 4-(1-aminopropyl)-n-(1h-pyrrolo[2,3-b]pyridin-4-yl)benzamide Chemical compound C1=CC(C(N)CC)=CC=C1C(=O)NC1=CC=NC2=C1C=CN2 ZZGFVFADCZZOTR-UHFFFAOYSA-N 0.000 claims 1
- GQRHXVADWRNQSJ-UHFFFAOYSA-N 4-(1-aminopropyl)-n-pyridin-4-ylbenzamide Chemical compound C1=CC(C(N)CC)=CC=C1C(=O)NC1=CC=NC=C1 GQRHXVADWRNQSJ-UHFFFAOYSA-N 0.000 claims 1
- BEIPZGFAWMRBKW-UHFFFAOYSA-N 4-(aminomethyl)-n-pyridin-4-ylbenzamide Chemical compound C1=CC(CN)=CC=C1C(=O)NC1=CC=NC=C1 BEIPZGFAWMRBKW-UHFFFAOYSA-N 0.000 claims 1
- XQKMBMGZZKVNKI-UHFFFAOYSA-N 4-[(1-aminocyclohexa-2,4-dien-1-yl)methyl]-n-pyridin-4-ylbenzamide Chemical compound C=1C=C(C(=O)NC=2C=CN=CC=2)C=CC=1CC1(N)CC=CC=C1 XQKMBMGZZKVNKI-UHFFFAOYSA-N 0.000 claims 1
- RXVVCDYBIKNPMY-UHFFFAOYSA-N 4-[(1-aminocyclohexyl)methyl]-n-pyridin-4-ylbenzamide Chemical compound C=1C=C(C(=O)NC=2C=CN=CC=2)C=CC=1CC1(N)CCCCC1 RXVVCDYBIKNPMY-UHFFFAOYSA-N 0.000 claims 1
- UTWIBGAVMAMFLG-UHFFFAOYSA-N 4-[(1-aminocyclopentyl)methyl]-n-pyridin-4-ylbenzamide Chemical compound C=1C=C(C(=O)NC=2C=CN=CC=2)C=CC=1CC1(N)CCCC1 UTWIBGAVMAMFLG-UHFFFAOYSA-N 0.000 claims 1
- KVEPLQYOHUJLRM-UHFFFAOYSA-N 4-[2-(1-aminocyclobutyl)ethyl]-n-pyridin-4-ylbenzamide Chemical compound C=1C=C(C(=O)NC=2C=CN=CC=2)C=CC=1CCC1(N)CCC1 KVEPLQYOHUJLRM-UHFFFAOYSA-N 0.000 claims 1
- DYNBQBMJMRSQIS-UHFFFAOYSA-N 4-[2-(1-aminocyclopropyl)ethyl]-n-(1h-pyrrolo[2,3-b]pyridin-4-yl)benzamide Chemical compound C=1C=C(C(=O)NC=2C=3C=CNC=3N=CC=2)C=CC=1CCC1(N)CC1 DYNBQBMJMRSQIS-UHFFFAOYSA-N 0.000 claims 1
- OAGHQOGYIPJBMH-UHFFFAOYSA-N 4-[2-(1-aminocyclopropyl)ethyl]-n-pyridin-4-ylbenzamide Chemical compound C=1C=C(C(=O)NC=2C=CN=CC=2)C=CC=1CCC1(N)CC1 OAGHQOGYIPJBMH-UHFFFAOYSA-N 0.000 claims 1
- HBQICHDVACJWLN-UHFFFAOYSA-N 4-[amino-(4-methoxyphenyl)methyl]-n-pyridin-4-ylbenzamide Chemical compound C1=CC(OC)=CC=C1C(N)C1=CC=C(C(=O)NC=2C=CN=CC=2)C=C1 HBQICHDVACJWLN-UHFFFAOYSA-N 0.000 claims 1
- NUKYPUAOHBNCPY-UHFFFAOYSA-N 4-aminopyridine Chemical compound NC1=CC=NC=C1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- NWUKZQQHKGVGHB-UHFFFAOYSA-N 5-amino-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid Chemical compound OC(=O)C1=CC=C2C(N)CCCC2=C1 NWUKZQQHKGVGHB-UHFFFAOYSA-N 0.000 claims 1
- SLRGZZIYYHTKSM-XYPYZODXSA-N C1C[C@@H](CN)CC[C@@H]1C(=O)NC1=CC=NC=C1 Chemical compound C1C[C@@H](CN)CC[C@@H]1C(=O)NC1=CC=NC=C1 SLRGZZIYYHTKSM-XYPYZODXSA-N 0.000 claims 1
- 201000005948 Donohue syndrome Diseases 0.000 claims 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 206010022491 Insulin resistant diabetes Diseases 0.000 claims 1
- 206010024604 Lipoatrophy Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000011032 Werner Syndrome Diseases 0.000 claims 1
- IYOZTVGMEWJPKR-IJLUTSLNSA-N Y-27632 Chemical compound C1C[C@@H]([C@H](N)C)CC[C@@H]1C(=O)NC1=CC=NC=C1 IYOZTVGMEWJPKR-IJLUTSLNSA-N 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 1
- 201000008980 hyperinsulinism Diseases 0.000 claims 1
- 208000015978 inherited metabolic disease Diseases 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 230000003212 lipotrophic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000007863 steatosis Effects 0.000 claims 1
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 1
- 0 CC1(*)C=NC=CC(C)=C1 Chemical compound CC1(*)C=NC=CC(C)=C1 0.000 description 5
- GPCQIJHZALEOMP-UHFFFAOYSA-N Cc1cc(CCC2N)c2cc1 Chemical compound Cc1cc(CCC2N)c2cc1 GPCQIJHZALEOMP-UHFFFAOYSA-N 0.000 description 1
- RVYMOWKHMXUHRS-UHFFFAOYSA-N Cc1ccc(C(CCC2)N)c2c1 Chemical compound Cc1ccc(C(CCC2)N)c2c1 RVYMOWKHMXUHRS-UHFFFAOYSA-N 0.000 description 1
- JQOUGGPGOWRLPX-UHFFFAOYSA-N Cc1ccc(CNCC2)c2c1 Chemical compound Cc1ccc(CNCC2)c2c1 JQOUGGPGOWRLPX-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54554504P | 2004-02-18 | 2004-02-18 | |
| GBGB0403635.6A GB0403635D0 (en) | 2004-02-18 | 2004-02-18 | Pyridinocarboxamides with improved activity as kinase inhibitors |
| PCT/IB2005/000600 WO2005082367A1 (en) | 2004-02-18 | 2005-02-18 | Kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007523155A JP2007523155A (ja) | 2007-08-16 |
| JP2007523155A5 true JP2007523155A5 (https=) | 2008-03-13 |
Family
ID=32039983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553706A Pending JP2007523155A (ja) | 2004-02-18 | 2005-02-18 | キナーゼ阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20070191420A1 (https=) |
| EP (1) | EP1715862A1 (https=) |
| JP (1) | JP2007523155A (https=) |
| GB (1) | GB0403635D0 (https=) |
| WO (1) | WO2005082367A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1925855B (zh) | 2003-12-19 | 2010-06-16 | 普莱希科公司 | 开发Ret调节剂的化合物和方法 |
| US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| EP1833832A1 (en) * | 2004-12-31 | 2007-09-19 | GPC Biotech AG | Napthyridine compounds as rock inhibitors |
| US7737279B2 (en) | 2005-05-10 | 2010-06-15 | Bristol-Myers Squibb Company | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same |
| US7846941B2 (en) | 2005-05-17 | 2010-12-07 | Plexxikon, Inc. | Compounds modulating c-kit and c-fms activity and uses therefor |
| UA95244C2 (ru) | 2005-06-22 | 2011-07-25 | Плексикон, Инк. | Соединения и способ модулирования активности киназ, и показания для их применения |
| US20100168102A9 (en) * | 2005-07-11 | 2010-07-01 | Devgen Nv | Amide Derivatives as Kinase Inhibitors |
| US8211919B2 (en) | 2005-09-02 | 2012-07-03 | Astellas Pharma Inc. | Amide derivatives as rock inhibitors |
| US7741290B2 (en) | 2006-06-01 | 2010-06-22 | The Board of Trustee of The Leland Stanford Juinior University | Method of preventing progression of hypertension-induced heart failure with PKC peptides |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| JP2010514695A (ja) | 2006-12-21 | 2010-05-06 | プレキシコン，インコーポレーテッド | キナーゼ調節のための化合物および方法およびそのための適応症 |
| WO2008079909A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| PE20121126A1 (es) | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
| CL2008001933A1 (es) | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
| WO2009012283A1 (en) | 2007-07-17 | 2009-01-22 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| KR20100103830A (ko) * | 2008-01-21 | 2010-09-28 | 가부시키가이샤 시세이도 | Ⅴｅｇｆｃ 생성 촉진제 |
| WO2010042925A2 (en) | 2008-10-10 | 2010-04-15 | Vm Discovery Inc. | Compositions and methods for treating alcohol use disorders, pain and other diseases |
| MY172424A (en) | 2009-04-03 | 2019-11-25 | Hoffmann La Roche | Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof |
| TW201103904A (en) * | 2009-06-11 | 2011-02-01 | Hoffmann La Roche | Janus kinase inhibitor compounds and methods |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| GB0914726D0 (en) * | 2009-08-24 | 2009-09-30 | Univ Manchester | Kinase inhibitors |
| CN106220623A (zh) | 2009-11-06 | 2016-12-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| RU2012132278A (ru) | 2010-01-12 | 2014-02-20 | Ф. Хоффманн-Ля Рош Аг | Трициклические гетероциклические соединения, содержащие их композиции и способы их применения |
| US8785648B1 (en) | 2010-08-10 | 2014-07-22 | The Regents Of The University Of California | PKC-epsilon inhibitors |
| US9624213B2 (en) | 2011-02-07 | 2017-04-18 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
| JP2014515368A (ja) | 2011-05-26 | 2014-06-30 | 第一三共株式会社 | プロテインキナーゼ阻害剤としての複素環化合物 |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| US20170114323A1 (en) * | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| WO2016003450A1 (en) | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Pkc-epsilon inhibitors |
| WO2017023684A2 (en) * | 2015-07-31 | 2017-02-09 | Progenra, Inc. | Covalent irreversible inhibitors of usp7 as anti-cancer agents |
| EP4088719A1 (en) | 2015-10-13 | 2022-11-16 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion |
| US12048761B2 (en) | 2015-10-13 | 2024-07-30 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion |
| WO2017209322A1 (ko) * | 2016-05-31 | 2017-12-07 | 한림대학교 산학협력단 | 5원 헤테로사이클릭 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| WO2018160944A1 (en) | 2017-03-03 | 2018-09-07 | Progenra, Inc. | Azole compounds as ubiquitin-specific protease usp7 inhibitors |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
| CR20230057A (es) | 2020-07-02 | 2023-08-15 | Incyte Corp | Compuestos tríciclicos de urea como inhibidores de jak2 v617f |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| AR125273A1 (es) | 2021-02-25 | 2023-07-05 | Incyte Corp | Lactamas espirocíclicas como inhibidores de jak2 v617f |
| AU2023235313A1 (en) | 2022-03-17 | 2024-10-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| JPWO2024071371A1 (https=) * | 2022-09-30 | 2024-04-04 | ||
| WO2025224050A1 (en) | 2024-04-22 | 2025-10-30 | Institut National de la Santé et de la Recherche Médicale | Methods of treatment of patients suffering from hypomelanosis of ito |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990005723A1 (fr) * | 1988-11-24 | 1990-05-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes de trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane et leur utilisation en medecine |
| KR0133372B1 (ko) * | 1991-09-06 | 1998-04-23 | 고야 다다시 | 4-아미노(알킬)시클로헥산-1-카르복사미드 화합물 및 그 용도 |
| EP1195372A1 (en) * | 1994-04-18 | 2002-04-10 | Mitsubishi Pharma Corporation | N-heterocyclic substituted benzamide derivatives with antihypertensive activity |
| JP2003073357A (ja) * | 2001-09-03 | 2003-03-12 | Mitsubishi Pharma Corp | アミド化合物を含有するＲｈｏキナーゼ阻害剤 |
| GB0206861D0 (en) * | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Medicaments |
| CA2551944A1 (en) * | 2003-12-15 | 2005-06-30 | Almirall Prodesfarma Ag | 2, 6 bisheteroaryl-4-aminopyrimidines as adenosine receptor antagonists |
| JP2008525355A (ja) * | 2004-12-23 | 2008-07-17 | エフ．ホフマン−ラ ロシュ アーゲー | ベンズアミド誘導体、これらの製造及び医薬剤としての使用。 |
-
2004
- 2004-02-18 GB GBGB0403635.6A patent/GB0403635D0/en not_active Ceased
-
2005
- 2005-02-18 JP JP2006553706A patent/JP2007523155A/ja active Pending
- 2005-02-18 WO PCT/IB2005/000600 patent/WO2005082367A1/en not_active Ceased
- 2005-02-18 EP EP05708700A patent/EP1715862A1/en not_active Withdrawn
- 2005-02-18 US US10/589,875 patent/US20070191420A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007523155A5 (https=) | ||
| RU2470011C2 (ru) | Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов | |
| TWI376370B (en) | Compounds for inflammation and immune-related uses | |
| JP2008513515A5 (https=) | ||
| JP2009531280A5 (https=) | ||
| CN1474818A (zh) | 含有稠合杂环化合物或其盐的糖尿病预防或治疗药 | |
| TW200819122A (en) | Chemical compounds | |
| JP2015523339A5 (https=) | ||
| CA2513092A1 (en) | Compounds for the treatment of metabolic disorders | |
| CN103097353A (zh) | 新型免疫调节剂和抗炎化合物 | |
| BR112021007101A2 (pt) | composto, composto para uso como neuroprotetor, sal de adição de ácido farmaceuticamente aceitável, derivado, n-óxido, solvato, tautômero, estereoisômero, racemato, sal fisiologicamente aceitável, composição farmacêutica, composições farmacêuticas neuroprotetiva e antienvelhecimento, meio tangível, agente de deleção, diminuição, ligação, inibição ou degradação de pfkfb3, inibidores de pfkfb3, de pfkfb3 para uso em neuroproteção, de atividade de quinase de pfkfb3 de molécula pequena, de atividade de quinase de pfkfb3, de molécula pequena de pfkfb3 e de molécula pequena de atividade de quinase de pfkfb3, kits para tratamento de um quadro mediado por pfkfb3 e/ou pfkfb4, de um câncer, para tratamento antienvelhecimento e para neuroproteção, métodos de imunossupressão e para tratamento de um câncer, de tumor sólido, de um câncer hematológico, de um câncer ósseo, de osteosarcoma, de doença, de isquemia cerebral, de derrame isquêmico neonatal, de insulto neurológico, de derrame isquêmico, de envelhecimento acelerado de sobrevivente de câncer, de envelhecimento acelerado de indivíduo sofrendo de hiv, de uma lesão traumática no cérebro, de um indivíduo humano após lesão no sistema nervoso central aguda, para o tratamento de um transtorno associado à modulação de níveis f-2,6-p2 em um mamífero, para tratamento ou prevenção de um transtorno ou doença relacionada à idade ou outro tratamento antienvelhecimento e para prevenção ou tratamento de consequências da quimioterapia e da radioterapia, para tratamento ou profilaxia de doença ou quadro no qual a inibição de glicólise tem efeito benéfico, de doença neurodegenerativa ou quadro no qual a inibição de glicólise tem efeito benéfico e de doença neurodegenerativa ou quadro neurodegenerativo, para intensificar o efeito de tratamento de câncer por radiação, o efeito de tratamento de câncer ósseo por radiação e o efeito de tratamento de osteosarcoma por radiação, para reduzir a capacidade de as células cancerosas repararem seu dna e reduzir inflamação aterosclerótica e/ou pelo menos uma de suas consequências clínicas, para sensibilizar a célula cancerosa para a terapia citostática e/ou de radiação, e, métodos para neuroproteção, para fabricação de uma medicação, para fabricação de uma medicação de neuroproteção, para aumento de capacidade antioxidante de célula, para reduzir uma absorção glicolítica no neurônio, para prevenção de morte apoptótica do neurônio, para reduzir uma absorção glicolítica no astrócito, para inibição reativa à proliferação de astrócito, para proteção de um neurônio contra a excitotoxicidade, para proteção de um neurônio entérico contra a excitotoxicidade, para atenuação ou prevenção de dano neuronal em um indivíduo humano, para prevenção ou tratamento de doença relacionada ao envelhecimento, para melhoria de um parâmetro, para rejuvenescimento, para radioproteção, para a mudança de biomarcador ou biomarcadores de mortalidade, para a mudança de biomarcador ou biomarcadores de longevidade ou | |
| JP2011504903A5 (https=) | ||
| JP2012521429A5 (https=) | ||
| JP2020502111A5 (https=) | ||
| JP2017505293A5 (https=) | ||
| CA2521621A1 (en) | Compounds for the treatment of metabolic disorders | |
| CN103102348B (zh) | 噁二唑类化合物及其制备方法、药物组合物及其用途 | |
| JP2007500145A5 (https=) | ||
| JP2010522710A5 (https=) | ||
| JP2015519322A5 (https=) | ||
| CN104640544A (zh) | 血脂异常症治疗剂 | |
| CA2522738A1 (en) | Compounds for the treatment of metabolic disorders | |
| JP2019520344A5 (https=) | ||
| CA2521589A1 (en) | Compounds for the treatment of metabolic disorders | |
| JP2020534266A5 (https=) |