JP2010540593A5 - - Google Patents
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- Publication number
- JP2010540593A5 JP2010540593A5 JP2010527450A JP2010527450A JP2010540593A5 JP 2010540593 A5 JP2010540593 A5 JP 2010540593A5 JP 2010527450 A JP2010527450 A JP 2010527450A JP 2010527450 A JP2010527450 A JP 2010527450A JP 2010540593 A5 JP2010540593 A5 JP 2010540593A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- asthma
- dermatitis
- syndrome
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc1ccccc1-c(cc1)c([C@@](*=O)[O-])cc1C1=NC(c(cccc2)c2OC)=*=CO1 Chemical compound Cc1ccccc1-c(cc1)c([C@@](*=O)[O-])cc1C1=NC(c(cccc2)c2OC)=*=CO1 0.000 description 11
- ZECNIOSRNLMLQL-UHFFFAOYSA-N CC(C(C=C1C2=[I]COC(c(cc3C)cnc3N3C(COC)CCC3)=N2)=CCC1OC)=C Chemical compound CC(C(C=C1C2=[I]COC(c(cc3C)cnc3N3C(COC)CCC3)=N2)=CCC1OC)=C ZECNIOSRNLMLQL-UHFFFAOYSA-N 0.000 description 1
- LMEIQOZLQFASPG-UHFFFAOYSA-N CC(C)Cc(cc1)ccc1C1=NC(c2ccccc2OC)=CCO1 Chemical compound CC(C)Cc(cc1)ccc1C1=NC(c2ccccc2OC)=CCO1 LMEIQOZLQFASPG-UHFFFAOYSA-N 0.000 description 1
- FJCWNYMWFMXWIG-UHFFFAOYSA-N CC(C1)C(OC)=CC(OC)=C1c(cc1)c(C)cc1-c1nc(-c(cccc2)c2OC)n[o]1 Chemical compound CC(C1)C(OC)=CC(OC)=C1c(cc1)c(C)cc1-c1nc(-c(cccc2)c2OC)n[o]1 FJCWNYMWFMXWIG-UHFFFAOYSA-N 0.000 description 1
- RDZNOCMUKDFOEB-UHFFFAOYSA-N CC(CCCC1)N1C(C=C1)=NCC=C1c1nc(-c(cc(cc2)F)c2OC)n[o]1 Chemical compound CC(CCCC1)N1C(C=C1)=NCC=C1c1nc(-c(cc(cc2)F)c2OC)n[o]1 RDZNOCMUKDFOEB-UHFFFAOYSA-N 0.000 description 1
- HBZMDATWKNBZOL-UHFFFAOYSA-N CN(CCOC1)C1I Chemical compound CN(CCOC1)C1I HBZMDATWKNBZOL-UHFFFAOYSA-N 0.000 description 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N CN1CCCCC1 Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 1
- GJSVCUHWEJFFMO-UHFFFAOYSA-N Cc(nccc1)c1I Chemical compound Cc(nccc1)c1I GJSVCUHWEJFFMO-UHFFFAOYSA-N 0.000 description 1
- YFSLWFVIZJXFTH-UHFFFAOYSA-N Cc1c(C)[o]nc1I Chemical compound Cc1c(C)[o]nc1I YFSLWFVIZJXFTH-UHFFFAOYSA-N 0.000 description 1
- MGGZZJQVRZTTSN-UHFFFAOYSA-N Cc1cc(-c2nc(-c(cccc3)c3OC(F)(F)F)n[o]2)ccc1-c1ccccc1OC Chemical compound Cc1cc(-c2nc(-c(cccc3)c3OC(F)(F)F)n[o]2)ccc1-c1ccccc1OC MGGZZJQVRZTTSN-UHFFFAOYSA-N 0.000 description 1
- XQPLNMPHXAMKKR-UHFFFAOYSA-N Cc1cc(-c2nc(-c(cccc3)c3OC)n[o]2)ccc1C1=CCCC=C1C Chemical compound Cc1cc(-c2nc(-c(cccc3)c3OC)n[o]2)ccc1C1=CCCC=C1C XQPLNMPHXAMKKR-UHFFFAOYSA-N 0.000 description 1
- FWIGHXDJQOUOMF-UHFFFAOYSA-N Cc1ccccc1-c(cc1)c(CN(C)C)cc1-c1nc(-c(cc(C=C)cc2)c2OC)n[o]1 Chemical compound Cc1ccccc1-c(cc1)c(CN(C)C)cc1-c1nc(-c(cc(C=C)cc2)c2OC)n[o]1 FWIGHXDJQOUOMF-UHFFFAOYSA-N 0.000 description 1
- PWMQGDXVGSGAHB-UHFFFAOYSA-N Cc1ccccc1-c(cc1)c(CN)cc1-c1nc(-c2cc(F)ccc2OC)n[o]1 Chemical compound Cc1ccccc1-c(cc1)c(CN)cc1-c1nc(-c2cc(F)ccc2OC)n[o]1 PWMQGDXVGSGAHB-UHFFFAOYSA-N 0.000 description 1
- MFQWILMXHRCFDY-UHFFFAOYSA-N Cc1ccccc1-c(ccc(-c1nc(-c2cc(F)ccc2OC)n[o]1)c1)c1C(O)=O Chemical compound Cc1ccccc1-c(ccc(-c1nc(-c2cc(F)ccc2OC)n[o]1)c1)c1C(O)=O MFQWILMXHRCFDY-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07117925 | 2007-10-04 | ||
| EP07117925.3 | 2007-10-04 | ||
| US99813607P | 2007-10-09 | 2007-10-09 | |
| US60/998,136 | 2007-10-09 | ||
| PCT/EP2008/063185 WO2009043890A1 (en) | 2007-10-04 | 2008-10-01 | Oxadiazole diaryl compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014197234A Division JP2015025001A (ja) | 2007-10-04 | 2014-09-26 | オキサジアゾール・ジアリール化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540593A JP2010540593A (ja) | 2010-12-24 |
| JP2010540593A5 true JP2010540593A5 (https=) | 2013-10-24 |
| JP5727223B2 JP5727223B2 (ja) | 2015-06-03 |
Family
ID=38961274
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527450A Expired - Fee Related JP5727223B2 (ja) | 2007-10-04 | 2008-10-01 | オキサジアゾール・ジアリール化合物 |
| JP2014197234A Withdrawn JP2015025001A (ja) | 2007-10-04 | 2014-09-26 | オキサジアゾール・ジアリール化合物 |
| JP2016100693A Expired - Fee Related JP6224771B2 (ja) | 2007-10-04 | 2016-05-19 | オキサジアゾール・ジアリール化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014197234A Withdrawn JP2015025001A (ja) | 2007-10-04 | 2014-09-26 | オキサジアゾール・ジアリール化合物 |
| JP2016100693A Expired - Fee Related JP6224771B2 (ja) | 2007-10-04 | 2016-05-19 | オキサジアゾール・ジアリール化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8404676B2 (https=) |
| EP (1) | EP2193126B1 (https=) |
| JP (3) | JP5727223B2 (https=) |
| KR (1) | KR20100083814A (https=) |
| CN (2) | CN104478821B (https=) |
| AR (1) | AR068730A1 (https=) |
| AU (1) | AU2008306886B2 (https=) |
| BR (1) | BRPI0817597A2 (https=) |
| CA (1) | CA2696829C (https=) |
| EA (1) | EA201070423A1 (https=) |
| ES (1) | ES2547877T3 (https=) |
| IL (1) | IL204520A (https=) |
| MX (1) | MX2010003614A (https=) |
| WO (1) | WO2009043890A1 (https=) |
| ZA (1) | ZA201001217B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2125797E (pt) | 2007-03-16 | 2014-03-11 | Actelion Pharmaceuticals Ltd | Derivados aminopiridina como agonistas do receptor s1p1/edg1 |
| AU2008306886B2 (en) * | 2007-10-04 | 2014-01-16 | Merck Serono S.A. | Oxadiazole diaryl compounds |
| ES2622423T3 (es) | 2007-10-04 | 2017-07-06 | Merck Serono S.A. | Derivados de oxadiazol |
| US8551463B2 (en) | 2007-10-22 | 2013-10-08 | Living Proof, Inc. | Hair care compositions and methods of treating hair |
| AU2008340113B2 (en) * | 2007-12-21 | 2014-01-09 | Merck Serono S.A. | Triazole oxadiazoles derivatives |
| JP5411877B2 (ja) * | 2008-03-06 | 2014-02-12 | アクテリオン ファーマシューティカルズ リミテッド | ピリジン化合物 |
| AU2009220893A1 (en) | 2008-03-07 | 2009-09-11 | Actelion Pharmaceuticals Ltd | Novel aminomethyl benzene derivatives |
| EP2389377B1 (en) | 2009-01-23 | 2014-07-16 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
| ES2405054T3 (es) | 2009-01-23 | 2013-05-30 | Bristol-Myers Squibb Company | Derivados de pirazol-1,2,4-oxadiazol como agonistas de esfingosina-1-fosfato |
| JP2012515787A (ja) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | 自己免疫疾患および炎症性疾患の処置におけるｓ１ｐアゴニストとしての置換オキサジアゾール誘導体 |
| CN102471328B (zh) | 2009-07-16 | 2015-04-01 | 埃科特莱茵药品有限公司 | 吡啶-4-基衍生物 |
| US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
| WO2011133734A1 (en) | 2010-04-23 | 2011-10-27 | Bristol-Myers Squibb Company | 4 - (5 - isoxazolyl or 5 - pyrrazolyl -1,2,4- oxadiazol - 3 - yl) -mandelic acid amides as sphingosin- 1 - phosphate 1 rreceptor agonists |
| ES2515415T3 (es) | 2010-04-27 | 2014-10-29 | Allergan, Inc. | Derivados de 3-(4-((1H-imidazol-1-il)metil)fenil)-5-aril-1,2,4-oxadiazol como moduladores de receptores de la esfingosina-1-fosfato |
| EP2619190B1 (en) * | 2010-09-24 | 2015-08-12 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds and their use as s1p1 agonists |
| HRP20150919T1 (hr) | 2011-01-19 | 2015-09-25 | Actelion Pharmaceuticals Ltd. | Derivati 2-metoksi-piridin-4-ila |
| US9073881B2 (en) * | 2011-09-23 | 2015-07-07 | Hoffmann-La Roche Inc. | Benzoic acid derivatives |
| BR112017024785B1 (pt) | 2015-05-20 | 2022-05-17 | Idorsia Pharmaceuticals Ltd | Forma cristalina do composto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4] oxadiazol-3- il]-2-etil-6-metilfenoxi}-propano-1,2-diol, composição farmacêutica, e, uso |
| WO2022099155A1 (en) * | 2020-11-09 | 2022-05-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| EP4050002A1 (en) * | 2021-02-26 | 2022-08-31 | First Health Pharmaceuticals B.V. | Anti-proliferative agents |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH623971B5 (de) | 1976-06-04 | 1982-01-15 | Hoechst Ag | Verfahren zur herstellung neuer benzofuranderivate und deren verwendung als optische aufheller. |
| US4135910A (en) | 1977-05-12 | 1979-01-23 | Monsanto Company | Oxadiazol-3-yl-benzoates as plant growth regulants |
| DE4320801A1 (de) | 1993-06-23 | 1995-01-05 | Fahlberg List Pharma Gmbh | 2-Hydroxyphenylsubstituierte 1,2,4-Triazole und 1,2,4-Oxadiazole, ihre Verwendung als pharmazeutische Wirkstoffe und sie enthaltende Arzneimittel |
| DE19643037A1 (de) * | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| AUPP999799A0 (en) | 1999-04-27 | 1999-05-20 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| EP4101846B1 (en) | 2003-04-11 | 2023-08-02 | PTC Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| US20060252741A1 (en) * | 2003-05-15 | 2006-11-09 | Colandrea Vincent J | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists |
| CN1859908A (zh) * | 2003-10-01 | 2006-11-08 | 默克公司 | 作为s1p受体激动剂的3,5－芳基、杂芳基或环烷基取代的－1,2,4－噁二唑类化合物 |
| US7605171B2 (en) * | 2003-12-17 | 2009-10-20 | Merck & Co., Inc. | (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists |
| JPWO2005108370A1 (ja) * | 2004-04-16 | 2008-03-21 | 味の素株式会社 | ベンゼン化合物 |
| BRPI0511676A (pt) | 2004-05-29 | 2008-01-08 | 7Tm Pharma As | uso medicinal de ligandos receptores |
| AU2005299851B2 (en) * | 2004-10-22 | 2011-03-17 | Merck Sharp & Dohme Corp. | 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists |
| BRPI0612028A2 (pt) * | 2005-06-08 | 2010-10-13 | Novartis Ag | oxadiazóis ou isodiazóis policìclicos e uso dos mesmos como ligantes de receptor s1p |
| KR20080066938A (ko) | 2005-10-07 | 2008-07-17 | 깃세이 야쿠힌 고교 가부시키가이샤 | 질소 함유 복소환 화합물 및 그것을 함유하는 의약 조성물 |
| TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
| JP2009269819A (ja) | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| RU2009115963A (ru) | 2006-09-29 | 2010-11-10 | Новартис АГ (CH) | Производные оксадиазола, обладающие противовоспалительными и иммунодепрессантными свойствами |
| SG177221A1 (en) | 2006-12-15 | 2012-01-30 | Abbott Lab | Novel oxadiazole compounds |
| EP2014653A1 (en) | 2007-06-15 | 2009-01-14 | Bioprojet | Novel dicarboxylic acid derivatives as S1P1 receptor agonists |
| ES2622423T3 (es) * | 2007-10-04 | 2017-07-06 | Merck Serono S.A. | Derivados de oxadiazol |
| AU2008306886B2 (en) * | 2007-10-04 | 2014-01-16 | Merck Serono S.A. | Oxadiazole diaryl compounds |
-
2008
- 2008-10-01 AU AU2008306886A patent/AU2008306886B2/en not_active Ceased
- 2008-10-01 CA CA2696829A patent/CA2696829C/en not_active Expired - Fee Related
- 2008-10-01 MX MX2010003614A patent/MX2010003614A/es not_active Application Discontinuation
- 2008-10-01 ES ES08804975.4T patent/ES2547877T3/es active Active
- 2008-10-01 KR KR1020107009974A patent/KR20100083814A/ko not_active Withdrawn
- 2008-10-01 US US12/675,254 patent/US8404676B2/en not_active Expired - Fee Related
- 2008-10-01 CN CN201410603560.6A patent/CN104478821B/zh not_active Expired - Fee Related
- 2008-10-01 CN CN200880110507.5A patent/CN101815707B/zh not_active Expired - Fee Related
- 2008-10-01 EA EA201070423A patent/EA201070423A1/ru unknown
- 2008-10-01 BR BRPI0817597 patent/BRPI0817597A2/pt not_active IP Right Cessation
- 2008-10-01 JP JP2010527450A patent/JP5727223B2/ja not_active Expired - Fee Related
- 2008-10-01 EP EP08804975.4A patent/EP2193126B1/en active Active
- 2008-10-01 WO PCT/EP2008/063185 patent/WO2009043890A1/en not_active Ceased
- 2008-10-03 AR ARP080104332A patent/AR068730A1/es not_active Application Discontinuation
-
2010
- 2010-02-19 ZA ZA2010/01217A patent/ZA201001217B/en unknown
- 2010-03-16 IL IL204520A patent/IL204520A/en not_active IP Right Cessation
-
2012
- 2012-12-12 US US13/711,934 patent/US8889668B2/en not_active Expired - Fee Related
-
2014
- 2014-09-26 JP JP2014197234A patent/JP2015025001A/ja not_active Withdrawn
-
2016
- 2016-05-19 JP JP2016100693A patent/JP6224771B2/ja not_active Expired - Fee Related
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