JP5727223B2 - オキサジアゾール・ジアリール化合物 - Google Patents

オキサジアゾール・ジアリール化合物 Download PDF

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JP5727223B2
JP5727223B2 JP2010527450A JP2010527450A JP5727223B2 JP 5727223 B2 JP5727223 B2 JP 5727223B2 JP 2010527450 A JP2010527450 A JP 2010527450A JP 2010527450 A JP2010527450 A JP 2010527450A JP 5727223 B2 JP5727223 B2 JP 5727223B2
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mmol
disease
acid
title compound
methyl
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JP2010540593A5 (https=
JP2010540593A (ja
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モンターニュ,シリル
カトロパニ,アンナ
ザウアー,ボルフガンク
ボンブラン,アニエス
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メルク セローノ ソシエテ アノニム
メルク セローノ ソシエテ アノニム
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    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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JP2010527450A 2007-10-04 2008-10-01 オキサジアゾール・ジアリール化合物 Expired - Fee Related JP5727223B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07117925 2007-10-04
EP07117925.3 2007-10-04
US99813607P 2007-10-09 2007-10-09
US60/998,136 2007-10-09
PCT/EP2008/063185 WO2009043890A1 (en) 2007-10-04 2008-10-01 Oxadiazole diaryl compounds

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JP2010540593A JP2010540593A (ja) 2010-12-24
JP2010540593A5 JP2010540593A5 (https=) 2013-10-24
JP5727223B2 true JP5727223B2 (ja) 2015-06-03

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JP2014197234A Withdrawn JP2015025001A (ja) 2007-10-04 2014-09-26 オキサジアゾール・ジアリール化合物
JP2016100693A Expired - Fee Related JP6224771B2 (ja) 2007-10-04 2016-05-19 オキサジアゾール・ジアリール化合物

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JP2016100693A Expired - Fee Related JP6224771B2 (ja) 2007-10-04 2016-05-19 オキサジアゾール・ジアリール化合物

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US (2) US8404676B2 (https=)
EP (1) EP2193126B1 (https=)
JP (3) JP5727223B2 (https=)
KR (1) KR20100083814A (https=)
CN (2) CN104478821B (https=)
AR (1) AR068730A1 (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015025001A (ja) * 2007-10-04 2015-02-05 メルク セローノ ソシエテ アノニム オキサジアゾール・ジアリール化合物

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0808789A2 (pt) 2007-03-16 2014-08-12 Actelion Pharmaceuticals Ltd Compostos e composição farmacêutica de derivados aminopiridina e uso destes
MX2010003612A (es) 2007-10-04 2010-04-30 Merck Serono Sa Derivados de oxadiazol.
US8551463B2 (en) 2007-10-22 2013-10-08 Living Proof, Inc. Hair care compositions and methods of treating hair
AU2008340113B2 (en) * 2007-12-21 2014-01-09 Merck Serono S.A. Triazole oxadiazoles derivatives
EP2262799B1 (en) * 2008-03-06 2012-07-04 Actelion Pharmaceuticals Ltd. Pyridine compounds
CA2715317A1 (en) 2008-03-07 2009-09-11 Actelion Pharmaceuticals Ltd Novel aminomethyl benzene derivatives
ES2405054T3 (es) 2009-01-23 2013-05-30 Bristol-Myers Squibb Company Derivados de pirazol-1,2,4-oxadiazol como agonistas de esfingosina-1-fosfato
WO2010085582A1 (en) 2009-01-23 2010-07-29 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
JP2012515787A (ja) 2009-01-23 2012-07-12 ブリストル−マイヤーズ スクイブ カンパニー 自己免疫疾患および炎症性疾患の処置におけるs1pアゴニストとしての置換オキサジアゾール誘導体
CA2767585C (en) 2009-07-16 2017-09-26 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
ES2548683T3 (es) 2010-04-23 2015-10-20 Bristol-Myers Squibb Company Amidas del ácido 4-(5-isoxazolil o 5-pirrazolil-1,2,4-oxadiazol-3-il)-mandélico como agonistas de receptor de esfingosina-1-fosfato 1
US8318783B2 (en) 2010-04-27 2012-11-27 Allergan, Inc. 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-aryl-1,2,4-oxadiazole derivatives as sphingosine-1 phosphate receptors modulators
EP2619190B1 (en) * 2010-09-24 2015-08-12 Bristol-Myers Squibb Company Substituted oxadiazole compounds and their use as s1p1 agonists
MA34910B1 (fr) 2011-01-19 2014-02-01 Actelion Pharmaceuticals Ltd Dérivés de 2-methoxy-pyridin-4-yl
US9073881B2 (en) * 2011-09-23 2015-07-07 Hoffmann-La Roche Inc. Benzoic acid derivatives
PH12017502097B1 (en) 2015-05-20 2023-05-05 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol
CA3201000A1 (en) * 2020-11-09 2022-05-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
EP4050002A1 (en) * 2021-02-26 2022-08-31 First Health Pharmaceuticals B.V. Anti-proliferative agents

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH623971B5 (de) 1976-06-04 1982-01-15 Hoechst Ag Verfahren zur herstellung neuer benzofuranderivate und deren verwendung als optische aufheller.
US4135910A (en) * 1977-05-12 1979-01-23 Monsanto Company Oxadiazol-3-yl-benzoates as plant growth regulants
DE4320801A1 (de) 1993-06-23 1995-01-05 Fahlberg List Pharma Gmbh 2-Hydroxyphenylsubstituierte 1,2,4-Triazole und 1,2,4-Oxadiazole, ihre Verwendung als pharmazeutische Wirkstoffe und sie enthaltende Arzneimittel
DE19643037A1 (de) * 1996-10-18 1998-04-23 Boehringer Ingelheim Kg Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
AUPP999799A0 (en) 1999-04-27 1999-05-20 Fujisawa Pharmaceutical Co., Ltd. New compound
HUE047569T2 (hu) 2003-04-11 2020-04-28 Ptc Therapeutics Inc 1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása
AU2004240586A1 (en) * 2003-05-15 2004-12-02 Merck & Co., Inc. 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as S1P receptor agonists
US20070043014A1 (en) * 2003-10-01 2007-02-22 Merck & Co., Inc. 3,5-Aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
EP1697333A4 (en) * 2003-12-17 2009-07-08 Merck & Co Inc (3,4-DISUBSTITUTED) PROPANE ACID BOXYLATES AS AGONISTS OF THE S1P (EDG) RECEPTOR
JPWO2005108370A1 (ja) * 2004-04-16 2008-03-21 味の素株式会社 ベンゼン化合物
EP1758579A1 (en) 2004-05-29 2007-03-07 7TM Pharma A/S Crth2 receptor ligands for medicinal uses
CA2583681A1 (en) * 2004-10-22 2006-05-04 Merck & Co., Inc. 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as s1p receptor agonists
WO2006131336A1 (en) * 2005-06-08 2006-12-14 Novartis Ag POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS
JP5222561B2 (ja) 2005-10-07 2013-06-26 キッセイ薬品工業株式会社 含窒素芳香族複素環化合物およびそれを含有する医薬組成物
TWI404706B (zh) * 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
JP2009269819A (ja) 2006-08-25 2009-11-19 Asahi Kasei Pharma Kk アミン化合物
CN101522646A (zh) 2006-09-29 2009-09-02 诺瓦提斯公司 具有抗炎和免疫抑制特性的二唑衍生物
EP2109364A4 (en) 2006-12-15 2010-04-14 Abbott Lab NOVEL OXADIAZONE COMPOUNDS
EP2014653A1 (en) 2007-06-15 2009-01-14 Bioprojet Novel dicarboxylic acid derivatives as S1P1 receptor agonists
CN104478821B (zh) * 2007-10-04 2016-09-28 默克雪兰诺有限公司 噁二唑二芳基化合物
MX2010003612A (es) 2007-10-04 2010-04-30 Merck Serono Sa Derivados de oxadiazol.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015025001A (ja) * 2007-10-04 2015-02-05 メルク セローノ ソシエテ アノニム オキサジアゾール・ジアリール化合物
JP2016169223A (ja) * 2007-10-04 2016-09-23 メルク セローノ ソシエテ アノニム オキサジアゾール・ジアリール化合物

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US20100305104A1 (en) 2010-12-02
KR20100083814A (ko) 2010-07-22
AR068730A1 (es) 2009-12-02
JP6224771B2 (ja) 2017-11-01
AU2008306886A1 (en) 2009-04-09
EA201070423A1 (ru) 2010-10-29
US20130109676A1 (en) 2013-05-02
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CA2696829A1 (en) 2009-04-09
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