JP2011509691A5 - - Google Patents
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- JP2011509691A5 JP2011509691A5 JP2010544425A JP2010544425A JP2011509691A5 JP 2011509691 A5 JP2011509691 A5 JP 2011509691A5 JP 2010544425 A JP2010544425 A JP 2010544425A JP 2010544425 A JP2010544425 A JP 2010544425A JP 2011509691 A5 JP2011509691 A5 JP 2011509691A5
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- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims description 276
- 108090000623 proteins and genes Proteins 0.000 claims description 220
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 180
- 102000004169 proteins and genes Human genes 0.000 claims description 94
- 238000000034 method Methods 0.000 claims description 91
- 230000037361 pathway Effects 0.000 claims description 87
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims description 80
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 77
- 102000004190 Enzymes Human genes 0.000 claims description 71
- 108090000790 Enzymes Proteins 0.000 claims description 71
- 230000000813 microbial effect Effects 0.000 claims description 68
- 244000005700 microbiome Species 0.000 claims description 58
- 102000039446 nucleic acids Human genes 0.000 claims description 58
- 108020004707 nucleic acids Proteins 0.000 claims description 58
- 150000007523 nucleic acids Chemical class 0.000 claims description 58
- 108700040121 Protein Methyltransferases Proteins 0.000 claims description 57
- 102000055027 Protein Methyltransferases Human genes 0.000 claims description 57
- 102100037458 Dephospho-CoA kinase Human genes 0.000 claims description 53
- 108010049285 dephospho-CoA kinase Proteins 0.000 claims description 53
- 102100025413 Formyltetrahydrofolate synthetase Human genes 0.000 claims description 52
- 108010031234 carbon monoxide dehydrogenase Proteins 0.000 claims description 45
- TZBGSHAFWLGWBO-ABLWVSNPSA-N (2s)-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1h-pteridin-6-yl)methylamino]benzoyl]amino]-5-methoxy-5-oxopentanoic acid Chemical compound C1=CC(C(=O)N[C@@H](CCC(=O)OC)C(O)=O)=CC=C1NCC1NC(C(=O)NC(N)=N2)=C2NC1 TZBGSHAFWLGWBO-ABLWVSNPSA-N 0.000 claims description 41
- 108010020056 Hydrogenase Proteins 0.000 claims description 33
- 108010081409 Iron-Sulfur Proteins Proteins 0.000 claims description 33
- 102000005298 Iron-Sulfur Proteins Human genes 0.000 claims description 33
- 108010010685 Methenyltetrahydrofolate cyclohydrolase Proteins 0.000 claims description 32
- 108010074122 Ferredoxins Proteins 0.000 claims description 29
- 102000004316 Oxidoreductases Human genes 0.000 claims description 28
- 108090000854 Oxidoreductases Proteins 0.000 claims description 28
- 101710159527 Maturation protein A Proteins 0.000 claims description 27
- 101710091157 Maturation protein A2 Proteins 0.000 claims description 27
- SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical compound OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 claims description 24
- 108090000698 Formate Dehydrogenases Proteins 0.000 claims description 20
- 108010080982 Formate-tetrahydrofolate ligase Proteins 0.000 claims description 20
- 230000015572 biosynthetic process Effects 0.000 claims description 19
- 238000003786 synthesis reaction Methods 0.000 claims description 19
- 102000005954 Methylenetetrahydrofolate Reductase (NADPH2) Human genes 0.000 claims description 18
- 108010030837 Methylenetetrahydrofolate Reductase (NADPH2) Proteins 0.000 claims description 18
- 108010031852 Pyruvate Synthase Proteins 0.000 claims description 18
- 108010055682 3-hydroxybutyryl-CoA dehydrogenase Proteins 0.000 claims description 15
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims description 15
- 102100037768 Acetyl-CoA acetyltransferase, mitochondrial Human genes 0.000 claims description 15
- 101710168556 Chromodomain Y-like protein Proteins 0.000 claims description 15
- 102100031668 Chromodomain Y-like protein Human genes 0.000 claims description 15
- 101710188748 Crotonyl-CoA hydratase Proteins 0.000 claims description 15
- 108010023922 Enoyl-CoA hydratase Proteins 0.000 claims description 15
- 102000011426 Enoyl-CoA hydratase Human genes 0.000 claims description 15
- 102100039894 Hemoglobin subunit delta Human genes 0.000 claims description 15
- 102000016397 Methyltransferase Human genes 0.000 claims description 15
- 108060004795 Methyltransferase Proteins 0.000 claims description 15
- 229920001184 polypeptide Polymers 0.000 claims description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 15
- BAMBWCGEVIAQBF-CITAKDKDSA-N 4-hydroxybutyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCO)O[C@H]1N1C2=NC=NC(N)=C2N=C1 BAMBWCGEVIAQBF-CITAKDKDSA-N 0.000 claims description 14
- 101100215658 Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) aflY gene Proteins 0.000 claims description 12
- 101100232322 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) hypA2 gene Proteins 0.000 claims description 12
- 101100297400 Rhizobium meliloti (strain 1021) phaAB gene Proteins 0.000 claims description 12
- 101100232321 Synechocystis sp. (strain PCC 6803 / Kazusa) hypA1 gene Proteins 0.000 claims description 12
- 101710167005 Thiol:disulfide interchange protein DsbD Proteins 0.000 claims description 12
- 101150081706 acsAB gene Proteins 0.000 claims description 12
- 101150006844 groES gene Proteins 0.000 claims description 12
- 101150081485 hypA gene Proteins 0.000 claims description 12
- ZNOVTXRBGFNYRX-UHFFFAOYSA-N 2-[[4-[(2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-UHFFFAOYSA-N 0.000 claims description 10
- 101100227555 Moorella thermoacetica (strain ATCC 39073 / JCM 9320) folD gene Proteins 0.000 claims description 9
- 238000012258 culturing Methods 0.000 claims description 9
- MEANFMOQMXYMCT-OLZOCXBDSA-N 5,10-methenyltetrahydrofolic acid Chemical compound C([C@H]1CNC2=C([N+]1=C1)C(=O)N=C(N2)N)N1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C([O-])=O)C=C1 MEANFMOQMXYMCT-OLZOCXBDSA-N 0.000 claims description 8
- -1 adhE2 Proteins 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 101710088194 Dehydrogenase Proteins 0.000 claims description 7
- QTXZASLUYMRUAN-QLQASOTGSA-N Acetyl coenzyme A (Acetyl-CoA) Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1.O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QTXZASLUYMRUAN-QLQASOTGSA-N 0.000 claims description 6
- 101100396130 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) hypD1 gene Proteins 0.000 claims description 6
- 101100018292 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) hypD2 gene Proteins 0.000 claims description 6
- 101100059802 Chlamydophila caviae (strain ATCC VR-813 / DSM 19441 / GPIC) groEL1 gene Proteins 0.000 claims description 6
- 101100338533 Clostridium aminobutyricum abfD gene Proteins 0.000 claims description 6
- 101100365080 Clostridium perfringens (strain 13 / Type A) scpB gene Proteins 0.000 claims description 6
- 101000636215 Crotalus durissus terrificus Crotamine Proteins 0.000 claims description 6
- 101100018311 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) hypF1 gene Proteins 0.000 claims description 6
- 101100071894 Escherichia coli (strain K12) hyfB gene Proteins 0.000 claims description 6
- 101100071895 Escherichia coli (strain K12) hyfC gene Proteins 0.000 claims description 6
- 101100071896 Escherichia coli (strain K12) hyfD gene Proteins 0.000 claims description 6
- 101100071902 Escherichia coli (strain K12) hyfG gene Proteins 0.000 claims description 6
- 101100071903 Escherichia coli (strain K12) hyfH gene Proteins 0.000 claims description 6
- 101100071904 Escherichia coli (strain K12) hyfI gene Proteins 0.000 claims description 6
- 101100071905 Escherichia coli (strain K12) hyfJ gene Proteins 0.000 claims description 6
- 101100071906 Escherichia coli (strain K12) hyfR gene Proteins 0.000 claims description 6
- 101100350700 Escherichia coli (strain K12) paaB gene Proteins 0.000 claims description 6
- 101100350708 Escherichia coli (strain K12) paaF gene Proteins 0.000 claims description 6
- 101100350709 Escherichia coli (strain K12) paaG gene Proteins 0.000 claims description 6
- 101100082074 Escherichia coli (strain K12) paaZ gene Proteins 0.000 claims description 6
- 101100111747 Eupenicillium brefeldianum Bref-PKS gene Proteins 0.000 claims description 6
- 101100236497 Klebsiella aerogenes maoC gene Proteins 0.000 claims description 6
- 101100331406 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) Msed_1933 gene Proteins 0.000 claims description 6
- 101100458377 Methanosarcina barkeri (strain Fusaro / DSM 804) mtaC gene Proteins 0.000 claims description 6
- 101100071901 Methylacidiphilum infernorum (isolate V4) hyfF gene Proteins 0.000 claims description 6
- 101100269045 Moorella thermoacetica acsE gene Proteins 0.000 claims description 6
- 101100445407 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) erg10B gene Proteins 0.000 claims description 6
- 101100226895 Phomopsis amygdali PaP450-3 gene Proteins 0.000 claims description 6
- 101100463818 Pseudomonas oleovorans phaC1 gene Proteins 0.000 claims description 6
- 101100350716 Pseudomonas putida paaK gene Proteins 0.000 claims description 6
- 101100000272 Rhizobium meliloti (strain 1021) acsA2 gene Proteins 0.000 claims description 6
- 101100332697 Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) fadB1 gene Proteins 0.000 claims description 6
- 101100440643 Rhodospirillum rubrum cooC gene Proteins 0.000 claims description 6
- 101100280476 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) fabM gene Proteins 0.000 claims description 6
- 102000004357 Transferases Human genes 0.000 claims description 6
- 108090000992 Transferases Proteins 0.000 claims description 6
- 101150116076 acsA gene Proteins 0.000 claims description 6
- 101150083305 acsA2 gene Proteins 0.000 claims description 6
- 101150095811 acsC gene Proteins 0.000 claims description 6
- 101150040108 acsD gene Proteins 0.000 claims description 6
- 101150006429 atoB gene Proteins 0.000 claims description 6
- 101150083238 bsc7 gene Proteins 0.000 claims description 6
- 101150044905 ctpC gene Proteins 0.000 claims description 6
- 101150032444 gadC gene Proteins 0.000 claims description 6
- 238000012239 gene modification Methods 0.000 claims description 6
- 230000005017 genetic modification Effects 0.000 claims description 6
- 235000013617 genetically modified food Nutrition 0.000 claims description 6
- 101150077981 groEL gene Proteins 0.000 claims description 6
- 101150082486 hyfE gene Proteins 0.000 claims description 6
- 101150020134 hyfF gene Proteins 0.000 claims description 6
- 101150019385 hypB gene Proteins 0.000 claims description 6
- 101150075728 hypC gene Proteins 0.000 claims description 6
- 101150013500 hypD gene Proteins 0.000 claims description 6
- 101150070280 hypE gene Proteins 0.000 claims description 6
- 101150007905 hypF gene Proteins 0.000 claims description 6
- 101150051471 metF gene Proteins 0.000 claims description 6
- 101150017594 mtaA gene Proteins 0.000 claims description 6
- 101150081621 mtaB gene Proteins 0.000 claims description 6
- 101150037784 paaA gene Proteins 0.000 claims description 6
- 101150046540 phaA gene Proteins 0.000 claims description 6
- 101150110984 phaB gene Proteins 0.000 claims description 6
- 101150096860 thlA gene Proteins 0.000 claims description 6
- 101150000552 ydbK gene Proteins 0.000 claims description 6
- 108091000080 Phosphotransferase Proteins 0.000 claims description 4
- CRFNGMNYKDXRTN-CITAKDKDSA-N butyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CRFNGMNYKDXRTN-CITAKDKDSA-N 0.000 claims description 4
- 101150056881 mcr gene Proteins 0.000 claims description 4
- 102000020233 phosphotransferase Human genes 0.000 claims description 4
- 101150078509 ADH2 gene Proteins 0.000 claims description 3
- 101150026777 ADH5 gene Proteins 0.000 claims description 3
- 101100460671 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) norA gene Proteins 0.000 claims description 3
- 101100098786 Bacillus subtilis (strain 168) tapA gene Proteins 0.000 claims description 3
- 101150116295 CAT2 gene Proteins 0.000 claims description 3
- 101100110009 Caenorhabditis elegans asd-2 gene Proteins 0.000 claims description 3
- 101100326920 Caenorhabditis elegans ctl-1 gene Proteins 0.000 claims description 3
- 101100269671 Dictyostelium discoideum alrA gene Proteins 0.000 claims description 3
- 101100186433 Dictyostelium discoideum napA gene Proteins 0.000 claims description 3
- 101100321116 Escherichia coli (strain K12) yqhD gene Proteins 0.000 claims description 3
- MBMLMWLHJBBADN-UHFFFAOYSA-N Ferrous sulfide Chemical compound [Fe]=S MBMLMWLHJBBADN-UHFFFAOYSA-N 0.000 claims description 3
- 108700023479 Glutamate 5-kinases Proteins 0.000 claims description 3
- 101100433987 Latilactobacillus sakei subsp. sakei (strain 23K) ackA1 gene Proteins 0.000 claims description 3
- 101100456321 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) Msed_0709 gene Proteins 0.000 claims description 3
- 101100269700 Mycolicibacterium smegmatis alr gene Proteins 0.000 claims description 3
- 101100126846 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) katG gene Proteins 0.000 claims description 3
- 101150006213 ackA gene Proteins 0.000 claims description 3
- 101150079502 acr1 gene Proteins 0.000 claims description 3
- 101150014383 adhE gene Proteins 0.000 claims description 3
- 101150008745 bphG gene Proteins 0.000 claims description 3
- 101150031417 buk1 gene Proteins 0.000 claims description 3
- 101150091767 buk2 gene Proteins 0.000 claims description 3
- 101150046501 proB gene Proteins 0.000 claims description 3
- 101150031436 sucD gene Proteins 0.000 claims description 3
- QYNUQALWYRSVHF-ABLWVSNPSA-N 5,10-methylenetetrahydrofolic acid Chemical compound C1N2C=3C(=O)NC(N)=NC=3NCC2CN1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-ABLWVSNPSA-N 0.000 claims description 2
- 229910002651 NO3 Inorganic materials 0.000 claims description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 2
- OSSQVWUXYUDQKW-LDUAJXOISA-N C1=CC(C(=O)N[C@@H](CC(C)C(O)=O)C(O)=O)=CC=C1NCC1NC(C(=O)NC(N)=N2)=C2NC1 Chemical compound C1=CC(C(=O)N[C@@H](CC(C)C(O)=O)C(O)=O)=CC=C1NCC1NC(C(=O)NC(N)=N2)=C2NC1 OSSQVWUXYUDQKW-LDUAJXOISA-N 0.000 claims 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- 229940100228 acetyl coenzyme a Drugs 0.000 description 49
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 6
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 5
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 5
- 239000001273 butane Substances 0.000 description 2
- KFOLGNOYFACKMH-SFPFKCOPSA-N [[(2r,3s,4r,5r)-5-(2-acetyl-6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3r)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate Chemical compound C12=NC(C(=O)C)=NC(N)=C2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)[C@@H](OP(O)(O)=O)[C@H]1O KFOLGNOYFACKMH-SFPFKCOPSA-N 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2280408P | 2008-01-22 | 2008-01-22 | |
| US5925608P | 2008-06-05 | 2008-06-05 | |
| PCT/US2009/031737 WO2009094485A1 (en) | 2008-01-22 | 2009-01-22 | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094703A Division JP2015142591A (ja) | 2008-01-22 | 2015-05-07 | 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体 |
| JP2017051533A Division JP2017104137A (ja) | 2008-01-22 | 2017-03-16 | 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011509691A JP2011509691A (ja) | 2011-03-31 |
| JP2011509691A5 true JP2011509691A5 (enExample) | 2013-02-07 |
Family
ID=40899629
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544425A Withdrawn JP2011509691A (ja) | 2008-01-22 | 2009-01-22 | 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体 |
| JP2015094703A Pending JP2015142591A (ja) | 2008-01-22 | 2015-05-07 | 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体 |
| JP2017051533A Pending JP2017104137A (ja) | 2008-01-22 | 2017-03-16 | 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体 |
| JP2019069875A Pending JP2019103519A (ja) | 2008-01-22 | 2019-04-01 | 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094703A Pending JP2015142591A (ja) | 2008-01-22 | 2015-05-07 | 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体 |
| JP2017051533A Pending JP2017104137A (ja) | 2008-01-22 | 2017-03-16 | 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体 |
| JP2019069875A Pending JP2019103519A (ja) | 2008-01-22 | 2019-04-01 | 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体 |
Country Status (8)
| Country | Link |
|---|---|
| US (9) | US8691553B2 (enExample) |
| EP (1) | EP2245137B1 (enExample) |
| JP (4) | JP2011509691A (enExample) |
| CN (2) | CN107090424A (enExample) |
| BR (1) | BRPI0907385A2 (enExample) |
| CA (1) | CA2712779C (enExample) |
| WO (1) | WO2009094485A1 (enExample) |
| ZA (2) | ZA201005574B (enExample) |
Families Citing this family (139)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8673601B2 (en) | 2007-01-22 | 2014-03-18 | Genomatica, Inc. | Methods and organisms for growth-coupled production of 3-hydroxypropionic acid |
| CA2678946C (en) | 2007-03-16 | 2019-02-12 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| CA2696018A1 (en) | 2007-08-10 | 2009-04-09 | Genomatica, Inc. | Methods for the synthesis of olefins and derivatives |
| US8048624B1 (en) | 2007-12-04 | 2011-11-01 | Opx Biotechnologies, Inc. | Compositions and methods for 3-hydroxypropionate bio-production from biomass |
| CA2712779C (en) | 2008-01-22 | 2021-03-16 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| JP5755884B2 (ja) | 2008-03-05 | 2015-07-29 | ジェノマティカ， インコーポレイテッド | 第一級アルコールを産生する生物 |
| SI2265709T1 (en) * | 2008-03-27 | 2018-03-30 | Genomatica, Inc. | MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS |
| JP2011519561A (ja) | 2008-05-01 | 2011-07-14 | ジェノマティカ， インコーポレイテッド | メタクリル酸の産生のための微生物 |
| AU2009258344B2 (en) | 2008-06-09 | 2013-11-07 | Lanzatech Nz, Inc. | Production of butanediol by anaerobic microbial fermentation |
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| EP2313491A4 (en) * | 2008-07-08 | 2011-12-07 | Opx Biotechnologies Inc | METHODS, COMPOSITIONS AND SYSTEMS FOR BIOSYNTHETIC BIOPRODUCTION OF 1,4-BUTANEDIOL |
| CA2735883C (en) | 2008-09-10 | 2020-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
| AU2009314175A1 (en) * | 2008-11-17 | 2010-05-20 | Rentech, Inc. | Multiple gasifiers manifolded to multiple Fischer-Tropsch reactors with optional recycle to the reactors |
| KR20110097951A (ko) * | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
| BRPI1013426A2 (pt) | 2009-04-30 | 2016-11-08 | Genomatica Inc | organismos para produção de 1,3-butanodiol |
| AU2013202629B2 (en) * | 2009-04-30 | 2016-03-10 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
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| CN102016006B (zh) | 2008-04-25 | 2013-04-10 | 财团法人地球环境产业技术研究机构 | 具有异丙醇生产能力的棒状细菌转化体 |
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| US20100021978A1 (en) | 2008-07-23 | 2010-01-28 | Genomatica, Inc. | Methods and organisms for production of 3-hydroxypropionic acid |
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| CA2735883C (en) * | 2008-09-10 | 2020-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
| US8357826B2 (en) | 2008-10-16 | 2013-01-22 | Karl Kharas | Methods and apparatus for synthesis of alcohols from syngas |
| US20100184173A1 (en) | 2008-11-14 | 2010-07-22 | Genomatica, Inc. | Microorganisms for the production of methyl ethyl ketone and 2-butanol |
| EP3260532A1 (en) | 2008-12-12 | 2017-12-27 | CJ Research Center LLC | Green process and compositions for producing poly(5hv) and 5 carbon chemicals |
| KR20110097951A (ko) | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
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| CN109136161A (zh) | 2009-12-10 | 2019-01-04 | 基因组股份公司 | 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体 |
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2009
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