JP2011137006A5 - - Google Patents

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JP2011137006A5
JP2011137006A5 JP2011015653A JP2011015653A JP2011137006A5 JP 2011137006 A5 JP2011137006 A5 JP 2011137006A5 JP 2011015653 A JP2011015653 A JP 2011015653A JP 2011015653 A JP2011015653 A JP 2011015653A JP 2011137006 A5 JP2011137006 A5 JP 2011137006A5
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alkyl
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cycloalkyl
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JP5543932B2 (ja
JP2011137006A (ja
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JP2011015653A 2004-07-02 2011-01-27 Cetp阻害薬 Expired - Fee Related JP5543932B2 (ja)

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US58527404P 2004-07-02 2004-07-02
US60/585,274 2004-07-02
US64610305P 2005-01-21 2005-01-21
US60/646,103 2005-01-21

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JP2007519533A Division JP4695139B2 (ja) 2004-07-02 2005-07-01 Cetp阻害薬

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JP2011137006A JP2011137006A (ja) 2011-07-14
JP2011137006A5 true JP2011137006A5 (cg-RX-API-DMAC10.html) 2012-04-12
JP5543932B2 JP5543932B2 (ja) 2014-07-09

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JP2007519533A Expired - Fee Related JP4695139B2 (ja) 2004-07-02 2005-07-01 Cetp阻害薬
JP2010031195A Expired - Fee Related JP4491062B1 (ja) 2004-07-02 2010-02-16 Cetp阻害薬
JP2011015653A Expired - Fee Related JP5543932B2 (ja) 2004-07-02 2011-01-27 Cetp阻害薬

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JP2007519533A Expired - Fee Related JP4695139B2 (ja) 2004-07-02 2005-07-01 Cetp阻害薬
JP2010031195A Expired - Fee Related JP4491062B1 (ja) 2004-07-02 2010-02-16 Cetp阻害薬

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US (5) US7652049B2 (cg-RX-API-DMAC10.html)
EP (2) EP1765793B1 (cg-RX-API-DMAC10.html)
JP (3) JP4695139B2 (cg-RX-API-DMAC10.html)
KR (1) KR101204336B1 (cg-RX-API-DMAC10.html)
CN (4) CN104447603A (cg-RX-API-DMAC10.html)
AR (2) AR049956A1 (cg-RX-API-DMAC10.html)
AU (1) AU2005270058B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0512910A (cg-RX-API-DMAC10.html)
CA (1) CA2570717C (cg-RX-API-DMAC10.html)
CR (1) CR8808A (cg-RX-API-DMAC10.html)
CY (1) CY1117930T1 (cg-RX-API-DMAC10.html)
DK (1) DK1765793T3 (cg-RX-API-DMAC10.html)
DO (1) DOP2005000123A (cg-RX-API-DMAC10.html)
EA (1) EA011130B1 (cg-RX-API-DMAC10.html)
EC (1) ECSP067124A (cg-RX-API-DMAC10.html)
EG (1) EG27138A (cg-RX-API-DMAC10.html)
ES (1) ES2393721T3 (cg-RX-API-DMAC10.html)
GE (1) GEP20094694B (cg-RX-API-DMAC10.html)
GT (1) GT200500175A (cg-RX-API-DMAC10.html)
HR (1) HRP20120993T1 (cg-RX-API-DMAC10.html)
IL (2) IL180432A (cg-RX-API-DMAC10.html)
JO (1) JO2994B1 (cg-RX-API-DMAC10.html)
MA (1) MA28780B1 (cg-RX-API-DMAC10.html)
MX (1) MX2007000035A (cg-RX-API-DMAC10.html)
MY (1) MY167430A (cg-RX-API-DMAC10.html)
NI (1) NI200600322A (cg-RX-API-DMAC10.html)
NO (1) NO339808B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ552061A (cg-RX-API-DMAC10.html)
PA (1) PA8638101A1 (cg-RX-API-DMAC10.html)
PE (1) PE20060525A1 (cg-RX-API-DMAC10.html)
PL (1) PL1765793T3 (cg-RX-API-DMAC10.html)
PT (1) PT1765793E (cg-RX-API-DMAC10.html)
RS (1) RS52563B (cg-RX-API-DMAC10.html)
SI (1) SI1765793T1 (cg-RX-API-DMAC10.html)
SV (1) SV2007002160A (cg-RX-API-DMAC10.html)
TW (1) TWI299991B (cg-RX-API-DMAC10.html)
WO (2) WO2006014357A1 (cg-RX-API-DMAC10.html)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270971B2 (en) * 2003-10-16 2007-09-18 Merck & Co., Inc. Fluorescence assay for measuring the rate of cholesterol ester transfer
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
CN101212966B (zh) * 2005-07-01 2012-03-14 默沙东公司 合成cetp抑制剂的方法
WO2007067593A2 (en) * 2005-12-05 2007-06-14 Merck & Co., Inc. Self-emulsifyng formulations of cetp inhibitors
AR057218A1 (es) * 2005-12-15 2007-11-21 Astra Ab Compuestos de oxazolidinona y su uso como pontenciadores del receptor metabotropico de glutamato
JP5199121B2 (ja) * 2005-12-30 2013-05-15 メルク・シャープ・エンド・ドーム・コーポレイション Cetp阻害剤
JP5229567B2 (ja) * 2005-12-30 2013-07-03 メルク・シャープ・アンド・ドーム・コーポレーション Cetp阻害剤
CN101365689A (zh) 2005-12-30 2009-02-11 默克公司 作为cetp抑制剂的1,3-唑烷-2-酮衍生物
WO2007081570A2 (en) * 2005-12-30 2007-07-19 Merck & Co., Inc. Cholesteryl ester transfer protein inhibitors
BRPI0707584A2 (pt) * 2006-02-09 2011-05-10 Merck & Co Inc composiÇço farmacÊutica, uso da composiÇço farmacÊutica, e, formulaÇço farmacÊutica
US8383660B2 (en) * 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
US7919506B2 (en) * 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
WO2007136672A2 (en) * 2006-05-19 2007-11-29 Merck & Co., Inc. Synthesis of a biaryl synthetic intermediate
WO2008082567A1 (en) * 2006-12-29 2008-07-10 Merck & Co., Inc. Process for synthesizing a cetp inhibitor
NZ578296A (en) 2007-01-26 2012-07-27 Kaneq Pharma Inc Fused aromatic ptp-1b inhibitors
WO2008115442A1 (en) 2007-03-16 2008-09-25 Concert Pharmceuticals, Inc. Inhibitors of cholesterol ester transfer protein
CA2688187C (en) 2007-05-07 2016-10-11 Merck & Co., Inc. Method of treament using fused aromatic compounds having anti-diabetic activity
EP2532643A1 (en) 2007-06-08 2012-12-12 MannKind Corporation IRE-1A Inhibitors
AU2008266956A1 (en) * 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. CETP inhibitors derived from benzoxazole arylamides
EP2170058B1 (en) * 2007-06-20 2013-07-03 Merck Sharp & Dohme Corp. Cetp inhibitors derived from benzoxazole arylamides
WO2008156718A1 (en) * 2007-06-20 2008-12-24 Merck & Co., Inc. Cetp inhibitors derived from benzoxazole arylamides
BRPI0814403A2 (pt) 2007-07-02 2015-01-27 Hoffmann La Roche Devirados de imidazol como antagonistas de receptor ccr2
AR067673A1 (es) * 2007-07-26 2009-10-21 Vitae Pharmaceuticals Inc Derivados de 1,3 oxazinan - 2 - ona como inhibidores ciclicos de la 11 beta -hidroxiesteroide deshidrogenasa 1. composiciones farmaceuticas.
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) * 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状カルバゼート及びセミカルバジドインヒビター
EP2245002A4 (en) * 2008-02-01 2011-08-17 Amira Pharmaceuticals Inc AMINOALKYLBIPHENYL ANTAGONISTS N, N 'DISUBSTITUTED FROM D2 RECEPTORS OF PROSTAGLANDIN
US8067445B2 (en) 2008-02-01 2011-11-29 Panmira Pharmaceuticals, Llc N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors
EP2252598A2 (en) * 2008-02-11 2010-11-24 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8242145B2 (en) 2008-02-14 2012-08-14 Panmira Pharmaceuticals, Llc Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors
WO2009102460A2 (en) * 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP2011513242A (ja) 2008-02-25 2011-04-28 アミラ ファーマシューティカルズ,インク. プロスタグランジンd2受容体アンタゴニスト
JP5538356B2 (ja) * 2008-03-18 2014-07-02 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 11β−ヒドロキシステロイドデヒドロゲナーゼ1型の阻害剤
JP2011518130A (ja) 2008-04-02 2011-06-23 アミラ ファーマシューティカルズ,インク. プロスタグランジンd2受容体のアミノアルキルフェニルアンタゴニスト
WO2009134392A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
MX2010011935A (es) 2008-05-01 2011-05-19 Vitae Pharmaceuticals Inc Inhibidores ciclicos de 11 beta-hidroxiesteroide deshidrogenasa 1.
WO2009134387A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8063088B2 (en) * 2008-06-11 2011-11-22 Hoffmann-La Roche Inc. Imidazolidine derivatives
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2324017B1 (en) 2008-07-25 2014-12-31 Boehringer Ingelheim International GmbH INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
WO2010010150A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
GB2463788B (en) 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
DE102008049675A1 (de) 2008-09-30 2010-04-01 Markus Dr. Heinrich Verfahren zur Herstellung von 3-Aminobiphenylen
US8378107B2 (en) 2008-10-01 2013-02-19 Panmira Pharmaceuticals, Llc Heteroaryl antagonists of prostaglandin D2 receptors
EP2348859B1 (en) * 2008-10-01 2013-12-04 Merck Sharp & Dohme Corp. Prodrugs of oxazolidinone cetp inhibitors
WO2010042652A2 (en) 2008-10-08 2010-04-15 Amira Pharmaceuticals, Inc. Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors
AU2009307884B2 (en) 2008-10-22 2014-07-31 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CN102271509A (zh) 2008-10-31 2011-12-07 默沙东公司 用于抗糖尿病药的新型环苯并咪唑衍生物
WO2010057118A2 (en) 2008-11-17 2010-05-20 Amira Pharmaceuticals, Inc. Heterocyclic antagonists of prostaglandin d2 receptors
TW201028414A (en) 2009-01-16 2010-08-01 Merck Sharp & Dohme Oxadiazole beta carboline derivatives as antidiabetic compounds
WO2010085528A1 (en) 2009-01-23 2010-07-29 Schering Corporation Bridged and fused antidiabetic compounds
WO2010085525A1 (en) 2009-01-23 2010-07-29 Schering Corporation Bridged and fused heterocyclic antidiabetic compounds
JP5679997B2 (ja) 2009-02-04 2015-03-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤
WO2010091176A1 (en) 2009-02-05 2010-08-12 Schering Corporation Phthalazine-containing antidiabetic compounds
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
US8883778B2 (en) 2009-07-01 2014-11-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
KR20120047273A (ko) * 2009-08-05 2012-05-11 판미라 파마슈티칼스, 엘엘씨 Dp2 길항제 및 이의 용도
JP2011057661A (ja) 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
WO2011056737A1 (en) 2009-11-05 2011-05-12 Boehringer Ingelheim International Gmbh Novel chiral phosphorus ligands
WO2011088025A1 (en) 2010-01-15 2011-07-21 Merck Sharp & Dohme Corp. Oxadiazole beta carboline derivatives as antidiabetic compounds
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US8648192B2 (en) 2010-05-26 2014-02-11 Boehringer Ingelheim International Gmbh 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
EP2397473A1 (en) 2010-06-14 2011-12-21 LEK Pharmaceuticals d.d. A stable highly crystalline anacetrapib
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
US20130225618A1 (en) 2010-10-04 2013-08-29 Kowa Co., Ltd. Agent for inhibiting expression of lipid metabolism related mrna
JP5852662B2 (ja) * 2010-10-29 2016-02-03 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 環状アミン置換されたオキサゾリジノン系cetp阻害薬
EA201300522A1 (ru) 2010-11-02 2013-11-29 Бёрингер Ингельхайм Интернациональ Гмбх Фармацевтические комбинации для лечения метаболических нарушений
EP2468736A1 (en) 2010-12-23 2012-06-27 LEK Pharmaceuticals d.d. Synthesis of intermediates for preparing anacetrapib and derivates thereof
EP2468735A1 (en) 2010-12-23 2012-06-27 LEK Pharmaceuticals d.d. Synthesis of intermediates for preparing anacetrapib and derivates thereof
WO2012101142A1 (en) 2011-01-26 2012-08-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for assessing a subject's risk of having a cardiovascular disease.
CN103476258B (zh) 2011-02-25 2017-04-26 默沙东公司 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
BR112013026280A2 (pt) * 2011-04-12 2024-04-30 Chong Kun Dang Pharmaceutical Corp Derivados de cicloalquenil arila para inibidor da cetp
US9345681B2 (en) 2011-07-07 2016-05-24 Mochida Pharmaceutical Co., Ltd. Anti-obesity agent comprising high-purity EPA
ES2683350T3 (es) 2011-07-08 2018-09-26 Novartis Ag Método para tratar la aterosclerosis en sujetos con alto nivel de triglicéridos
JO3210B1 (ar) 2011-10-28 2018-03-08 Merck Sharp & Dohme مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة
US9145348B2 (en) * 2011-10-31 2015-09-29 Merck Sharpe & Dohme Corp. Process for synthesizing a CETP inhibitor
WO2013064188A1 (en) 2011-11-03 2013-05-10 Lek Pharmaceuticals D.D. A stable highly crystalline anacetrapib
EP2789347A4 (en) 2011-11-29 2015-12-16 Kowa Co MEANS TO INHIBIT THE EXPRESSION OF NPC1L1 AND / OR LIPG-MRNA AND MEDICAMENTS FOR THE PREVENTION AND / OR TREATMENT OF ADIPOSITAS
WO2013081373A1 (en) 2011-11-30 2013-06-06 Daewoong Pharmaceutical Co., Ltd. Pharmaceutical composition for preventing or treating hypertriglyceridemia or hypertriglyceridemia-associated diseases
WO2013091696A1 (en) 2011-12-21 2013-06-27 Lek Pharmaceuticals D.D. Synthesis of intermediates for preparing anacetrapib and derivatives thereof
WO2013165854A1 (en) * 2012-05-02 2013-11-07 Merck Sharp & Dohme Corp. Cyclic amine substituted heterocyclic cetp inhibitors
MX347400B (es) 2012-06-29 2017-04-18 Univ Nac Autónoma De México Vacuna de aplicacion nasal contra el desarrollo de la enfermedad aterosclerotica y el higado graso.
WO2014012428A1 (zh) * 2012-07-19 2014-01-23 上海恒瑞医药有限公司 噁唑烷酮类衍生物、其制备方法及其在医药上的应用
EP2888006B1 (en) 2012-08-22 2019-04-24 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydropyran derivatives useful as ampk activators
EP2934518B1 (en) 2012-12-19 2020-02-19 Merck Sharp & Dohme Corp. Spirocyclic cetp inhibitors
WO2014099834A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Therapeutic thiazolidinone compounds
WO2014111953A1 (en) * 2013-01-17 2014-07-24 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for preparation of anacetrapib and intermediates thereof
JP6166385B2 (ja) * 2013-01-31 2017-07-19 チョン クン ダン ファーマシューティカル コーポレーション コレステロールエステル転送蛋白質(cetp)抑制剤としてのビアリールまたは複素環式ビアリール置換シクロヘキセン誘導体化合物
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
US9981970B2 (en) 2013-07-30 2018-05-29 Merck Sharp & Dohme Corp. Bicyclic ureas and thiadiazolidine-1, 1-dioxides as CETP inhibitors
US9688630B2 (en) 2013-10-10 2017-06-27 Merck Sharp & Dohme Corp. 3,3′-disubstituted indolines as inhibitors of cholesterol ester transfer protein
WO2015094932A1 (en) 2013-12-17 2015-06-25 Merck Sharp & Dohme Corp. Fused bicyclic isoxazolines as inhibitors of cholesterol ester transfer protein
WO2015106674A1 (zh) * 2014-01-14 2015-07-23 杭州普晒医药科技有限公司 一种安塞曲匹的晶型及其制备方法、其药物组合物和用途
CN103923030B (zh) * 2014-03-27 2015-07-22 汕头经济特区鮀滨制药厂 一种安塞曲匹的关键中间体的合成方法
CN103923031A (zh) * 2014-04-01 2014-07-16 汕头经济特区鮀滨制药厂 一种安塞曲匹的中间体的合成方法
WO2016018729A1 (en) * 2014-07-29 2016-02-04 Merck Sharp & Dohme Corp. Monocyclic isoxazolines as inhibitors of cholesterol ester transfer protein
PT3174995T (pt) 2014-07-30 2020-10-15 Hoffmann La Roche Marcadores genéticos para prever o tipo de resposta ao tratamento com um fármaco de aumento do hdl ou mimetizador do hdl
CN104230835B (zh) * 2014-09-01 2017-01-25 福建师范大学 一种合成n‑苯乙烯基恶唑烷‑2‑酮衍生物的方法
WO2016067194A1 (en) * 2014-10-27 2016-05-06 Sun Pharmaceutical Industries Limited Process for the preparation of anacetrapib and an intermediate thereof
CN106032362B (zh) * 2015-03-10 2018-06-19 湖南千金湘江药业股份有限公司 安塞曲匹的制备方法
KR20190020343A (ko) 2016-06-29 2019-02-28 오리온 코포레이션 벤조디옥산 유도체 및 이의 약제학적 용도
WO2018016743A1 (ko) * 2016-07-19 2018-01-25 재단법인 대구경북첨단의료산업진흥재단 Cetp 억제제로서의 옥사졸리딘온 유도체 화합물
US10851059B2 (en) * 2016-08-17 2020-12-01 Novartis Ag Processes and intermediates for NEP inhibitor synthesis
CN106496154A (zh) * 2016-10-18 2017-03-15 湖南德魅信息技术有限公司 安塞曲匹的制备方法
CN106496211A (zh) * 2016-10-18 2017-03-15 湖南德魅信息技术有限公司 二氟甲基取代的噁唑烷酮化合物及其用途
CN106749075A (zh) * 2016-11-24 2017-05-31 山东新华制药股份有限公司 阿那曲波的恶唑烷酮中间体的晶型及其制备方法
US20190070178A1 (en) 2017-08-29 2019-03-07 Dalcor Pharma Uk Ltd., Stockport Zug Branch Methods for treating or preventing cardiovascular disorders and lowering risk of cardiovascular events
JOP20180092A1 (ar) 2017-10-13 2019-04-13 Gilead Sciences Inc مثبطات hiv بروتياز
JP2021534236A (ja) 2018-08-09 2021-12-09 ダルコア ファーマ ユーケー リミテッド,レザーヘッド,ツーク ブランチ 新規発症2型糖尿病の発生遅延並びに2型糖尿病の進行緩徐化及び治療の方法
KR20210137442A (ko) 2019-03-07 2021-11-17 달코어 파마 유케이 리미티드 레더헤드 저그 브랜치 심부전을 치료 또는 예방하고 심부전의 위험을 감소시키는 방법
TW202104210A (zh) 2019-04-17 2021-02-01 美商基利科學股份有限公司 Hiv蛋白酶抑制劑
EP4471042A3 (en) 2019-07-19 2025-03-05 Biosynth AG Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof
WO2021226269A1 (en) 2020-05-05 2021-11-11 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents
MX2022013657A (es) 2020-05-05 2023-02-01 Nuvalent Inc Quimioterápicos de éter macrocíclico heteroaromático.
KR102651062B1 (ko) * 2020-10-08 2024-03-25 재단법인 대구경북첨단의료산업진흥재단 Pcsk9 억제제로서 아미노알콜 유도체 및 이를 함유하는 고콜레스테롤 혈증의 예방 또는 치료용 약학적 조성물
US20240360103A1 (en) * 2021-06-30 2024-10-31 Apellis Pharmaceuticals, Inc. Complement inhibition
EP4408844A1 (en) 2021-10-01 2024-08-07 Nuvalent, Inc. Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds
WO2025093129A1 (en) 2023-11-01 2025-05-08 Newamsterdam Pharma B.V. Treatment and prevention of age-related macular degeneration using a cetp inhibitor

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179442A (en) * 1975-08-29 1979-12-18 York Hartleben 4-(Alpha-hydroxy-isopropyl)-5-phenyl-oxazolidin-2-one
DE2655369A1 (de) 1976-12-03 1978-06-08 Schering Ag 5-(subst. phenyl)-oxazolidinone und deren schwefelanaloga sowie verfahren zu deren herstellung
US4851423A (en) 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
US4968707A (en) * 1987-06-10 1990-11-06 Pfizer Inc. Oxazolidin-2-one derivatives as hypoglycemic agents
DE69329106T2 (de) * 1992-04-30 2001-03-22 Taiho Pharmaceutical Co., Ltd. Oxazolidinderivat und sein pharmazeutisch verträgliches salz
US5482971A (en) 1993-10-01 1996-01-09 American Cyanamid Company Beta3 -adrenergic agents and their use in pharmaceutical compositions
AU684316B2 (en) * 1993-10-15 1997-12-11 Shionogi & Co., Ltd. Oxazolinone derivative having intracellular phospholipase A2 inhibitor activity
DE69532238T2 (de) * 1994-04-21 2004-10-21 Schering Ag Pde iv-inhibitoren zur behandlung der multiplen sklerose
FR2729954B1 (fr) * 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
IL117090A (en) * 1995-02-10 2000-07-26 Schering Ag Pharmaceutical compositions containing oxazolidinone derivatives
BR9608756A (pt) * 1995-05-17 1999-07-06 Du Pont Composto composição fungicida e método para controle de doenças de plantas
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
KR19990028230A (ko) 1995-06-20 1999-04-15 미리암 디. 메코너헤이 살절지동물성 및 살진균성 시클릭 아미드
US5846990A (en) 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
US6310095B1 (en) 1995-11-06 2001-10-30 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
AU1856997A (en) 1996-02-02 1997-08-22 Merck & Co., Inc. Method for raising hdl cholesterol levels
DE19647380A1 (de) 1996-11-15 1998-05-20 Hoechst Ag 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
WO1998023155A1 (en) 1996-11-26 1998-06-04 E.I. Du Pont De Nemours And Company Arthropodicidal and fungicidal cyclic amides
DE19704243A1 (de) * 1997-02-05 1998-08-06 Bayer Ag Neue 2-Amino-substituierte Pyridine
EE9900481A (et) * 1997-03-03 2000-06-15 Boehringer Ingelheim Pharmaceuticals, Inc. Väikesed molekulid, mida kasutatakse põletikuliste haiguste raviks
PH11998001073B1 (en) 1997-05-07 2007-07-23 Univ Pittsburgh Inhibitors of protein isoprenyl transferases
DE19741400A1 (de) 1997-09-19 1999-03-25 Bayer Ag Benzyl-biphenyle
NZ505902A (en) 1998-01-23 2003-08-29 Upjohn Co Oxazolidinone compounds useful as antimicrobial agents and combinatorial libraries
IT1300055B1 (it) * 1998-04-17 2000-04-05 Boehringer Ingelheim Italia Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici
GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
JP4744050B2 (ja) 1999-09-17 2011-08-10 ミレニアム・ファーマシューティカルズ・インコーポレイテッド ベンズアミドおよび関連するXa因子阻害剤
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
US6462063B1 (en) 2000-02-04 2002-10-08 Fibrogen, Inc. C-proteinase inhibitors
JPWO2001072723A1 (ja) 2000-03-28 2004-01-08 日本曹達株式会社 オキサ(チア)ゾリジン誘導体および抗炎症薬
KR100833089B1 (ko) * 2000-12-21 2008-05-29 사노피-아벤티스 도이칠란트 게엠베하 신규한 1,2-디페닐아제티딘온 및 당해 화합물을 함유하는 지질 대사 장애를 치료하기 위한 약제학적 조성물
WO2003022824A1 (en) 2001-09-11 2003-03-20 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
EP1435944B1 (en) * 2001-10-16 2009-09-30 Memory Pharmaceutical Corporation 4(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes
US7091196B2 (en) * 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
EP1603553B9 (en) 2003-03-17 2012-06-20 Japan Tobacco Inc. Pharmaceutical compositions of cetp inhibitors
UA90269C2 (ru) 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006103527A1 (en) 2005-03-31 2006-10-05 Council Of Scientific And Industrial Research Aromatic substituted pentadienoic acid amide for combination with anti-infective drugs
CN101365689A (zh) * 2005-12-30 2009-02-11 默克公司 作为cetp抑制剂的1,3-唑烷-2-酮衍生物
JP5229567B2 (ja) 2005-12-30 2013-07-03 メルク・シャープ・アンド・ドーム・コーポレーション Cetp阻害剤
JP5199121B2 (ja) 2005-12-30 2013-05-15 メルク・シャープ・エンド・ドーム・コーポレイション Cetp阻害剤

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