JP2016515560A5 - - Google Patents

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Publication number
JP2016515560A5
JP2016515560A5 JP2016504660A JP2016504660A JP2016515560A5 JP 2016515560 A5 JP2016515560 A5 JP 2016515560A5 JP 2016504660 A JP2016504660 A JP 2016504660A JP 2016504660 A JP2016504660 A JP 2016504660A JP 2016515560 A5 JP2016515560 A5 JP 2016515560A5
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JP
Japan
Prior art keywords
alkyl
compound according
compound
optionally substituted
pyridyl
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JP2016504660A
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English (en)
Japanese (ja)
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JP6370368B2 (ja
JP2016515560A (ja
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Priority claimed from PCT/EP2014/056079 external-priority patent/WO2014154760A1/en
Publication of JP2016515560A publication Critical patent/JP2016515560A/ja
Publication of JP2016515560A5 publication Critical patent/JP2016515560A5/ja
Application granted granted Critical
Publication of JP6370368B2 publication Critical patent/JP6370368B2/ja
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JP2016504660A 2013-03-27 2014-03-26 Brd4阻害剤としてのインドリノン類似体 Active JP6370368B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13161486 2013-03-27
EP13161486.9 2013-03-27
PCT/EP2014/056079 WO2014154760A1 (en) 2013-03-27 2014-03-26 Indolinone analogues as brd4 inhibitors

Publications (3)

Publication Number Publication Date
JP2016515560A JP2016515560A (ja) 2016-05-30
JP2016515560A5 true JP2016515560A5 (cg-RX-API-DMAC10.html) 2017-04-27
JP6370368B2 JP6370368B2 (ja) 2018-08-08

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JP2016504660A Active JP6370368B2 (ja) 2013-03-27 2014-03-26 Brd4阻害剤としてのインドリノン類似体

Country Status (4)

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US (1) US9102684B2 (cg-RX-API-DMAC10.html)
EP (1) EP2978757B1 (cg-RX-API-DMAC10.html)
JP (1) JP6370368B2 (cg-RX-API-DMAC10.html)
WO (1) WO2014154760A1 (cg-RX-API-DMAC10.html)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266891B2 (en) 2012-11-16 2016-02-23 Boehringer Ingelheim International Gmbh Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
CN105073744B (zh) 2012-12-21 2019-11-08 齐尼思表观遗传学有限公司 作为溴结构域抑制剂的新型杂环化合物
MX366703B (es) 2013-03-15 2019-07-22 Incyte Holdings Corp Heterociclos tricíclicos como inhibidores de la proteína bet.
MX366623B (es) 2013-04-26 2019-07-16 Beigene Ltd 5-(3,5-dimetilisoxazol-4-il)indolina-2-onas sustituidas.
US9636328B2 (en) 2013-06-21 2017-05-02 Zenith Epigenetics Ltd. Substituted bicyclic compounds as bromodomain inhibitors
CA2915838C (en) 2013-06-21 2023-04-18 Zenith Epigenetics Corp. Bicyclic bromodomain inhibitors
US9290514B2 (en) 2013-07-08 2016-03-22 Incyte Holdings Corporation Tricyclic heterocycles as BET protein inhibitors
CN105593224B (zh) 2013-07-31 2021-05-25 恒元生物医药科技(苏州)有限公司 作为溴结构域抑制剂的新型喹唑啉酮类化合物
US9315501B2 (en) 2013-11-26 2016-04-19 Incyte Corporation Bicyclic heterocycles as BET protein inhibitors
US9399640B2 (en) 2013-11-26 2016-07-26 Incyte Corporation Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
EA034972B1 (ru) 2014-04-23 2020-04-13 Инсайт Корпорейшн 1h-пирроло[2,3-c]пиридин-7(6h)-оны в качестве ингибиторов белков bet
US9902702B2 (en) * 2014-07-15 2018-02-27 Bristol-Myers Squibb Company Spirocycloheptanes as inhibitors of rock
EP3194406B8 (en) 2014-09-15 2021-03-31 Incyte Corporation Tricyclic heterocycles for use as bet protein inhibitors
US20190100769A1 (en) 2014-10-31 2019-04-04 Massachusetts Institute Of Technology Massively parallel combinatorial genetics for crispr
EP3227280B1 (en) * 2014-12-01 2019-04-24 Zenith Epigenetics Ltd. Substituted pyridines as bromodomain inhibitors
EP3227281A4 (en) 2014-12-01 2018-05-30 Zenith Epigenetics Ltd. Substituted pyridinones as bromodomain inhibitors
US10292968B2 (en) 2014-12-11 2019-05-21 Zenith Epigenetics Ltd. Substituted heterocycles as bromodomain inhibitors
HK1245247A1 (zh) 2014-12-17 2018-08-24 恒翼生物医药科技(上海)有限公司 溴结构域的抑制剂
JP2018527293A (ja) * 2015-06-16 2018-09-20 オリオン コーポレーション ブロモドメイン阻害剤としてのスピロ[シクロブタン−1,3’−インドリン]−2’−オン誘導体
WO2016203335A1 (en) 2015-06-18 2016-12-22 Pfizer Inc. Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors
AR106520A1 (es) 2015-10-29 2018-01-24 Incyte Corp Forma sólida amorfa de un inhibidor de proteína bet
PT3472157T (pt) 2016-06-20 2023-05-30 Incyte Corp Formas sólidas cristalinas de um inibidor bet
WO2018109271A1 (en) * 2016-12-13 2018-06-21 Orion Corporation New bromodomain inhibitors
CN107739370B (zh) * 2017-10-26 2021-03-30 中国药科大学 吡咯酮类brd4蛋白抑制剂的制备方法以及用途
CN109928979B (zh) * 2017-12-15 2021-08-06 四川科伦博泰生物医药股份有限公司 吲哚酮类衍生物及其制备方法和用途
CN108383771A (zh) * 2018-01-08 2018-08-10 华东师范大学 手性3,3-二取代异吲哚啉-1-酮衍生物及其合成方法和应用
WO2020046813A1 (en) * 2018-08-27 2020-03-05 Arcus Biosciences, Inc. Cd73 inhibitors
WO2020102150A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Heterocyclic derivatives as pi3k inhibitors
WO2020102216A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Substituted heterocyclic derivatives as pi3k inhibitors
WO2020102198A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Heterocyclic derivatives as pi3k inhibitors
BR112021019957A2 (pt) 2019-04-09 2021-12-07 Plexxikon Inc Azinas condensadas para modulação de ep300 ou cbp e indicações da mesma
CN120623106A (zh) 2019-09-30 2025-09-12 协和麒麟株式会社 Bet降解剂
WO2021175432A1 (en) 2020-03-04 2021-09-10 Boehringer Ingelheim International Gmbh Method for administration of an anti cancer agent
EP3912625A1 (en) 2020-05-20 2021-11-24 Kaerus Bioscience Limited Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
JP2025529185A (ja) * 2022-08-30 2025-09-04 パンネックス セラピューティクス インコーポレイテッド パネキシン-1調節剤及びパネキシン-1が関与する疾患の治療方法
WO2025233532A1 (en) 2024-05-10 2025-11-13 Les Laboratoires Servier Maxi-k potassium channel openers and therapeutic applications thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0919423D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds

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