JP2019524883A5 - - Google Patents
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- Publication number
- JP2019524883A5 JP2019524883A5 JP2019529309A JP2019529309A JP2019524883A5 JP 2019524883 A5 JP2019524883 A5 JP 2019524883A5 JP 2019529309 A JP2019529309 A JP 2019529309A JP 2019529309 A JP2019529309 A JP 2019529309A JP 2019524883 A5 JP2019524883 A5 JP 2019524883A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cyclyl
- heterocyclyl
- group
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610647295.0A CN107698593A (zh) | 2016-08-09 | 2016-08-09 | 作为fgfr抑制剂的杂环化合物 |
| CN201610647295.0 | 2016-08-09 | ||
| PCT/CN2017/094620 WO2018028438A1 (zh) | 2016-08-09 | 2017-07-27 | 作为fgfr抑制剂的杂环化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524883A JP2019524883A (ja) | 2019-09-05 |
| JP2019524883A5 true JP2019524883A5 (cg-RX-API-DMAC10.html) | 2020-07-16 |
| JP6959663B2 JP6959663B2 (ja) | 2021-11-02 |
Family
ID=61162708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529309A Expired - Fee Related JP6959663B2 (ja) | 2016-08-09 | 2017-07-27 | Ｆｇｆｒ阻害剤としての複素環化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10752631B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3498706A4 (cg-RX-API-DMAC10.html) |
| JP (1) | JP6959663B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR20190035870A (cg-RX-API-DMAC10.html) |
| CN (2) | CN107698593A (cg-RX-API-DMAC10.html) |
| CA (1) | CA3032921A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2018028438A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200003390A (ko) | 2017-05-08 | 2020-01-09 | 그릿스톤 온콜로지, 인코포레이티드 | 알파바이러스 신생항원 벡터 |
| CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
| AU2020278566A1 (en) * | 2019-05-17 | 2021-12-23 | Kinnate Biopharma Inc. | Inhibitors of fibroblast growth factor receptor kinases |
| WO2020243719A1 (en) | 2019-05-30 | 2020-12-03 | Gritstone Oncology, Inc. | Modified adenoviruses |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CA3181162A1 (en) | 2020-06-05 | 2021-12-09 | Stephen W. Kaldor | Inhibitors of fibroblast growth factor receptor kinases |
| CA3181209A1 (en) * | 2020-06-05 | 2021-12-09 | Stephen W. Kaldor | Inhibitors of fibroblast growth factor receptor kinases |
| CN116438308A (zh) | 2020-08-06 | 2023-07-14 | 磨石生物公司 | 多表位疫苗盒 |
| CN112480109B (zh) * | 2020-11-16 | 2022-04-01 | 浙江大学 | 吡啶并[2,3-b]吡嗪-3(4H)-酮类衍生物及其用途 |
| EP4277903A4 (en) * | 2021-01-12 | 2024-11-27 | Beijing InnoCare Pharma Tech Co., Ltd. | PROCESS FOR PREPARING (S)-1-(1-ACRYLOYLPYRROLIDIN-3-YL)-3-((3,5-DIMETHOXYPHENYL)ETHINYL)-5-(METHYLAMINO)-1H-PYRAZOL-4-CARBOXAMIDE |
| CN114853739B (zh) * | 2021-02-03 | 2023-09-22 | 药雅科技(上海)有限公司 | 一种炔代吡嗪类fgfr抑制剂及其制备方法和用途 |
| CN115043832B (zh) * | 2021-03-08 | 2023-08-22 | 药雅科技(上海)有限公司 | 一种fgfr抑制剂炔代杂环类化合物及其制备方法和用途 |
| CN120051471A (zh) * | 2022-10-18 | 2025-05-27 | 首药控股(北京)股份有限公司 | 一种新型杂环化合物 |
| CR20250458A (es) | 2023-03-30 | 2025-11-21 | Revolution Medicines Inc | Composiciones para inducir la hidrólisis de ras gtp y sus usos |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1981890A2 (en) * | 2006-01-25 | 2008-10-22 | OSI Pharmaceuticals, Inc. | UNSATURATED mTOR INHIBITORS |
| EP2657233B1 (en) | 2012-01-19 | 2014-08-27 | Taiho Pharmaceutical Co., Ltd. | 3,5-disubstituted alkynylbenzene compound and salt thereof |
| MX2015011456A (es) * | 2013-03-13 | 2016-05-31 | Boston Biomedical Inc | Derivados de 3-(arilo o heteroailo) metilenindolino-2-ona como inhibidores de cinasas de la via de las celulas madres cancerosas para el tratamiento del cancer. |
| JP6084292B2 (ja) | 2013-07-18 | 2017-02-22 | 大鵬薬品工業株式会社 | Ｆｇｆｒ阻害剤耐性癌の治療薬 |
| KR101974254B1 (ko) * | 2013-07-18 | 2019-04-30 | 다이호야쿠힌고교 가부시키가이샤 | Fgfr 저해제의 간헐 투여용 항종양제 |
| CN104341425B (zh) * | 2013-08-08 | 2018-11-02 | 上海医药集团股份有限公司 | 氘代乙炔衍生物、其药物组合物及应用 |
| SI3052476T1 (sl) * | 2013-09-30 | 2020-12-31 | Guangzhou Innocare Pharma Tech Co., Ltd. | Substituirani nikotinimidni inhibitorji BTK in njihova priprava in uporaba pri zdravljenju raka, vnetja in avtoimunske bolezni |
| EP3184521B1 (en) * | 2014-08-19 | 2021-10-06 | Shanghai Haihe Pharmaceutical Co., Ltd. | Indazole compounds as fgfr kinase inhibitors, preparation and use thereof |
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2016
- 2016-08-09 CN CN201610647295.0A patent/CN107698593A/zh active Pending
-
2017
- 2017-07-27 KR KR1020197006637A patent/KR20190035870A/ko not_active Ceased
- 2017-07-27 WO PCT/CN2017/094620 patent/WO2018028438A1/zh not_active Ceased
- 2017-07-27 US US16/324,189 patent/US10752631B2/en not_active Expired - Fee Related
- 2017-07-27 CA CA3032921A patent/CA3032921A1/en active Pending
- 2017-07-27 CN CN201780045675.XA patent/CN109715626B/zh active Active
- 2017-07-27 JP JP2019529309A patent/JP6959663B2/ja not_active Expired - Fee Related
- 2017-07-27 EP EP17838568.8A patent/EP3498706A4/en not_active Withdrawn