JP2010536767A5 - - Google Patents
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- Publication number
- JP2010536767A5 JP2010536767A5 JP2010521081A JP2010521081A JP2010536767A5 JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5 JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- ring
- independently
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96511507P | 2007-08-17 | 2007-08-17 | |
| US60/965,115 | 2007-08-17 | ||
| US4345908P | 2008-04-09 | 2008-04-09 | |
| US61/043,459 | 2008-04-09 | ||
| US8045408P | 2008-07-14 | 2008-07-14 | |
| US61/080,454 | 2008-07-14 | ||
| PCT/US2008/072074 WO2009025983A2 (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125041A Division JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536767A JP2010536767A (ja) | 2010-12-02 |
| JP2010536767A5 true JP2010536767A5 (OSRAM) | 2011-09-15 |
| JP5965102B2 JP5965102B2 (ja) | 2016-08-03 |
Family
ID=40350174
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521081A Active JP5965102B2 (ja) | 2007-08-17 | 2008-08-04 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
| JP2014125041A Pending JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125041A Pending JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8217180B2 (OSRAM) |
| EP (1) | EP2176244B1 (OSRAM) |
| JP (2) | JP5965102B2 (OSRAM) |
| KR (2) | KR101597839B1 (OSRAM) |
| CN (2) | CN101855215A (OSRAM) |
| AR (1) | AR067948A1 (OSRAM) |
| AU (1) | AU2008289321B2 (OSRAM) |
| BR (1) | BRPI0814153B8 (OSRAM) |
| CA (1) | CA2693067C (OSRAM) |
| CO (1) | CO6260136A2 (OSRAM) |
| ES (1) | ES2587386T3 (OSRAM) |
| IL (1) | IL203174A (OSRAM) |
| MX (2) | MX337588B (OSRAM) |
| MY (2) | MY176115A (OSRAM) |
| PT (1) | PT2176244T (OSRAM) |
| RU (1) | RU2536039C2 (OSRAM) |
| TW (3) | TWI600639B (OSRAM) |
| WO (1) | WO2009025983A2 (OSRAM) |
| ZA (1) | ZA201000214B (OSRAM) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102558082B (zh) | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
| TW200803740A (en) * | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| US8623875B2 (en) * | 2007-06-13 | 2014-01-07 | E.I. Du Pont De Nemours And Company | Isoxazoline insecticides |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| PT2957284T (pt) | 2007-06-27 | 2018-04-23 | Du Pont | Método de controlo de pragas em animais |
| WO2009001942A1 (ja) | 2007-06-27 | 2008-12-31 | Nissan Chemical Industries, Ltd. | 3-ヒドロキシプロパン-1-オン化合物、2-プロペン-1-オン化合物およびイソキサゾリン化合物の製造方法 |
| TWI600639B (zh) | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | 製備5-鹵烷基-4,5-二氫異唑衍生物之化合物 |
| US8367584B2 (en) | 2007-10-03 | 2013-02-05 | E.I. Du Pont De Nemours And Company | Naphthalene isoxazoline compounds for control of invertebrate pests |
| TW201444787A (zh) | 2008-04-09 | 2014-12-01 | Du Pont | 製備3-三氟甲基查耳酮(chalcone)之方法 |
| JP2011527307A (ja) | 2008-07-09 | 2011-10-27 | ビーエーエスエフ ソシエタス・ヨーロピア | イソオキサゾリン化合物iを含む殺有害生物活性混合物 |
| EP2317856A1 (en) | 2008-07-09 | 2011-05-11 | Basf Se | Pesticidal mixtures comprising isoxazoline compounds ii |
| BRPI0917369A2 (pt) | 2008-08-22 | 2015-08-04 | Syngenta Participations Ag | Compostos inseticidas |
| CN105294668A (zh) | 2008-08-22 | 2016-02-03 | 先正达参股股份有限公司 | 杀虫化合物 |
| WO2010025998A1 (en) | 2008-09-04 | 2010-03-11 | Syngenta Participations Ag | Insecticidal compounds |
| AU2009331476B2 (en) | 2008-12-23 | 2015-05-28 | Basf Se | Imine compounds for combating invertebrate pests |
| AU2009331664A1 (en) | 2008-12-23 | 2011-07-14 | Basf Se | Substituted amidine compounds for combating animal pests |
| US20120030841A1 (en) * | 2009-04-01 | 2012-02-02 | Basf Se | Isoxazoline compounds for combating invertebrate pests |
| ME03475B (me) | 2009-12-17 | 2020-01-20 | Merial Inc | Antiparazitske kompozicije dihidroazola |
| JP2013518084A (ja) | 2010-02-01 | 2013-05-20 | ビーエーエスエフ ソシエタス・ヨーロピア | 有害動物を駆除するための置換されたケトン性イソオキサゾリン化合物および誘導体 |
| KR102060464B1 (ko) * | 2010-05-27 | 2019-12-30 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 4-[5-[3-클로로-5-(트라이플루오로메틸)페닐]-4,5-다이하이드로-5-(트라이플루오로메틸)-3-아이속사졸릴]-n-[2-옥소-2-[(2,2,2-트라이플루오로에틸)아미노]에틸]-1-나프탈렌카르복스아미드의 결정 형태 |
| UY33403A (es) | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
| ES2793481T3 (es) | 2010-09-24 | 2020-11-16 | Zoetis Services Llc | Oximas de isoxazolina como agentes antiparasitarios |
| PT3150575T (pt) | 2010-09-27 | 2023-11-13 | Corteva Agriscience Llc | Método de preparação de 2-amino-n-(2,2,2- trifluoroetil)acetamida |
| AU2012215440B2 (en) | 2011-02-10 | 2015-08-27 | Novartis Tiergesundheit Ag | Isoxazoline derivatives for controlling invertebrate pests |
| AU2012224521B2 (en) | 2011-03-10 | 2015-10-29 | Novartis Tiergesundheit Ag | Isoxazole derivatives |
| US9126995B2 (en) | 2011-11-08 | 2015-09-08 | Nissan Chemical Industries, Ltd. | Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound |
| CN104169278B (zh) | 2011-12-23 | 2017-10-24 | 巴斯夫欧洲公司 | 防治无脊椎动物害虫的异噻唑啉化合物 |
| AU2013348175B2 (en) | 2012-11-20 | 2016-11-17 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic compounds and compositions and method of using thereof |
| JP6484641B2 (ja) | 2013-11-01 | 2019-03-13 | メリアル インコーポレイテッド | 駆虫性かつ殺有害生物性のイソオキサゾリン化合物 |
| US10045979B2 (en) | 2014-05-19 | 2018-08-14 | Merial Inc. | Anthelmintic compounds |
| EP3211998B1 (en) | 2014-10-31 | 2021-04-07 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal composition comprising fipronil |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| US10433552B2 (en) | 2016-04-06 | 2019-10-08 | Merial, Inc. | Process for the preparation of isoxazoline compounds |
| CN110381738B (zh) | 2016-10-14 | 2021-07-16 | 勃林格殷格翰动物保健美国公司 | 农药的和杀寄生物的乙烯基异噁唑啉化合物 |
| MY188420A (en) * | 2017-04-05 | 2021-12-08 | Boehringer Ingelheim Animal Health Usa Inc | Crystalline forms of (s)-afoxolaner |
| US11589586B2 (en) | 2017-08-14 | 2023-02-28 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal pyrazole-isoxazoline compounds |
| MX2020008404A (es) | 2018-02-13 | 2020-09-25 | Gilead Sciences Inc | Inhibidores de molecula de muerte programada 1 (pd-1)/ligando de molecula de muerte programada 1 (pd-l1). |
| ES3035911T3 (en) | 2018-04-19 | 2025-09-11 | Gilead Sciences Inc | Pd-1/pd-l1 inhibitors |
| CN112004805B (zh) * | 2018-04-27 | 2024-06-14 | 组合化学工业株式会社 | 5,5-二取代-4,5-二氢异噁唑的制造方法 |
| SI3820572T1 (sl) | 2018-07-13 | 2023-12-29 | Gilead Sciences, Inc. | Inhibitorji pd-1/pd-l1 |
| JP7158577B2 (ja) | 2018-10-24 | 2022-10-21 | ギリアード サイエンシーズ, インコーポレイテッド | Pd-1/pd-l1阻害剤 |
| EP4041431A1 (en) | 2019-10-08 | 2022-08-17 | Donaldson Company, Inc. | Filter media layers including mixed diameter fine fibers |
| AR120804A1 (es) | 2019-12-18 | 2022-03-16 | Elanco Tiergesundheit Ag | Derivados de isoxazolina |
| CN115666553A (zh) | 2020-05-27 | 2023-01-31 | 轴向治疗公司 | Tlr2调节剂化合物及其药物组合物和用途 |
| US11591544B2 (en) | 2020-11-25 | 2023-02-28 | Akagera Medicines, Inc. | Ionizable cationic lipids |
| WO2023012821A1 (en) * | 2021-08-01 | 2023-02-09 | Zenfold Sustainable Technologies Private Limited | A process for the preparation of carbamoyl benzamide phenyl isoxazoline class drug/s and its intermediates |
| CN115710185B (zh) * | 2021-08-23 | 2024-05-03 | 中国石油化工股份有限公司 | 利用金属碳化物催化剂生产甲胺的方法 |
| EP4531819A2 (en) | 2022-05-25 | 2025-04-09 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| CN116253658B (zh) * | 2022-11-25 | 2023-08-11 | 济南久隆医药科技有限公司 | 一种阿福拉纳中间体合成方法 |
| CN115772091B (zh) * | 2023-01-05 | 2023-06-23 | 济南久隆医药科技有限公司 | 一种2-氨基-n-(2,2,2-三氟乙基)乙酰胺的合成方法 |
| CN119899156A (zh) * | 2023-10-27 | 2025-04-29 | 华北制药集团动物保健品有限责任公司 | 一种阿福拉纳的制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3879532A (en) * | 1974-01-18 | 1975-04-22 | Shell Oil Co | Control by isoxazoles of endoparasitic nematodes |
| US4129568A (en) * | 1977-05-12 | 1978-12-12 | Monsanto Company | 2-[3-Aryl-2-isoxazolin-5-yl]benzoates |
| US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| GB9505651D0 (en) | 1995-03-21 | 1995-05-10 | Agrevo Uk Ltd | AgrEvo UK Limited |
| CN1076351C (zh) | 1996-04-26 | 2001-12-19 | 日本曹达株式会社 | 被杂环取代的苯的衍生物和除草剂 |
| CA2206151A1 (en) | 1996-06-06 | 1997-12-06 | Rohm And Haas Company | Benzyloxy substituted aromatics and their use as fungicides and insecticides |
| GB2351081A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Pharmaceutically active imidazoline compounds and analogues thereof |
| DE10114597A1 (de) | 2001-03-23 | 2002-10-02 | Bayer Cropscience Gmbh | Arylisoxazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| EP1538138A4 (en) | 2002-08-26 | 2007-07-25 | Nissan Chemical Ind Ltd | SUBSTITUTED BENZANILIDE COMPOUND AND PROTECTIVE AGENTS |
| DE10320782A1 (de) | 2003-05-09 | 2004-11-25 | Bayer Cropscience Ag | Substituierte Oxyarene |
| JP2005272452A (ja) | 2004-02-23 | 2005-10-06 | Nissan Chem Ind Ltd | 置換ベンズアニリド化合物及び有害生物防除剤 |
| CN102558082B (zh) | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
| AU2005228417A1 (en) | 2004-03-26 | 2005-10-13 | Cytokine Pharmasciences, Inc. | Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor |
| JP5051340B2 (ja) * | 2005-06-06 | 2012-10-17 | 日産化学工業株式会社 | 置換イソキサゾリン化合物及び有害生物防除剤 |
| MY146795A (en) | 2005-06-09 | 2012-09-28 | Novartis Ag | Process for the synthesis of organic compounds |
| GB0514071D0 (en) | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
| KR100546831B1 (ko) | 2005-08-31 | 2006-01-25 | (주) 마이크로프랜드 | 프로브 카드의 탐침팁 공정 방법 |
| BRPI0617076B1 (pt) * | 2005-09-02 | 2021-07-06 | Nissan Chemical Corporation | Composto benzamida substituída por isoxazolina da fórmula (1) ou sal do mesmo; composto benzamida substituido por 4-hidroxiiminametila da fórmula (2) ou sal do mesmo; pesticida; agente agroquímico; parasiticida interno ou externo para mamíferos ou aves; inseticida ou acaricida |
| JP2007106756A (ja) | 2005-09-14 | 2007-04-26 | Nissan Chem Ind Ltd | 置換イソキサゾリン化合物及び有害生物防除剤 |
| TWI266597B (en) * | 2005-09-27 | 2006-11-11 | Delta Electronics Inc | Electronic apparatus capable of dissipating heat uniformly |
| JP2009519937A (ja) * | 2005-12-14 | 2009-05-21 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 無脊椎有害生物防除用イソオキサゾリン |
| TW200803740A (en) * | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| US7700808B2 (en) | 2005-12-26 | 2010-04-20 | Nissan Chemical Industries, Ltd. | 1-3-bis(substituted phenyl)-3-hydroxypropan-1-one or 2-propen-1-one compound, and salt thereof |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| BRPI0707091B8 (pt) * | 2006-03-10 | 2018-02-14 | Nissan Chemical Ind Ltd | composto de isoxalina e benzaldoxima substituído ou um sal do mesmo; pesticida, agroquímico, endo- ou ecto-parasiticidapara mamíferos ou pássaros, inseticida e acaricida contendo como um ou mais ingredientes ativos selecionados a partir do composto de isoxalina substituído e o sal do mesmo |
| WO2007123855A2 (en) | 2006-04-20 | 2007-11-01 | E. I. Du Pont De Nemours And Company | Pyrazolines for controlling invertebrate pests |
| JPWO2007125984A1 (ja) | 2006-04-28 | 2009-09-10 | 日本農薬株式会社 | イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法 |
| JP2008044880A (ja) | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | 殺虫性イソオキサゾリン類 |
| JP5206993B2 (ja) | 2007-03-07 | 2013-06-12 | 日産化学工業株式会社 | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
| MY146638A (en) * | 2007-04-10 | 2012-09-14 | Bayer Cropscience Ag | Insecticidal aryl isoxazoline derivatives |
| US8623875B2 (en) * | 2007-06-13 | 2014-01-07 | E.I. Du Pont De Nemours And Company | Isoxazoline insecticides |
| TWI430995B (zh) * | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| PT2957284T (pt) * | 2007-06-27 | 2018-04-23 | Du Pont | Método de controlo de pragas em animais |
| WO2009001942A1 (ja) * | 2007-06-27 | 2008-12-31 | Nissan Chemical Industries, Ltd. | 3-ヒドロキシプロパン-1-オン化合物、2-プロペン-1-オン化合物およびイソキサゾリン化合物の製造方法 |
| TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| TWI600639B (zh) * | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | 製備5-鹵烷基-4,5-二氫異唑衍生物之化合物 |
| KR20100064382A (ko) | 2007-09-10 | 2010-06-14 | 닛산 가가쿠 고교 가부시키 가이샤 | 치환 이속사졸린 화합물 및 유해생물 방제제 |
| US8367584B2 (en) * | 2007-10-03 | 2013-02-05 | E.I. Du Pont De Nemours And Company | Naphthalene isoxazoline compounds for control of invertebrate pests |
-
2008
- 2008-07-31 TW TW103118216A patent/TWI600639B/zh active
- 2008-07-31 TW TW106102361A patent/TWI649303B/zh active
- 2008-07-31 TW TW97129034A patent/TWI461411B/zh active
- 2008-08-04 KR KR1020107005776A patent/KR101597839B1/ko active Active
- 2008-08-04 MX MX2013011829A patent/MX337588B/es unknown
- 2008-08-04 MX MX2010001773A patent/MX2010001773A/es active IP Right Grant
- 2008-08-04 PT PT87970919T patent/PT2176244T/pt unknown
- 2008-08-04 US US12/679,382 patent/US8217180B2/en active Active
- 2008-08-04 KR KR1020157017534A patent/KR20150082693A/ko not_active Ceased
- 2008-08-04 CN CN200880103362A patent/CN101855215A/zh active Pending
- 2008-08-04 EP EP08797091.9A patent/EP2176244B1/en active Active
- 2008-08-04 AU AU2008289321A patent/AU2008289321B2/en active Active
- 2008-08-04 JP JP2010521081A patent/JP5965102B2/ja active Active
- 2008-08-04 MY MYPI2014000219A patent/MY176115A/en unknown
- 2008-08-04 MY MYPI20100137 patent/MY150980A/en unknown
- 2008-08-04 CA CA2693067A patent/CA2693067C/en active Active
- 2008-08-04 RU RU2010109881/04A patent/RU2536039C2/ru active
- 2008-08-04 ES ES08797091.9T patent/ES2587386T3/es active Active
- 2008-08-04 CN CN201610091532.XA patent/CN105693646A/zh active Pending
- 2008-08-04 BR BRPI0814153A patent/BRPI0814153B8/pt active IP Right Grant
- 2008-08-04 WO PCT/US2008/072074 patent/WO2009025983A2/en not_active Ceased
- 2008-08-15 AR ARP080103565 patent/AR067948A1/es active IP Right Grant
-
2010
- 2010-01-06 IL IL203174A patent/IL203174A/en active IP Right Grant
- 2010-01-12 ZA ZA2010/00214A patent/ZA201000214B/en unknown
- 2010-02-17 CO CO10018337A patent/CO6260136A2/es active IP Right Grant
-
2012
- 2012-07-09 US US13/544,113 patent/US8513431B2/en active Active
-
2014
- 2014-06-18 JP JP2014125041A patent/JP2014221775A/ja active Pending
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