JP2010536767A5 - - Google Patents
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- Publication number
- JP2010536767A5 JP2010536767A5 JP2010521081A JP2010521081A JP2010536767A5 JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5 JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- ring
- independently
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96511507P | 2007-08-17 | 2007-08-17 | |
| US60/965,115 | 2007-08-17 | ||
| US4345908P | 2008-04-09 | 2008-04-09 | |
| US61/043,459 | 2008-04-09 | ||
| US8045408P | 2008-07-14 | 2008-07-14 | |
| US61/080,454 | 2008-07-14 | ||
| PCT/US2008/072074 WO2009025983A2 (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125041A Division JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536767A JP2010536767A (ja) | 2010-12-02 |
| JP2010536767A5 true JP2010536767A5 (OSRAM) | 2011-09-15 |
| JP5965102B2 JP5965102B2 (ja) | 2016-08-03 |
Family
ID=40350174
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521081A Active JP5965102B2 (ja) | 2007-08-17 | 2008-08-04 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
| JP2014125041A Pending JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125041A Pending JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8217180B2 (OSRAM) |
| EP (1) | EP2176244B1 (OSRAM) |
| JP (2) | JP5965102B2 (OSRAM) |
| KR (2) | KR20150082693A (OSRAM) |
| CN (2) | CN101855215A (OSRAM) |
| AR (1) | AR067948A1 (OSRAM) |
| AU (1) | AU2008289321B2 (OSRAM) |
| BR (1) | BRPI0814153B8 (OSRAM) |
| CA (1) | CA2693067C (OSRAM) |
| CO (1) | CO6260136A2 (OSRAM) |
| ES (1) | ES2587386T3 (OSRAM) |
| IL (1) | IL203174A (OSRAM) |
| MX (2) | MX2010001773A (OSRAM) |
| MY (2) | MY176115A (OSRAM) |
| PT (1) | PT2176244T (OSRAM) |
| RU (1) | RU2536039C2 (OSRAM) |
| TW (3) | TWI461411B (OSRAM) |
| WO (1) | WO2009025983A2 (OSRAM) |
| ZA (1) | ZA201000214B (OSRAM) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102558082B (zh) | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
| TW200803740A (en) * | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| BRPI0809770B8 (pt) | 2007-06-13 | 2022-12-06 | Du Pont | Composto e composição para controlar uma praga de invertebrados |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| US8952175B2 (en) | 2007-06-27 | 2015-02-10 | Nissan Chemical Industries, Ltd. | Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound |
| KR101769728B1 (ko) | 2007-06-27 | 2017-08-18 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 동물 해충 방제 방법 |
| TWI461411B (zh) * | 2007-08-17 | 2014-11-21 | Du Pont | 製備5-鹵烷基-4,5-二氫異唑衍生物之方法 |
| KR20100075996A (ko) | 2007-10-03 | 2010-07-05 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 무척추 해충의 방제를 위한 나프탈렌 이속사졸린 화합물 |
| TWI583664B (zh) | 2008-04-09 | 2017-05-21 | 杜邦股份有限公司 | 羰基化合物及其製備方法 |
| BRPI0915818A2 (pt) | 2008-07-09 | 2015-08-04 | Basf Se | Mistura pesticida, composição pesticida, método para controlar fungos nocivos fitopatogênicos, para proteger plantas de fungos nocivos fitopatogênicos, para controlar insetos, aracnídeos ou nematódeos, para proteger plantas do ataque ou infestação por insetos, acarídeos ou nematódeos, e para a proteção de semente, semente, e, uso de uma mistura. |
| WO2010003923A1 (en) | 2008-07-09 | 2010-01-14 | Basf Se | Pestcidal active mixtures comprising isoxazoline compounds i |
| BRPI0917188A2 (pt) | 2008-08-22 | 2015-08-18 | Syngenta Participations Ag | Compostos inseticidas |
| US20110269804A1 (en) | 2008-08-22 | 2011-11-03 | Syngenta Crop Protection Llc | Insecticidal compounds |
| WO2010025998A1 (en) | 2008-09-04 | 2010-03-11 | Syngenta Participations Ag | Insecticidal compounds |
| BRPI0918305A2 (pt) | 2008-12-23 | 2015-08-11 | Basf Se | Compostos de amidina substituídos da fórmula (i), composto de amidina substituído da fórmula (i-5), composto de amidina substituído de 4-hidróximinometil da fórmula geral (ii-a), composto de amidina substituído de 4-hidróximinometil da fórmula geral (ii-b), composição agrícola, composição veterinária, uso de um composto, método para controlar pragas de invertebrados, método para proteger culturas ou plantas de ataque ou infestação por pragas de invertebrados, método para proteger material de propagação da planta e/ou as plantas, material de propagação da planta, método para tratar ou proteger um animal de infestação ou infecção por pragas de invertebrados e uso de um composto da fórmula i |
| WO2010072781A2 (en) | 2008-12-23 | 2010-07-01 | Basf Se | Imine compounds for combating invertebrate pests |
| JP2012522750A (ja) * | 2009-04-01 | 2012-09-27 | ビーエーエスエフ ソシエタス・ヨーロピア | 無脊椎動物害虫を駆除するためのイソキサゾリン化合物 |
| EA021522B9 (ru) | 2009-12-17 | 2016-08-31 | Мериал Лимитед | Противопаразитарные дигидроазоловые соединения и содержащие их композиции |
| EP2531493B1 (en) | 2010-02-01 | 2015-07-22 | Basf Se | Substituted ketonic isoxazoline compounds and derivatives for combating animal pests |
| PL2576523T3 (pl) * | 2010-05-27 | 2016-08-31 | Du Pont | Krystaliczna postać 4-[5 - [3 -chloro-5 -(trifluorometylo)fenylo] -4,5 -dihydro-5 -(trifluorometylo)-3 - izoksazolilo]-n-[2-okso-2-[(2,2,2-trifluoroetylo)amino]etylo]-1- naftalenokarboksyamidu |
| UY33403A (es) | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
| BR112013006686A2 (pt) | 2010-09-24 | 2017-11-14 | Zoetis Llc | isoxazolina oximas como agentes antiparasitários |
| KR101901466B1 (ko) * | 2010-09-27 | 2018-09-21 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 2-아미노-n-(2,2,2-트라이플루오로에틸)아세트아미드의 제조 방법 |
| JP2014505089A (ja) | 2011-02-10 | 2014-02-27 | ノバルティス アーゲー | 無脊椎有害動物を防除するためのイソオキサゾリン誘導体 |
| ES2542409T3 (es) | 2011-03-10 | 2015-08-05 | Novartis Tiergesundheit Ag | Derivados de isoxazol |
| JP6075563B2 (ja) | 2011-11-08 | 2017-02-08 | 日産化学工業株式会社 | 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物 |
| EP2794601B1 (en) | 2011-12-23 | 2019-02-20 | Basf Se | Isothiazoline compounds for combating invertebrate pests |
| EA030814B1 (ru) | 2012-11-20 | 2018-10-31 | Мериал, Инк. | Антигельминтные соединения, композиции и способы их применения |
| SG11201603430XA (en) | 2013-11-01 | 2016-05-30 | Merial Ltd | Antiparasitic and pesticidal isoxazoline compounds |
| WO2015179414A1 (en) | 2014-05-19 | 2015-11-26 | Merial, Inc. | Anthelmintic compounds |
| AU2015339096B2 (en) | 2014-10-31 | 2018-08-02 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal composition comprising fipronil |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| HRP20211979T1 (hr) | 2016-04-06 | 2022-04-01 | Boehringer Ingelheim Animal Health USA Inc. | Postupak za pripravu enantiomerno obogaćenih spojeva izoksazolina – kristalnog toluen solvata (s)-afoksolanera |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| CA3059114A1 (en) * | 2017-04-05 | 2018-10-11 | Boehringer Ingelheim Animal Health USA Inc. | Crystalline forms of (s)-afoxolaner |
| WO2019036407A1 (en) | 2017-08-14 | 2019-02-21 | Merial, Inc. | PYRAZOLE-ISOXAZOLINE COMPOUNDS WITH PESTICIDE AND PARASITICIDE ACTIVITY |
| CR20200347A (es) | 2018-02-13 | 2020-09-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| MX2020011267A (es) | 2018-04-27 | 2020-11-12 | Kumiai Chemical Industry Co | Metodo de produccion para 4,5-dihidroisoxazol 5,5-disustituido. |
| PT3820572T (pt) | 2018-07-13 | 2023-11-10 | Gilead Sciences Inc | Inibidores pd-1/pd-l1 |
| JP7158577B2 (ja) | 2018-10-24 | 2022-10-21 | ギリアード サイエンシーズ, インコーポレイテッド | Pd-1/pd-l1阻害剤 |
| CN114938636A (zh) | 2019-10-08 | 2022-08-23 | 唐纳森公司 | 包括混合直径细纤维的过滤介质层 |
| US12497370B2 (en) | 2019-12-18 | 2025-12-16 | Elanco Tiergesundheit Ag | Isoxazoline derivatives |
| BR112022024071A2 (pt) | 2020-05-27 | 2022-12-20 | Axial Therapeutics Inc | Compostos moduladores de tlr2, composições farmacêuticas e usos dos mesmos |
| MX2023006056A (es) | 2020-11-25 | 2023-06-06 | Akagera Medicines Inc | Nanoparticulas lipidicas para suministro de acidos nucleicos y metodos de uso de las mismas. |
| US20250091998A1 (en) * | 2021-08-01 | 2025-03-20 | Zenfold Sustainable Technologies Private Limited | A process for the preparation of carbamoyl benzamide phenyl isoxazoline class drug/s and its intermediates |
| CN115710185B (zh) * | 2021-08-23 | 2024-05-03 | 中国石油化工股份有限公司 | 利用金属碳化物催化剂生产甲胺的方法 |
| KR20250031230A (ko) | 2022-05-25 | 2025-03-06 | 아카제라 메디신즈, 인크. | 핵산 전달을 위한 지질 나노입자 및 이의 사용 방법 |
| CN116903488B (zh) * | 2022-11-25 | 2023-12-15 | 济南久隆医药科技有限公司 | 一种阿福拉纳的合成方法 |
| CN115772091B (zh) * | 2023-01-05 | 2023-06-23 | 济南久隆医药科技有限公司 | 一种2-氨基-n-(2,2,2-三氟乙基)乙酰胺的合成方法 |
| CN119899156A (zh) * | 2023-10-27 | 2025-04-29 | 华北制药集团动物保健品有限责任公司 | 一种阿福拉纳的制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3879532A (en) * | 1974-01-18 | 1975-04-22 | Shell Oil Co | Control by isoxazoles of endoparasitic nematodes |
| US4129568A (en) * | 1977-05-12 | 1978-12-12 | Monsanto Company | 2-[3-Aryl-2-isoxazolin-5-yl]benzoates |
| US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| GB9505651D0 (en) | 1995-03-21 | 1995-05-10 | Agrevo Uk Ltd | AgrEvo UK Limited |
| DE69728761T2 (de) | 1996-04-26 | 2004-08-12 | Nippon Soda Co. Ltd. | Heterocyclisch substituierte benzolderivate und herbizide |
| CA2206151A1 (en) | 1996-06-06 | 1997-12-06 | Rohm And Haas Company | Benzyloxy substituted aromatics and their use as fungicides and insecticides |
| GB2351081A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Pharmaceutically active imidazoline compounds and analogues thereof |
| DE10114597A1 (de) * | 2001-03-23 | 2002-10-02 | Bayer Cropscience Gmbh | Arylisoxazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| AU2003261713A1 (en) | 2002-08-26 | 2004-03-11 | Nissan Chemical Industries, Ltd. | Substituted benzanilide compound and pest control agent |
| DE10320782A1 (de) | 2003-05-09 | 2004-11-25 | Bayer Cropscience Ag | Substituierte Oxyarene |
| JP2005272452A (ja) | 2004-02-23 | 2005-10-06 | Nissan Chem Ind Ltd | 置換ベンズアニリド化合物及び有害生物防除剤 |
| CN102558082B (zh) | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
| WO2005094329A2 (en) | 2004-03-26 | 2005-10-13 | Cytokine Pharmasciences, Inc. | Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor |
| JP5051340B2 (ja) | 2005-06-06 | 2012-10-17 | 日産化学工業株式会社 | 置換イソキサゾリン化合物及び有害生物防除剤 |
| MY146795A (en) | 2005-06-09 | 2012-09-28 | Novartis Ag | Process for the synthesis of organic compounds |
| GB0514071D0 (en) | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
| KR100546831B1 (ko) | 2005-08-31 | 2006-01-25 | (주) 마이크로프랜드 | 프로브 카드의 탐침팁 공정 방법 |
| AU2006285613B2 (en) * | 2005-09-02 | 2011-11-17 | Nissan Chemical Corporation | Isoxazoline-substituted benzamide compound and harmful organism-controlling agent |
| JP2007106756A (ja) | 2005-09-14 | 2007-04-26 | Nissan Chem Ind Ltd | 置換イソキサゾリン化合物及び有害生物防除剤 |
| TWI266597B (en) * | 2005-09-27 | 2006-11-11 | Delta Electronics Inc | Electronic apparatus capable of dissipating heat uniformly |
| US20090143410A1 (en) * | 2005-12-14 | 2009-06-04 | Kanu Maganbhai Patel | Isoxazolines for Controlling Invertebrate Pests |
| TW200803740A (en) * | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| JP5304981B2 (ja) * | 2005-12-26 | 2013-10-02 | 日産化学工業株式会社 | 1,3−ビス(置換フェニル)−3−ヒドロキシプロパン−1−オンおよび2−プロペン−1−オン化合物およびその塩 |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| DE602007006288D1 (de) | 2006-03-10 | 2010-06-17 | Nissan Chemical Ind Ltd | Substituierte isoxazolin-verbindung und schädlingsbekämpfungsmittel |
| AU2007240954A1 (en) | 2006-04-20 | 2007-11-01 | E. I. Du Pont De Nemours And Company | Pyrazolines for controlling invertebrate pests |
| JPWO2007125984A1 (ja) | 2006-04-28 | 2009-09-10 | 日本農薬株式会社 | イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法 |
| JP2008044880A (ja) | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | 殺虫性イソオキサゾリン類 |
| JP5206993B2 (ja) | 2007-03-07 | 2013-06-12 | 日産化学工業株式会社 | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
| BRPI0810196A2 (pt) | 2007-04-10 | 2011-12-06 | Bayer Cropscience Ag | inseticidas de derivados de aril isoxazolina |
| BRPI0809770B8 (pt) * | 2007-06-13 | 2022-12-06 | Du Pont | Composto e composição para controlar uma praga de invertebrados |
| TWI430995B (zh) * | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| KR101769728B1 (ko) | 2007-06-27 | 2017-08-18 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 동물 해충 방제 방법 |
| US8952175B2 (en) * | 2007-06-27 | 2015-02-10 | Nissan Chemical Industries, Ltd. | Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound |
| TWI461411B (zh) | 2007-08-17 | 2014-11-21 | Du Pont | 製備5-鹵烷基-4,5-二氫異唑衍生物之方法 |
| TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| EP2199287A4 (en) | 2007-09-10 | 2011-04-27 | Nissan Chemical Ind Ltd | SUBSTITUTED ISOXAZOLINE COMPOUND AND AGENT FOR CONTROLLING PESTS |
| KR20100075996A (ko) * | 2007-10-03 | 2010-07-05 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 무척추 해충의 방제를 위한 나프탈렌 이속사졸린 화합물 |
-
2008
- 2008-07-31 TW TW97129034A patent/TWI461411B/zh active
- 2008-07-31 TW TW103118216A patent/TWI600639B/zh active
- 2008-07-31 TW TW106102361A patent/TWI649303B/zh active
- 2008-08-04 RU RU2010109881/04A patent/RU2536039C2/ru active
- 2008-08-04 MX MX2010001773A patent/MX2010001773A/es active IP Right Grant
- 2008-08-04 KR KR1020157017534A patent/KR20150082693A/ko not_active Ceased
- 2008-08-04 AU AU2008289321A patent/AU2008289321B2/en active Active
- 2008-08-04 PT PT87970919T patent/PT2176244T/pt unknown
- 2008-08-04 ES ES08797091.9T patent/ES2587386T3/es active Active
- 2008-08-04 US US12/679,382 patent/US8217180B2/en active Active
- 2008-08-04 JP JP2010521081A patent/JP5965102B2/ja active Active
- 2008-08-04 KR KR1020107005776A patent/KR101597839B1/ko active Active
- 2008-08-04 CA CA2693067A patent/CA2693067C/en active Active
- 2008-08-04 MY MYPI2014000219A patent/MY176115A/en unknown
- 2008-08-04 MY MYPI20100137 patent/MY150980A/en unknown
- 2008-08-04 CN CN200880103362A patent/CN101855215A/zh active Pending
- 2008-08-04 CN CN201610091532.XA patent/CN105693646A/zh active Pending
- 2008-08-04 MX MX2013011829A patent/MX337588B/es unknown
- 2008-08-04 EP EP08797091.9A patent/EP2176244B1/en active Active
- 2008-08-04 WO PCT/US2008/072074 patent/WO2009025983A2/en not_active Ceased
- 2008-08-04 BR BRPI0814153A patent/BRPI0814153B8/pt active IP Right Grant
- 2008-08-15 AR ARP080103565 patent/AR067948A1/es active IP Right Grant
-
2010
- 2010-01-06 IL IL203174A patent/IL203174A/en active IP Right Grant
- 2010-01-12 ZA ZA2010/00214A patent/ZA201000214B/en unknown
- 2010-02-17 CO CO10018337A patent/CO6260136A2/es active IP Right Grant
-
2012
- 2012-07-09 US US13/544,113 patent/US8513431B2/en active Active
-
2014
- 2014-06-18 JP JP2014125041A patent/JP2014221775A/ja active Pending
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