ME02432B - Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže - Google Patents

Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže

Info

Publication number
ME02432B
ME02432B MEP-2016-77A MEP7716A ME02432B ME 02432 B ME02432 B ME 02432B ME P7716 A MEP7716 A ME P7716A ME 02432 B ME02432 B ME 02432B
Authority
ME
Montenegro
Prior art keywords
alkyl
haloalkyl
hydrogen
compound according
independently hydrogen
Prior art date
Application number
MEP-2016-77A
Other languages
German (de)
English (en)
French (fr)
Inventor
Hir De Falois Loic Patrick Le
Hyoung Lk Lee
Douglas Edward Wilkinson
Brent Christopher Beck
Original Assignee
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Inc filed Critical Merial Inc
Publication of ME02432B publication Critical patent/ME02432B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (28)

1. Jedinjenje dihidroazola formule (I), ili njegovafarmaceutski ili poljoprivredno prihvatljiva so:u kome:R1je vodonik, halogen, -CN, ili alkil, haloalkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, halocikloalkil, alkilcikloalkil ili cikloalkilalkil,od kojih je svaki nesupstituisan ili supstituisan sa jednim ili više odhalogena, hidroksi, amino, alkil- ili di(alkil)amino, alkil, cikloalkil,haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi, haloalkoksi,alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-, R7C(O)-,R7R8NC(O)-, R7OC(O)-, R7C(O)O-, R7C(O)NR8-,-CN ili NO2;X jearil ili heteroaril, koji mogu biti nesupstituisani ili supstituisani sa jednimili više od halogen, hidroksi, amino, alkil- ili di(alkil)amino, alkil,cikloalkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi,haloalkoksi, alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-,R7C(O)-, R7R8NC(O)-, R7OC(O)-, R7C(O)O-,R7C(O)NR8-, -CN ili NO2;A1i A2 su nezavisno kiseonik, NR2 ili CR7R8;G jeG-1 ili G-2;B1,B2, B3, B4 i B5 su nezavisno N iliC-R9;Y je vodonik,halogen, -CN; ili Y je alkil, haloalkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, alkilcikloalkil, cikloalkilalkil, aril iliheterociklil ili heteroaril od kojih je svaki nesupstituisan ili supstituisansa jednim ili više od halogena, hidroksi, amino, alkil- ili di(alkil)amino,alkil, cikloalkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil,alkoksi, haloalkoksi, alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-,R7C(O)-, R7R8NC(O)-, R7OC(O)-, R7C(O)O-,R7C(O)NR8-, -CN ili -NO2; ili Y je Y-1, Y-2,Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10, Y-11, Y-12 ili Y-13;ili R2,R3 su nezavisno vodonik, alkil, haloalkil, tioalkil, alkiltioalkil,hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkenil, haloalkinil,cikloalkil, R10S(O)-, R10S(O)2-, R10C(O)-,R10C(S)-, R10R11NC(O)-, R10R11NC(S)-,R10OC(O)-;R4,R5 i R6 su nezavisno vodonik, alkil, haloalkil, tioalkil,alkiltioalkil, hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, aril ili heteroaril;R7i R8 su nezavisno vodonik, alkil, haloalkil, tioalkil,alkiltioalkil, hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkinil ilihaloalkinil;R9je vodonik, halogen, -CN ili alkil, haloalkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, halocikloalkil, alkilcikloalkil ili cikloalkilalkil,od kojih je svaki nesupstituisan ili supstituisan sa jednim ili više odhalogena, hidroksi, amino, alkil- ili di(alkil)amino, alkil, cikloalkil,haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi, haloalkoksi,alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-, R7C(O)-,R7R8NC(O)-, R7OC(O)-, R7C(O)O-, R7C(O)NR8-,-CN ili -NO2;R10,R11, R12 i R13 su svaki nezavisno vodonik,alkil, haloalkil, tioalkil, alkiltioalkil, hidroksialkil, alkoksialkil,alkenil, haloalkenil, alkinil ili haloalkinil; iliR10zajedno sa R11 formiraju =O, =S ili =NR2; iliR12zajedno sa R13 formiraju =O, =S ili =NR2;W je 0,S ili NR2;n je1-4; im je0,1 ili 2.
2. Jedinjenje prema patentnom zahtevu 1, naznačeno time što G je G-1.
3. Jedinjenje prema patentnom zahtevu 1, naznačeno time što G je G-2.
4. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-1; A1 je kiseonik; i X je izborno supstituisani aril.
5. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-2; A1 je kiseonik; i X je izborno supstituisani aril.
6. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: A1 je kiseonik; X je izborno supstituisani aril; R1 je vodonik, halogen, alkil ili haloalkil; i Y je Y-1, Y-2, Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10, Y-11, Y-12 ili Y-13.
7. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: A1 je kiseonik; X je aril; R1 je vodonik, alkil ili haloalkil; Y je Y-1, Y-2 Y-3, Y-4, Y-5 ili Y-6; i R2, R3 su nezavisno vodonik, alkil, haloalkil, tioalkil, alkiltioalkil.
8. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: A1 je kiseonik; X je izborno supstituisani aril; R1 je vodonik, halogen, alkil ili haloalkil; i Y je pirazolil ili triazolil.
9. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-1; B1, B2, B3, B4 i B5 su svaki C-R9; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4lalkoksi-C1-C4alkil ili C1-C4alkiltio-C4-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
10. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-2; B1 B2, B3, B4 i B5 su svaki C-R9; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4 alkoksi-C1-C4alkil ili C1-C4alkiltio-C1-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
11. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-1; B1, B2, B4 i B5 su svaki C-R9; B3 je N; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4 alkoksi-C1-C4alkil ili C1-C4alkiltio-C1-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
12. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-2; B2, B3, B4 i B5 su svaki C-R9; B1 je N; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4 alkoksi-C1-C4alkil ili C1-C4alkiltio-C1-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
13. Jedinjenje prema patentnom zahtevu 9 ili patentnom zahtevu 10, naznačeno time što: A2 je CH2; R9 je vodonik; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
14. Jedinjenje prema patentnom zahtevu 1 naznačeno time što R10 zajedno sa R11 formiraju =O.
15. Jedinjenje prema patentnom zahtevu 1 naznačeno time što R12 zajedno sa R13 formiraju =O.
16. Jedinjenje prema patentnom zahtevu 9 ili patentnom zahtevu 10, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
17. Jedinjenje prema patentnom zahtevu 9, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili =NR2; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil; i R3, R7 i R8 su vodonik.
18. Jedinjenje prema patentnom zahtevu 11 ili patentnom zahtevu 12, naznačeno time što: A2 je CH2; R9 je vodonik; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
19. Jedinjenje prema patentnom zahtevu 11 ili patentnom zahtevu 12, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
20. Jedinjenje prema patentnom zahtevu 11 ili patentnom zahtevu 12, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili =NR2; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil; i R3, R7 i R8 su vodonik.
21. Jedinjenje prema patentnom zahtevu 1 izabrano od sledećih: (Z)p B5 B4 B3 B2 B1 R15 R16 3,5-Cl2 C-H C-H C-H C-H N H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-H C-H N H CH2CF3 3,5-(CF3)2 C-H C-H C-H C-H N CH3 CH2CO2CH3 3,5-(CF3)2 C-H C-H C-H C-H N CH3 CH2CO2H 3,5-(CF3)2 C-H C-H C-H C-H N CH3 CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-H C-H N H CH2C(O)NHCH2CF3 3,5-(CH3)2 C-H C-H C-H C-H N H CH2CH2SCH3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3,5-(CH3)2 C-H C-H C-H C-H C-H H CH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3-Cl, 5-CF3 C-H C-H C-H C-H C-H H CH2CF3 3-Cl, 5-CF3 C-H C-H C-H C-H C-H H CH2CH2SCH3 3,5-Cl2 C-H C-H C-Me C-H C-Me H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-Me C-H C-Me H CH2CF3 3,5-Cl2 C-H C-H C-Me C-H C-Me H CH2CH2SCH3 3,5-(CH3)2 C-H C-H C-Me C-H C-Me H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-Me C-H C-Me H CH2CF3 3,5-(CH3)2 C-H C-H C-Me C-H C-Me H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H C-Me C-H C-Me H CH2C(O)NHCH2CF3 3-Cl,5-CF3 C-H C-H C-Me C-H C-Me H CH2CF3 3-Cl,5-CF3 C-H C-H C-Me C-H C-Me H CH2CH2SCH3
22. Jedinjenje prema patentnom zahtevu 1 izabrano od sledećih: <!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"> <v:stroke joinstyle="miter"/> <v:formulas> <v:f eqn="if lineDrawn pixelLineWidth 0"/> <v:f eqn="sum @0 1 0"/> <v:f eqn="sum 0 0 @1"/> <v:f eqn="prod @2 1 2"/> <v:f eqn="prod @3 21600 pixelWidth"/> <v:f eqn="prod @3 21600 pixelHeight"/> <v:f eqn="sum @0 0 1"/> <v:f eqn="prod @6 1 2"/> <v:f eqn="prod @7 21600 pixelWidth"/> <v:f eqn="sum @8 21600 0"/> <v:f eqn="prod @7 21600 pixelHeight"/> <v:f eqn="sum @10 21600 0"/> </v:formulas> <v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/> <o:lock v:ext="edit" aspectratio="t"/> </v:shapetype><v:shape id="Picture_x0020_8" o:spid="_x0000_i1025" type="#_x0000_t75" style='width:166.5pt;height:191.25pt;visibility:visible;mso-wrap-style:square'> <v:imagedata src="file:///C:\Users\User\AppData\Local\Temp\msohtmlclip1\01\clip_image001.emz" o:title=""/> </v:shape><![endif]--><!--[if !vml]--><!--[endif]--> (Z)p B5 B4 B3 B2 B1 R15 R16 3,5-Cl2 C-H C-H N C-H C-H H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H N C-H C-H H CH2CF3 3,5-Cl2 C-H C-H N C-H C-H H CH2CH2SCH3 3,5-(CF3)2 C-H C-H N C-H C-H H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H N C-H C-H H CH2CF3 3,5-(CF3)2 C-H C-H N C-H C-H H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H N C-H C-H H CH2C(O)NHCH2CF3 3-Cl,5-CF3 C-H C-H N C-H C-H H CH2CF3 3-Cl,5-CF3 C-H C-H N C-H C-H H CH2CH2SCH3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2CF3 3,5-(CH3)2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2CF3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2CH2SCH3
23. Kompozicija za upotrebu u tretmanu ili prevenciji parazitske infekcije ili infestacije kod životinje koja sadrži efikasnu količinu jedinjenja formule (I) prema patentnom zahtevu 1 u kombinaciji sa farmaceutski prihvatljivim nosačem.
24. Kompozicija za zaštitu kulturnih biljaka, biljaka, materijala za razmnožavanje biljaka ili materijala napravljenog od drveta, od štetočina, koja sadrži pesticidno efikasnu količinu jedinjenja formule (I) prema patentnom zahtevu 1 u kombinaciji sa poljoprivredno prihvatljivim nosačem ili razblaživačem.
25. Postupak za zaštitu kulturnih biljaka i rastućih biljaka od napada ili infestacije štetočinama životinja, koji sadrži dovođenje u kontakt biljke, ili zemljišta ili vode u kome/kojoj biljka raste, sa jedinjenjem formule (I) prema patrntnom zahtevu 1.
26. Postupak za prevenciju ili kontrolu infestacije štetočina životinja na lokusu, koji sadrži primenu pesticidno efikasne količine ili paraziticidno efikasne količine jedinjenja formule (I) prema patentnom zahtevu 1 na lokus; pri čemu lokus obuhvata ljudsko ili životinjsko telo.
27. Jedinjenje prema patentnom zahtevu 1 za upotrebu u tretmanu ili prevenciji parazitske infekcije ili infestacije kod životinje.
28. Upotreba jedinjenja prema patentnom zahtevu 1 u proizvodnji leka za tretman ili prevenciju parazitske infekcije ili infestacije kod životinje.
MEP-2016-77A 2009-12-17 2010-12-16 Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže ME02432B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28754509P 2009-12-17 2009-12-17
PCT/US2010/060833 WO2011075591A1 (en) 2009-12-17 2010-12-16 Anti parasitic dihydroazole compounds and compositions comprising same
EP10796566.7A EP2513104B1 (en) 2009-12-17 2010-12-16 Antiparasitic dihydroazole compounds and compositions comprising same

Publications (1)

Publication Number Publication Date
ME02432B true ME02432B (me) 2016-09-20

Family

ID=43501207

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-2019-141A ME03475B (me) 2009-12-17 2010-12-16 Antiparazitske kompozicije dihidroazola
MEP-2016-77A ME02432B (me) 2009-12-17 2010-12-16 Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MEP-2019-141A ME03475B (me) 2009-12-17 2010-12-16 Antiparazitske kompozicije dihidroazola

Country Status (36)

Country Link
US (4) US8618126B2 (me)
EP (3) EP2513104B1 (me)
JP (1) JP5844275B2 (me)
KR (2) KR101826977B1 (me)
CN (1) CN102741247B (me)
AP (1) AP3106A (me)
AU (1) AU2010330843B2 (me)
BR (1) BR112012014921B1 (me)
CA (1) CA2784122C (me)
CL (1) CL2012001655A1 (me)
CO (1) CO6640203A2 (me)
CR (1) CR20120328A (me)
CY (1) CY1122240T1 (me)
DK (2) DK3078664T3 (me)
EA (2) EA201401222A1 (me)
ES (3) ES2727588T3 (me)
HR (2) HRP20160677T1 (me)
HU (2) HUE043607T2 (me)
IL (2) IL220281A (me)
LT (1) LT3078664T (me)
ME (2) ME03475B (me)
MX (2) MX336189B (me)
MY (1) MY162636A (me)
NZ (1) NZ600922A (me)
PH (1) PH12012501220A1 (me)
PL (3) PL3078664T3 (me)
PT (2) PT2513104E (me)
RS (2) RS58691B1 (me)
RU (1) RU2549900C9 (me)
SG (1) SG181679A1 (me)
SI (2) SI3078664T1 (me)
SM (2) SMT201900263T1 (me)
TR (1) TR201907244T4 (me)
UA (1) UA108219C2 (me)
WO (1) WO2011075591A1 (me)
ZA (1) ZA201204370B (me)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2445906B1 (en) 2009-06-22 2014-07-23 Syngenta Participations AG Insecticidal compounds
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
TW201200518A (en) 2010-03-10 2012-01-01 Kalypsys Inc Heterocyclic inhibitors of histamine receptors for the treatment of disease
JP2014028758A (ja) 2010-11-19 2014-02-13 Nissan Chem Ind Ltd 寄生虫及び衛生害虫防除剤
WO2012089622A2 (en) 2010-12-27 2012-07-05 Intervet International B.V. Topical localized isoxazoline formulation
JP2014506249A (ja) 2010-12-27 2014-03-13 インターベツト・インターナシヨナル・ベー・ベー グリコフロールを含む経表面局所イソオキサゾリン製剤
TWI632135B (zh) * 2011-09-12 2018-08-11 美商龍馬躍有限公司 包含異唑啉活性劑之殺寄生蟲組合物、方法及其用途
WO2013039785A2 (en) 2011-09-12 2013-03-21 Kalypsys, Inc. Heterocyclic inhibitors of histamine receptors for the treatment of disease
SG11201404595TA (en) 2012-02-06 2014-09-26 Merial Ltd Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
EP2833866B2 (en) 2012-04-04 2024-11-27 Intervet International B.V. Soft chewable pharmaceutical products
AU2013245478A1 (en) * 2012-11-01 2014-05-15 Sumitomo Chemical Company, Limited Method for administering agent for controlling ectoparasite to dog
US9532946B2 (en) 2012-11-20 2017-01-03 Intervet Inc. Manufacturing of semi-plastic pharmaceutical dosage units
AU2013348175B2 (en) 2012-11-20 2016-11-17 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic compounds and compositions and method of using thereof
LT2953942T (lt) 2013-02-06 2018-02-12 Bayer Cropscience Aktiengesellschaft Halogenpakeistieji pirazolo dariniai kaip pesticidai
US9371293B2 (en) 2013-10-25 2016-06-21 Sumitomo Chemical Company, Limited Isoxazoline compound composition
JP6484641B2 (ja) 2013-11-01 2019-03-13 メリアル インコーポレイテッド 駆虫性かつ殺有害生物性のイソオキサゾリン化合物
US10273226B2 (en) 2014-01-03 2019-04-30 Bayer Animal Health Gmbh Pyrazolyl-heteroarylamides as pesticides
ES2765405T3 (es) 2014-04-17 2020-06-09 Boehringer Ingelheim Animal Health Usa Inc Utilización de compuestos de malononitrilo para proteger animales de parásitos
US10045979B2 (en) 2014-05-19 2018-08-14 Merial Inc. Anthelmintic compounds
JP2017521441A (ja) 2014-07-15 2017-08-03 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ａｎｉｍａｌ Ｈｅａｌｔｈ Ｇｍｂｈ 有害生物防除剤としてのアリール−トリアゾリルピリジン類
EP3211998B1 (en) 2014-10-31 2021-04-07 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal composition comprising fipronil
UY36570A (es) * 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
SG10201912724SA (en) * 2015-04-08 2020-02-27 Boehringer Ingelheim Animal Health Usa Inc Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
NZ737610A (en) 2015-05-20 2023-07-28 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic depsipeptide compounds
EP3313400B1 (en) 2015-06-23 2022-06-15 Intervet International B.V. Isoxazoline solution containing vitamin e for use with sanitized drinking water
CN104880428B (zh) * 2015-06-23 2016-07-06 山西振东安特生物制药有限公司 一种胶体果胶铋或含胶体果胶铋制剂中铋含量的测定方法
UY37137A (es) * 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
US11384032B2 (en) 2016-05-12 2022-07-12 Verdesian Life Sciences, U.S., Llc Compositions for controlling enzyme-induced urea decomposition
EP3527560A4 (en) 2016-10-13 2020-04-08 Nihon Nohyaku Co., Ltd. 1H-PYRROLOPYRIDINE COMPOUND, N-OXIDE THEREOF, SALT THEREOF, PESTICIDE FOR AGRICULTURE AND GARDENING WITH THIS COMPOUND AND METHOD FOR USE THEREOF
CN110381738B (zh) 2016-10-14 2021-07-16 勃林格殷格翰动物保健美国公司 农药的和杀寄生物的乙烯基异噁唑啉化合物
AU2017361099A1 (en) 2016-11-16 2019-06-06 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
CA3058394A1 (en) 2017-03-28 2018-10-04 Verdesian Life Sciences U.S., Llc Triarylmethane compounds for controlling enzyme-induced urea decomposition
TWI683808B (zh) 2017-07-18 2020-02-01 德商菲尼克斯 Ｆｘｒ有限責任公司 含有胺或(硫)醯胺之lxr調節劑
US11589586B2 (en) 2017-08-14 2023-02-28 Boehringer Ingelheim Animal Health USA Inc. Pesticidal and parasiticidal pyrazole-isoxazoline compounds
AU2018363682B2 (en) 2017-11-07 2023-11-23 Intervet International B.V. Injectable isoxazoline pharmaceutical compositions and their use against parasite infestation
AR113997A1 (es) 2017-12-21 2020-07-08 Intervet Int Bv Composiciones antiparasitarias para unción dorsal continua
US12269822B2 (en) 2018-07-09 2025-04-08 Boehringer Ingelheim Animal Health USA Inc. Anthelminthic heterocyclic compounds
WO2020112374A1 (en) 2018-11-20 2020-06-04 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
CN119285648A (zh) 2019-03-19 2025-01-10 勃林格殷格翰动物保健有限公司 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物
TWI696911B (zh) 2019-04-15 2020-06-21 友達光電股份有限公司 顯示裝置
MX2022007309A (es) 2019-12-16 2022-07-12 Intervet Int Bv Composicion para control de piojos en aves de corral.
US20230095926A1 (en) 2019-12-16 2023-03-30 Intervet Inc. Parasite control in ruminants
EP4075981A1 (en) 2019-12-16 2022-10-26 Intervet International B.V. Composition for lice control
WO2021242481A1 (en) 2020-05-28 2021-12-02 Boehringer Ingelheim Animal Health USA Inc. Bi-modal release intra-ruminal capsule device and methods of use thereof
PH12022553222A1 (en) 2020-05-29 2024-02-12 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic heterocyclic compounds
CN111588698B (zh) * 2020-06-23 2022-06-24 南京大方生物工程有限公司 一种提高水溶性的氟苯尼考粉剂及其制备方法和应用
KR20230043904A (ko) 2020-07-24 2023-03-31 엘랑코 유에스 인코포레이티드 이속사졸린 화합물 및 이의 중간체의 제조 공정
CN116897044A (zh) 2020-12-21 2023-10-17 勃林格殷格翰动物保健有限公司 包含异噁唑啉化合物的杀寄生虫环
US20240116854A1 (en) 2021-01-27 2024-04-11 Intervet Inc. Cyclopropylamide compounds against parasites in fish
EP4656047A3 (en) 2021-01-27 2025-12-24 Intervet International B.V. Cyclopropylamide compounds against parasites in fish
CN113040136B (zh) * 2021-03-17 2022-05-06 湖南嘉诚农业科技有限公司 一种航空施药助剂及其制备方法和应用
EP4351341A1 (en) 2021-06-11 2024-04-17 Intervet International B.V. Tick control methods
PE20250117A1 (es) 2021-06-25 2025-01-16 Intervet Int Bv Composiciones veterinarias apetecibles
MX2024005264A (es) 2021-11-01 2024-05-14 Boehringer Ingelheim Vetmedica Gmbh Compuestos de pirrolopiridazina como antihelminticos.
JP2025507585A (ja) 2022-02-17 2025-03-21 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 流体製品メーラーを提供する方法及びシステム
CA3264674A1 (en) 2022-09-02 2024-03-07 Intervet International B.V. TREATMENT OF FASCIOLOSIS
NO20240925A1 (en) 2023-09-15 2025-03-17 Evah Atlantic Inc Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2753377B1 (fr) 1996-09-19 1999-09-24 Rhone Merieux Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides
US6426333B1 (en) 1996-09-19 2002-07-30 Merial Spot-on formulations for combating parasites
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
JPS4914624A (me) 1972-06-08 1974-02-08
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US3818047A (en) 1972-08-07 1974-06-18 C Henrick Substituted pyrones
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
CH604517A5 (me) 1976-08-19 1978-09-15 Ciba Geigy Ag
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
DE3235931A1 (de) 1982-09-29 1984-03-29 Bayer Ag, 5090 Leverkusen Koeder zur bekaempfung von ungeziefer
JPS59199673A (ja) 1983-04-25 1984-11-12 Sumitomo Chem Co Ltd 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤
EP0179022B1 (de) 1984-10-18 1990-11-07 Ciba-Geigy Ag Benzoylphenylharnstoffe
DE3681465D1 (me) 1985-02-04 1991-10-24 Nihon Bayer Agrochem K.K., Tokio/Tokyo, Jp
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
ES2057027T3 (es) 1986-03-25 1994-10-16 Sankyo Co Un procedimiento para preparar un compuesto macrolido.
EP0252879B1 (de) 1986-07-02 1992-05-06 Ciba-Geigy Ag Pestizide
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
DE3888936T2 (de) 1987-11-03 1994-07-21 Beecham Group Plc Zwischenprodukte für die Herstellung makrolider Antibiotika mit anthelmintischer Wirkung.
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
IE904606A1 (en) 1989-12-21 1991-07-03 Beecham Group Plc Novel products
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
WO1992022555A1 (en) 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
JPH06247969A (ja) * 1992-12-28 1994-09-06 Takeda Chem Ind Ltd 縮合複素環化合物及びそれを含む農園芸用殺虫剤
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
DE19520613A1 (de) 1995-06-06 1996-12-12 Bayer Ag Phenylpyridazinone
TW334436B (en) 1995-07-21 1998-06-21 Upjohn Co Antiparasitic marcfortines and paraherquamides
FR2739255B1 (fr) 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
US5885607A (en) 1996-03-29 1999-03-23 Rhone Merieux N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs
FR2752525B1 (fr) 1996-08-20 2000-05-05 Rhone Merieux Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede
US6010710A (en) 1996-03-29 2000-01-04 Merial Direct pour-on skin solution for antiparasitic use in cattle and sheep
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US6998131B2 (en) 1996-09-19 2006-02-14 Merial Limited Spot-on formulations for combating parasites
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
DE19823396A1 (de) 1998-05-26 1999-12-02 Bayer Ag Synergistische insektizide Mischungen
WO2000006556A1 (en) * 1998-07-27 2000-02-10 Abbott Laboratories Substituted oxazolines as antiproliferative agents
US6228868B1 (en) * 1998-07-27 2001-05-08 Abbott Laboratories Oxazoline antiproliferative agents
US6174540B1 (en) 1998-09-14 2001-01-16 Merck & Co., Inc. Long acting injectable formulations containing hydrogenated caster oil
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
PE20011289A1 (es) 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
US6399786B1 (en) 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
US7001889B2 (en) 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
AR042420A1 (es) 2002-09-11 2005-06-22 Novartis Ag Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica
EP1572668A4 (en) 2002-12-18 2006-12-06 Fmc Corp N- (SUBSTITUTED ARYLMETHYL) -4- (DISUBSTITUTE-METHYL) PIPERIDINE AND PIPERAZINE
WO2004103991A1 (en) * 2003-05-20 2004-12-02 'chemical Diversity Research Institute', Ltd. 2-substituted piperidines, focused library and a pharmaceutical compound
DE10331675A1 (de) 2003-07-14 2005-02-10 Bayer Cropscience Ag Hetarylsubstituierte Pyrazolidindion-Derivate
ES2302038T3 (es) 2003-11-03 2008-07-01 Bayer Cropscience Ag Agente activo como herbicida.
CN102558082B (zh) * 2004-03-05 2015-09-30 日产化学工业株式会社 异噁唑啉取代苯甲酰胺化合物的制备中间体
CA2598489A1 (en) 2005-02-16 2006-08-24 Schering Corporation Piperazine-piperidines with cxcr3 antagonist activity
BRPI0617076B1 (pt) 2005-09-02 2021-07-06 Nissan Chemical Corporation Composto benzamida substituída por isoxazolina da fórmula (1) ou sal do mesmo; composto benzamida substituido por 4-hidroxiiminametila da fórmula (2) ou sal do mesmo; pesticida; agente agroquímico; parasiticida interno ou externo para mamíferos ou aves; inseticida ou acaricida
DE102005053680A1 (de) 2005-11-10 2007-05-16 Bayer Cropscience Ag Synergistische insektizide Mischungen zur Behandlung von Saatgut
JP2009519937A (ja) * 2005-12-14 2009-05-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 無脊椎有害生物防除用イソオキサゾリン
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) * 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
BRPI0707091B8 (pt) 2006-03-10 2018-02-14 Nissan Chemical Ind Ltd composto de isoxalina e benzaldoxima substituído ou um sal do mesmo; pesticida, agroquímico, endo- ou ecto-parasiticidapara mamíferos ou pássaros, inseticida e acaricida contendo como um ou mais ingredientes ativos selecionados a partir do composto de isoxalina substituído e o sal do mesmo
WO2007123855A2 (en) * 2006-04-20 2007-11-01 E. I. Du Pont De Nemours And Company Pyrazolines for controlling invertebrate pests
JPWO2007125984A1 (ja) 2006-04-28 2009-09-10 日本農薬株式会社 イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
JP5164525B2 (ja) 2006-11-01 2013-03-21 日本曹達株式会社 含窒素へテロ環化合物および有害生物防除剤
JP5206993B2 (ja) 2007-03-07 2013-06-12 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
JP5256753B2 (ja) 2007-03-29 2013-08-07 住友化学株式会社 イソオキサゾリン化合物とその有害生物防除用途
MY146638A (en) 2007-04-10 2012-09-14 Bayer Cropscience Ag Insecticidal aryl isoxazoline derivatives
WO2008130651A2 (en) 2007-04-20 2008-10-30 Dow Agrosciences Llc Diarylisoxazolines
JP2010116389A (ja) 2008-10-17 2010-05-27 Bayer Cropscience Ag 殺虫性アリールピロリジン類
JP2008266230A (ja) 2007-04-23 2008-11-06 Bayer Cropscience Ag 殺虫性アリールピロリジン類
TW200900398A (en) 2007-05-31 2009-01-01 Du Pont 3-cyano-4-triazolyl phenylisoxazoline invertebrate pest control agents
US8623875B2 (en) 2007-06-13 2014-01-07 E.I. Du Pont De Nemours And Company Isoxazoline insecticides
EP2171450B1 (en) 2007-06-22 2012-03-21 GENERA ISTRAZIVANJA d.o.o. Adamts4 as a blood biomarker and therapeutic target for chronic renal failure
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
WO2009001942A1 (ja) 2007-06-27 2008-12-31 Nissan Chemical Industries, Ltd. ３－ヒドロキシプロパン－１－オン化合物、２－プロペン－１－オン化合物およびイソキサゾリン化合物の製造方法
PT2957284T (pt) 2007-06-27 2018-04-23 Du Pont Método de controlo de pragas em animais
CN101686962B (zh) 2007-06-29 2012-05-23 辉瑞大药厂 驱虫药联合用药
JP4941133B2 (ja) 2007-07-03 2012-05-30 トヨタ自動車株式会社 車両用無段変速機の変速制御装置
CN101778833A (zh) * 2007-08-10 2010-07-14 日本曹达株式会社 含氮杂环化合物和有害生物防除剂
TWI600639B (zh) 2007-08-17 2017-10-01 杜邦股份有限公司 製備５-鹵烷基-４，５-二氫異唑衍生物之化合物
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
KR20100064382A (ko) 2007-09-10 2010-06-14 닛산 가가쿠 고교 가부시키 가이샤 치환 이속사졸린 화합물 및 유해생물 방제제
US8367584B2 (en) 2007-10-03 2013-02-05 E.I. Du Pont De Nemours And Company Naphthalene isoxazoline compounds for control of invertebrate pests
GB0720232D0 (en) 2007-10-16 2007-11-28 Syngenta Participations Ag Insecticidal compounds
WO2009051956A2 (en) 2007-10-16 2009-04-23 E. I. Du Pont De Nemours And Company Pyrazole-substituted isoxazoline insecticides
GB0720320D0 (en) 2007-10-17 2007-11-28 Syngenta Participations Ag Insecticidal compounds
JPWO2009072621A1 (ja) 2007-12-07 2011-04-28 日産化学工業株式会社 置換ジヒドロアゾール化合物及び有害生物防除剤
WO2009097992A1 (en) 2008-02-07 2009-08-13 Bayer Cropscience Ag Insecticidal arylpyrrolines
JP2009286773A (ja) 2008-03-14 2009-12-10 Bayer Cropscience Ag 殺虫性縮環式アリール類
TW201444787A (zh) 2008-04-09 2014-12-01 Du Pont 製備３-三氟甲基查耳酮（ｃｈａｌｃｏｎｅ）之方法
CA2725156A1 (en) 2008-05-23 2009-11-26 Coughlan Engineering (Tullamore) Ltd. Masonry support system and method
CN104844531A (zh) 2008-07-09 2015-08-19 日产化学工业株式会社 异*唑啉取代的苯甲酰胺化合物的制造方法
CN105294668A (zh) 2008-08-22 2016-02-03 先正达参股股份有限公司 杀虫化合物
BRPI0917369A2 (pt) 2008-08-22 2015-08-04 Syngenta Participations Ag Compostos inseticidas
WO2010027051A1 (ja) 2008-09-04 2010-03-11 日産化学工業株式会社 置換アセトフェノン化合物、その製造方法及び用途
JP2010083883A (ja) 2008-09-08 2010-04-15 Nissan Chem Ind Ltd イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
CA2747060A1 (en) 2008-12-18 2010-07-15 Novartis Ag Isoxazolines derivatives and their use as pesticide
ES2395704T3 (es) 2008-12-19 2013-02-14 Novartis Ag Derivados de isoxazolina y su uso como pesticida
AU2009331476B2 (en) 2008-12-23 2015-05-28 Basf Se Imine compounds for combating invertebrate pests
JP2010168367A (ja) 2008-12-25 2010-08-05 Nissan Chem Ind Ltd 置換イソキサゾリン化合物又は置換エノンオキシム化合物及び有害生物防除剤
BRPI1007310A2 (pt) 2009-01-22 2015-08-25 Syngenta Participations Ag Compostos inseticidas.
BRPI1007878A2 (pt) 2009-01-29 2015-09-01 Syngenta Participations Ag "compostos inseticidas"
JP5747440B2 (ja) 2009-02-06 2015-07-15 住友化学株式会社 ヒドラジド化合物及びその有害生物防除用途
JP2010235590A (ja) 2009-03-09 2010-10-21 Nissan Chem Ind Ltd 置換イソキサゾリン化合物及び有害生物防除剤
CN102365278B (zh) 2009-03-26 2015-05-06 先正达参股股份有限公司 杀虫化合物
US20120030841A1 (en) 2009-04-01 2012-02-02 Basf Se Isoxazoline compounds for combating invertebrate pests

Also Published As

Publication number Publication date
AU2010330843B2 (en) 2014-05-29
EA021522B9 (ru) 2016-08-31
WO2011075591A1 (en) 2011-06-23
KR101826977B1 (ko) 2018-02-07
BR112012014921A2 (pt) 2017-07-25
CN102741247A (zh) 2012-10-17
RU2549900C2 (ru) 2015-05-10
HRP20190892T1 (hr) 2019-07-12
SG181679A1 (en) 2012-07-30
RS54772B1 (sr) 2016-10-31
EA201200904A1 (ru) 2013-01-30
ES2894036T3 (es) 2022-02-11
US9776999B2 (en) 2017-10-03
MX336189B (es) 2016-01-11
CO6640203A2 (es) 2013-03-22
ME03475B (me) 2020-01-20
RS58691B1 (sr) 2019-06-28
US8980893B2 (en) 2015-03-17
PL2513104T3 (pl) 2016-08-31
EP2513104B1 (en) 2016-03-16
EA021522B1 (ru) 2015-07-30
CA2784122A1 (en) 2011-06-23
JP2013514978A (ja) 2013-05-02
PT3078664T (pt) 2019-05-31
BR112012014921B1 (pt) 2020-11-03
EP3078664B1 (en) 2019-02-20
EP3078664A1 (en) 2016-10-12
HUE043607T2 (hu) 2019-08-28
CN102741247B (zh) 2016-01-20
US20170022197A1 (en) 2017-01-26
AP2012006314A0 (en) 2012-06-30
EP2513104A1 (en) 2012-10-24
US20140315794A1 (en) 2014-10-23
UA108219C2 (uk) 2015-04-10
HRP20160677T1 (hr) 2016-07-15
NZ600922A (en) 2013-10-25
CL2012001655A1 (es) 2012-12-07
MY162636A (en) 2017-06-30
PT2513104E (pt) 2016-06-03
DK2513104T3 (en) 2016-04-11
IL220281A0 (en) 2012-07-31
SI2513104T1 (sl) 2016-07-29
DK3078664T3 (da) 2019-05-13
US20150183785A1 (en) 2015-07-02
HK1172612A1 (zh) 2013-04-26
SMT201600181B (it) 2016-08-31
US9376434B2 (en) 2016-06-28
AU2010330843A1 (en) 2012-07-19
PL3560923T3 (pl) 2021-12-27
IL220281A (en) 2015-09-24
EA201401222A1 (ru) 2015-10-30
KR101920201B1 (ko) 2018-11-21
TR201907244T4 (tr) 2019-06-21
CY1122240T1 (el) 2020-11-25
PL3078664T3 (pl) 2019-08-30
JP5844275B2 (ja) 2016-01-13
ES2569486T3 (es) 2016-05-11
KR20120104608A (ko) 2012-09-21
CA2784122C (en) 2017-10-31
MX384937B (es) 2025-03-14
IL240140A0 (en) 2015-09-24
US8618126B2 (en) 2013-12-31
KR20180015765A (ko) 2018-02-13
RU2549900C9 (ru) 2016-09-20
EP3560923B1 (en) 2021-05-05
MX2020001453A (es) 2021-07-29
RU2012130140A (ru) 2014-01-27
PH12012501220A1 (en) 2012-11-05
SI3078664T1 (sl) 2019-05-31
CR20120328A (es) 2012-08-16
US20110152312A1 (en) 2011-06-23
ZA201204370B (en) 2013-02-27
ES2727588T3 (es) 2019-10-17
EP3560923A1 (en) 2019-10-30
LT3078664T (lt) 2019-05-10
MX2012006926A (es) 2012-11-23
SMT201900263T1 (it) 2019-07-11
AP3106A (en) 2015-01-31
HUE029006T2 (en) 2017-02-28

Similar Documents

Publication Publication Date Title
ME02432B (me) Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže
US6010710A (en) Direct pour-on skin solution for antiparasitic use in cattle and sheep
JP2013514978A5 (me)
JP2016537415A5 (me)
HRP20250386T1 (hr) Derivati piperidinil-indola za upotrebu u liječenju c3 glomerulopatije
RU2014104501A (ru) Фунгицидная композиция и способ борьбы с болезнями растений
RU2018146743A (ru) Замещенные оксадиазолы для борьбы с фитопатогенными грибами
BRPI0516575A (pt) composições fungicidas sinergìsticas
RU2007128523A (ru) Бензамиды и композиции на их основе для использования в качестве фунгицидов
WO2007113327A3 (en) Fungicide n-cyclopropyl-sulfonylamide derivatives
NZ599312A (en) Plant disease controlling composition and method for controlling plant disease
UA95796C2 (ru) Производные n-циклопропил-бензиламида, способ их получения, фунгицидная композиция и способ борьбы с фитопатогенными грибами
UA109421C2 (uk) Фармацевтична композиція, яка містить ліганди сигма-рецептора
MX2010001004A (es) Derivados de n-cicloalquil-bencil-tiocarboxamida o n-cicloalquil-bencil-amidina-n´-sustituida como fungicidas.
MX2009013262A (es) Derivados de heterociclil-pirimidinil-amino fungicidas.
UA95819C2 (ru) Кристаллическая модификация iv фипронила, способ ее получения, применения, способы получения кристаллических модификаций v и i, пестицидная или паразитицидная композиция, способ контроля вредителей, способ защиты растения от заражения или нападения вредителей, способ защиты семян и способ лечения, контроля, предотвращения или защиты животных от заражения или инфекции паразитами
WO2007137874A3 (en) Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
BR112016023556A2 (pt) composto, composição agroquímica, método para controlar vegetação indesejada e uso de um composto
WO2009016218A3 (en) Fungicide n-cycloalkyl-n-bicyclic-carboxamide derivatives
MX378497B (es) Mezclas pesticidas que incluyen pirrolidindionas espiroheterociclicas.
US6797724B2 (en) Direct spot-on antiparasitic skin solution for domestic animals
NO20091766L (no) Spiro-piperidinderivater
BR112012027387A2 (pt) composição para controle de doenças de plantas e uso da mesma
ES2984588T3 (es) Composición para controlar los ácaros Mesostigmata
NO20092149L (no) Spiro-piperidinderivater