ME02432B - Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže - Google Patents

Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže

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Publication number
ME02432B
ME02432B MEP-2016-77A MEP7716A ME02432B ME 02432 B ME02432 B ME 02432B ME P7716 A MEP7716 A ME P7716A ME 02432 B ME02432 B ME 02432B
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Montenegro
Prior art keywords
alkyl
haloalkyl
hydrogen
compound according
independently hydrogen
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MEP-2016-77A
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German (de)
English (en)
French (fr)
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Hir De Falois Loic Patrick Le
Hyoung Lk Lee
Douglas Edward Wilkinson
Brent Christopher Beck
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Merial Inc
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Publication of ME02432B publication Critical patent/ME02432B/me

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (28)

1. Jedinjenje dihidroazola formule (I), ili njegovafarmaceutski ili poljoprivredno prihvatljiva so:u kome:R1je vodonik, halogen, -CN, ili alkil, haloalkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, halocikloalkil, alkilcikloalkil ili cikloalkilalkil,od kojih je svaki nesupstituisan ili supstituisan sa jednim ili više odhalogena, hidroksi, amino, alkil- ili di(alkil)amino, alkil, cikloalkil,haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi, haloalkoksi,alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-, R7C(O)-,R7R8NC(O)-, R7OC(O)-, R7C(O)O-, R7C(O)NR8-,-CN ili NO2;X jearil ili heteroaril, koji mogu biti nesupstituisani ili supstituisani sa jednimili više od halogen, hidroksi, amino, alkil- ili di(alkil)amino, alkil,cikloalkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi,haloalkoksi, alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-,R7C(O)-, R7R8NC(O)-, R7OC(O)-, R7C(O)O-,R7C(O)NR8-, -CN ili NO2;A1i A2 su nezavisno kiseonik, NR2 ili CR7R8;G jeG-1 ili G-2;B1,B2, B3, B4 i B5 su nezavisno N iliC-R9;Y je vodonik,halogen, -CN; ili Y je alkil, haloalkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, alkilcikloalkil, cikloalkilalkil, aril iliheterociklil ili heteroaril od kojih je svaki nesupstituisan ili supstituisansa jednim ili više od halogena, hidroksi, amino, alkil- ili di(alkil)amino,alkil, cikloalkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil,alkoksi, haloalkoksi, alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-,R7C(O)-, R7R8NC(O)-, R7OC(O)-, R7C(O)O-,R7C(O)NR8-, -CN ili -NO2; ili Y je Y-1, Y-2,Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10, Y-11, Y-12 ili Y-13;ili R2,R3 su nezavisno vodonik, alkil, haloalkil, tioalkil, alkiltioalkil,hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkenil, haloalkinil,cikloalkil, R10S(O)-, R10S(O)2-, R10C(O)-,R10C(S)-, R10R11NC(O)-, R10R11NC(S)-,R10OC(O)-;R4,R5 i R6 su nezavisno vodonik, alkil, haloalkil, tioalkil,alkiltioalkil, hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, aril ili heteroaril;R7i R8 su nezavisno vodonik, alkil, haloalkil, tioalkil,alkiltioalkil, hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkinil ilihaloalkinil;R9je vodonik, halogen, -CN ili alkil, haloalkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, halocikloalkil, alkilcikloalkil ili cikloalkilalkil,od kojih je svaki nesupstituisan ili supstituisan sa jednim ili više odhalogena, hidroksi, amino, alkil- ili di(alkil)amino, alkil, cikloalkil,haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi, haloalkoksi,alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-, R7C(O)-,R7R8NC(O)-, R7OC(O)-, R7C(O)O-, R7C(O)NR8-,-CN ili -NO2;R10,R11, R12 i R13 su svaki nezavisno vodonik,alkil, haloalkil, tioalkil, alkiltioalkil, hidroksialkil, alkoksialkil,alkenil, haloalkenil, alkinil ili haloalkinil; iliR10zajedno sa R11 formiraju =O, =S ili =NR2; iliR12zajedno sa R13 formiraju =O, =S ili =NR2;W je 0,S ili NR2;n je1-4; im je0,1 ili 2.
2. Jedinjenje prema patentnom zahtevu 1, naznačeno time što G je G-1.
3. Jedinjenje prema patentnom zahtevu 1, naznačeno time što G je G-2.
4. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-1; A1 je kiseonik; i X je izborno supstituisani aril.
5. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-2; A1 je kiseonik; i X je izborno supstituisani aril.
6. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: A1 je kiseonik; X je izborno supstituisani aril; R1 je vodonik, halogen, alkil ili haloalkil; i Y je Y-1, Y-2, Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10, Y-11, Y-12 ili Y-13.
7. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: A1 je kiseonik; X je aril; R1 je vodonik, alkil ili haloalkil; Y je Y-1, Y-2 Y-3, Y-4, Y-5 ili Y-6; i R2, R3 su nezavisno vodonik, alkil, haloalkil, tioalkil, alkiltioalkil.
8. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: A1 je kiseonik; X je izborno supstituisani aril; R1 je vodonik, halogen, alkil ili haloalkil; i Y je pirazolil ili triazolil.
9. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-1; B1, B2, B3, B4 i B5 su svaki C-R9; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4lalkoksi-C1-C4alkil ili C1-C4alkiltio-C4-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
10. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-2; B1 B2, B3, B4 i B5 su svaki C-R9; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4 alkoksi-C1-C4alkil ili C1-C4alkiltio-C1-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
11. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-1; B1, B2, B4 i B5 su svaki C-R9; B3 je N; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4 alkoksi-C1-C4alkil ili C1-C4alkiltio-C1-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
12. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-2; B2, B3, B4 i B5 su svaki C-R9; B1 je N; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4 alkoksi-C1-C4alkil ili C1-C4alkiltio-C1-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
13. Jedinjenje prema patentnom zahtevu 9 ili patentnom zahtevu 10, naznačeno time što: A2 je CH2; R9 je vodonik; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
14. Jedinjenje prema patentnom zahtevu 1 naznačeno time što R10 zajedno sa R11 formiraju =O.
15. Jedinjenje prema patentnom zahtevu 1 naznačeno time što R12 zajedno sa R13 formiraju =O.
16. Jedinjenje prema patentnom zahtevu 9 ili patentnom zahtevu 10, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
17. Jedinjenje prema patentnom zahtevu 9, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili =NR2; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil; i R3, R7 i R8 su vodonik.
18. Jedinjenje prema patentnom zahtevu 11 ili patentnom zahtevu 12, naznačeno time što: A2 je CH2; R9 je vodonik; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
19. Jedinjenje prema patentnom zahtevu 11 ili patentnom zahtevu 12, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
20. Jedinjenje prema patentnom zahtevu 11 ili patentnom zahtevu 12, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili =NR2; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil; i R3, R7 i R8 su vodonik.
21. Jedinjenje prema patentnom zahtevu 1 izabrano od sledećih: (Z)p B5 B4 B3 B2 B1 R15 R16 3,5-Cl2 C-H C-H C-H C-H N H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-H C-H N H CH2CF3 3,5-(CF3)2 C-H C-H C-H C-H N CH3 CH2CO2CH3 3,5-(CF3)2 C-H C-H C-H C-H N CH3 CH2CO2H 3,5-(CF3)2 C-H C-H C-H C-H N CH3 CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-H C-H N H CH2C(O)NHCH2CF3 3,5-(CH3)2 C-H C-H C-H C-H N H CH2CH2SCH3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3,5-(CH3)2 C-H C-H C-H C-H C-H H CH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3-Cl, 5-CF3 C-H C-H C-H C-H C-H H CH2CF3 3-Cl, 5-CF3 C-H C-H C-H C-H C-H H CH2CH2SCH3 3,5-Cl2 C-H C-H C-Me C-H C-Me H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-Me C-H C-Me H CH2CF3 3,5-Cl2 C-H C-H C-Me C-H C-Me H CH2CH2SCH3 3,5-(CH3)2 C-H C-H C-Me C-H C-Me H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-Me C-H C-Me H CH2CF3 3,5-(CH3)2 C-H C-H C-Me C-H C-Me H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H C-Me C-H C-Me H CH2C(O)NHCH2CF3 3-Cl,5-CF3 C-H C-H C-Me C-H C-Me H CH2CF3 3-Cl,5-CF3 C-H C-H C-Me C-H C-Me H CH2CH2SCH3
22. Jedinjenje prema patentnom zahtevu 1 izabrano od sledećih: <!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"> <v:stroke joinstyle="miter"/> <v:formulas> <v:f eqn="if lineDrawn pixelLineWidth 0"/> <v:f eqn="sum @0 1 0"/> <v:f eqn="sum 0 0 @1"/> <v:f eqn="prod @2 1 2"/> <v:f eqn="prod @3 21600 pixelWidth"/> <v:f eqn="prod @3 21600 pixelHeight"/> <v:f eqn="sum @0 0 1"/> <v:f eqn="prod @6 1 2"/> <v:f eqn="prod @7 21600 pixelWidth"/> <v:f eqn="sum @8 21600 0"/> <v:f eqn="prod @7 21600 pixelHeight"/> <v:f eqn="sum @10 21600 0"/> </v:formulas> <v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/> <o:lock v:ext="edit" aspectratio="t"/> </v:shapetype><v:shape id="Picture_x0020_8" o:spid="_x0000_i1025" type="#_x0000_t75" style='width:166.5pt;height:191.25pt;visibility:visible;mso-wrap-style:square'> <v:imagedata src="file:///C:\Users\User\AppData\Local\Temp\msohtmlclip1\01\clip_image001.emz" o:title=""/> </v:shape><![endif]--><!--[if !vml]--><!--[endif]--> (Z)p B5 B4 B3 B2 B1 R15 R16 3,5-Cl2 C-H C-H N C-H C-H H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H N C-H C-H H CH2CF3 3,5-Cl2 C-H C-H N C-H C-H H CH2CH2SCH3 3,5-(CF3)2 C-H C-H N C-H C-H H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H N C-H C-H H CH2CF3 3,5-(CF3)2 C-H C-H N C-H C-H H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H N C-H C-H H CH2C(O)NHCH2CF3 3-Cl,5-CF3 C-H C-H N C-H C-H H CH2CF3 3-Cl,5-CF3 C-H C-H N C-H C-H H CH2CH2SCH3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2CF3 3,5-(CH3)2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2CF3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2CH2SCH3
23. Kompozicija za upotrebu u tretmanu ili prevenciji parazitske infekcije ili infestacije kod životinje koja sadrži efikasnu količinu jedinjenja formule (I) prema patentnom zahtevu 1 u kombinaciji sa farmaceutski prihvatljivim nosačem.
24. Kompozicija za zaštitu kulturnih biljaka, biljaka, materijala za razmnožavanje biljaka ili materijala napravljenog od drveta, od štetočina, koja sadrži pesticidno efikasnu količinu jedinjenja formule (I) prema patentnom zahtevu 1 u kombinaciji sa poljoprivredno prihvatljivim nosačem ili razblaživačem.
25. Postupak za zaštitu kulturnih biljaka i rastućih biljaka od napada ili infestacije štetočinama životinja, koji sadrži dovođenje u kontakt biljke, ili zemljišta ili vode u kome/kojoj biljka raste, sa jedinjenjem formule (I) prema patrntnom zahtevu 1.
26. Postupak za prevenciju ili kontrolu infestacije štetočina životinja na lokusu, koji sadrži primenu pesticidno efikasne količine ili paraziticidno efikasne količine jedinjenja formule (I) prema patentnom zahtevu 1 na lokus; pri čemu lokus obuhvata ljudsko ili životinjsko telo.
27. Jedinjenje prema patentnom zahtevu 1 za upotrebu u tretmanu ili prevenciji parazitske infekcije ili infestacije kod životinje.
28. Upotreba jedinjenja prema patentnom zahtevu 1 u proizvodnji leka za tretman ili prevenciju parazitske infekcije ili infestacije kod životinje.
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Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2764422A1 (en) 2009-06-22 2010-12-29 Syngenta Participations Ag Insecticidal compounds
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
TW201200518A (en) 2010-03-10 2012-01-01 Kalypsys Inc Heterocyclic inhibitors of histamine receptors for the treatment of disease
JP2014028758A (ja) 2010-11-19 2014-02-13 Nissan Chem Ind Ltd 寄生虫及び衛生害虫防除剤
FI2658541T4 (fi) 2010-12-27 2026-03-12 Intervet Int Bv Paikallisesti rajoitetulle alueelle käytettävä glykofurolia käsittävä isoksatsoliiniformulaatio
EP2658542B2 (en) 2010-12-27 2025-06-04 Intervet International B.V. Topical localized isoxazoline formulation
WO2013039785A2 (en) 2011-09-12 2013-03-21 Kalypsys, Inc. Heterocyclic inhibitors of histamine receptors for the treatment of disease
JP6366102B2 (ja) 2011-09-12 2018-08-01 メリアル インコーポレイテッド イソオキサゾリン活性薬を含む殺寄生虫性組成物、その方法および使用
RS58370B1 (sr) * 2012-02-06 2019-03-29 Merial Inc Paraziticidne oralne veterinarske kompozicije koje sadrže sistemski delujuća aktivna sredstva, metodi i primene istih
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
WO2013150052A1 (en) 2012-04-04 2013-10-10 Intervet International B.V. Soft chewable pharmaceutical products
AU2013245478A1 (en) * 2012-11-01 2014-05-15 Sumitomo Chemical Company, Limited Method for administering agent for controlling ectoparasite to dog
CA2891926A1 (en) 2012-11-20 2014-05-30 Merial, Inc. Anthelmintic compounds and compositions and method of using thereof
US9532946B2 (en) 2012-11-20 2017-01-03 Intervet Inc. Manufacturing of semi-plastic pharmaceutical dosage units
AU2014214140B2 (en) 2013-02-06 2017-08-31 Vetoquinol Sa Halogen-substituted pyrazol derivatives as pest-control agents
US9371293B2 (en) 2013-10-25 2016-06-21 Sumitomo Chemical Company, Limited Isoxazoline compound composition
DK3063144T3 (da) 2013-11-01 2021-10-25 Boehringer Ingelheim Animal Health Usa Inc Antiparasitære og pesticid-isoxazolinforbindelser
CR20160311A (es) 2014-01-03 2016-08-16 Bayer Animal Health Gmbh Nuevas pirazolil-heteroarilamidas como agentes plaguicidas
NZ726251A (en) 2014-04-17 2017-11-24 Merial Inc Use of malononitrile compounds for protecting animals from parasites
JP6616786B2 (ja) 2014-05-19 2019-12-04 メリアル インコーポレイテッド 駆虫性化合物
CA2955153A1 (en) 2014-07-15 2016-01-21 Bayer Animal Health Gmbh Aryl-triazolyl pyridines as pest control agents
US10864193B2 (en) 2014-10-31 2020-12-15 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising fipronil at high concentrations
PY1609250A (es) * 2015-02-26 2018-03-01 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
WO2016164487A1 (en) * 2015-04-08 2016-10-13 Merial, Inc. Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
PT3298027T (pt) 2015-05-20 2022-01-26 Boehringer Ingelheim Animal Health Usa Inc Compostos depsipéptidos antelmínticos
CN104880428B (zh) * 2015-06-23 2016-07-06 山西振东安特生物制药有限公司 一种胶体果胶铋或含胶体果胶铋制剂中铋含量的测定方法
ES2920394T3 (es) 2015-06-23 2022-08-03 Intervet Int Bv Solución de isoxazolina que contiene vitamina E para usar con agua potable desinfectada
UY40429A (es) * 2016-02-24 2023-10-13 Boehringer Ingelheim Animal Health Usa Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2017195173A1 (en) 2016-05-12 2017-11-16 Verdesian Life Sciences, U.S., Llc Compositions for controlling enzyme-induced urea decomposition
US10779537B2 (en) 2016-10-13 2020-09-22 Nihon Nohyaku Co., Ltd. 1H-pyrrolopyridine compound, N-oxide thereof or salt thereof, agricultural and horticultural insecticide comprising the compound, and method for using the insecticide
WO2018071535A1 (en) 2016-10-14 2018-04-19 Merial, Inc. Pesticidal and parasiticidal vinyl isoxazoline compounds
CN110167921A (zh) 2016-11-16 2019-08-23 勃林格殷格翰动物保健美国公司 驱蠕虫缩肽化合物
JP7026415B2 (ja) 2017-03-28 2022-02-28 ヴェルデシアン ライフ サイエンシーズ，ユー．エス．，エルエルシー 酵素によって誘導される尿素分解を抑制するためのトリアリールメタン化合物
TWI683808B (zh) 2017-07-18 2020-02-01 德商菲尼克斯 Ｆｘｒ有限責任公司 含有胺或(硫)醯胺之lxr調節劑
WO2019036407A1 (en) 2017-08-14 2019-02-21 Merial, Inc. PYRAZOLE-ISOXAZOLINE COMPOUNDS WITH PESTICIDE AND PARASITICIDE ACTIVITY
FI3707128T3 (fi) 2017-11-07 2024-03-01 Intervet Int Bv Injektoitavia farmaseuttisia isoksatsoliinikoostumuksia ja niiden käyttö parasiitti-infestaatiota vastaan
AR113997A1 (es) 2017-12-21 2020-07-08 Intervet Int Bv Composiciones antiparasitarias para unción dorsal continua
KR20250044476A (ko) 2018-07-09 2025-03-31 베링거잉겔하임베트메디카게엠베하 구충성 헤테로시클릭 화합물
CN113260419A (zh) 2018-11-20 2021-08-13 勃林格殷格翰动物保健美国公司 吲唑基氰基乙基氨基化合物、其组合物、其制备方法和其使用方法
PE20220281A1 (es) 2019-03-19 2022-02-25 Boehringer Ingelheim Animal Health Usa Inc Compuestos de aza-benzotiofeno y aza-benzofurano como antihelminticos
TWI696911B (zh) 2019-04-15 2020-06-21 友達光電股份有限公司 顯示裝置
BR112022011046A2 (pt) 2019-12-16 2022-08-23 Intervet Int Bv Composição para controle de piolhos em avinos
WO2021122513A1 (en) 2019-12-16 2021-06-24 Intervet International B.V. Composition for lice control
WO2021122515A1 (en) 2019-12-16 2021-06-24 Intervet International B.V. Parasite control in ruminants
AU2021278871A1 (en) 2020-05-28 2023-01-19 Boehringer Ingelheim Animal Health USA Inc. Bi-modal release intra-ruminal capsule device and methods of use thereof
CN116249704B (zh) 2020-05-29 2025-12-16 勃林格殷格翰动物保健有限公司 驱虫用杂环化合物
CN111588698B (zh) * 2020-06-23 2022-06-24 南京大方生物工程有限公司 一种提高水溶性的氟苯尼考粉剂及其制备方法和应用
JP7724845B2 (ja) 2020-07-24 2025-08-18 エランコ・ユーエス・インコーポレイテッド イソオキサゾリン化合物及びその中間体を作製するための方法
AU2021335500A1 (en) 2020-09-04 2023-05-04 Elanco Us Inc. Palatable formulations
CA3205997A1 (en) 2020-12-21 2022-06-30 University Of Georgia Research Foundation Inc. Parasiticidal collar comprising isoxazoline compounds
US20240116854A1 (en) 2021-01-27 2024-04-11 Intervet Inc. Cyclopropylamide compounds against parasites in fish
JP7824305B2 (ja) 2021-01-27 2026-03-04 コルテバ アグリサイエンス エルエルシー 魚における寄生生物に対するシクロプロピルアミド化合物
CN113040136B (zh) * 2021-03-17 2022-05-06 湖南嘉诚农业科技有限公司 一种航空施药助剂及其制备方法和应用
IL309139A (en) 2021-06-11 2024-02-01 Intervet Int Bv Tick control methods
US20250248976A1 (en) 2021-06-25 2025-08-07 Intervet Inc. Palatable veterinary compositions
MX2024005264A (es) 2021-11-01 2024-05-14 Boehringer Ingelheim Vetmedica Gmbh Compuestos de pirrolopiridazina como antihelminticos.
CN118715163A (zh) 2022-02-17 2024-09-27 勃林格殷格翰动物保健有限公司 用于提供流体制品邮寄封的方法和系统
WO2024047241A1 (en) 2022-09-02 2024-03-07 Intervet International B.V. Treatment of fasciolosis
NO20240925A1 (en) 2023-09-15 2025-03-17 Evah Atlantic Inc Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish
WO2026041786A1 (en) 2024-08-23 2026-02-26 Intervet International B.V. Injectable veterinary composition and uses thereof

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2753377B1 (fr) 1996-09-19 1999-09-24 Rhone Merieux Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides
US6426333B1 (en) 1996-09-19 2002-07-30 Merial Spot-on formulations for combating parasites
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
JPS4914624A (me) 1972-06-08 1974-02-08
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US3818047A (en) 1972-08-07 1974-06-18 C Henrick Substituted pyrones
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
CH604517A5 (me) 1976-08-19 1978-09-15 Ciba Geigy Ag
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
DE3235931A1 (de) 1982-09-29 1984-03-29 Bayer Ag, 5090 Leverkusen Koeder zur bekaempfung von ungeziefer
JPS59199673A (ja) 1983-04-25 1984-11-12 Sumitomo Chem Co Ltd 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤
IL76708A (en) 1984-10-18 1990-01-18 Ciba Geigy Ag Substituted n-benzoyl-n'-(2,5-dichloro-4(1,1,2,3,3,3-hexafluoropropyloxy)-phenyl)ureas,their preparation and pesticidal compositions containing them
ATE67493T1 (de) 1985-02-04 1991-10-15 Bayer Agrochem Kk Heterocyclische verbindungen.
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
EP0246739B1 (en) 1986-03-25 1991-01-23 Sankyo Company Limited Macrolide compounds, their preparation and their use
EP0252879B1 (de) 1986-07-02 1992-05-06 Ciba-Geigy Ag Pestizide
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
DE3888936T2 (de) 1987-11-03 1994-07-21 Beecham Group Plc Zwischenprodukte für die Herstellung makrolider Antibiotika mit anthelmintischer Wirkung.
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
IE904606A1 (en) 1989-12-21 1991-07-03 Beecham Group Plc Novel products
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
WO1992022555A1 (en) 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
JPH06247969A (ja) * 1992-12-28 1994-09-06 Takeda Chem Ind Ltd 縮合複素環化合物及びそれを含む農園芸用殺虫剤
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
DE19520613A1 (de) 1995-06-06 1996-12-12 Bayer Ag Phenylpyridazinone
TW334436B (en) 1995-07-21 1998-06-21 Upjohn Co Antiparasitic marcfortines and paraherquamides
FR2739255B1 (fr) 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
US6010710A (en) 1996-03-29 2000-01-04 Merial Direct pour-on skin solution for antiparasitic use in cattle and sheep
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US5885607A (en) 1996-03-29 1999-03-23 Rhone Merieux N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs
FR2752525B1 (fr) 1996-08-20 2000-05-05 Rhone Merieux Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede
US6998131B2 (en) 1996-09-19 2006-02-14 Merial Limited Spot-on formulations for combating parasites
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
DE19823396A1 (de) 1998-05-26 1999-12-02 Bayer Ag Synergistische insektizide Mischungen
US6228868B1 (en) * 1998-07-27 2001-05-08 Abbott Laboratories Oxazoline antiproliferative agents
WO2000006556A1 (en) * 1998-07-27 2000-02-10 Abbott Laboratories Substituted oxazolines as antiproliferative agents
US6174540B1 (en) 1998-09-14 2001-01-16 Merck & Co., Inc. Long acting injectable formulations containing hydrogenated caster oil
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
PE20011289A1 (es) 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
US6399786B1 (en) 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
US7001889B2 (en) 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
AR042420A1 (es) 2002-09-11 2005-06-22 Novartis Ag Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica
JP2006516149A (ja) 2002-12-18 2006-06-22 エフ　エム　シー　コーポレーション Ｎ−（置換アリールメチル）−４−（二置換メチル）ピペリジン及びピリジン
WO2004103991A1 (en) * 2003-05-20 2004-12-02 'chemical Diversity Research Institute', Ltd. 2-substituted piperidines, focused library and a pharmaceutical compound
DE10331675A1 (de) 2003-07-14 2005-02-10 Bayer Cropscience Ag Hetarylsubstituierte Pyrazolidindion-Derivate
DK1681932T3 (da) 2003-11-03 2008-07-21 Bayer Cropscience Ag Herbicidt aktivt middel
CN101768129B (zh) * 2004-03-05 2012-05-23 日产化学工业株式会社 异*唑啉取代苯甲酰胺化合物的制备中间体
CN101189238A (zh) 2005-02-16 2008-05-28 先灵公司 具有cxcr3拮抗剂活性的哌嗪-哌啶
BRPI0617076B1 (pt) 2005-09-02 2021-07-06 Nissan Chemical Corporation Composto benzamida substituída por isoxazolina da fórmula (1) ou sal do mesmo; composto benzamida substituido por 4-hidroxiiminametila da fórmula (2) ou sal do mesmo; pesticida; agente agroquímico; parasiticida interno ou externo para mamíferos ou aves; inseticida ou acaricida
DE102005053680A1 (de) 2005-11-10 2007-05-16 Bayer Cropscience Ag Synergistische insektizide Mischungen zur Behandlung von Saatgut
US20090143410A1 (en) 2005-12-14 2009-06-04 Kanu Maganbhai Patel Isoxazolines for Controlling Invertebrate Pests
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) * 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
JP5152518B2 (ja) * 2006-03-10 2013-02-27 日産化学工業株式会社 置換イソキサゾリン化合物及び有害生物防除剤
BRPI0710403A2 (pt) 2006-04-20 2011-08-09 Du Pont composto composição, composição de controle, de pulverização, de isca, dispositivo de armadilha, métodos de controle, métodos de proteção, semente tratada, composição de proteção
JPWO2007125984A1 (ja) 2006-04-28 2009-09-10 日本農薬株式会社 イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
JP5164525B2 (ja) 2006-11-01 2013-03-21 日本曹達株式会社 含窒素へテロ環化合物および有害生物防除剤
JP5206993B2 (ja) 2007-03-07 2013-06-12 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
JP5256753B2 (ja) 2007-03-29 2013-08-07 住友化学株式会社 イソオキサゾリン化合物とその有害生物防除用途
EP2181100A2 (en) 2007-04-10 2010-05-05 Bayer CropScience AG Insecticidal aryl isoxazoline derivatives
WO2008130651A2 (en) 2007-04-20 2008-10-30 Dow Agrosciences Llc Diarylisoxazolines
JP2008266230A (ja) 2007-04-23 2008-11-06 Bayer Cropscience Ag 殺虫性アリールピロリジン類
JP2010116389A (ja) 2008-10-17 2010-05-27 Bayer Cropscience Ag 殺虫性アリールピロリジン類
TW200900398A (en) 2007-05-31 2009-01-01 Du Pont 3-cyano-4-triazolyl phenylisoxazoline invertebrate pest control agents
JP5473906B2 (ja) * 2007-06-13 2014-04-16 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー イソキサゾリン殺虫剤
US8263072B2 (en) 2007-06-22 2012-09-11 Genera Istrazivanja, d.o.o. ADAMTS4 as a blood biomarker and therapeutic target for chronic renal failure
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
EP2172462A4 (en) * 2007-06-27 2010-12-15 Nissan Chemical Ind Ltd METHOD FOR PRODUCING A 3-HYDROXYPROPAN-1-ON COMPOUND, METHOD FOR PRODUCING A 2-PROPENE-1-ON COMPOUND, AND METHOD FOR PRODUCING AN ISOXAZOLINE COMPOUND
NO2957284T3 (me) 2007-06-27 2018-06-16
US8440633B2 (en) 2007-06-29 2013-05-14 Ah Usa 42 Llc Anthelmintic combination
JP4941133B2 (ja) 2007-07-03 2012-05-30 トヨタ自動車株式会社 車両用無段変速機の変速制御装置
US8288393B2 (en) * 2007-08-10 2012-10-16 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and pest control agent
TWI649303B (zh) 2007-08-17 2019-02-01 杜邦股份有限公司 製備４-乙醯基-ｎ-〔２-側氧基-２-〔（２，２，２-三氟乙基）胺基〕乙基〕-１-萘甲醯胺之化合物及方法
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
WO2009035004A1 (ja) 2007-09-10 2009-03-19 Nissan Chemical Industries, Ltd. 置換イソキサゾリン化合物および有害生物防除剤
US8367584B2 (en) 2007-10-03 2013-02-05 E.I. Du Pont De Nemours And Company Naphthalene isoxazoline compounds for control of invertebrate pests
GB0720232D0 (en) 2007-10-16 2007-11-28 Syngenta Participations Ag Insecticidal compounds
WO2009051956A2 (en) 2007-10-16 2009-04-23 E. I. Du Pont De Nemours And Company Pyrazole-substituted isoxazoline insecticides
GB0720320D0 (en) 2007-10-17 2007-11-28 Syngenta Participations Ag Insecticidal compounds
WO2009072621A1 (ja) 2007-12-07 2009-06-11 Nissan Chemical Industries, Ltd. 置換ジヒドロアゾール化合物及び有害生物防除剤
WO2009097992A1 (en) 2008-02-07 2009-08-13 Bayer Cropscience Ag Insecticidal arylpyrrolines
JP2009286773A (ja) * 2008-03-14 2009-12-10 Bayer Cropscience Ag 殺虫性縮環式アリール類
TWI583664B (zh) 2008-04-09 2017-05-21 杜邦股份有限公司 羰基化合物及其製備方法
CA2725156A1 (en) 2008-05-23 2009-11-26 Coughlan Engineering (Tullamore) Ltd. Masonry support system and method
EP2308857B1 (en) 2008-07-09 2016-04-27 Nissan Chemical Industries, Ltd. Process for production of isoxazoline-substituted benzoic acid amide compound
US8822502B2 (en) 2008-08-22 2014-09-02 Syngenta Crop Protection Llc Insecticidal compounds
EP2331536B1 (en) 2008-08-22 2013-08-21 Syngenta Participations AG Insecticidal compounds
WO2010027051A1 (ja) 2008-09-04 2010-03-11 日産化学工業株式会社 置換アセトフェノン化合物、その製造方法及び用途
JP2010083883A (ja) 2008-09-08 2010-04-15 Nissan Chem Ind Ltd イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
ES2442342T3 (es) 2008-12-18 2014-02-11 Novartis Ag Derivados de las isoxazolinas y su uso como pesticida
AU2009327079B2 (en) 2008-12-19 2013-02-14 Elanco Tiergesundheit Ag Isoxazoline derivatives and their use as pesticide
KR20110098848A (ko) 2008-12-23 2011-09-01 바스프 에스이 무척추동물 해충을 퇴치하기 위한 이민 화합물
JP2010168367A (ja) 2008-12-25 2010-08-05 Nissan Chem Ind Ltd 置換イソキサゾリン化合物又は置換エノンオキシム化合物及び有害生物防除剤
US20110288089A1 (en) * 2009-01-22 2011-11-24 Syngenta Crop Protection Llc Insecticidal compounds
WO2010086225A1 (en) 2009-01-29 2010-08-05 Syngenta Participations Ag Insecticidal compounds
JP5747440B2 (ja) 2009-02-06 2015-07-15 住友化学株式会社 ヒドラジド化合物及びその有害生物防除用途
JP2010235590A (ja) 2009-03-09 2010-10-21 Nissan Chem Ind Ltd 置換イソキサゾリン化合物及び有害生物防除剤
EP2411384B1 (en) 2009-03-26 2013-01-30 Syngenta Participations AG Insecticidal compounds
WO2010112545A1 (en) 2009-04-01 2010-10-07 Basf Se Isoxazoline compounds for combating invertebrate pests

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