ME02432B - Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže - Google Patents

Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže

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Publication number
ME02432B
ME02432B MEP-2016-77A MEP7716A ME02432B ME 02432 B ME02432 B ME 02432B ME P7716 A MEP7716 A ME P7716A ME 02432 B ME02432 B ME 02432B
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Prior art keywords
alkyl
haloalkyl
hydrogen
compound according
independently hydrogen
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MEP-2016-77A
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German (de)
English (en)
French (fr)
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Hir De Falois Loic Patrick Le
Hyoung Lk Lee
Douglas Edward Wilkinson
Brent Christopher Beck
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Merial Inc
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Publication of ME02432B publication Critical patent/ME02432B/me

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (28)

1. Jedinjenje dihidroazola formule (I), ili njegovafarmaceutski ili poljoprivredno prihvatljiva so:u kome:R1je vodonik, halogen, -CN, ili alkil, haloalkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, halocikloalkil, alkilcikloalkil ili cikloalkilalkil,od kojih je svaki nesupstituisan ili supstituisan sa jednim ili više odhalogena, hidroksi, amino, alkil- ili di(alkil)amino, alkil, cikloalkil,haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi, haloalkoksi,alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-, R7C(O)-,R7R8NC(O)-, R7OC(O)-, R7C(O)O-, R7C(O)NR8-,-CN ili NO2;X jearil ili heteroaril, koji mogu biti nesupstituisani ili supstituisani sa jednimili više od halogen, hidroksi, amino, alkil- ili di(alkil)amino, alkil,cikloalkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi,haloalkoksi, alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-,R7C(O)-, R7R8NC(O)-, R7OC(O)-, R7C(O)O-,R7C(O)NR8-, -CN ili NO2;A1i A2 su nezavisno kiseonik, NR2 ili CR7R8;G jeG-1 ili G-2;B1,B2, B3, B4 i B5 su nezavisno N iliC-R9;Y je vodonik,halogen, -CN; ili Y je alkil, haloalkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, alkilcikloalkil, cikloalkilalkil, aril iliheterociklil ili heteroaril od kojih je svaki nesupstituisan ili supstituisansa jednim ili više od halogena, hidroksi, amino, alkil- ili di(alkil)amino,alkil, cikloalkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil,alkoksi, haloalkoksi, alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-,R7C(O)-, R7R8NC(O)-, R7OC(O)-, R7C(O)O-,R7C(O)NR8-, -CN ili -NO2; ili Y je Y-1, Y-2,Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10, Y-11, Y-12 ili Y-13;ili R2,R3 su nezavisno vodonik, alkil, haloalkil, tioalkil, alkiltioalkil,hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkenil, haloalkinil,cikloalkil, R10S(O)-, R10S(O)2-, R10C(O)-,R10C(S)-, R10R11NC(O)-, R10R11NC(S)-,R10OC(O)-;R4,R5 i R6 su nezavisno vodonik, alkil, haloalkil, tioalkil,alkiltioalkil, hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, aril ili heteroaril;R7i R8 su nezavisno vodonik, alkil, haloalkil, tioalkil,alkiltioalkil, hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkinil ilihaloalkinil;R9je vodonik, halogen, -CN ili alkil, haloalkil, alkenil, haloalkenil, alkinil,haloalkinil, cikloalkil, halocikloalkil, alkilcikloalkil ili cikloalkilalkil,od kojih je svaki nesupstituisan ili supstituisan sa jednim ili više odhalogena, hidroksi, amino, alkil- ili di(alkil)amino, alkil, cikloalkil,haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi, haloalkoksi,alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-, R7C(O)-,R7R8NC(O)-, R7OC(O)-, R7C(O)O-, R7C(O)NR8-,-CN ili -NO2;R10,R11, R12 i R13 su svaki nezavisno vodonik,alkil, haloalkil, tioalkil, alkiltioalkil, hidroksialkil, alkoksialkil,alkenil, haloalkenil, alkinil ili haloalkinil; iliR10zajedno sa R11 formiraju =O, =S ili =NR2; iliR12zajedno sa R13 formiraju =O, =S ili =NR2;W je 0,S ili NR2;n je1-4; im je0,1 ili 2.
2. Jedinjenje prema patentnom zahtevu 1, naznačeno time što G je G-1.
3. Jedinjenje prema patentnom zahtevu 1, naznačeno time što G je G-2.
4. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-1; A1 je kiseonik; i X je izborno supstituisani aril.
5. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-2; A1 je kiseonik; i X je izborno supstituisani aril.
6. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: A1 je kiseonik; X je izborno supstituisani aril; R1 je vodonik, halogen, alkil ili haloalkil; i Y je Y-1, Y-2, Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10, Y-11, Y-12 ili Y-13.
7. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: A1 je kiseonik; X je aril; R1 je vodonik, alkil ili haloalkil; Y je Y-1, Y-2 Y-3, Y-4, Y-5 ili Y-6; i R2, R3 su nezavisno vodonik, alkil, haloalkil, tioalkil, alkiltioalkil.
8. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: A1 je kiseonik; X je izborno supstituisani aril; R1 je vodonik, halogen, alkil ili haloalkil; i Y je pirazolil ili triazolil.
9. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-1; B1, B2, B3, B4 i B5 su svaki C-R9; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4lalkoksi-C1-C4alkil ili C1-C4alkiltio-C4-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
10. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-2; B1 B2, B3, B4 i B5 su svaki C-R9; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4 alkoksi-C1-C4alkil ili C1-C4alkiltio-C1-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
11. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-1; B1, B2, B4 i B5 su svaki C-R9; B3 je N; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4 alkoksi-C1-C4alkil ili C1-C4alkiltio-C1-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
12. Jedinjenje prema patentnom zahtevu 1, naznačeno time što: G je G-2; B2, B3, B4 i B5 su svaki C-R9; B1 je N; R1 je C1-C4alkil ili C1-C4haloalkil; X je fenil, koji može biti nesupstituisan ili supstituisan sa jednim ili više halogena, C1-C4alkil ili C1-C4haloalkil; A1 je kiseonik; A2 je CR7R8; Y je Y-1, Y-4, Y-5, Y-6; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil, C1-C4 alkoksi-C1-C4alkil ili C1-C4alkiltio-C1-C4alkil; i R3 i R9 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil.
13. Jedinjenje prema patentnom zahtevu 9 ili patentnom zahtevu 10, naznačeno time što: A2 je CH2; R9 je vodonik; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
14. Jedinjenje prema patentnom zahtevu 1 naznačeno time što R10 zajedno sa R11 formiraju =O.
15. Jedinjenje prema patentnom zahtevu 1 naznačeno time što R12 zajedno sa R13 formiraju =O.
16. Jedinjenje prema patentnom zahtevu 9 ili patentnom zahtevu 10, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
17. Jedinjenje prema patentnom zahtevu 9, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili =NR2; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil; i R3, R7 i R8 su vodonik.
18. Jedinjenje prema patentnom zahtevu 11 ili patentnom zahtevu 12, naznačeno time što: A2 je CH2; R9 je vodonik; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
19. Jedinjenje prema patentnom zahtevu 11 ili patentnom zahtevu 12, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil, C1-C4haloalkil; i R3, R7 i R8 su svaki vodonik.
20. Jedinjenje prema patentnom zahtevu 11 ili patentnom zahtevu 12, naznačeno time što: A2 je CH2; R9 je vodonik; R10 zajedno sa R11 formiraju =O, =S ili =NR2; R12 zajedno sa R13 formiraju =O, =S ili =NR2; R2 i R4 su nezavisno vodonik, C1-C4alkil ili C1-C4haloalkil; i R3, R7 i R8 su vodonik.
21. Jedinjenje prema patentnom zahtevu 1 izabrano od sledećih: (Z)p B5 B4 B3 B2 B1 R15 R16 3,5-Cl2 C-H C-H C-H C-H N H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-H C-H N H CH2CF3 3,5-(CF3)2 C-H C-H C-H C-H N CH3 CH2CO2CH3 3,5-(CF3)2 C-H C-H C-H C-H N CH3 CH2CO2H 3,5-(CF3)2 C-H C-H C-H C-H N CH3 CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-H C-H N H CH2C(O)NHCH2CF3 3,5-(CH3)2 C-H C-H C-H C-H N H CH2CH2SCH3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3,5-(CH3)2 C-H C-H C-H C-H C-H H CH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3-Cl, 5-CF3 C-H C-H C-H C-H C-H H CH2CF3 3-Cl, 5-CF3 C-H C-H C-H C-H C-H H CH2CH2SCH3 3,5-Cl2 C-H C-H C-Me C-H C-Me H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-Me C-H C-Me H CH2CF3 3,5-Cl2 C-H C-H C-Me C-H C-Me H CH2CH2SCH3 3,5-(CH3)2 C-H C-H C-Me C-H C-Me H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-Me C-H C-Me H CH2CF3 3,5-(CH3)2 C-H C-H C-Me C-H C-Me H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H C-Me C-H C-Me H CH2C(O)NHCH2CF3 3-Cl,5-CF3 C-H C-H C-Me C-H C-Me H CH2CF3 3-Cl,5-CF3 C-H C-H C-Me C-H C-Me H CH2CH2SCH3
22. Jedinjenje prema patentnom zahtevu 1 izabrano od sledećih: <!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"> <v:stroke joinstyle="miter"/> <v:formulas> <v:f eqn="if lineDrawn pixelLineWidth 0"/> <v:f eqn="sum @0 1 0"/> <v:f eqn="sum 0 0 @1"/> <v:f eqn="prod @2 1 2"/> <v:f eqn="prod @3 21600 pixelWidth"/> <v:f eqn="prod @3 21600 pixelHeight"/> <v:f eqn="sum @0 0 1"/> <v:f eqn="prod @6 1 2"/> <v:f eqn="prod @7 21600 pixelWidth"/> <v:f eqn="sum @8 21600 0"/> <v:f eqn="prod @7 21600 pixelHeight"/> <v:f eqn="sum @10 21600 0"/> </v:formulas> <v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/> <o:lock v:ext="edit" aspectratio="t"/> </v:shapetype><v:shape id="Picture_x0020_8" o:spid="_x0000_i1025" type="#_x0000_t75" style='width:166.5pt;height:191.25pt;visibility:visible;mso-wrap-style:square'> <v:imagedata src="file:///C:\Users\User\AppData\Local\Temp\msohtmlclip1\01\clip_image001.emz" o:title=""/> </v:shape><![endif]--><!--[if !vml]--><!--[endif]--> (Z)p B5 B4 B3 B2 B1 R15 R16 3,5-Cl2 C-H C-H N C-H C-H H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H N C-H C-H H CH2CF3 3,5-Cl2 C-H C-H N C-H C-H H CH2CH2SCH3 3,5-(CF3)2 C-H C-H N C-H C-H H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H N C-H C-H H CH2CF3 3,5-(CF3)2 C-H C-H N C-H C-H H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H N C-H C-H H CH2C(O)NHCH2CF3 3-Cl,5-CF3 C-H C-H N C-H C-H H CH2CF3 3-Cl,5-CF3 C-H C-H N C-H C-H H CH2CH2SCH3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CF3 3,5-Cl2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3,5-(CF3)2 C-H C-H C-H C-H C-H H CH2CF3 3,5-(CH3)2 C-H C-H C-H C-H C-H H CH2CH2SCH3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2C(O)NHCH2CF3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2CF3 3-Cl,5-CF3 C-H C-H C-H C-H C-H H CH2CH2SCH3
23. Kompozicija za upotrebu u tretmanu ili prevenciji parazitske infekcije ili infestacije kod životinje koja sadrži efikasnu količinu jedinjenja formule (I) prema patentnom zahtevu 1 u kombinaciji sa farmaceutski prihvatljivim nosačem.
24. Kompozicija za zaštitu kulturnih biljaka, biljaka, materijala za razmnožavanje biljaka ili materijala napravljenog od drveta, od štetočina, koja sadrži pesticidno efikasnu količinu jedinjenja formule (I) prema patentnom zahtevu 1 u kombinaciji sa poljoprivredno prihvatljivim nosačem ili razblaživačem.
25. Postupak za zaštitu kulturnih biljaka i rastućih biljaka od napada ili infestacije štetočinama životinja, koji sadrži dovođenje u kontakt biljke, ili zemljišta ili vode u kome/kojoj biljka raste, sa jedinjenjem formule (I) prema patrntnom zahtevu 1.
26. Postupak za prevenciju ili kontrolu infestacije štetočina životinja na lokusu, koji sadrži primenu pesticidno efikasne količine ili paraziticidno efikasne količine jedinjenja formule (I) prema patentnom zahtevu 1 na lokus; pri čemu lokus obuhvata ljudsko ili životinjsko telo.
27. Jedinjenje prema patentnom zahtevu 1 za upotrebu u tretmanu ili prevenciji parazitske infekcije ili infestacije kod životinje.
28. Upotreba jedinjenja prema patentnom zahtevu 1 u proizvodnji leka za tretman ili prevenciju parazitske infekcije ili infestacije kod životinje.
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