HRP20190892T1 - Antiparazitni sastavi dihidroazola - Google Patents
Antiparazitni sastavi dihidroazola Download PDFInfo
- Publication number
- HRP20190892T1 HRP20190892T1 HRP20190892TT HRP20190892T HRP20190892T1 HR P20190892 T1 HRP20190892 T1 HR P20190892T1 HR P20190892T T HRP20190892T T HR P20190892TT HR P20190892 T HRP20190892 T HR P20190892T HR P20190892 T1 HRP20190892 T1 HR P20190892T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- veterinary
- composition according
- haloalkyl
- agricultural composition
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims 43
- 230000002141 anti-parasite Effects 0.000 title 1
- 239000003096 antiparasitic agent Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 29
- 239000001257 hydrogen Substances 0.000 claims 29
- 150000002431 hydrogen Chemical group 0.000 claims 21
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 125000001188 haloalkyl group Chemical group 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical group 0.000 claims 13
- 125000000232 haloalkynyl group Chemical group 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 11
- 125000000304 alkynyl group Chemical group 0.000 claims 11
- 125000000262 haloalkenyl group Chemical group 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 239000013543 active substance Substances 0.000 claims 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- -1 hydroxy, amino Chemical group 0.000 claims 9
- 239000001301 oxygen Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 238000009472 formulation Methods 0.000 claims 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- SHENXRCDBJGWNU-GOSISDBHSA-N 6-(1,3-benzothiazol-6-ylamino)-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide Chemical compound CC(C)(O)[C@H](F)CNC(=O)C1=CN=C(NC=2C=C3SC=NC3=CC=2)C=C1NC1CC1 SHENXRCDBJGWNU-GOSISDBHSA-N 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 125000004995 haloalkylthio group Chemical group 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 125000004001 thioalkyl group Chemical group 0.000 claims 4
- 239000005660 Abamectin Substances 0.000 claims 3
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 108010002156 Depsipeptides Proteins 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000001679 anti-nematodal effect Effects 0.000 claims 2
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical group C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims 2
- 239000003630 growth substance Substances 0.000 claims 2
- 125000005347 halocycloalkyl group Chemical group 0.000 claims 2
- 150000002596 lactones Chemical class 0.000 claims 2
- FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 claims 2
- 102220315634 rs1196125127 Human genes 0.000 claims 2
- 102200160920 rs35304565 Human genes 0.000 claims 2
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 2
- LMUVYJCAFWGNSY-VIFPVBQESA-N (3s)-5-(2-chlorophenyl)-3-methyl-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(C=C11)[N+]([O-])=O)=O)C)=C1C1=CC=CC=C1Cl LMUVYJCAFWGNSY-VIFPVBQESA-N 0.000 claims 1
- OTPDWCMLUKMQNO-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrimidine Chemical compound C1NCC=CN1 OTPDWCMLUKMQNO-UHFFFAOYSA-N 0.000 claims 1
- LAOOXBLMIJHMFO-UHFFFAOYSA-N 1-[2-(diethylamino)ethylamino]-4-methylthioxanthen-9-one;hydron;chloride Chemical compound Cl.S1C2=CC=CC=C2C(=O)C2=C1C(C)=CC=C2NCCN(CC)CC LAOOXBLMIJHMFO-UHFFFAOYSA-N 0.000 claims 1
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 1
- FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 claims 1
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims 1
- UMZCLZPXPCNKML-UHFFFAOYSA-N 2h-imidazo[4,5-d][1,3]thiazole Chemical compound C1=NC2=NCSC2=N1 UMZCLZPXPCNKML-UHFFFAOYSA-N 0.000 claims 1
- QOVTVIYTBRHADL-UHFFFAOYSA-N 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide Chemical compound NC1=CC(C(Cl)=C(Cl)Cl)=C(S(N)(=O)=O)C=C1S(N)(=O)=O QOVTVIYTBRHADL-UHFFFAOYSA-N 0.000 claims 1
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 claims 1
- NQPDXQQQCQDHHW-UHFFFAOYSA-N 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole Chemical compound ClC=1C=C2NC(SC)=NC2=CC=1OC1=CC=CC(Cl)=C1Cl NQPDXQQQCQDHHW-UHFFFAOYSA-N 0.000 claims 1
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims 1
- 239000005891 Cyromazine Substances 0.000 claims 1
- 239000005894 Emamectin Substances 0.000 claims 1
- MBYXEBXZARTUSS-QLWBXOBMSA-N Emetamine Natural products O(C)c1c(OC)cc2c(c(C[C@@H]3[C@H](CC)CN4[C@H](c5c(cc(OC)c(OC)c5)CC4)C3)ncc2)c1 MBYXEBXZARTUSS-QLWBXOBMSA-N 0.000 claims 1
- PNKUSGQVOMIXLU-UHFFFAOYSA-N Formamidine Chemical class NC=N PNKUSGQVOMIXLU-UHFFFAOYSA-N 0.000 claims 1
- 239000005912 Lufenuron Substances 0.000 claims 1
- 239000005918 Milbemectin Substances 0.000 claims 1
- BWCRYQGQPDBOAU-UHFFFAOYSA-N Milbemycin D Natural products C1CC(C)C(C(C)C)OC21OC(CC=C(C)CC(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 BWCRYQGQPDBOAU-UHFFFAOYSA-N 0.000 claims 1
- PYCSFZRHAYWHQB-UHFFFAOYSA-N Mirasan Chemical compound CCN(CC)CCNC1=CC=C(C)C(Cl)=C1 PYCSFZRHAYWHQB-UHFFFAOYSA-N 0.000 claims 1
- RDXLYGJSWZYTFJ-UHFFFAOYSA-N Niridazole Chemical compound S1C([N+](=O)[O-])=CN=C1N1C(=O)NCC1 RDXLYGJSWZYTFJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005927 Pyriproxyfen Substances 0.000 claims 1
- AUVVAXYIELKVAI-UHFFFAOYSA-N SJ000285215 Natural products N1CCC2=CC(OC)=C(OC)C=C2C1CC1CC2C3=CC(OC)=C(OC)C=C3CCN2CC1CC AUVVAXYIELKVAI-UHFFFAOYSA-N 0.000 claims 1
- VAKIESMDOCVMDV-HNNXBMFYSA-N Spinosine Chemical group C1C2=CC(O)=C(O)C=C2C[C@@H]2N1CCC1=C2C=C(OC)C(OC)=C1 VAKIESMDOCVMDV-HNNXBMFYSA-N 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- ICKMASVVMCGZLR-UHFFFAOYSA-N [2-[(4-chlorophenyl)carbamoyl]-4,6-diiodophenyl] acetate Chemical compound CC(=O)OC1=C(I)C=C(I)C=C1C(=O)NC1=CC=C(Cl)C=C1 ICKMASVVMCGZLR-UHFFFAOYSA-N 0.000 claims 1
- NRFGEDASJHBPPN-UHFFFAOYSA-N [2-bromo-6-[(4-bromophenyl)carbamothioyl]-4-chlorophenyl] acetate Chemical compound CC(=O)OC1=C(Br)C=C(Cl)C=C1C(=S)NC1=CC=C(Br)C=C1 NRFGEDASJHBPPN-UHFFFAOYSA-N 0.000 claims 1
- 229950008167 abamectin Drugs 0.000 claims 1
- DFNYGALUNNFWKJ-UHFFFAOYSA-N aminoacetonitrile Chemical group NCC#N DFNYGALUNNFWKJ-UHFFFAOYSA-N 0.000 claims 1
- DKVNAGXPRSYHLB-UHFFFAOYSA-N amoscanate Chemical compound C1=CC([N+](=O)[O-])=CC=C1NC1=CC=C(N=C=S)C=C1 DKVNAGXPRSYHLB-UHFFFAOYSA-N 0.000 claims 1
- 229950008286 amoscanate Drugs 0.000 claims 1
- VEMKTZHHVJILDY-UXHICEINSA-N bioresmethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-UXHICEINSA-N 0.000 claims 1
- 229960002326 bithionol Drugs 0.000 claims 1
- JFIOVJDNOJYLKP-UHFFFAOYSA-N bithionol Chemical compound OC1=C(Cl)C=C(Cl)C=C1SC1=CC(Cl)=CC(Cl)=C1O JFIOVJDNOJYLKP-UHFFFAOYSA-N 0.000 claims 1
- 229950009518 bromoxanide Drugs 0.000 claims 1
- 229950005372 brotianide Drugs 0.000 claims 1
- 229950010946 clioxanide Drugs 0.000 claims 1
- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 claims 1
- 229960003120 clonazepam Drugs 0.000 claims 1
- 229960000275 clorsulon Drugs 0.000 claims 1
- LVQDKIWDGQRHTE-UHFFFAOYSA-N cyromazine Chemical compound NC1=NC(N)=NC(NC2CC2)=N1 LVQDKIWDGQRHTE-UHFFFAOYSA-N 0.000 claims 1
- 229950000775 cyromazine Drugs 0.000 claims 1
- 229950010198 diamfenetide Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- CMZOLQQGUABKKN-STGYROPVSA-N dimadectin Chemical compound O([C@H]1C[C@@H](C2)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C\C=C/[C@H](C)[C@@H](C(=C/C1)\C)OCOCCOC)[C@]12CC[C@H](C)[C@@H](C(C)C)O1 CMZOLQQGUABKKN-STGYROPVSA-N 0.000 claims 1
- 229950004439 dimadectin Drugs 0.000 claims 1
- QLFZZSKTJWDQOS-YDBLARSUSA-N doramectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C3CCCCC3)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C QLFZZSKTJWDQOS-YDBLARSUSA-N 0.000 claims 1
- 229960003997 doramectin Drugs 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 claims 1
- AUVVAXYIELKVAI-CKBKHPSWSA-N emetine Chemical compound N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@@H]1CC AUVVAXYIELKVAI-CKBKHPSWSA-N 0.000 claims 1
- 229960002694 emetine Drugs 0.000 claims 1
- AUVVAXYIELKVAI-UWBTVBNJSA-N emetine Natural products N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@H]1CC AUVVAXYIELKVAI-UWBTVBNJSA-N 0.000 claims 1
- 108010056417 emodepside Proteins 0.000 claims 1
- ZMQMTKVVAMWKNY-YSXLEBCMSA-N emodepside Chemical group C([C@@H]1C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@H](C(O[C@H](CC=2C=CC(=CC=2)N2CCOCC2)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O1)=O)CC(C)C)C(C=C1)=CC=C1N1CCOCC1 ZMQMTKVVAMWKNY-YSXLEBCMSA-N 0.000 claims 1
- 229960001575 emodepside Drugs 0.000 claims 1
- WPNHOHPRXXCPRA-TVXIRPTOSA-N eprinomectin Chemical compound O1[C@@H](C)[C@@H](NC(C)=O)[C@H](OC)C[C@@H]1O[C@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C\C=C/[C@@H]2C)\C)O[C@H]1C WPNHOHPRXXCPRA-TVXIRPTOSA-N 0.000 claims 1
- 229960002346 eprinomectin Drugs 0.000 claims 1
- YOWNVPAUWYHLQX-UHFFFAOYSA-N fluazuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(Cl)C(OC=2C(=CC(=CN=2)C(F)(F)F)Cl)=C1 YOWNVPAUWYHLQX-UHFFFAOYSA-N 0.000 claims 1
- 229950006719 fluazuron Drugs 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 claims 1
- 229960004068 hexachlorophene Drugs 0.000 claims 1
- FYQGBXGJFWXIPP-UHFFFAOYSA-N hydroprene Chemical compound CCOC(=O)C=C(C)C=CCC(C)CCCC(C)C FYQGBXGJFWXIPP-UHFFFAOYSA-N 0.000 claims 1
- 229930000073 hydroprene Natural products 0.000 claims 1
- HICUREFSAIZXFQ-JOWPUVSESA-N i9z29i000j Chemical compound C1C[C@H](C)[C@@H](CC)O[C@@]21O[C@H](C\C=C(C)\[C@H](OC(=O)C(=N/OC)\C=1C=CC=CC=1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 HICUREFSAIZXFQ-JOWPUVSESA-N 0.000 claims 1
- 239000007972 injectable composition Substances 0.000 claims 1
- 125000003971 isoxazolinyl group Chemical group 0.000 claims 1
- 229960002418 ivermectin Drugs 0.000 claims 1
- 229950000961 latidectin Drugs 0.000 claims 1
- PWPJGUXAGUPAHP-UHFFFAOYSA-N lufenuron Chemical compound C1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=CC(Cl)=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F PWPJGUXAGUPAHP-UHFFFAOYSA-N 0.000 claims 1
- 229960000521 lufenuron Drugs 0.000 claims 1
- 229950002184 meclonazepam Drugs 0.000 claims 1
- 229930002897 methoprene Natural products 0.000 claims 1
- 229950003442 methoprene Drugs 0.000 claims 1
- ZLBGSRMUSVULIE-GSMJGMFJSA-N milbemycin A3 Chemical compound O1[C@H](C)[C@@H](C)CC[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 ZLBGSRMUSVULIE-GSMJGMFJSA-N 0.000 claims 1
- BWCRYQGQPDBOAU-WZBVPYLGSA-N milbemycin D Chemical compound C1C[C@H](C)[C@@H](C(C)C)O[C@@]21O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 BWCRYQGQPDBOAU-WZBVPYLGSA-N 0.000 claims 1
- YZBLFMPOMVTDJY-CBYMMZEQSA-N moxidectin Chemical compound O1[C@H](C(\C)=C\C(C)C)[C@@H](C)C(=N/OC)\C[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 YZBLFMPOMVTDJY-CBYMMZEQSA-N 0.000 claims 1
- 229960004816 moxidectin Drugs 0.000 claims 1
- JNEZCZPNQCQCFK-UHFFFAOYSA-N n-[4-[2-[2-(4-acetamidophenoxy)ethoxy]ethoxy]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1OCCOCCOC1=CC=C(NC(C)=O)C=C1 JNEZCZPNQCQCFK-UHFFFAOYSA-N 0.000 claims 1
- WRPRKPMHLLGGIZ-UHFFFAOYSA-N n-[4-bromo-2-(trifluoromethyl)phenyl]-3-tert-butyl-2-hydroxy-6-methyl-5-nitrobenzamide Chemical compound CC1=C([N+]([O-])=O)C=C(C(C)(C)C)C(O)=C1C(=O)NC1=CC=C(Br)C=C1C(F)(F)F WRPRKPMHLLGGIZ-UHFFFAOYSA-N 0.000 claims 1
- YNFMRVVYUVPIAN-AQUURSMBSA-N nemadectin Chemical compound C1[C@H](O)[C@H](C)[C@@H](C(/C)=C/C(C)C)O[C@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 YNFMRVVYUVPIAN-AQUURSMBSA-N 0.000 claims 1
- 229950009729 nemadectin Drugs 0.000 claims 1
- YNFMRVVYUVPIAN-UHFFFAOYSA-N nemadectin alpha Natural products C1C(O)C(C)C(C(C)=CC(C)C)OC11OC(CC=C(C)CC(C)C=CC=C2C3(C(C(=O)O4)C=C(C)C(O)C3OC2)O)CC4C1 YNFMRVVYUVPIAN-UHFFFAOYSA-N 0.000 claims 1
- 229960005130 niridazole Drugs 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- CKNAQFVBEHDJQV-UHFFFAOYSA-N oltipraz Chemical compound S1SC(=S)C(C)=C1C1=CN=CC=N1 CKNAQFVBEHDJQV-UHFFFAOYSA-N 0.000 claims 1
- 229950008687 oltipraz Drugs 0.000 claims 1
- 229930188716 paraherquamide Natural products 0.000 claims 1
- UVZZDDLIOJPDKX-ITKQZBBDSA-N paraherquamide Chemical group O1C(C)(C)C=COC2=C1C=CC1=C2NC(=O)[C@]11C(C)(C)[C@@H]2C[C@]3(N(C4)CC[C@@]3(C)O)C(=O)N(C)[C@]42C1 UVZZDDLIOJPDKX-ITKQZBBDSA-N 0.000 claims 1
- UVZZDDLIOJPDKX-UHFFFAOYSA-N paraherquamide A Natural products O1C(C)(C)C=COC2=C1C=CC1=C2NC(=O)C11C(C)(C)C2CC3(N(C4)CCC3(C)O)C(=O)N(C)C42C1 UVZZDDLIOJPDKX-UHFFFAOYSA-N 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 239000004540 pour-on Substances 0.000 claims 1
- 229960002957 praziquantel Drugs 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 1
- NHDHVHZZCFYRSB-UHFFFAOYSA-N pyriproxyfen Chemical compound C=1C=CC=NC=1OC(C)COC(C=C1)=CC=C1OC1=CC=CC=C1 NHDHVHZZCFYRSB-UHFFFAOYSA-N 0.000 claims 1
- NEMNPWINWMHUMR-UHFFFAOYSA-N rafoxanide Chemical compound OC1=C(I)C=C(I)C=C1C(=O)NC(C=C1Cl)=CC=C1OC1=CC=C(Cl)C=C1 NEMNPWINWMHUMR-UHFFFAOYSA-N 0.000 claims 1
- 229950002980 rafoxanide Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- AFJYYKSVHJGXSN-KAJWKRCWSA-N selamectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1C(/C)=C/C[C@@H](O[C@]2(O[C@@H]([C@@H](C)CC2)C2CCCCC2)C2)C[C@@H]2OC(=O)[C@@H]([C@]23O)C=C(C)C(=N\O)/[C@H]3OC\C2=C/C=C/[C@@H]1C AFJYYKSVHJGXSN-KAJWKRCWSA-N 0.000 claims 1
- 229960002245 selamectin Drugs 0.000 claims 1
- 239000004544 spot-on Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000007916 tablet composition Substances 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- KVSKGMLNBAPGKH-UHFFFAOYSA-N tribromosalicylanilide Chemical compound OC1=C(Br)C=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 KVSKGMLNBAPGKH-UHFFFAOYSA-N 0.000 claims 1
- 229950001807 tribromsalan Drugs 0.000 claims 1
- 229960000323 triclabendazole Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Claims (36)
1. Veterinarski ili agrikulturni sastav za suzbijanje štetnika i parazita, naznačen time, da obuhvaća sljedeće:
(a) spoj dihidroazola formule (I), ili njegovu veterinarski ili agrikulturno prihvatljivu sol:
u kojoj:
R1 je vodik, halogen, -CN, ili alkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, cikloalkil, halocikloalkil, alkilcikloalkil ili cikloalkilalkil, od kojih je svaki nesupstituiran ili supstituiran s jednim ili više od sljedećih: halogen, hidroksi, amino, alkil- ili di(alkil)amino, alkil, cikloalkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi, haloalkoksi, alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-, R7C(O)-, R7R8NC(O)-, R7OC(O)-, R7C(O)O-, R7C(O)NR8-, -CN ili -NO2;
X je aril ili heteroaril koji može biti nesupstituiran ili supstituiran s jednim ili više od sljedećih: halogen, hidroksi, amino, alkil- ili di(alkil)amino, alkil, cikloalkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi, haloalkoksi, alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-, R7C(O)-, R7R8NC(O)-, R7OC(O)-, R7C(O)O-, R7C(O)NR8-, -CN ili
-NO2;
A1 i A2 su neovisno kisik, NR2 ili CR7R8;
G je G-1 ili G-2;
B1, B2, B3, B4 i B5 su neovisno N ili C-R9;
Y je vodik, halogen, -CN; ili Y je alkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, haloalkinil, cikloalkil, alkilcikloalkil, cikloalkilalkil, aril, ili heterociklil ili heteroaril od kojih je svaki nesupstituiran ili supstituiran s jednim ili više od sljedećih: halogen, hidroksi, amino, alkil- ili di(alkil)amino, alkil, cikloalkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi, haloalkoksi, alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-, R7C(O)-, R7R8NC(O)-, R7OC(O)-, R7C(O)O-, R7C(O)NR8-, -CN ili -NO2; ili
Y je Y-1, Y-2, Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10, Y-11, Y-12 ili Y-13;
R2, R3 su neovisno vodik, alkil, haloalkil, tioalkil, alkiltioalkil, hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkinil, haloalkinil, cikloalkil, R10S(O)-, R10S(O)2-, R10C(O)-, R10C(S)-, R10R11NC(O)-, ili R10R11NC(S)-R10OC(O)-;
R4, R5 i R6 su neovisno vodik, alkil, haloalkil, tioalkil, alkiltioalkil, hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkinil, haloalkinil, cikloalkil, aril ili heteroaril;
R7 i R8 su neovisno vodik, alkil, haloalkil, tioalkil, alkiltioalkil, hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkinil, haloalkinil;
R9 je vodik, halogen, -CN, ili alkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, cikloalkil, halocikloalkil, alkilcikloalkil ili cikloalkilalkil, od kojih je svaki nesupstituiran ili supstituiran s jednim ili više od sljedećih: halogen, hidroksi, amino, alkil- ili di(alkil)amino, alkil, cikloalkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, alkoksi, haloalkoksi, alkiltio, haloalkiltio, R7S(O)-, R7S(O)2-, R7C(O)-, R7R8NC(O)-, R7OC(O)-, R7C(O)O-, R7C(O)NR8-, -CN ili -NO2;
svaki od R10, R11, R12 i R13 je neovisno vodik, alkil, haloalkil, tioalkil, alkiltioalkil, hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkinil ili haloalkinil; ili
R10 zajedno s R11 tvore =O, =S ili =NR2;
ili
R12 zajedno s R13 tvore =O, =S ili =NR2;
W je O, S ili NR2;
n je 1 do 4; i
m je 0, 1 ili 2;
(b) jedan ili više dodatnih djelatnih tvari; i
veterinarski ili agrikulturno prihvatljiv nosač ili razrjeđivač.
2. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da G je G-1 u spoju dihidroazola formule (I).
3. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da G je G-2 u spoju dihidroazola formule (I).
4. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da u spoju dihidroazola formule (I):
G je G-1;
A1 je kisik; i
X je opcionalno supstituirani aril.
5. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da u spoju dihidroazola formule (I):
G je G-2;
A1 je kisik; i
X je opcionalno supstituirani aril.
6. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da u spoju dihidroazola formule (I):
A1 je kisik;
X je opcionalno supstituirani aril;
R1 je vodik, halogen, alkil ili haloalkil; i
Y je Y-1, Y-2, Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10, Y-11, Y-12 ili Y-13.
7. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da u spoju dihidroazola formule (I):
A1 je kisik;
X je opcionalno supstituirani aril;
R1 je vodik, halogen, alkil ili haloalkil; i
Y je pirazolil ili triazolil.
8. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da u spoju dihidroazola formule (I):
G je G-1;
svaki od B1, B2, B3, B4 i B5 je C-R9;
R1 je C1-C4alkil ili C1-C4haloalkil;
X je fenil koji može biti nesupstituiran ili supstituiran s jednim ili više od sljedećih: halogen, C1-C4alkil ili C1-C4haloalkil;
A1 je kisik;
A2 je CR7R8;
Y je Y-1, Y-4, Y-5 ili Y-6;
R2 i R4 su neovisno vodik, C1-C4alkil, C1-C4haloalkil, C1-C4alkoksi-C1-C4alkil ili
C1-C4alkiltio-C1-C4alkil; i
R3 i R9 su neovisno vodik, C1-C4alkil ili C1-C4haloalkil.
9. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da u spoju dihidroazola formule (I):
G je G-2;
svaki od B1, B2, B3, B4 i B5 je C-R9;
R1 je C1-C4alkil ili C1-C4haloalkil;
X je fenil koji može biti nesupstituiran ili supstituiran s jednim ili više od sljedećih: halogen, C1-C4alkil ili C1-C4haloalkil;
A1 je kisik;
A2 je CR7R8;
Y je Y-1, Y-4, Y-5 ili Y-6;
R2 i R4 su neovisno vodik, C1-C4alkil, C1-C4haloalkil, C1-C4alkoksi-C1-C4alkil ili
C1-C4alkiltio-C1-C4alkil; i
R3 i R9 su neovisno vodik, C1-C4alkil ili C1-C4haloalkil.
10. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da u spoju dihidroazola formule (I):
G je G-1;
svaki od B1, B2, B4 i B5 je C-R9;
B3 je N;
R1 je C1-C4alkil ili C1-C4haloalkil;
X je fenil koji može biti nesupstituiran ili supstituiran s jednim ili više od sljedećih: halogen, C1-C4alkil ili C1-C4haloalkil;
A1 je kisik;
A2 je CR7R8;
Y je Y-1, Y-4, Y-5 ili Y-6;
R2 i R4 su neovisno vodik, C1-C4alkil, C1-C4haloalkil, C1-C4alkoksi-C1-C4alkil ili
C1-C4alkiltio-C1-C4alkil; i
R3 i R9 su neovisno vodik, C1-C4alkil ili C1-C4haloalkil.
11. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da u spoju dihidroazola formule (I):
G je G-2;
svaki od B2, B3, B4 i B5 je C-R9;
B1 je N;
R1 je C1-C4alkil ili C1-C4haloalkil;
X je fenil koji može biti nesupstituiran ili supstituiran s jednim ili više od sljedećih: halogen, C1-C4alkil ili C1-C4haloalkil;
A1 je kisik;
A2 je CR7R8;
Y je Y-1, Y-4, Y-5 ili Y-6;
R2 i R4 su neovisno vodik, C1-C4alkil, C1-C4haloalkil, C1-C4alkoksi-C1-C4alkil ili
C1-C4alkiltio-C1-C4alkil; i
R3 i R9 su neovisno vodik, C1-C4alkil ili C1-C4haloalkil.
12. Veterinarski ili agrikulturni sastav prema zahtjevu 8 ili zahtjevu 9, naznačen time, da u spoju dihidroazola formule (I):
A2 je CH2;
R9 je vodik;
R10 zajedno s R11 tvore =O, =S ili =NR2;
R2 i R4 su neovisno vodik, C1-C4alkil ili C1-C4haloalkil; i
svaki od R3, R7 i R8 je vodik.
13. Veterinarski ili agrikulturni sastav prema zahtjevu 8, naznačen time, da u spoju dihidroazola formule (I):
A2 je CH2;
R9 je vodik;
R10 zajedno s R11 tvore =O, =S ili =NR2;
R12 zajedno s R13 tvore =O, =S ili =NR2;
R2 i R4 su neovisno vodik, C1-C4alkil ili C1-C4haloalkil; i
R3, R7 i R8 su vodik.
14. Veterinarski ili agrikulturni sastav prema zahtjevu 10 ili zahtjevu 11, naznačen time, da u spoju dihidroazola formule (I):
A2 je CH2;
R9 je vodik;
R12 zajedno s R13 tvore =O, =S ili =NR2;
R2 i R4 su neovisno vodik, C1-C4alkil ili C1-C4haloalkil; i
svaki od R3, R7 i R8 je vodik.
15. Veterinarski ili agrikulturni sastav prema zahtjevu 10 ili zahtjevu 11, naznačen time, da u spoju dihidroazola formule (I):
A2 je CH2;
R9 je vodik;
R10 zajedno s R11 tvore =O, =S ili =NR2;
R12 zajedno s R13 tvore =O, =S ili =NR2;
R2 i R4 su neovisno vodik, C1-C4alkil ili C1-C4haloalkil; i
R3, R7 i R8 su vodik.
16. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da je spoj dihidroazola formule (I) odabran od sljedećih:
17. Veterinarski ili agrikulturni sastav prema zahtjevu 1, naznačen time, da je spoj dihidroazola formule (I) odabran od sljedećih:
18. Veterinarski ili agrikulturni sastav prema zahtjevima od 1 do 17, naznačen time, da je dodatna djelatna tvar arilpirazol.
19. Veterinarski ili agrikulturni sastav prema zahtjevima od 1 do 17, naznačen time, da je dodatna djelatna tvar aminoacetonitril.
20. Veterinarski ili agrikulturni sastav prema zahtjevima od 1 do 17, naznačen time, da je dodatna djelatna tvar izoksazolin.
21. Veterinarski ili agrikulturni sastav prema zahtjevima od 1 do 17, naznačen time, da je dodatna djelatna tvar paraherkvamid.
22. Veterinarski ili agrikulturni sastav prema zahtjevima od 1 do 17, naznačen time, da je dodatna djelatna tvar ciklički depsipeptid.
23. Veterinarski ili agrikulturni sastav prema zahtjevima od 1 do 17, naznačen time, da dodatna djelatna tvar je antinematodno sredstvo.
24. Veterinarski ili agrikulturni sastav prema zahtjevima od 1 do 17, naznačen time, da dodatna djelatna tvar je antitrematodno sredstvo.
25. Veterinarski ili agrikulturni sastav prema zahtjevima od 1 do 17, naznačen time, da je dodatna djelatna tvar makrociklički lakton.
26. Veterinarski ili agrikulturni sastav prema zahtjevima od 1 do 17, naznačen time, da dodatna djelatna tvar je regulator rasta kukaca.
27. Veterinarski ili agrikulturni sastav prema zahtjevima od 1 do 17, naznačen time, da dodatna djelatna tvar je spinozin ili supstituirani derivat piridilmetila.
28. Veterinarski ili agrikulturni sastav prema zahtjevu 22, naznačen time, da ciklički depsipeptid je emodepsid.
29. Veterinarski ili agrikulturni sastav prema zahtjevu 23, naznačen time, da je antinematodno sredstvo odabrano iz skupine koja se sastoji od benzimidazola, imidazotiazola, tetrahidropirimidina i organofosfata.
30. Veterinarski ili agrikulturni sastav prema zahtjevu 24, naznačen time, da je antitrematodno sredstvo odabrano iz skupine koja se sastoji od sljedećih: miracil D, mirasan, prazikvantel, klonazepam, meklonazepam, oltipraz, lukanton, hikanton, oksamnikin, amoskanat, niridazol, nitroksibil, heksaklorofen, bitionol, bitionol-sulfoksid, meniklofolan, tribromsalan, oksiklonazid, klioksanid, rafoksanid, brotianid, bromoksanid, klozantel, triklabendazol, diamfenetid, klorsulon, hetolin i emetin.
31. Veterinarski ili agrikulturni sastav prema zahtjevu 25, naznačen time, da makrociklički lakton je avermektin ili milbemicin.
32. Veterinarski ili agrikulturni sastav prema zahtjevu 31, naznačen time, da je avermektin ili milbemicin odabran iz skupine koja se sastoji od sljedećih: abamektin, dimadektin, doramektin, emamektin, eprinomektin, ivermektin, latidektin, lepimektin, selamektin, milbemektin, milbemicin D, moksidektin i nemadektin.
33. Veterinarski ili agrikulturni sastav prema zahtjevu 26, naznačen time, da je regulator rasta kukaca odabran iz skupine koja se sastoji od sljedećih: metopren, piriproksifen, hidropren, ciromazin, fluazuron, lufenuron, novalouron, piretroidi, formamidini i 1-(2,6-difluorobenzoil)-3-(2-fluoro-4-(trifluorometil)fenilurea.
34. Veterinarski ili agrikulturni sastav prema bilo kojem od prethodnih zahtjeva, naznačen time, da je sastav odabran od oralne formulacije, injektibilne formulacije, topikalne formulacije, dermalne formulacije i subdermalne formulacije.
35. Veterinarski ili agrikulturni sastav prema zahtjevu 34, naznačen time, da oralna formulacija je formulacija za žvakanje ili tableta.
36. Veterinarski ili agrikulturni sastav prema zahtjevu 34, naznačen time, da se kod topikalne formulacije radi o formulaciji za koncentrirano ulijevanje na potrebno mjesto (engl. pour-on) i za preciznu primjenu točno na potrebnom mjestu (engl. spot-on).
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