HUE056909T2 - Eljárás enantiomerben dúsított izoxazolinvegyületek elõállítására -(S)-afoxolaner kristályos toluolszolvátja - Google Patents

Eljárás enantiomerben dúsított izoxazolinvegyületek elõállítására -(S)-afoxolaner kristályos toluolszolvátja

Info

Publication number
HUE056909T2
HUE056909T2 HUE17718286A HUE17718286A HUE056909T2 HU E056909 T2 HUE056909 T2 HU E056909T2 HU E17718286 A HUE17718286 A HU E17718286A HU E17718286 A HUE17718286 A HU E17718286A HU E056909 T2 HUE056909 T2 HU E056909T2
Authority
HU
Hungary
Prior art keywords
afoxolaner
preparation
enantiomerically enriched
isoxazoline compounds
toluene solvate
Prior art date
Application number
HUE17718286A
Other languages
English (en)
Inventor
Chunhua Yang
Hir De Fallois Loic Le
Charles Meng
Alan Long
De Vries Roelof Gorter
Bruno Baillon
Sylvaine Lafont
De Saint Michel Myriam Gay
Stephane Kozlovic
Original Assignee
Boehringer Ingelheim Animal Health Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Animal Health Usa Inc filed Critical Boehringer Ingelheim Animal Health Usa Inc
Publication of HUE056909T2 publication Critical patent/HUE056909T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HUE17718286A 2016-04-06 2017-04-05 Eljárás enantiomerben dúsított izoxazolinvegyületek elõállítására -(S)-afoxolaner kristályos toluolszolvátja HUE056909T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662319207P 2016-04-06 2016-04-06

Publications (1)

Publication Number Publication Date
HUE056909T2 true HUE056909T2 (hu) 2022-04-28

Family

ID=58549312

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17718286A HUE056909T2 (hu) 2016-04-06 2017-04-05 Eljárás enantiomerben dúsított izoxazolinvegyületek elõállítására -(S)-afoxolaner kristályos toluolszolvátja

Country Status (30)

Country Link
US (3) US10433552B2 (hu)
EP (2) EP3440062B1 (hu)
KR (2) KR102403531B1 (hu)
CN (2) CN109195955B (hu)
AR (1) AR108184A1 (hu)
AU (2) AU2017246305B2 (hu)
CA (2) CA3019947A1 (hu)
CL (2) CL2018002838A1 (hu)
CO (3) CO2019013841A2 (hu)
CY (1) CY1124797T1 (hu)
DK (1) DK3440062T3 (hu)
EA (1) EA201892245A1 (hu)
ES (1) ES2903286T3 (hu)
HR (1) HRP20211979T1 (hu)
HU (1) HUE056909T2 (hu)
IL (2) IL262093B (hu)
LT (1) LT3440062T (hu)
MD (2) MD4846C1 (hu)
MX (2) MX2020013754A (hu)
MY (1) MY189534A (hu)
NZ (1) NZ747676A (hu)
PL (1) PL3440062T3 (hu)
PT (1) PT3440062T (hu)
RS (1) RS62755B1 (hu)
SG (1) SG11201808756XA (hu)
SI (1) SI3440062T1 (hu)
TW (1) TWI753897B (hu)
UA (1) UA127309C2 (hu)
UY (1) UY37196A (hu)
WO (1) WO2017176948A1 (hu)

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CN114113388B (zh) * 2021-11-24 2023-05-23 丽珠集团新北江制药股份有限公司 一种4-肟甲基-1-萘甲酸中有关物质的检测方法
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CN115959979A (zh) * 2022-12-29 2023-04-14 南京正荣医药化学有限公司 一种3-氯-4-氟-5-三氟甲基三氟苯乙酮的制备方法
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Also Published As

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SG11201808756XA (en) 2018-11-29
US11324220B2 (en) 2022-05-10
ES2903286T3 (es) 2022-03-31
UA127309C2 (uk) 2023-07-19
KR20180132834A (ko) 2018-12-12
AR108184A1 (es) 2018-07-25
CO2019013841A2 (es) 2020-04-01
AU2017246305A1 (en) 2018-11-15
CL2018002838A1 (es) 2018-11-30
CL2019003235A1 (es) 2020-02-14
MY189534A (en) 2022-02-16
US20210022344A1 (en) 2021-01-28
KR102403531B1 (ko) 2022-05-27
US10433552B2 (en) 2019-10-08
IL262093A (en) 2018-11-29
EP3978483B1 (en) 2024-09-25
CN114805234A (zh) 2022-07-29
PT3440062T (pt) 2021-12-24
KR20220003635A (ko) 2022-01-10
WO2017176948A1 (en) 2017-10-12
NZ747676A (en) 2023-05-26
EP3978483A1 (en) 2022-04-06
US20190133129A1 (en) 2019-05-09
CO2018010719A2 (es) 2018-12-28
HRP20211979T1 (hr) 2022-04-01
LT3440062T (lt) 2021-12-10
AU2021203129A1 (en) 2021-06-10
CA3019947A1 (en) 2017-10-12
IL280679A (en) 2021-03-25
CN109195955A (zh) 2019-01-11
KR102438541B1 (ko) 2022-08-30
MX2018012184A (es) 2019-02-07
EA201892245A1 (ru) 2019-07-31
DK3440062T3 (da) 2022-01-03
US20170311601A1 (en) 2017-11-02
CO2019013500A2 (es) 2020-02-28
TWI753897B (zh) 2022-02-01
UY37196A (es) 2017-10-31
EP3440062B1 (en) 2021-10-06
BR112018070663A2 (pt) 2019-02-05
CA3214922A1 (en) 2017-10-12
IL262093B (en) 2021-02-28
MD20220052A2 (ro) 2023-05-31
IL280679B (en) 2021-12-01
RS62755B1 (sr) 2022-01-31
AU2017246305B2 (en) 2021-04-29
SI3440062T1 (sl) 2021-12-31
MD20180090A2 (ro) 2019-02-28
MD4846B1 (ro) 2023-02-28
AU2021203129B2 (en) 2023-03-16
EP3440062A1 (en) 2019-02-13
MX2020013754A (es) 2022-07-25
CY1124797T1 (el) 2022-11-25
MD4846C1 (ro) 2023-10-31
CN109195955B (zh) 2022-10-18
PL3440062T3 (pl) 2022-02-07
US10750744B2 (en) 2020-08-25
TW201739740A (zh) 2017-11-16

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