PL3228619T3 - Sposób wytwarzania apiksabanu - Google Patents

Sposób wytwarzania apiksabanu

Info

Publication number
PL3228619T3
PL3228619T3 PL16460019T PL16460019T PL3228619T3 PL 3228619 T3 PL3228619 T3 PL 3228619T3 PL 16460019 T PL16460019 T PL 16460019T PL 16460019 T PL16460019 T PL 16460019T PL 3228619 T3 PL3228619 T3 PL 3228619T3
Authority
PL
Poland
Prior art keywords
apixaban
preparation
Prior art date
Application number
PL16460019T
Other languages
English (en)
Inventor
Barbara Piotrkowska
Marcin Szulc
Mariusz Krzyżanowski
Original Assignee
Zakłady Farmaceutyczne Polpharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zakłady Farmaceutyczne Polpharma Sa filed Critical Zakłady Farmaceutyczne Polpharma Sa
Publication of PL3228619T3 publication Critical patent/PL3228619T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL16460019T 2016-04-04 2016-04-04 Sposób wytwarzania apiksabanu PL3228619T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16460019.9A EP3228619B1 (en) 2016-04-04 2016-04-04 Process for the preparation of apixaban

Publications (1)

Publication Number Publication Date
PL3228619T3 true PL3228619T3 (pl) 2020-12-28

Family

ID=55808540

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16460019T PL3228619T3 (pl) 2016-04-04 2016-04-04 Sposób wytwarzania apiksabanu

Country Status (3)

Country Link
EP (1) EP3228619B1 (pl)
ES (1) ES2827459T3 (pl)
PL (1) PL3228619T3 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102188341B1 (ko) 2018-10-24 2020-12-08 하나제약 주식회사 아픽사반의 제조방법
CN109400606B (zh) * 2018-12-26 2020-01-17 山东鲁抗医药股份有限公司 一种从阿哌沙班粗品中精制阿哌沙班的方法
CN110467614A (zh) * 2019-09-12 2019-11-19 江西国药有限责任公司 一种阿哌沙班酸杂质的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI320039B (en) 2001-09-21 2010-02-01 Lactam-containing compounds and derivatives thereof as factor xa inhibitors
TW200303201A (en) * 2001-12-10 2003-09-01 Bristol Myers Squibb Co Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
WO2014072884A1 (en) 2012-11-12 2014-05-15 Alembic Pharmaceuticals Limited Process for the synthesis of apixaban
CN104045637B (zh) * 2014-04-18 2016-04-06 河北科技大学 一种阿哌沙班的制备方法
CN103992314A (zh) * 2014-04-25 2014-08-20 济南大学 一种抗凝血药阿哌沙班的合成方法改进
HU231122B1 (hu) * 2014-08-06 2020-11-30 Egis Gyógyszergyár Zrt Eljárás apixaban előállítására

Also Published As

Publication number Publication date
EP3228619B1 (en) 2020-07-29
ES2827459T3 (es) 2021-05-21
EP3228619A1 (en) 2017-10-11

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