HUP1400543A2 - Eljárás és köztitermék apixaban elõállítására - Google Patents
Eljárás és köztitermék apixaban elõállításáraInfo
- Publication number
- HUP1400543A2 HUP1400543A2 HU1400543A HUP1400543A HUP1400543A2 HU P1400543 A2 HUP1400543 A2 HU P1400543A2 HU 1400543 A HU1400543 A HU 1400543A HU P1400543 A HUP1400543 A HU P1400543A HU P1400543 A2 HUP1400543 A2 HU P1400543A2
- Authority
- HU
- Hungary
- Prior art keywords
- apixaban
- preparation
- Prior art date
Links
- QNZCBYKSOIHPEH-UHFFFAOYSA-N Apixaban Chemical compound C1=CC(OC)=CC=C1N1C(C(=O)N(CC2)C=3C=CC(=CC=3)N3C(CCCC3)=O)=C2C(C(N)=O)=N1 QNZCBYKSOIHPEH-UHFFFAOYSA-N 0.000 title 1
- 229960003886 apixaban Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU1400543A HU230991B1 (hu) | 2014-11-19 | 2014-11-19 | Eljárás és köztitermék apixaban előállítására |
PCT/HU2015/050018 WO2016079549A1 (en) | 2014-11-19 | 2015-11-18 | Process and intermediate for the preparation of apixaban |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU1400543A HU230991B1 (hu) | 2014-11-19 | 2014-11-19 | Eljárás és köztitermék apixaban előállítására |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP1400543A2 true HUP1400543A2 (hu) | 2016-05-30 |
HU230991B1 HU230991B1 (hu) | 2019-08-28 |
Family
ID=89991646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU1400543A HU230991B1 (hu) | 2014-11-19 | 2014-11-19 | Eljárás és köztitermék apixaban előállítására |
Country Status (2)
Country | Link |
---|---|
HU (1) | HU230991B1 (hu) |
WO (1) | WO2016079549A1 (hu) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107434806A (zh) * | 2016-12-09 | 2017-12-05 | 陕西科技大学 | 一种阿哌沙班羧酸衍生物的γ晶型固体物质及其制备方法与用途 |
WO2018127936A1 (en) * | 2017-01-05 | 2018-07-12 | Hikal Limited | Novel economic metal free process for apixaban |
CN109400606B (zh) * | 2018-12-26 | 2020-01-17 | 山东鲁抗医药股份有限公司 | 一种从阿哌沙班粗品中精制阿哌沙班的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04002526A (es) | 2001-09-21 | 2004-05-31 | Bristol Myers Squibb Co | Compuestos que contienen lactama y sus derivados como inhibidores del factor xa. |
TW200738672A (en) * | 2001-12-10 | 2007-10-16 | Bristol Myers Squibb Co | Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones |
US7396932B2 (en) | 2004-09-28 | 2008-07-08 | Bristol-Myers Squibb Company | Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
US20100130543A1 (en) | 2008-09-15 | 2010-05-27 | Auspex Pharmaceuticals, Inc. | Pyrazole carboxamide inhibitors of factor xa |
CN101967145B (zh) | 2010-09-09 | 2012-07-04 | 华东理工大学 | 一种抗血栓药物阿匹沙班的制备方法 |
US8884016B2 (en) | 2011-06-10 | 2014-11-11 | Dipharma Francis S.R.L. | Apixaban preparation process |
CN104045637B (zh) * | 2014-04-18 | 2016-04-06 | 河北科技大学 | 一种阿哌沙班的制备方法 |
-
2014
- 2014-11-19 HU HU1400543A patent/HU230991B1/hu unknown
-
2015
- 2015-11-18 WO PCT/HU2015/050018 patent/WO2016079549A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2016079549A1 (en) | 2016-05-26 |
HU230991B1 (hu) | 2019-08-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL279627A (en) | A method for treating depression | |
ZA201707303B (en) | Compositions and methods for the treatment of immunodeficiency | |
ZA201706795B (en) | Process for the preparation of dicycloplatin | |
EP3212620A4 (en) | Process for the preparation of apixaban and intermediates thereof | |
EP3189053A4 (en) | An improved process for the preparation of apixaban and intermediates thereof | |
EP3227298A4 (en) | Process for the preparation of baricitinib and an intermediate thereof | |
IL248267A0 (en) | A process for preparing converted cycloserines | |
ZA201703336B (en) | Novel products and methods | |
PL3113774T3 (pl) | Kompozycje grapiprantu i sposoby ich zastosowania | |
IL251946B (en) | Process for making micro particles | |
PL3228619T3 (pl) | Sposób wytwarzania apiksabanu | |
HUP1400543A2 (hu) | Eljárás és köztitermék apixaban elõállítására | |
SG11201702700UA (en) | Methods for the treatment of peri-implantitis | |
IL253077A0 (en) | Process and intermediates for the preparation of Fermpanel | |
ZA201701973B (en) | Process for the preparation of halo-substituted trifluoroacetophenones | |
HUE061732T2 (hu) | Eljárás részecskék elõállítására | |
HUP1500647A2 (en) | Intermediate of baricitinib and process for its preparation | |
HUP1400378A2 (hu) | Eljárás apixaban elõállítására | |
IL237572A0 (en) | Process and intermediates for the preparation of dastinib | |
ZA201608823B (en) | Processes for the preparation of azd5363 and novel intermediate used therein | |
IL241974A0 (en) | Process for making erlotinib | |
HUP1400518A2 (hu) | Eljárás tofacitinib elõállítására | |
SI3230268T1 (sl) | Proces za pripravo tetrakonazola | |
IL253175A0 (en) | A process for the preparation of ospemifene and fispemifene | |
IL247443B (en) | Process for the preparation of 5-fluorotryptophol |