|
US3758475A
(en)
|
1971-07-20 |
1973-09-11 |
Sandoz Ag |
Pyrido(2,3-d)pyrimidin 2 ones
|
|
DE3263567D1
(en)
|
1981-12-14 |
1985-06-20 |
Medea Res Srl |
New compounds with antiinflammatory and antitussive activity, process for their preparation and relative pharmaceutical compositions
|
|
IT1226048B
(it)
|
1981-12-14 |
1990-12-10 |
Medea Res Srl |
Composti ad attivita'antiinfiammatoria, processo per la loro preparazione e composizioni farmaceutiche relative
|
|
US4501729A
(en)
|
1982-12-13 |
1985-02-26 |
Research Corporation |
Aerosolized amiloride treatment of retained pulmonary secretions
|
|
US5304121A
(en)
|
1990-12-28 |
1994-04-19 |
Boston Scientific Corporation |
Drug delivery system making use of a hydrogel polymer coating
|
|
US5981714A
(en)
|
1990-03-05 |
1999-11-09 |
Genzyme Corporation |
Antibodies specific for cystic fibrosis transmembrane conductance regulator and uses therefor
|
|
JP3167762B2
(ja)
|
1990-11-27 |
2001-05-21 |
武田薬品工業株式会社 |
ピリドピリダジン誘導体およびその用途
|
|
US5612360A
(en)
|
1992-06-03 |
1997-03-18 |
Eli Lilly And Company |
Angiotensin II antagonists
|
|
CA2107196A1
(en)
|
1992-09-29 |
1994-03-30 |
Mitsubishi Chemical Corporation |
Carboxamide derivatives
|
|
US5716981A
(en)
|
1993-07-19 |
1998-02-10 |
Angiogenesis Technologies, Inc. |
Anti-angiogenic compositions and methods of use
|
|
GB9317764D0
(en)
|
1993-08-26 |
1993-10-13 |
Pfizer Ltd |
Therapeutic compound
|
|
AU688811B2
(en)
|
1993-10-21 |
1998-03-19 |
G.D. Searle & Co. |
Amidino derivatives useful as nitric oxide synthase inhibitors
|
|
DE4405712A1
(de)
|
1994-02-23 |
1995-08-24 |
Basf Ag |
Substituierte Naphthyridine und deren Verwendung
|
|
NO305987B1
(no)
|
1994-04-11 |
1999-08-30 |
Sankyo Co |
Heterosykliske forbindelser med antidiabetisk aktivitet, deres anvendelse og farmasoeytisk preparat inneholdende disse
|
|
WO1996010027A1
(en)
|
1994-09-27 |
1996-04-04 |
Janssen Pharmaceutica N.V. |
N-substituted piperidinyl bicyclic benzoate derivatives
|
|
US5656256A
(en)
|
1994-12-14 |
1997-08-12 |
The University Of North Carolina At Chapel Hill |
Methods of treating lung disease by an aerosol containing benzamil or phenamil
|
|
US5510379A
(en)
|
1994-12-19 |
1996-04-23 |
Warner-Lambert Company |
Sulfonate ACAT inhibitors
|
|
US6099562A
(en)
|
1996-06-13 |
2000-08-08 |
Schneider (Usa) Inc. |
Drug coating with topcoat
|
|
EP0891334A1
(en)
|
1996-04-03 |
1999-01-20 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
AU4159297A
(en)
|
1996-08-23 |
1998-03-06 |
Agouron Acquisition Corp. |
Neuropeptide-y ligands
|
|
AU6013998A
(en)
|
1996-12-30 |
1998-07-31 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
US5948814A
(en)
|
1997-02-20 |
1999-09-07 |
The Curators Of The University Of Missouri |
Genistein for the treatment of cystic fibrosis
|
|
WO1998047868A1
(en)
|
1997-04-18 |
1998-10-29 |
Smithkline Beecham Plc |
Heterocycle-containing urea derivatives as 5ht1a, 5ht1b and 5ht1d receptor antagonists
|
|
NZ503712A
(en)
|
1997-10-02 |
2003-07-25 |
Sankyo Co |
Amidopropionic acid derivatives
|
|
DK1054996T3
(da)
|
1998-02-17 |
2004-05-24 |
Searle & Co |
Fremgangsmåde til den enzymatiske adskillelse af lactamer
|
|
KR20010052587A
(ko)
|
1998-06-08 |
2001-06-25 |
둘락 노먼 씨. |
뉴로펩티드 y5 수용체 길항제
|
|
US6426331B1
(en)
|
1998-07-08 |
2002-07-30 |
Tularik Inc. |
Inhibitors of STAT function
|
|
AUPP609198A0
(en)
|
1998-09-22 |
1998-10-15 |
Curtin University Of Technology |
Use of non-peptidyl compounds for the treatment of insulin related ailments
|
|
IL142768A0
(en)
|
1998-12-18 |
2002-03-10 |
Du Pont Pharm Co |
N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
|
|
CA2364662C
(en)
|
1999-02-24 |
2009-10-20 |
F. Hoffmann-La Roche Ag |
3-phenylpyridine derivatives and their use as nk-1 receptor antagonists
|
|
ES2359235T3
(es)
|
1999-02-24 |
2011-05-19 |
F. Hoffmann-La Roche Ag |
Derivados de 4-fenilpiridina y su empleo como antagonistas del receptor nk-1.
|
|
IL144717A0
(en)
|
1999-02-24 |
2002-06-30 |
Hoffmann La Roche |
Phenyl-and pyridinyl derivatives
|
|
UA71971C2
(en)
|
1999-06-04 |
2005-01-17 |
Agoron Pharmaceuticals Inc |
Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
|
|
EP1194417A1
(de)
|
1999-06-18 |
2002-04-10 |
Bayer Ag |
Phenoxyfluorpyrimidine
|
|
UA74539C2
(en)
|
1999-12-08 |
2006-01-16 |
Pharmacia Corp |
Crystalline polymorphous forms of celecoxib (variants), a method for the preparation thereof (variants), a pharmaceutical composition (variants)
|
|
WO2001046165A2
(en)
|
1999-12-16 |
2001-06-28 |
Novartis Ag |
N-heteroaryl-amides and their use as parasiticides
|
|
NZ519984A
(en)
|
2000-01-07 |
2004-03-26 |
Transform Pharmaceuticals Inc |
High-throughput formation, identification, and analysis of diverse solid-forms
|
|
AU2001233069A1
(en)
|
2000-01-28 |
2001-08-07 |
Biogen, Inc. |
Pharmaceutical compositions containing anti-beta 1 integrin compounds and uses
|
|
WO2001056989A2
(en)
|
2000-02-01 |
2001-08-09 |
Cor Therapeutics, Inc. |
Inhibitors of factor xa
|
|
WO2001081317A1
(en)
|
2000-04-26 |
2001-11-01 |
Gliatech, Inc. |
Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives
|
|
AU2000249828A1
(en)
|
2000-05-03 |
2001-11-12 |
Taisho Pharmaceutical Co. Ltd. |
Stat4 and stat6 binding dipeptide derivatives
|
|
CN1386118A
(zh)
|
2000-06-01 |
2002-12-18 |
布里斯托尔-迈尔斯斯奎布药品公司 |
作为Aβ蛋白产生抑制剂的被环状琥珀酸酯取代的内酰胺类化合物
|
|
TWI259180B
(en)
|
2000-08-08 |
2006-08-01 |
Hoffmann La Roche |
4-Phenyl-pyridine derivatives
|
|
MXPA03002297A
(es)
|
2000-09-15 |
2003-06-06 |
Vertex Pharma |
Compuestos de triazol utiles como inhibidores de proteina cinasa.
|
|
JP4272338B2
(ja)
|
2000-09-22 |
2009-06-03 |
バイエル アクチェンゲゼルシャフト |
ピリジン誘導体
|
|
WO2002028348A2
(en)
|
2000-10-04 |
2002-04-11 |
The Children's Hospital Of Philadelphia |
Compositions and methods for treatment of cystic fibrosis
|
|
GB2367816A
(en)
|
2000-10-09 |
2002-04-17 |
Bayer Ag |
Urea- and thiourea-containing derivatives of beta-amino acids
|
|
ATE269856T1
(de)
|
2000-10-20 |
2004-07-15 |
Merck Patent Gmbh |
Chirale binaphtol-verbindungen
|
|
US6884782B2
(en)
|
2000-11-08 |
2005-04-26 |
Amgen Inc. |
STAT modulators
|
|
US6887996B2
(en)
|
2000-12-01 |
2005-05-03 |
Guilford Pharmaceuticals Inc. |
Compounds and their use
|
|
GB0102687D0
(en)
|
2001-02-02 |
2001-03-21 |
Pharmacia & Upjohn Spa |
Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
|
|
US6531597B2
(en)
|
2001-02-13 |
2003-03-11 |
Hoffmann-La Roche Inc. |
Process for preparation of 2-phenyl acetic acid derivatives
|
|
CA2442654A1
(en)
|
2001-04-10 |
2002-10-10 |
Transtech Pharma, Inc. |
Probes, systems, and methods for drug discovery
|
|
AU2002250876B2
(en)
|
2001-04-23 |
2005-03-03 |
F. Hoffmann-La Roche Ag |
Use of NK-1 receptor antagonists against benign prostatic hyperplasia
|
|
HUP0400316A2
(hu)
|
2001-05-22 |
2005-02-28 |
Neurogen Corporation |
CRF1 modulátor hatású 5-szubsztituált-2-arilpiridin származékok és ezeket tartalmazó gyógyszerkészítmények
|
|
US20030083345A1
(en)
|
2001-07-10 |
2003-05-01 |
Torsten Hoffmann |
Method of treatment and/or prevention of brain, spinal or nerve injury
|
|
US6627646B2
(en)
|
2001-07-17 |
2003-09-30 |
Sepracor Inc. |
Norastemizole polymorphs
|
|
AU2002322585A1
(en)
|
2001-07-20 |
2003-03-03 |
Adipogenix, Inc. |
Fat accumulation-modulating compounds
|
|
EP1411928A1
(en)
|
2001-07-20 |
2004-04-28 |
Boehringer Ingelheim (Canada) Ltd. |
Viral polymerase inhibitors
|
|
JP2005508904A
(ja)
|
2001-09-11 |
2005-04-07 |
スミスクライン ビーチャム コーポレーション |
血管新生阻害剤としてのフロ−及びチエノピリミジン誘導体
|
|
PA8557501A1
(es)
|
2001-11-12 |
2003-06-30 |
Pfizer Prod Inc |
Benzamida, heteroarilamida y amidas inversas
|
|
JP2003155285A
(ja)
|
2001-11-19 |
2003-05-27 |
Toray Ind Inc |
環状含窒素誘導体
|
|
JP2003221386A
(ja)
|
2001-11-26 |
2003-08-05 |
Takeda Chem Ind Ltd |
二環性誘導体、その製造法およびその用途
|
|
CN100506807C
(zh)
|
2001-12-21 |
2009-07-01 |
诺沃挪第克公司 |
作为gk活化剂的酰胺衍生物
|
|
TW200307539A
(en)
|
2002-02-01 |
2003-12-16 |
Bristol Myers Squibb Co |
Cycloalkyl inhibitors of potassium channel function
|
|
TW200304820A
(en)
|
2002-03-25 |
2003-10-16 |
Avanir Pharmaceuticals |
Use of benzimidazole analogs in the treatment of cell proliferation
|
|
TW200403058A
(en)
|
2002-04-19 |
2004-03-01 |
Bristol Myers Squibb Co |
Heterocyclo inhibitors of potassium channel function
|
|
FR2840807B1
(fr)
|
2002-06-12 |
2005-03-11 |
|
Composition cosmetique de soin et/ou de maquillage, structuree par des polymeres silicones et des organogelateurs, sous forme rigide
|
|
GB0221443D0
(en)
|
2002-09-16 |
2002-10-23 |
Glaxo Group Ltd |
Pyridine derivates
|
|
WO2004035571A1
(en)
|
2002-10-15 |
2004-04-29 |
Rigel Pharmaceuticals, Inc. |
Substituted indoles and their use as hcv inhibitors
|
|
EP1558576A4
(en)
|
2002-10-30 |
2008-04-16 |
Merck & Co Inc |
PIPERIDINYLCYCLOPENTYLARYLBENZYLAMIDE MODULATORS OF CHEMOKIN RECEPTORACTIVITY
|
|
EP1569645A2
(en)
|
2002-12-12 |
2005-09-07 |
Pharmacia Corporation |
Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors
|
|
JP4716734B2
(ja)
|
2003-01-06 |
2011-07-06 |
イーライ リリー アンド カンパニー |
グルコキナーゼ活性化物質としての置換されたアリールシクロプロピルアセトアミド
|
|
MXPA05008450A
(es)
|
2003-02-10 |
2005-10-18 |
Vertex Pharma |
Procesos para la preparacion de n-heteroaril-n-aril-aminas mediante reaccion de un ester de acido n-aril-carbamico con un halo-heteroarilo y procesos analogos.
|
|
EP1601657A1
(en)
|
2003-03-12 |
2005-12-07 |
Vertex Pharmaceuticals Incorporated |
Pyrazole modulators of atp-binding cassette transporters
|
|
KR20060006953A
(ko)
|
2003-04-30 |
2006-01-20 |
디 인스티튜트스 포 파마슈티컬 디스커버리, 엘엘씨 |
치환된 카르복실산
|
|
WO2004111014A1
(en)
|
2003-06-06 |
2004-12-23 |
Vertex Pharmaceuticals Incorporated |
Pyrimidine derivatives as modulators of atp-binding cassette transporters
|
|
EP1638505B1
(en)
|
2003-06-27 |
2012-04-25 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. |
Amphiphilic pyridinium compounds, method of making and use thereof
|
|
GB0315111D0
(en)
|
2003-06-27 |
2003-07-30 |
Cancer Rec Tech Ltd |
Substituted 5-membered ring compounds and their use
|
|
JP2005053902A
(ja)
|
2003-07-18 |
2005-03-03 |
Nippon Nohyaku Co Ltd |
フェニルピリジン類、その中間体及びこれを有効成分とする除草剤
|
|
CA2537829A1
(en)
|
2003-09-05 |
2005-03-17 |
Neurogen Corporation |
Heteroaryl fused pyridines, pyrazines and pyrimidines as crf1 receptor ligands
|
|
KR20060088537A
(ko)
|
2003-09-06 |
2006-08-04 |
버텍스 파마슈티칼스 인코포레이티드 |
Atp-결합 카세트 수송체의 조절자
|
|
US7534894B2
(en)
|
2003-09-25 |
2009-05-19 |
Wyeth |
Biphenyloxy-acids
|
|
US20050070718A1
(en)
|
2003-09-30 |
2005-03-31 |
Abbott Gmbh & Co. Kg |
Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
|
|
EP1680411A2
(en)
|
2003-10-08 |
2006-07-19 |
Vertex Pharmaceuticals Incorporated |
Modulators of atp-binding cassette transporters containing cycloalkyl or pyranyl groups
|
|
FR2861304B1
(fr)
|
2003-10-23 |
2008-07-18 |
Univ Grenoble 1 |
Modulateurs des canaux cftr
|
|
GB0325956D0
(en)
|
2003-11-06 |
2003-12-10 |
Addex Pharmaceuticals Sa |
Novel compounds
|
|
WO2005049018A1
(en)
|
2003-11-14 |
2005-06-02 |
Vertex Pharmaceuticals Incorporated |
Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters
|
|
WO2005049034A2
(en)
|
2003-11-19 |
2005-06-02 |
Glaxo Group Limited |
Use of cyclooxygenase-2 selective inhibitors for the treatment of schizophrenic disorders
|
|
AU2005210474B2
(en)
|
2004-01-30 |
2011-07-07 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding cassette transporters
|
|
US7977322B2
(en)
|
2004-08-20 |
2011-07-12 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
|
US7691860B2
(en)
|
2004-02-19 |
2010-04-06 |
Banyu Pharmaceutical Co., Ltd. |
Sulfonamide derivatives
|
|
ES2241496B1
(es)
|
2004-04-15 |
2006-12-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de piridina.
|
|
US20080015196A1
(en)
|
2004-04-16 |
2008-01-17 |
Neurogen Corporation |
Imidazopyrazines, Imidazopyridines, and Imidazopyrimidines as Crf1 Receptor Ligands
|
|
WO2005108358A2
(en)
|
2004-04-22 |
2005-11-17 |
Eli Lilly And Company |
Pyrrolidine derivatives useful as bace inhibitors
|
|
US7585885B2
(en)
|
2004-04-22 |
2009-09-08 |
Eli Lilly And Company |
Pyrrolidine derivatives useful as BACE inhibitors
|
|
AU2005249154B2
(en)
|
2004-06-01 |
2011-02-10 |
Luminex Molecular Diagnostics, Inc. |
Method of detecting cystic fibrosis associated mutations
|
|
US8354427B2
(en)
|
2004-06-24 |
2013-01-15 |
Vertex Pharmaceutical Incorporated |
Modulators of ATP-binding cassette transporters
|
|
PL2489659T3
(pl)
|
2004-06-24 |
2018-06-29 |
Vertex Pharma |
Modulatory transporterów posiadających kasetę wiążącą atp
|
|
US20140343098A1
(en)
|
2004-06-24 |
2014-11-20 |
Vertex Pharmaceuticals Incorporated |
Modulators of atp-binding cassette transporters
|
|
CA2572549A1
(en)
|
2004-07-01 |
2006-01-12 |
Warner-Lambert Company Llc |
Preparation of pharmaceutical compositions containing nanoparticles
|
|
EP1771158A4
(en)
|
2004-07-02 |
2008-03-12 |
Advancis Pharmaceutical Corp |
TABLET FOR PULSE DISTRIBUTION
|
|
EP1773797A2
(en)
|
2004-08-06 |
2007-04-18 |
Otsuka Pharmaceutical Co., Ltd. |
Aromatic compounds
|
|
WO2006037117A1
(en)
|
2004-09-27 |
2006-04-06 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
CA2581516C
(en)
|
2004-10-12 |
2013-06-11 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
CA2587461A1
(en)
|
2004-11-15 |
2006-05-18 |
Pfizer Products Inc. |
Azabenzoxazoles for the treatment of cns disorders
|
|
ES2322487T3
(es)
*
|
2004-12-15 |
2009-06-22 |
Dompe' Pha.R.Ma S.P.A. |
Derivados de acido 2-arilpropionico y composiciones farmaceuticas que los contienen.
|
|
JP4790260B2
(ja)
|
2004-12-22 |
2011-10-12 |
出光興産株式会社 |
アントラセン誘導体を用いた有機エレクトロルミネッセンス素子
|
|
EP1844003A4
(en)
|
2005-01-27 |
2010-09-22 |
Astrazeneca Ab |
NEW BIAROMATIC COMPOUNDS AS INHIBITORS OF THE P2X7 RECEPTOR
|
|
US7888374B2
(en)
|
2005-01-28 |
2011-02-15 |
Abbott Laboratories |
Inhibitors of c-jun N-terminal kinases
|
|
US20090048258A1
(en)
|
2005-02-01 |
2009-02-19 |
Masaki Ogino |
Amide Compound
|
|
EP2363128B1
(en)
|
2005-03-11 |
2016-02-17 |
Vertex Pharmaceuticals Incorporated |
Indole modulators of ATP-binding cassette transporters
|
|
US7402596B2
(en)
|
2005-03-24 |
2008-07-22 |
Renovis, Inc. |
Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
|
|
EP1710246A1
(en)
|
2005-04-08 |
2006-10-11 |
Schering Aktiengesellschaft |
Sulfoximine-pyrimidine Macrocycles and the salts thereof, a process for making them, and their pharmaceutical use against cancer
|
|
JP2008536950A
(ja)
|
2005-04-18 |
2008-09-11 |
ニューロジェン・コーポレーション |
置換ヘテロアリールのcb1拮抗薬
|
|
AU2006236155A1
(en)
|
2005-04-19 |
2006-10-26 |
Bayer Pharmaceuticals Corporation |
Aryl alkyl acid derivatives for and use thereof
|
|
GB0510139D0
(en)
|
2005-05-18 |
2005-06-22 |
Addex Pharmaceuticals Sa |
Novel compounds B1
|
|
EP1891018B1
(en)
|
2005-05-24 |
2011-11-16 |
Vertex Pharmaceuticals, Inc. |
Modulators of atp-binding cassette transporters
|
|
EP1890694A4
(en)
|
2005-06-02 |
2010-10-27 |
Bayer Cropscience Ag |
SUBSTITUTED PHENYLALKYL HETEROARYL DERIVATIVES
|
|
EP1919875A2
(en)
|
2005-06-21 |
2008-05-14 |
Astex Therapeutics Limited |
Pyrazole derivatives and their use as pka and pkb modulators
|
|
ZA200802172B
(en)
|
2005-08-11 |
2009-06-24 |
Vertex Pharma |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
JP5143738B2
(ja)
|
2005-08-11 |
2013-02-13 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
嚢胞性線維症膜コンダクタンス制御因子の調節物質
|
|
PL1928886T3
(pl)
|
2005-09-09 |
2011-09-30 |
Nerre Therapeutics Ltd |
Pochodne pirydyny i ich zastosowanie w leczeniu zaburzeń psychotycznych
|
|
WO2007039420A1
(en)
|
2005-09-23 |
2007-04-12 |
F. Hoffmann-La Roche Ag |
Novel dosage formulation
|
|
EP1933831A2
(en)
|
2005-10-06 |
2008-06-25 |
Vertex Pharmaceuticals, Inc. |
Modulators of atp-binding cassette transporters
|
|
BRPI0618417A2
(pt)
|
2005-10-19 |
2012-07-31 |
Gruenenthal Chemie |
novos ligandos de receptores de vanilàide e seu uso para produzir medicamentos
|
|
DK1945632T3
(da)
|
2005-11-08 |
2013-12-16 |
Vertex Pharma |
Heterocycliske modulatorer af ATP-bindende kassettetransportører
|
|
WO2007054480A1
(en)
|
2005-11-08 |
2007-05-18 |
N.V. Organon |
2-(benzimidazol-1-yl)-acetamide biaryl derivatives and their use as inhibitors of the trpv1 receptor
|
|
US20120232059A1
(en)
|
2005-11-08 |
2012-09-13 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette Transporters
|
|
CN101326182B
(zh)
|
2005-12-05 |
2011-09-28 |
史密丝克莱恩比彻姆公司 |
2-嘧啶基吡唑并吡啶ErbB激酶抑制剂
|
|
JP2009521468A
(ja)
|
2005-12-24 |
2009-06-04 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Abc輸送体の調節因子としてのキノリン−4−オン誘導体
|
|
AU2006331565A1
(en)
|
2005-12-27 |
2007-07-05 |
Vertex Pharmaceuticals Incorporated |
Compounds useful in CFTR assays and methods therewith
|
|
EP2016065B1
(en)
|
2005-12-28 |
2012-09-19 |
Vertex Pharmaceuticals Incorporated |
1-(benzo[d][1,3]dioxol-5-yl)-n-(phenyl)cyclopropane-carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis
|
|
US7671221B2
(en)
|
2005-12-28 |
2010-03-02 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette transporters
|
|
PL1993360T3
(pl)
|
2005-12-28 |
2017-08-31 |
Vertex Pharmaceuticals Incorporated |
Stałe postacie n-[2,4-bis(1,1-dimetyloetylo)-5-hydroksyfenylo]-1,4- dihydro-4-oksochinolino-3-karboksyamidu
|
|
PL2674428T3
(pl)
|
2006-04-07 |
2017-01-31 |
Vertex Pharmaceuticals Incorporated |
Modulatory transporterów z kasetą wiążącą ATP
|
|
US10022352B2
(en)
|
2006-04-07 |
2018-07-17 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
|
US7645789B2
(en)
|
2006-04-07 |
2010-01-12 |
Vertex Pharmaceuticals Incorporated |
Indole derivatives as CFTR modulators
|
|
WO2007134279A2
(en)
|
2006-05-12 |
2007-11-22 |
Vertex Pharmaceuticals Incorporated |
Compositions of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
|
CN101715450B
(zh)
|
2006-11-03 |
2013-03-13 |
沃泰克斯药物股份有限公司 |
作为cftr调控剂的氮杂吲哚衍生物
|
|
US8563573B2
(en)
|
2007-11-02 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Azaindole derivatives as CFTR modulators
|
|
US7754739B2
(en)
|
2007-05-09 |
2010-07-13 |
Vertex Pharmaceuticals Incorporated |
Modulators of CFTR
|
|
CN101541759A
(zh)
|
2006-11-27 |
2009-09-23 |
诺瓦提斯公司 |
取代的二氢咪唑类及其在治疗肿瘤中的用途
|
|
US20080260820A1
(en)
|
2007-04-19 |
2008-10-23 |
Gilles Borrelly |
Oral dosage formulations of protease-resistant polypeptides
|
|
CA2686838C
(en)
|
2007-05-09 |
2017-03-14 |
Vertex Pharmaceuticals Incorporated |
Modulators of cftr
|
|
AU2008256717B2
(en)
|
2007-05-25 |
2013-11-21 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
WO2009023509A2
(en)
|
2007-08-09 |
2009-02-19 |
Vertex Pharmaceuticals Incorporated |
Therapeutic combinations useful in treating cftr related diseases
|
|
JP5389030B2
(ja)
|
2007-08-24 |
2014-01-15 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
(特に)嚢胞性線維症の処置に有用なイソチアゾロピリジノン
|
|
DE102007042754A1
(de)
|
2007-09-07 |
2009-03-12 |
Bayer Healthcare Ag |
Substituierte 6-Phenylnikotinsäuren und ihre Verwendung
|
|
NZ620027A
(en)
|
2007-09-14 |
2015-05-29 |
Vertex Pharma |
Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
|
ES2445442T3
(es)
|
2007-09-14 |
2014-03-03 |
Vertex Pharmaceuticals Inc. |
Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
|
|
FR2921657A1
(fr)
|
2007-09-28 |
2009-04-03 |
Sanofi Aventis Sa |
Derives de nicotinamide, leur preparation et leur application en therapeutique
|
|
DK2578571T3
(en)
|
2007-11-16 |
2015-10-05 |
Vertex Pharma |
Isoquinoline modulators of ATP binding cassette transporters
|
|
CN101998854A
(zh)
|
2007-12-07 |
2011-03-30 |
沃泰克斯药物股份有限公司 |
3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的制剂
|
|
US20100036130A1
(en)
|
2007-12-07 |
2010-02-11 |
Vertex Pharmaceuticals Incorporated |
Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
|
|
LT3170818T
(lt)
|
2007-12-07 |
2020-05-25 |
Vertex Pharmaceuticals Incorporated |
Kietos 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzoinės rūgšties formos
|
|
DK2639222T3
(en)
|
2007-12-07 |
2016-10-03 |
Vertex Pharma |
Methods for preparing cycloalkylcarboxamido-pyridinbenzoesyrer
|
|
NZ586271A
(en)
|
2007-12-13 |
2012-08-31 |
Vertex Pharma |
Fused pyrimidinone derivatives as modulators of cystic fibrosis transmembrane conductance regulator
|
|
WO2009108657A2
(en)
|
2008-02-28 |
2009-09-03 |
Vertex Pharmaceuticals Incorporated |
Heteroaryl derivatives as cftr modulators
|
|
AU2009231993B2
(en)
|
2008-03-31 |
2013-10-10 |
Vertex Pharmaceuticals Incorporated |
Pyridyl derivatives as CFTR modulators
|
|
GB0813709D0
(en)
|
2008-07-26 |
2008-09-03 |
Univ Dundee |
Method and product
|
|
US20100074949A1
(en)
|
2008-08-13 |
2010-03-25 |
William Rowe |
Pharmaceutical composition and administration thereof
|
|
SMT201800074T1
(it)
|
2008-08-13 |
2018-05-02 |
Vertex Pharma |
Composizione farmaceutica di n-[2,4-bis(1,1-dimetiletil)-5-idrossifenil]-1,4-diidro-4-ossochinolin-3-carbossammide e sua somministrazione
|
|
US20100256184A1
(en)
|
2008-08-13 |
2010-10-07 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical composition and administrations thereof
|
|
EP2349223A2
(en)
|
2008-09-29 |
2011-08-03 |
Vertex Pharmaceuticals Incorporated |
Dosage units of 3-(6-(1-(2,2-difluorobenzo [d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
|
|
US20110257223A1
(en)
|
2008-10-23 |
2011-10-20 |
Vertex Pharmaceuticals Incorporated |
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
|
|
HRP20130536T1
(en)
|
2008-10-23 |
2013-07-31 |
Vertex Pharmaceuticals Incorporated |
Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
|
|
AU2009308232B2
(en)
|
2008-10-23 |
2016-02-04 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
CN102227424B
(zh)
|
2008-10-23 |
2013-08-14 |
沃泰克斯药物股份有限公司 |
囊性纤维化跨膜传导调节因子的调节剂
|
|
RS53868B1
(sr)
|
2008-11-06 |
2015-08-31 |
Vertex Pharmaceuticals Incorporated |
Modulatori atp-vezujućih kasetnih transportera
|
|
UA104876C2
(uk)
|
2008-11-06 |
2014-03-25 |
Вертекс Фармасьютікалз Інкорпорейтед |
Модулятори atф-зв'язувальних касетних транспортерів
|
|
EP2382197B1
(en)
|
2008-12-30 |
2016-10-05 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
HRP20181261T1
(hr)
|
2009-03-20 |
2018-12-14 |
Vertex Pharmaceuticals Incorporated |
Modulatori regulatora transmembranske provodljivosti cistične fibroze
|
|
ES2654414T3
(es)
|
2009-03-20 |
2018-02-13 |
Vertex Pharmaceuticals Incorporated |
Proceso de preparación de moduladores del regulador de la conductancia transmembrana de la fibrosis quística
|
|
DK2427166T3
(da)
|
2009-05-07 |
2014-01-27 |
Gea Pharma Systems Ltd |
Tabletfremstillingsmodul og fremgangsmåde til kontinuerlig fremstilling af tabletter
|
|
JP5793496B2
(ja)
|
2009-09-17 |
2015-10-14 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
アザ二環式化合物を調製するプロセス
|
|
CA2777245A1
(en)
|
2009-10-22 |
2011-04-28 |
Vertex Pharmaceuticals Incorporated |
Compositions for treatment of cystic fibrosis and other chronic diseases
|
|
AU2010310612A1
(en)
|
2009-10-23 |
2012-06-14 |
Vertex Pharmaceuticals Incorporated |
Process for preparing modulators of cystic fibrosis transmembrane conductance regulator
|
|
CA2778493A1
(en)
|
2009-10-23 |
2011-04-28 |
Vertex Pharmaceuticals Incorporated |
Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
|
|
US8471029B2
(en)
|
2010-03-19 |
2013-06-25 |
Vertex Pharmaceutical Incorporated |
Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
|
US20110251253A1
(en)
|
2010-03-25 |
2011-10-13 |
Vertex Pharmaceuticals Incorporated |
Solid forms of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide
|
|
US8802868B2
(en)
|
2010-03-25 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
|
|
RS62767B1
(sr)
|
2010-04-07 |
2022-01-31 |
Vertex Pharma |
Farmaceutski sastavi 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiriodin-2-il)benzojeve kiseline i njihova primena
|
|
MX2012011655A
(es)
|
2010-04-07 |
2012-11-23 |
Vertex Pharma |
Formas solidas de acido 3-(6-(1-(2,2-difluorobenzo [d][1-3]dioxol-5-il]ciclopropanocarboxamido)-3-metilpiridin-2-il) benzoico.
|
|
EP3045452A1
(en)
|
2010-04-22 |
2016-07-20 |
Vertex Pharmaceuticals Inc. |
Process of producing cycloalkylcarboxamido-indole compounds
|
|
AU2011242457A1
(en)
|
2010-04-22 |
2012-11-08 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions and administrations thereof
|
|
AU2011242454A1
(en)
|
2010-04-22 |
2012-11-08 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions and administrations thereof
|
|
EP2560649A1
(en)
|
2010-04-22 |
2013-02-27 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions and administrations thereof
|
|
EP2575814A1
(en)
|
2010-05-20 |
2013-04-10 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions and administrations thereof
|
|
TW201202250A
(en)
|
2010-05-20 |
2012-01-16 |
Vertex Pharma |
Processes for producing modulators of cystic fibrosis transmembrane conductance regulator
|
|
US8563593B2
(en)
|
2010-06-08 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
|
|
EP2608779A2
(en)
|
2010-08-23 |
2013-07-03 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof
|
|
WO2012027731A2
(en)
|
2010-08-27 |
2012-03-01 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical composition and administrations thereof
|
|
EP2452972B2
(de)
|
2010-11-10 |
2022-04-13 |
Continental Reifen Deutschland GmbH |
Nutzfahrzeugluftreifen
|
|
US8802700B2
(en)
|
2010-12-10 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette transporters
|
|
EP2773349A1
(en)
|
2011-11-02 |
2014-09-10 |
Vertex Pharmaceuticals Incorporated |
Use of (n- [2, 4 -bis (1, 1 -dimethylethyl) - 5 - hydroxyphenyl]- 1, 4 - dihydro - 4 - oxoquinoline - 3 - carboxamide) for treating cftr mediated diseases
|
|
US20140127901A1
(en)
|
2012-11-08 |
2014-05-08 |
Taiwan Semiconductor Manufacturing Company, Ltd. |
Low-k damage free integration scheme for copper interconnects
|
|
US9254291B2
(en)
|
2011-11-08 |
2016-02-09 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
|
LT2806859T
(lt)
|
2012-01-25 |
2019-10-25 |
Vertex Pharma |
3-(6-(1-(2,2-difluorbenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiridin-2-il)benzenkarboksirūgšties kompozicijos
|
|
BR112014021090B1
(pt)
|
2012-02-27 |
2023-01-24 |
Vertex Pharmaceuticals Incorporated |
Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma
|
|
US8674108B2
(en)
|
2012-04-20 |
2014-03-18 |
Vertex Pharmaceuticals Incorporated |
Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
|
WO2013185112A1
(en)
|
2012-06-08 |
2013-12-12 |
Vertex Pharmaceuticals Incorporated |
Pharmaceuticl compositions for the treatment of cftr -mediated disorders
|
|
US9012496B2
(en)
|
2012-07-16 |
2015-04-21 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide and administration thereof
|
|
SMT201800590T1
(it)
|
2012-11-02 |
2019-01-11 |
Vertex Pharma |
Composizioni farmaceutiche per il trattamento di malattie mediate da cftr
|
|
US20140221424A1
(en)
|
2013-01-30 |
2014-08-07 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions for use in the treatment of cystic fibrosis
|
|
PL3925607T3
(pl)
|
2014-04-15 |
2023-10-30 |
Vertex Pharmaceuticals Incorporated |
Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
|
|
IL313498A
(en)
|
2014-10-06 |
2024-08-01 |
Vertex Pharma |
Modulators of the cystic fibrosis transmembrane conductance regulator
|
|
ES2702288T3
(es)
|
2014-10-07 |
2019-02-28 |
Vertex Pharma |
Co-cristales de moduladores de regulador de conductancia transmembrana de la fibrosis quística
|
|
WO2016086136A1
(en)
|
2014-11-26 |
2016-06-02 |
Catabasis Pharmaceuticals, Inc. |
Fatty acid cysteamine conjugates of cftr modulators and their use in treating medical disorders
|
|
MA41031A
(fr)
|
2014-11-26 |
2017-10-03 |
Catabasis Pharmaceuticals Inc |
Conjugués cystéamine-acide gras et leur utilisation comme activateurs de l'autophagie
|
|
US10414768B2
(en)
|
2014-12-05 |
2019-09-17 |
Centre National De La Recherche Scientifique (Cnrs) |
Compounds for treating cystic fibrosis
|
|
EP3250565B1
(en)
|
2015-01-26 |
2019-07-03 |
Rigel Pharmaceuticals, Inc. |
Tetrazolones as carboxylic acid bioisosteres
|
|
TWI730959B
(zh)
|
2015-05-19 |
2021-06-21 |
英商葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之雜環醯胺
|