JP2013508407A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013508407A5 JP2013508407A5 JP2012535394A JP2012535394A JP2013508407A5 JP 2013508407 A5 JP2013508407 A5 JP 2013508407A5 JP 2012535394 A JP2012535394 A JP 2012535394A JP 2012535394 A JP2012535394 A JP 2012535394A JP 2013508407 A5 JP2013508407 A5 JP 2013508407A5
- Authority
- JP
- Japan
- Prior art keywords
- peak
- degrees
- disease
- hcl
- ppm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25461409P | 2009-10-23 | 2009-10-23 | |
| US61/254,614 | 2009-10-23 | ||
| PCT/US2010/053633 WO2011050220A1 (en) | 2009-10-23 | 2010-10-21 | Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013508407A JP2013508407A (ja) | 2013-03-07 |
| JP2013508407A5 true JP2013508407A5 (enExample) | 2013-12-05 |
| JP5877157B2 JP5877157B2 (ja) | 2016-03-02 |
Family
ID=43334525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012535394A Expired - Fee Related JP5877157B2 (ja) | 2009-10-23 | 2010-10-21 | Ｎ−（４−（７−アザビシクロ［２．２．１］ヘプタン−７−イル）−２−（トリフルオロメチル）フェニル）−４−オキソ−５−（トリフルオロメチル）−１，４−ジヒドロキノリン−３−カルボキサミドの固体形態 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8389727B2 (enExample) |
| EP (1) | EP2491042A1 (enExample) |
| JP (1) | JP5877157B2 (enExample) |
| KR (1) | KR20120102645A (enExample) |
| CN (1) | CN102666546B (enExample) |
| AR (1) | AR078766A1 (enExample) |
| AU (1) | AU2010310617A1 (enExample) |
| BR (1) | BR112012009584A2 (enExample) |
| CA (1) | CA2778493A1 (enExample) |
| CL (1) | CL2012001007A1 (enExample) |
| IL (1) | IL219327A0 (enExample) |
| MX (1) | MX2012004791A (enExample) |
| NZ (1) | NZ599703A (enExample) |
| RU (1) | RU2568608C2 (enExample) |
| TW (1) | TWI507409B (enExample) |
| UA (1) | UA108087C2 (enExample) |
| WO (1) | WO2011050220A1 (enExample) |
| ZA (1) | ZA201202919B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06002567A (es) | 2003-09-06 | 2006-09-04 | Vertex Pharma | Moduladores de transportadores con casete de union de atp. |
| US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| CN101891680B (zh) | 2004-06-24 | 2014-10-29 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的调控剂 |
| ATE512145T1 (de) | 2005-08-11 | 2011-06-15 | Vertex Pharma | Modulatoren des cystic fibrosis transmembrane conductance regulators |
| EP2774925B1 (en) | 2005-11-08 | 2016-12-28 | Vertex Pharmaceuticals Incorporated | Heterocyclic modulators of ATP-binding cassette transporters |
| DK3219705T3 (da) | 2005-12-28 | 2020-04-14 | Vertex Pharma | Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid |
| AU2006336504C9 (en) | 2005-12-28 | 2015-05-14 | Vertex Pharmaceuticals Incorporated | 1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis |
| US7776905B2 (en) | 2006-04-07 | 2010-08-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| WO2008141119A2 (en) | 2007-05-09 | 2008-11-20 | Vertex Pharmaceuticals Incorporated | Modulators of cftr |
| WO2009038913A2 (en) | 2007-08-24 | 2009-03-26 | Vertex Pharmaceuticals Incorporated | Isothiazolopyridinones useful for the treatment of (inter alia) cystic fibrosis |
| HRP20140103T1 (hr) | 2007-11-16 | 2014-05-09 | Vertex Pharmaceuticals Inc. | Izokinolinski modulatori transportera atp-vežuä†e kazete |
| HUE031913T2 (en) | 2007-12-07 | 2017-08-28 | Vertex Pharma | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid |
| US20100036130A1 (en) | 2007-12-07 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
| PL2231606T3 (pl) * | 2007-12-07 | 2013-07-31 | Vertex Pharma | Sposoby wytwarzania kwasów cykloalkilokarboksyamidopirydynobenzoesowych |
| US20090176839A1 (en) * | 2007-12-07 | 2009-07-09 | Ali Keshavarz-Shokri | Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| JP5523352B2 (ja) | 2008-02-28 | 2014-06-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｃｆｔｒ修飾因子としてのへテロアリール誘導体 |
| DK2615085T3 (en) | 2008-03-31 | 2015-10-05 | Vertex Pharma | Pyridyl derivatives as CFTR modulators |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| AU2009296271A1 (en) | 2008-09-29 | 2010-04-01 | Vertex Pharmaceuticals Incorporated | Dosage units of 3-(6-(1-(2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| TWI465449B (zh) * | 2008-10-23 | 2014-12-21 | Vertex Pharma | 囊腫性纖維化跨膜傳導調節因子之調控因子 |
| EP2358680B1 (en) * | 2008-10-23 | 2013-03-20 | Vertex Pharmaceuticals Incorporated | Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide |
| KR101727762B1 (ko) | 2009-03-20 | 2017-04-17 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법 |
| CN102498112B (zh) * | 2009-09-17 | 2015-05-20 | 沃泰克斯药物股份有限公司 | 制备氮杂二环化合物的方法 |
| KR20120102645A (ko) * | 2009-10-23 | 2012-09-18 | 버텍스 파마슈티칼스 인코포레이티드 | Ｎ-(4-(7-아자비시클로［2.2.1］헵탄-7-일)-2-(트리플루오로메틸)페닐)-4-옥소-5-(트리플루오로메틸)-1,4-디히드로퀴놀린-3-카르복사미드의 고체 형태 |
| JP5789611B2 (ja) * | 2009-10-23 | 2015-10-07 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターを調製するためのプロセス |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| NZ602795A (en) | 2010-04-07 | 2015-01-30 | Vertex Pharma | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| RS62767B1 (sr) | 2010-04-07 | 2022-01-31 | Vertex Pharma | Farmaceutski sastavi 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiriodin-2-il)benzojeve kiseline i njihova primena |
| CN105130948A (zh) | 2010-04-22 | 2015-12-09 | 弗特克斯药品有限公司 | 制备环烷基甲酰胺基-吲哚化合物的方法 |
| AR081920A1 (es) * | 2010-05-20 | 2012-10-31 | Vertex Pharma | Procesos de produccion de moduladores del regulador de conductancia transmembrana de fibrosis quistica |
| US8563593B2 (en) | 2010-06-08 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
| RU2640420C2 (ru) | 2011-11-08 | 2018-01-09 | Вертекс Фармасьютикалз Инкорпорейтед | Модуляторы транспортеров атф-связывающей кассеты |
| MX355183B (es) | 2012-01-25 | 2018-04-09 | Vertex Pharma | Formulaciones de acido 3- (6- (1- (2.2- difluorobenzo [d] [1,3] dioxol-5-il) ciclopropancarboxamido) -3- metilpiridin-2-il) benzoico. |
| JP2015511583A (ja) | 2012-02-27 | 2015-04-20 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 薬学的組成物およびその投与 |
| US8674108B2 (en) | 2012-04-20 | 2014-03-18 | Vertex Pharmaceuticals Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| CA2878057A1 (en) | 2012-07-16 | 2014-01-23 | Rossitza Gueorguieva Alargova | Pharmaceutical compositions of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof |
| HRP20210516T2 (hr) | 2013-11-12 | 2021-10-01 | Vertex Pharmaceuticals Incorporated | Postupak proizvodnje farmaceutskih pripravaka za liječenje bolesti koje su posredovane putem cftr |
| JP6543268B2 (ja) | 2014-04-15 | 2019-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物 |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
| KR102576006B1 (ko) | 2014-11-18 | 2023-09-06 | 버텍스 파마슈티칼스 인코포레이티드 | 고처리량 시험 고성능 액체 크로마토그래피의 수행 방법 |
| CR20230120A (es) | 2020-08-07 | 2023-09-01 | Vertex Pharma | Moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| US12324802B2 (en) | 2020-11-18 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5716981A (en) | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
| ITMI941099A1 (it) * | 1994-05-27 | 1995-11-27 | Smithkline Beecham Farma | Derivati chinolinici |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| CN101891680B (zh) | 2004-06-24 | 2014-10-29 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的调控剂 |
| DK3219705T3 (da) * | 2005-12-28 | 2020-04-14 | Vertex Pharma | Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid |
| EA017919B1 (ru) | 2007-12-10 | 2013-04-30 | Новартис Аг | Производные пиразин-2-карбоксамида для лечения заболеваний, которые поддаются лечению путем блокирования эпителиальных натриевых каналов |
| TWI465449B (zh) * | 2008-10-23 | 2014-12-21 | Vertex Pharma | 囊腫性纖維化跨膜傳導調節因子之調控因子 |
| US20110257223A1 (en) * | 2008-10-23 | 2011-10-20 | Vertex Pharmaceuticals Incorporated | Modulators of Cystic Fibrosis Transmembrane Conductance Regulator |
| EP2358680B1 (en) * | 2008-10-23 | 2013-03-20 | Vertex Pharmaceuticals Incorporated | Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide |
| JP5789611B2 (ja) * | 2009-10-23 | 2015-10-07 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターを調製するためのプロセス |
| KR20120102645A (ko) * | 2009-10-23 | 2012-09-18 | 버텍스 파마슈티칼스 인코포레이티드 | Ｎ-(4-(7-아자비시클로［2.2.1］헵탄-7-일)-2-(트리플루오로메틸)페닐)-4-옥소-5-(트리플루오로메틸)-1,4-디히드로퀴놀린-3-카르복사미드의 고체 형태 |
-
2010
- 2010-10-21 KR KR1020127013139A patent/KR20120102645A/ko not_active Withdrawn
- 2010-10-21 UA UAA201206183A patent/UA108087C2/uk unknown
- 2010-10-21 NZ NZ599703A patent/NZ599703A/en not_active IP Right Cessation
- 2010-10-21 CA CA2778493A patent/CA2778493A1/en not_active Abandoned
- 2010-10-21 US US12/909,789 patent/US8389727B2/en active Active
- 2010-10-21 MX MX2012004791A patent/MX2012004791A/es active IP Right Grant
- 2010-10-21 BR BR112012009584A patent/BR112012009584A2/pt not_active IP Right Cessation
- 2010-10-21 JP JP2012535394A patent/JP5877157B2/ja not_active Expired - Fee Related
- 2010-10-21 EP EP10774360A patent/EP2491042A1/en not_active Withdrawn
- 2010-10-21 CN CN201080053379.2A patent/CN102666546B/zh not_active Expired - Fee Related
- 2010-10-21 WO PCT/US2010/053633 patent/WO2011050220A1/en not_active Ceased
- 2010-10-21 RU RU2012121168/04A patent/RU2568608C2/ru not_active IP Right Cessation
- 2010-10-21 AU AU2010310617A patent/AU2010310617A1/en not_active Abandoned
- 2010-10-22 TW TW099136177A patent/TWI507409B/zh not_active IP Right Cessation
- 2010-10-25 AR ARP100103915A patent/AR078766A1/es unknown
-
2012
- 2012-04-20 ZA ZA2012/02919A patent/ZA201202919B/en unknown
- 2012-04-20 CL CL2012001007A patent/CL2012001007A1/es unknown
- 2012-04-22 IL IL219327A patent/IL219327A0/en unknown
-
2013
- 2013-01-28 US US13/751,656 patent/US8741922B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2012121168A (ru) | Твердые формы n-(4-(7-азабицикло[2.2.1]гептан-7-ил)-2-(трифторметил)фенил)-4-оксо-5-(трифторметил)-1,4-дигидрохинолин-3-карбоксамида | |
| JP2011505338A5 (enExample) | ||
| JP2013513617A5 (enExample) | ||
| RU2011120327A (ru) | Твердые формы n-(4-(7-азабицикло[2.2.1]гептан-7-ил-)-2-(трифторметил)фенил)-4-оксо-5-(трифторметил)-1,4-дигидрохинолин-3-карбоксамида | |
| US8471029B2 (en) | Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide | |
| JP2013501787A5 (enExample) | ||
| JP2012521361A5 (enExample) | ||
| US20230263794A1 (en) | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide | |
| RU2012129206A (ru) | Модуляторы атф-связывающих транспортеров | |
| JP2019513741A5 (enExample) | ||
| JP2015511583A5 (enExample) | ||
| JP2013508414A5 (enExample) | ||
| JP2013536231A5 (enExample) | ||
| IL273752B2 (en) | Ingredients, compounds and methods for increasing CFTR activity | |
| HRP20160682T1 (hr) | Čvrsti oblici 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksiamido)-3-metilpiridin-2-il)benzojeve kiseline | |
| SI2328618T1 (en) | A pharmaceutical composition of N- (2,4-bis (1,1-dimethylethyl) -5-hydroxyphenyl) -1,4-dihyro-4-oxyloquinoline-3-carboxamide and its administration | |
| HRP20210165T1 (hr) | Čvrsta disperzija amorfnog oblika (r)-1(2,2-difluorobenzo(d)(1,3)dioksol-5-il)-n-(1-(2,3-dihidroksipropil)-6-fluoro-2-(1-hidroksi-2-metilpropan-2-il)-1h-indol-5-il)-ciklopropankarboksamida | |
| JP2011516420A5 (enExample) | ||
| US8674108B2 (en) | Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide | |
| JP2010526831A5 (enExample) | ||
| JP2013245219A5 (enExample) | ||
| NZ603044A (en) | Pharmaceutical compositions comprising cftr modulators and administrations thereof | |
| RU2014134456A (ru) | Препараты 3-(6-(1-(2, 2-дифторбензо[d][1, 3]диоксол-5-ил)циклопропанкарбоксамидо)-3-метилпиридин-2-ил)бензойной кислоты | |
| HK40035480A (en) | A solid form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide | |
| RU2009142031A (ru) | Способ модуляции транспортеров атф-связывающей кассеты |