|
DE3812225A1
(de)
|
1988-04-13 |
1989-10-26 |
Basf Ag |
Isoxazol(isothiazol)-5-carbonsaeureamide
|
|
CA2201478A1
(en)
|
1995-08-02 |
1997-02-13 |
J. Uriach & Cia S.A. |
New carboxamides with antifungal activity
|
|
ATE243204T1
(de)
|
1995-08-24 |
2003-07-15 |
Basf Ag |
Isoxazole- und isothiazole-5-carboxamid derivate, deren herstellung und deren verwendung als herbizide
|
|
PT957099E
(pt)
|
1998-04-15 |
2003-02-28 |
Pfizer Prod Inc |
Carboxamidas heterociclicas
|
|
AU2001273040A1
(en)
|
2000-06-27 |
2002-01-08 |
Du Pont Pharmaceuticals Company |
Factor xa inhibitors
|
|
JP4901102B2
(ja)
|
2002-05-03 |
2012-03-21 |
エクセリクシス， インク． |
プロテインキナーゼモジュレーターおよびその使用方法
|
|
AU2004279855A1
(en)
|
2003-10-08 |
2005-04-21 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters containing cycloalkyl or pyranyl groups
|
|
EP1682127B1
(en)
|
2003-11-14 |
2009-07-29 |
Vertex Pharmaceuticals Incorporated |
Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters
|
|
WO2005077373A2
(en)
|
2004-02-03 |
2005-08-25 |
Astrazeneca Ab |
Treatment of gastro-esophageal reflux disease (gerd)
|
|
WO2005077345A1
(en)
|
2004-02-03 |
2005-08-25 |
Astrazeneca Ab |
Compounds for the treatment of gastro-esophageal reflux disease
|
|
CA2565965A1
(en)
|
2004-05-06 |
2006-07-27 |
Plexxikon, Inc. |
Pde4b inhibitors and uses therefor
|
|
SE0401969D0
(sv)
|
2004-08-02 |
2004-08-02 |
Astrazeneca Ab |
Piperidine derivatives
|
|
US20060100226A1
(en)
|
2004-09-10 |
2006-05-11 |
Sikorski James A |
2-Thiopyrimidinones as therapeutic agents
|
|
DE102004051277A1
(de)
|
2004-10-21 |
2006-04-27 |
Merck Patent Gmbh |
Heterocyclische Carbonylverbindungen
|
|
JP2006176443A
(ja)
|
2004-12-22 |
2006-07-06 |
Shionogi & Co Ltd |
メラニン凝集ホルモン受容体アンタゴニスト
|
|
DE602006018301D1
(de)
|
2005-06-22 |
2010-12-30 |
Pfizer Prod Inc |
Histamin-3-rezeptorantagonisten
|
|
JP4822406B2
(ja)
|
2005-09-26 |
2011-11-24 |
ルネサスエレクトロニクス株式会社 |
表示制御駆動装置および表示システム
|
|
WO2007075896A2
(en)
|
2005-12-22 |
2007-07-05 |
Kemia, Inc. |
Heterocyclic cytokine inhibitors
|
|
KR101394245B1
(ko)
|
2005-12-30 |
2014-05-14 |
에스케이바이오팜 주식회사 |
아이속사졸 유도체 및 이의 용도
|
|
WO2007086584A1
(ja)
|
2006-01-30 |
2007-08-02 |
Meiji Seika Kaisha, Ltd. |
新規ＦａｂＫおよびＦａｂＩ／Ｋ阻害剤
|
|
TW200815351A
(en)
|
2006-05-02 |
2008-04-01 |
Astrazeneca Ab |
Novel compounds
|
|
WO2008046072A2
(en)
|
2006-10-13 |
2008-04-17 |
The Board Of Regents Of The University Of Texas System |
Chemical inducers of neurogenesis
|
|
US8193225B2
(en)
|
2006-10-13 |
2012-06-05 |
The Board Of Regents Of The University Of Texas System |
Isoxazole amides, derivatives and methods of chemical induction of neurogenesis
|
|
US7678792B2
(en)
|
2006-10-20 |
2010-03-16 |
Irm Llc |
Compositions and methods for modulating c-kit and PDGFR receptors
|
|
WO2008070739A1
(en)
|
2006-12-06 |
2008-06-12 |
Cytokinetics, Inc. |
Ksp activators
|
|
JP5311075B2
(ja)
|
2007-06-29 |
2013-10-09 |
エスケー バイオファーマスティカルズ カンパニー リミテッド |
イソキサゾール誘導体を含む、再狭窄の予防及び治療のための医薬組成物
|
|
WO2009011850A2
(en)
|
2007-07-16 |
2009-01-22 |
Abbott Laboratories |
Novel therapeutic compounds
|
|
US8211927B2
(en)
|
2007-08-02 |
2012-07-03 |
MSD, Oss B.V. |
5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators
|
|
US8642660B2
(en)
|
2007-12-21 |
2014-02-04 |
The University Of Rochester |
Method for altering the lifespan of eukaryotic organisms
|
|
US8236838B2
(en)
|
2008-04-21 |
2012-08-07 |
Institute For Oneworld Health |
Compounds, compositions and methods comprising isoxazole derivatives
|
|
US20090318429A1
(en)
|
2008-04-28 |
2009-12-24 |
Institute For Oneworld Health |
Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives
|
|
US20120095002A1
(en)
|
2009-02-04 |
2012-04-19 |
N.V. Organon |
Isoxazole-5-carboxamide derivatives
|
|
BRPI1008974A2
(pt)
|
2009-03-11 |
2017-06-06 |
Kyorin Seiyaku Kk |
composto, composição farmacêutica, e, método para tratar, prevenir ou melhorar uma doença mediada com gsk-3
|
|
MX384179B
(es)
*
|
2009-03-20 |
2025-03-14 |
Vertex Pharma |
Proceso para producir moduladores del regulador de conductancia transmembrana de fibrosis quística.
|
|
GB0910003D0
(en)
|
2009-06-11 |
2009-07-22 |
Univ Leuven Kath |
Novel compounds for the treatment of neurodegenerative diseases
|
|
IN2012DN00352A
(enExample)
|
2009-06-16 |
2015-08-21 |
Bikam Pharmaceuticals Inc |
|
|
WO2011008931A2
(en)
|
2009-07-15 |
2011-01-20 |
Cystic Fibrosis Foundation Therapeutics, Inc. |
Arylpyrimidine compounds and combination therapy comprising same for treating cystic fibrosis & related disorders
|
|
US9212177B2
(en)
|
2009-08-05 |
2015-12-15 |
Versitech Limited |
Antiviral compounds and methods of making and using thereof
|
|
GB2474120B
(en)
|
2009-10-01 |
2011-12-21 |
Amira Pharmaceuticals Inc |
Compounds as Lysophosphatidic acid receptor antagonists
|
|
US8569899B2
(en)
|
2009-12-30 |
2013-10-29 |
Stmicroelectronics, Inc. |
Device and method for alignment of vertically stacked wafers and die
|
|
US8247436B2
(en)
|
2010-03-19 |
2012-08-21 |
Novartis Ag |
Pyridine and pyrazine derivative for the treatment of CF
|
|
WO2011133953A1
(en)
|
2010-04-22 |
2011-10-27 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions and administrations thereof
|
|
ES2603032T3
(es)
|
2010-07-15 |
2017-02-23 |
Bayer Intellectual Property Gmbh |
Compuestos de 3-piridil-heteroarilcarboxamida como pesticidas
|
|
DK2684880T3
(en)
|
2011-03-10 |
2018-05-22 |
Daiichi Sankyo Co Ltd |
DISPIROPYRROLIDINE DERIVATIVES
|
|
CA2736441A1
(en)
|
2011-04-06 |
2012-10-06 |
The Regents Of The University Of California |
Pyrazolylthiazole compounds as .delta.f508-cystic fibrosis transmembrane conductance regulator correctors
|
|
PL2709986T3
(pl)
|
2011-05-18 |
2017-09-29 |
Concert Pharmaceuticals Inc. |
Deuterowane pochodne iwakaftoru
|
|
HUE047354T2
(hu)
|
2011-05-18 |
2020-04-28 |
Vertex Pharmaceuticals Europe Ltd |
Ivacaftor deuterizált származékai
|
|
CA2842364A1
(en)
|
2011-07-29 |
2013-02-07 |
Karyopharm Therapeutics, Inc. |
Nuclear transport modulators and uses thereof
|
|
ES2558457T3
(es)
|
2011-09-16 |
2016-02-04 |
Novartis Ag |
Compuestos heterocíclicos para el tratamiento de fibrosis quística
|
|
US9056867B2
(en)
|
2011-09-16 |
2015-06-16 |
Novartis Ag |
N-substituted heterocyclyl carboxamides
|
|
US8623860B2
(en)
|
2011-12-30 |
2014-01-07 |
Boehringer Ingelheim International Gmbh |
Azetidine derivatives, pharmaceutical compositions and uses thereof
|
|
JP6138834B2
(ja)
|
2012-02-16 |
2017-05-31 |
ダウ アグロサイエンシィズ エルエルシー |
スルフィルイミン化合物の製造方法
|
|
UA110436C2
(en)
|
2012-03-06 |
2015-12-25 |
Zoetis Llc |
Antibacterial phenol compounds
|
|
WO2013146970A1
(ja)
|
2012-03-29 |
2013-10-03 |
第一三共株式会社 |
新規キノリン誘導体
|
|
ES2713988T3
(es)
|
2012-08-01 |
2019-05-24 |
United Therapeutics Corp |
Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina
|
|
WO2014045283A1
(en)
|
2012-09-24 |
2014-03-27 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Restoration of the cftr function by splicing modulation
|
|
WO2014081821A2
(en)
|
2012-11-20 |
2014-05-30 |
Discoverybiomed, Inc. |
Small Molecule Bicyclic and Tricyclic CFTR Correctors
|
|
AU2013348018A1
(en)
|
2012-11-20 |
2015-06-04 |
Discoverybiomed, Inc. |
Small molecule CFTR correctors
|
|
CN103833630B
(zh)
*
|
2012-11-21 |
2018-11-13 |
顶点制药（欧洲）有限公司 |
氘化cftr增效剂
|
|
WO2014160478A1
(en)
|
2013-03-13 |
2014-10-02 |
Flatley Discovery Lab |
Compounds and methods for the treatment of cystic fibrosis
|
|
US9783529B2
(en)
|
2013-03-13 |
2017-10-10 |
Flatley Discovery Lab, Llc |
Pyridazinone compounds and methods for the treatment of cystic fibrosis
|
|
CA2903103C
(en)
|
2013-03-15 |
2020-06-09 |
Discoverybiomed, Inc. |
Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders
|
|
CA2907260A1
(en)
|
2013-03-15 |
2014-09-18 |
The University Of North Carolina Chapel Hill |
Correctors acting through msd1 of cftr protein
|
|
WO2014176553A1
(en)
|
2013-04-26 |
2014-10-30 |
Vertex Pharmaceuticals Incorporated |
Correctors acting through msd1 of cftr protein
|
|
MX368263B
(es)
|
2013-05-07 |
2019-09-26 |
Galapagos Nv |
Compuestos novedosos y composiciones farmaceuticas de los mismos para el tratamiento de fibrosis quistica.
|
|
WO2014181287A1
(en)
|
2013-05-09 |
2014-11-13 |
Piramal Enterprises Limited |
Heterocyclyl compounds and uses thereof
|
|
US20160151335A1
(en)
|
2013-06-26 |
2016-06-02 |
Proteostasis Therapeutics, Inc. |
Methods of modulating cftr activity
|
|
WO2015051230A1
(en)
|
2013-10-04 |
2015-04-09 |
Drexel University |
Novel compositions useful for inhibiting hiv-1 infection and methods using same
|
|
EP3116501A1
(en)
|
2014-03-13 |
2017-01-18 |
Proteostasis Therapeutics, Inc. |
Compounds, compositions, and methods for increasing cftr activity
|
|
EP3116870A1
(en)
|
2014-03-13 |
2017-01-18 |
Proteostasis Therapeutics, Inc. |
Compounds, compositions, and methods for increasing cftr activity
|
|
CA2952862A1
(en)
|
2014-06-19 |
2015-12-23 |
Proteostasis Therapeutics, Inc. |
Compounds, compositions and methods of increasing cftr activity
|
|
US9855249B2
(en)
|
2014-10-02 |
2018-01-02 |
Flatley Discovery Lab, Llc |
Isoxazole compounds and methods for the treatment of cystic fibrosis
|
|
US10344023B2
(en)
|
2014-12-23 |
2019-07-09 |
Proteostasis Therapeutics, Inc. |
Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis
|
|
US10738011B2
(en)
|
2014-12-23 |
2020-08-11 |
Proteostasis Therapeutics, Inc. |
Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis
|
|
US10392378B2
(en)
|
2014-12-23 |
2019-08-27 |
Proteostasis Therapeutics, Inc. |
Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis
|
|
MA41253A
(fr)
|
2014-12-23 |
2017-10-31 |
Proteostasis Therapeutics Inc |
Composés, compositions et procédés pour augmenter l'activité du cftr
|
|
US20180147187A1
(en)
|
2015-01-12 |
2018-05-31 |
Proteostasis Therapeutics, Inc. |
Compounds, compositions, and methods for increasing cftr activity
|
|
US10548878B2
(en)
|
2015-07-24 |
2020-02-04 |
Proteostasis Therapeutics, Inc. |
Compounds, compositions, and methods of increasing CFTR activity
|
|
WO2017040606A1
(en)
|
2015-08-31 |
2017-03-09 |
Proteostasis Therapeutics, Inc. |
Isoxazole derivatives for use in the treatment of pulmonary diseases and disorders
|
|
NZ741093A
(en)
|
2015-10-06 |
2022-12-23 |
Proteostasis Therapeutics Inc |
Compounds, compositions, and methods for modulating cftr
|
|
EP3393465A1
(en)
|
2015-12-22 |
2018-10-31 |
Proteostasis Therapeutics, Inc. |
Methods of treating pulmonary diseases and disorders
|
|
BR112018070747B1
(pt)
|
2016-04-07 |
2024-01-09 |
Proteostasis Therapeutics, Inc |
Átomos de silicone contendo análogos de ivacaftor, composições farmacêuticas e usos terapêuticos
|
|
EP3455624A1
(en)
|
2016-05-09 |
2019-03-20 |
Proteostasis Therapeutics, Inc. |
Methods of identifying cftr modulators
|
|
EP3472156B1
(en)
|
2016-06-21 |
2023-06-07 |
Proteostasis Therapeutics, Inc. |
Compounds, compositions, and methods for increasing cftr activity
|