JP2012521361A5 - - Google Patents
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- JP2012521361A5 JP2012521361A5 JP2012501021A JP2012501021A JP2012521361A5 JP 2012521361 A5 JP2012521361 A5 JP 2012521361A5 JP 2012501021 A JP2012501021 A JP 2012501021A JP 2012501021 A JP2012501021 A JP 2012501021A JP 2012521361 A5 JP2012521361 A5 JP 2012521361A5
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- 150000001875 compounds Chemical class 0.000 claims description 37
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 claims description 22
- 102000008371 intracellularly ATP-gated chloride channel activity proteins Human genes 0.000 claims description 22
- 239000012472 biological sample Substances 0.000 claims description 18
- 230000000694 effects Effects 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 11
- 230000007812 deficiency Effects 0.000 claims description 10
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 claims description 8
- 201000010064 diabetes insipidus Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims description 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 4
- 206010033645 Pancreatitis Diseases 0.000 claims description 4
- 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims description 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 206010010356 Congenital anomaly Diseases 0.000 claims description 3
- 208000011580 syndromic disease Diseases 0.000 claims description 3
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 102000014461 Ataxins Human genes 0.000 claims description 2
- 108010078286 Ataxins Proteins 0.000 claims description 2
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- 206010006458 Bronchitis chronic Diseases 0.000 claims description 2
- 206010008025 Cerebellar ataxia Diseases 0.000 claims description 2
- 206010010774 Constipation Diseases 0.000 claims description 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 2
- 206010013883 Dwarfism Diseases 0.000 claims description 2
- 206010014561 Emphysema Diseases 0.000 claims description 2
- 208000017701 Endocrine disease Diseases 0.000 claims description 2
- 208000024720 Fabry Disease Diseases 0.000 claims description 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 2
- 206010019860 Hereditary angioedema Diseases 0.000 claims description 2
- 208000033981 Hereditary haemochromatosis Diseases 0.000 claims description 2
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims description 2
- 206010051125 Hypofibrinogenaemia Diseases 0.000 claims description 2
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- 208000019693 Lung disease Diseases 0.000 claims description 2
- 208000007466 Male Infertility Diseases 0.000 claims description 2
- 208000008955 Mucolipidoses Diseases 0.000 claims description 2
- 206010072928 Mucolipidosis type II Diseases 0.000 claims description 2
- 208000002678 Mucopolysaccharidoses Diseases 0.000 claims description 2
- 102100026784 Myelin proteolipid protein Human genes 0.000 claims description 2
- 206010068871 Myotonic dystrophy Diseases 0.000 claims description 2
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims description 2
- 206010033799 Paralysis Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 208000017493 Pelizaeus-Merzbacher disease Diseases 0.000 claims description 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 2
- 208000024777 Prion disease Diseases 0.000 claims description 2
- 201000005660 Protein C Deficiency Diseases 0.000 claims description 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims description 2
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims description 2
- 208000004622 abetalipoproteinemia Diseases 0.000 claims description 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 229960005475 antiinfective agent Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
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- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims description 2
- 230000002146 bilateral effect Effects 0.000 claims description 2
- 206010006451 bronchitis Diseases 0.000 claims description 2
- 229940124630 bronchodilator Drugs 0.000 claims description 2
- 239000000168 bronchodilator agent Substances 0.000 claims description 2
- 210000003591 cerebellar nuclei Anatomy 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 208000007451 chronic bronchitis Diseases 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
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- 208000030172 endocrine system disease Diseases 0.000 claims description 2
- 239000003172 expectorant agent Substances 0.000 claims description 2
- 208000013746 hereditary thrombophilia due to congenital protein C deficiency Diseases 0.000 claims description 2
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims description 2
- 201000008980 hyperinsulinism Diseases 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 208000019423 liver disease Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 208000020460 mucolipidosis II alpha/beta Diseases 0.000 claims description 2
- 229940066491 mucolytics Drugs 0.000 claims description 2
- 206010028093 mucopolysaccharidosis Diseases 0.000 claims description 2
- 208000000638 myeloperoxidase deficiency Diseases 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 201000001119 neuropathy Diseases 0.000 claims description 2
- 230000007823 neuropathy Effects 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 claims description 2
- 108010040003 polyglutamine Proteins 0.000 claims description 2
- 229920000155 polyglutamine Polymers 0.000 claims description 2
- 230000020978 protein processing Effects 0.000 claims description 2
- 201000009890 sinusitis Diseases 0.000 claims description 2
- 230000000391 smoking effect Effects 0.000 claims description 2
- 208000002320 spinal muscular atrophy Diseases 0.000 claims description 2
- 210000001215 vagina Anatomy 0.000 claims description 2
- 208000010693 Charcot-Marie-Tooth Disease Diseases 0.000 claims 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
- 208000000563 Hyperlipoproteinemia Type II Diseases 0.000 claims 1
- 102100024640 Low-density lipoprotein receptor Human genes 0.000 claims 1
- 208000015439 Lysosomal storage disease Diseases 0.000 claims 1
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 claims 1
- 208000019409 dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome Diseases 0.000 claims 1
- 201000001386 familial hypercholesterolemia Diseases 0.000 claims 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
- 208000021090 palsy Diseases 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 210000000463 red nucleus Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 102100034452 Alternative prion protein Human genes 0.000 description 1
- JYPYTFLCNPMVBC-UHFFFAOYSA-N CC(C)(C)c(c(NC(C1=CNc2ccccc2C1=O)=O)c1)cc(C(C)(C)C(O)=O)c1O Chemical compound CC(C)(C)c(c(NC(C1=CNc2ccccc2C1=O)=O)c1)cc(C(C)(C)C(O)=O)c1O JYPYTFLCNPMVBC-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010062264 Congenital hyperthyroidism Diseases 0.000 description 1
- 208000001819 Crigler-Najjar Syndrome Diseases 0.000 description 1
- 108091000054 Prion Proteins 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- -1 cholesterol Lipid Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001898 pallidal effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16213009P | 2009-03-20 | 2009-03-20 | |
| US61/162,130 | 2009-03-20 | ||
| PCT/US2010/028062 WO2010108155A1 (en) | 2009-03-20 | 2010-03-19 | Modulators of cystic fibrosis transmembrane conductance regulator |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014179861A Division JP2015013881A (ja) | 2009-03-20 | 2014-09-04 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012521361A JP2012521361A (ja) | 2012-09-13 |
| JP2012521361A5 true JP2012521361A5 (enExample) | 2013-05-02 |
| JP5636418B2 JP5636418B2 (ja) | 2014-12-03 |
Family
ID=42136194
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012501021A Active JP5636418B2 (ja) | 2009-03-20 | 2010-03-19 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
| JP2014179861A Withdrawn JP2015013881A (ja) | 2009-03-20 | 2014-09-04 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
| JP2016002485A Pending JP2016104788A (ja) | 2009-03-20 | 2016-01-08 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014179861A Withdrawn JP2015013881A (ja) | 2009-03-20 | 2014-09-04 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
| JP2016002485A Pending JP2016104788A (ja) | 2009-03-20 | 2016-01-08 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US8614325B2 (enExample) |
| EP (1) | EP2408749B1 (enExample) |
| JP (3) | JP5636418B2 (enExample) |
| CN (1) | CN102361856A (enExample) |
| AU (1) | AU2010226393B2 (enExample) |
| BR (1) | BRPI1012549B8 (enExample) |
| CA (1) | CA2755969C (enExample) |
| CY (1) | CY1120593T1 (enExample) |
| DK (1) | DK2408749T3 (enExample) |
| ES (1) | ES2683633T3 (enExample) |
| HR (1) | HRP20181261T1 (enExample) |
| HU (1) | HUE038854T2 (enExample) |
| IL (1) | IL215261A (enExample) |
| LT (1) | LT2408749T (enExample) |
| MX (1) | MX2011009868A (enExample) |
| NZ (1) | NZ595151A (enExample) |
| PL (1) | PL2408749T3 (enExample) |
| PT (1) | PT2408749T (enExample) |
| RU (1) | RU2518897C2 (enExample) |
| SI (1) | SI2408749T1 (enExample) |
| SM (1) | SMT201800416T1 (enExample) |
| WO (1) | WO2010108155A1 (enExample) |
| ZA (1) | ZA201106618B (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2006111093A (ru) | 2003-09-06 | 2007-10-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы атр-связывающих кассетных транспортеров |
| US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| PL2489659T3 (pl) | 2004-06-24 | 2018-06-29 | Vertex Pharma | Modulatory transporterów posiadających kasetę wiążącą atp |
| KR20080053297A (ko) | 2005-08-11 | 2008-06-12 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유종 트랜스막 전도도 조정자의 조절자 |
| DK2774925T3 (en) | 2005-11-08 | 2017-02-27 | Vertex Pharma | Heterocyclic modulators of ATP binding cassette transporters |
| PT1993360T (pt) | 2005-12-28 | 2017-05-25 | Vertex Pharma | Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida |
| NZ569327A (en) | 2005-12-28 | 2011-09-30 | Vertex Pharma | 1-(benzo [d] [1,3] dioxol-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-binding cassette transporters for the treatment of cystic fibrosis |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| ES2882684T3 (es) | 2006-04-07 | 2021-12-02 | Vertex Pharma | Preparación de moduladores de transportadores del casete de unión a ATP |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| NZ581259A (en) | 2007-05-09 | 2012-07-27 | Vertex Pharma | Modulators of cystic fibrosis transmembrane conductance regulator |
| ES2578735T3 (es) | 2007-08-24 | 2016-07-29 | Vertex Pharmaceuticals Incorporated | Isotiazolopiridinonas útiles para el tratamiento de (entre otros) fibrosis quística |
| EP2578571B1 (en) | 2007-11-16 | 2015-09-16 | Vertex Pharmaceuticals Incorporated | Isoquinoline modulators of ATP-binding cassette transporters |
| CN103626744B (zh) | 2007-12-07 | 2016-05-11 | 沃泰克斯药物股份有限公司 | 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的固体形式 |
| AU2008335440B2 (en) | 2007-12-07 | 2013-11-07 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
| US20100036130A1 (en) | 2007-12-07 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
| JP5523352B2 (ja) | 2008-02-28 | 2014-06-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｃｆｔｒ修飾因子としてのへテロアリール誘導体 |
| PT2615085E (pt) | 2008-03-31 | 2015-10-09 | Vertex Pharma | Derivados piridilo como moduladores cftr |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| BRPI0919550A2 (pt) | 2008-09-29 | 2019-09-10 | Vertex Pharma | unidades de dosagem de ácido 3-(6-(1-(2,2-difluorobenzo]d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il)benzoico |
| SI2349263T1 (sl) * | 2008-10-23 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Modulatorji cistiäśno-fibroznega transmembranskega regulatorja prevodnosti |
| EP3330255B1 (en) | 2009-03-20 | 2020-12-09 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| ES2683633T3 (es) * | 2009-03-20 | 2018-09-27 | Vertex Pharmaceuticals Incorporated | Moduladores de regulador de conductancia transmembrana de la fibrosis quística |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| EP2555755B2 (en) | 2010-04-07 | 2019-07-10 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof |
| AR081069A1 (es) | 2010-04-07 | 2012-06-06 | Vertex Pharma | Formas solidas del acido 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico |
| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| US8563593B2 (en) | 2010-06-08 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| US9254291B2 (en) | 2011-11-08 | 2016-02-09 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| IL311180A (en) | 2012-02-27 | 2024-04-01 | Vertex Pharma | Pharmaceutical preparations containing a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide and uses thereof |
| US8674108B2 (en) | 2012-04-20 | 2014-03-18 | Vertex Pharmaceuticals Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US9012496B2 (en) | 2012-07-16 | 2015-04-21 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide and administration thereof |
| CN104030981A (zh) * | 2013-03-06 | 2014-09-10 | 上海特化医药科技有限公司 | Ivacaftor的制备方法及其中间体 |
| WO2014141110A2 (en) * | 2013-03-14 | 2014-09-18 | Curadev Pharma Pvt. Ltd. | Aminonitriles as kynurenine pathway inhibitors |
| US9345023B2 (en) * | 2013-04-24 | 2016-05-17 | Alcatel Lucent | Method and apparatus for determination of almost blank subframe pattern by network listening |
| HRP20210516T2 (hr) | 2013-11-12 | 2021-10-01 | Vertex Pharmaceuticals Incorporated | Postupak proizvodnje farmaceutskih pripravaka za liječenje bolesti koje su posredovane putem cftr |
| PT3131582T (pt) | 2014-04-15 | 2018-10-08 | Vertex Pharma | Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística |
| PT3203840T (pt) | 2014-10-06 | 2020-10-27 | Vertex Pharma | Moduladores do regulador da condutância transmembranar da fibrose quística |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
| KR101721029B1 (ko) | 2014-10-16 | 2017-03-29 | 연세대학교 산학협력단 | 인돌리지노[3,2-c]퀴놀린 유도체, 이의 약제학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 낭포성 섬유증 예방 또는 치료용 약학조성물 |
| DK3221692T3 (da) | 2014-11-18 | 2021-08-23 | Vertex Pharma | Fremgangsmåde til udførsel af tests med høj kapacitet ved hjælp af højtryksvæskekromatografi |
| WO2017053711A2 (en) | 2015-09-25 | 2017-03-30 | Concert Pharmaceuticals, Inc. | Deuterated cftr potentiators |
| WO2017147216A1 (en) | 2016-02-22 | 2017-08-31 | Mars, Incorporated | Pet food |
| WO2018029336A1 (en) | 2016-08-12 | 2018-02-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for determining whether a subject was administered with an activator of the ppar beta/delta pathway. |
| MX2021013639A (es) | 2016-12-09 | 2022-09-30 | Vertex Pharma | Forma cristalina del compuesto 1, un modulador del regulador de conductancia transmembrana de fibrosis quística, procesos para su preparación, composiciones farmacéuticas del compuesto 1, y su uso en el tratamiento de fibrosis quística. |
| CA3066084A1 (en) | 2017-06-08 | 2018-12-13 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| AU2018304168B2 (en) | 2017-07-17 | 2023-05-04 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| US11339192B2 (en) | 2017-10-04 | 2022-05-24 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitors |
| CN111479804B (zh) | 2017-12-01 | 2023-12-22 | 弗特克斯药品有限公司 | 用于制备囊性纤维化跨膜传导调节因子的调节剂的方法 |
| MA51039A (fr) | 2017-12-08 | 2020-10-14 | Vertex Pharma | Procédés pour préparer des modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose |
| WO2019148195A2 (en) | 2018-01-29 | 2019-08-01 | Ohio State Innovation Foundation | Cyclic peptidyl inhibitors of cal-pdz binding domain |
| CR20230120A (es) | 2020-08-07 | 2023-09-01 | Vertex Pharma | Moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| US12324802B2 (en) | 2020-11-18 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2236751B (en) | 1989-10-14 | 1993-04-28 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| RU2047614C1 (ru) * | 1992-06-15 | 1995-11-10 | Джон Вайс энд Бразер Лимитед | Гетероциклические соединения, или их фармацевтически приемлемые аддитивные соли кислоты, или n-оксид гетероциклического соединения, или его аддитивная соль кислоты |
| US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| PL2489659T3 (pl) * | 2004-06-24 | 2018-06-29 | Vertex Pharma | Modulatory transporterów posiadających kasetę wiążącą atp |
| EP1979367A2 (en) * | 2005-12-24 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Quinolin-4-one derivatives as modulators of abc transporters |
| EP1974212A1 (en) * | 2005-12-27 | 2008-10-01 | Vertex Pharmaceuticals Incorporated | Compounds useful in cftr assays and methods therewith |
| PT1993360T (pt) | 2005-12-28 | 2017-05-25 | Vertex Pharma | Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida |
| AU2008298545B2 (en) * | 2007-09-14 | 2013-12-12 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| ES2683633T3 (es) * | 2009-03-20 | 2018-09-27 | Vertex Pharmaceuticals Incorporated | Moduladores de regulador de conductancia transmembrana de la fibrosis quística |
-
2010
- 2010-03-19 ES ES10710748.4T patent/ES2683633T3/es active Active
- 2010-03-19 PL PL10710748T patent/PL2408749T3/pl unknown
- 2010-03-19 AU AU2010226393A patent/AU2010226393B2/en active Active
- 2010-03-19 PT PT10710748T patent/PT2408749T/pt unknown
- 2010-03-19 BR BRPI1012549A patent/BRPI1012549B8/pt active IP Right Grant
- 2010-03-19 SM SM20180416T patent/SMT201800416T1/it unknown
- 2010-03-19 HR HRP20181261TT patent/HRP20181261T1/hr unknown
- 2010-03-19 DK DK10710748.4T patent/DK2408749T3/en active
- 2010-03-19 HU HUE10710748A patent/HUE038854T2/hu unknown
- 2010-03-19 RU RU2011142297/04A patent/RU2518897C2/ru active
- 2010-03-19 JP JP2012501021A patent/JP5636418B2/ja active Active
- 2010-03-19 CN CN2010800126048A patent/CN102361856A/zh active Pending
- 2010-03-19 NZ NZ595151A patent/NZ595151A/xx unknown
- 2010-03-19 EP EP10710748.4A patent/EP2408749B1/en active Active
- 2010-03-19 MX MX2011009868A patent/MX2011009868A/es active IP Right Grant
- 2010-03-19 SI SI201031726T patent/SI2408749T1/sl unknown
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- 2010-03-19 CA CA2755969A patent/CA2755969C/en active Active
- 2010-03-19 WO PCT/US2010/028062 patent/WO2010108155A1/en not_active Ceased
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2011
- 2011-09-09 ZA ZA2011/06618A patent/ZA201106618B/en unknown
- 2011-09-20 US US13/237,303 patent/US8614325B2/en active Active
- 2011-09-20 IL IL215261A patent/IL215261A/en active IP Right Grant
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2013
- 2013-11-19 US US14/084,203 patent/US8796308B2/en active Active
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2014
- 2014-06-20 US US14/310,634 patent/US20140303205A1/en not_active Abandoned
- 2014-09-04 JP JP2014179861A patent/JP2015013881A/ja not_active Withdrawn
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2015
- 2015-12-31 US US14/985,650 patent/US20160221952A1/en not_active Abandoned
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2016
- 2016-01-08 JP JP2016002485A patent/JP2016104788A/ja active Pending
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2018
- 2018-08-13 CY CY181100855T patent/CY1120593T1/el unknown
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