JP2011505338A5 - - Google Patents
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- JP2011505338A5 JP2011505338A5 JP2010534201A JP2010534201A JP2011505338A5 JP 2011505338 A5 JP2011505338 A5 JP 2011505338A5 JP 2010534201 A JP2010534201 A JP 2010534201A JP 2010534201 A JP2010534201 A JP 2010534201A JP 2011505338 A5 JP2011505338 A5 JP 2011505338A5
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- 150000001875 compounds Chemical class 0.000 claims description 104
- 229910052739 hydrogen Inorganic materials 0.000 claims description 45
- 125000001931 aliphatic group Chemical group 0.000 claims description 35
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 22
- 229910052799 carbon Inorganic materials 0.000 claims description 22
- 125000001072 heteroaryl group Chemical group 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 19
- 239000001257 hydrogen Substances 0.000 claims description 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 claims description 15
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 claims description 15
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 14
- 125000003107 substituted aryl group Chemical group 0.000 claims description 14
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 claims description 12
- 125000003118 aryl group Chemical group 0.000 claims description 12
- 201000010064 diabetes insipidus Diseases 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
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- 230000000694 effects Effects 0.000 claims description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 230000007812 deficiency Effects 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 8
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- 125000003545 alkoxy group Chemical group 0.000 claims description 6
- 239000012472 biological sample Substances 0.000 claims description 6
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 5
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- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims description 3
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims description 3
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims description 3
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 3
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- 206010013883 Dwarfism Diseases 0.000 claims description 3
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- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 3
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- 208000000563 Hyperlipoproteinemia Type II Diseases 0.000 claims description 3
- 102100024640 Low-density lipoprotein receptor Human genes 0.000 claims description 3
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- 206010072928 Mucolipidosis type II Diseases 0.000 claims description 3
- 208000002678 Mucopolysaccharidoses Diseases 0.000 claims description 3
- 102100026784 Myelin proteolipid protein Human genes 0.000 claims description 3
- 208000012902 Nervous system disease Diseases 0.000 claims description 3
- 208000025966 Neurological disease Diseases 0.000 claims description 3
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims description 3
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- 208000017493 Pelizaeus-Merzbacher disease Diseases 0.000 claims description 3
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 3
- 206010036697 Primary hypothyroidism Diseases 0.000 claims description 3
- 201000005660 Protein C Deficiency Diseases 0.000 claims description 3
- 208000021386 Sjogren Syndrome Diseases 0.000 claims description 3
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims description 3
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 claims description 3
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims description 3
- 210000003591 cerebellar nuclei Anatomy 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 claims description 3
- 201000001386 familial hypercholesterolemia Diseases 0.000 claims description 3
- 208000013746 hereditary thrombophilia due to congenital protein C deficiency Diseases 0.000 claims description 3
- 208000003532 hypothyroidism Diseases 0.000 claims description 3
- 150000002632 lipids Chemical class 0.000 claims description 3
- 201000001441 melanoma Diseases 0.000 claims description 3
- 208000020460 mucolipidosis II alpha/beta Diseases 0.000 claims description 3
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- 201000000585 muscular atrophy Diseases 0.000 claims description 3
- 208000000638 myeloperoxidase deficiency Diseases 0.000 claims description 3
- 230000004770 neurodegeneration Effects 0.000 claims description 3
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- 108010040003 polyglutamine Proteins 0.000 claims description 3
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- 201000002212 progressive supranuclear palsy Diseases 0.000 claims description 3
- 210000000463 red nucleus Anatomy 0.000 claims description 3
- 206010006458 Bronchitis chronic Diseases 0.000 claims description 2
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims description 2
- 206010010356 Congenital anomaly Diseases 0.000 claims description 2
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- 206010019860 Hereditary angioedema Diseases 0.000 claims description 2
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- 206010060378 Hyperinsulinaemia Diseases 0.000 claims description 2
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- 208000015439 Lysosomal storage disease Diseases 0.000 claims description 2
- 208000007466 Male Infertility Diseases 0.000 claims description 2
- 108091000054 Prion Proteins 0.000 claims description 2
- 208000004622 abetalipoproteinemia Diseases 0.000 claims description 2
- 150000007824 aliphatic compounds Chemical class 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 229960005475 antiinfective agent Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 230000002146 bilateral effect Effects 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 206010006451 bronchitis Diseases 0.000 claims description 2
- 229940124630 bronchodilator Drugs 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 208000007451 chronic bronchitis Diseases 0.000 claims description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
- 230000007547 defect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000003172 expectorant agent Substances 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims description 2
- 201000008980 hyperinsulinism Diseases 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 208000019423 liver disease Diseases 0.000 claims description 2
- 229940066491 mucolytics Drugs 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 201000009890 sinusitis Diseases 0.000 claims description 2
- 239000000779 smoke Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 108010066305 Parkinson Disease Associated Proteins Proteins 0.000 claims 1
- 102000018315 Parkinson Disease Associated Proteins Human genes 0.000 claims 1
- 102000029797 Prion Human genes 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000020978 protein processing Effects 0.000 claims 1
- 230000001256 tonic effect Effects 0.000 claims 1
- 210000001177 vas deferen Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 6
- 0 *c(cc1)cc2c1OCO2 Chemical compound *c(cc1)cc2c1OCO2 0.000 description 3
- 208000017701 Endocrine disease Diseases 0.000 description 2
- 206010051125 Hypofibrinogenaemia Diseases 0.000 description 2
- 206010068871 Myotonic dystrophy Diseases 0.000 description 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 2
- 208000030172 endocrine system disease Diseases 0.000 description 2
- 102100034452 Alternative prion protein Human genes 0.000 description 1
- 208000028185 Angioedema Diseases 0.000 description 1
- 102100022548 Beta-hexosaminidase subunit alpha Human genes 0.000 description 1
- KRLRXJANBUGNSF-UHFFFAOYSA-N CC(C)c(cc1)cc(OC)c1OC Chemical compound CC(C)c(cc1)cc(OC)c1OC KRLRXJANBUGNSF-UHFFFAOYSA-N 0.000 description 1
- CHLICZRVGGXEOD-UHFFFAOYSA-N Cc(cc1)ccc1OC Chemical compound Cc(cc1)ccc1OC CHLICZRVGGXEOD-UHFFFAOYSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000022292 Tay-Sachs disease Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- -1 aliphatic group Compound Chemical class 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 208000015532 congenital bilateral absence of vas deferens Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 230000004203 pancreatic function Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98855907P | 2007-11-16 | 2007-11-16 | |
| US60/988,559 | 2007-11-16 | ||
| PCT/US2008/083517 WO2009064959A1 (en) | 2007-11-16 | 2008-11-14 | Isoquinoline modulators of atp-binding cassette transporters |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014018471A Division JP5885359B2 (ja) | 2007-11-16 | 2014-02-03 | Ａｔｐ結合カセットトランスポーターのイソキノリン調節因子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011505338A JP2011505338A (ja) | 2011-02-24 |
| JP2011505338A5 true JP2011505338A5 (enExample) | 2012-12-06 |
| JP5646338B2 JP5646338B2 (ja) | 2014-12-24 |
Family
ID=40303494
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534201A Active JP5646338B2 (ja) | 2007-11-16 | 2008-11-14 | Ａｔｐ結合カセットトランスポーターのイソキノリン調節因子 |
| JP2014018471A Active JP5885359B2 (ja) | 2007-11-16 | 2014-02-03 | Ａｔｐ結合カセットトランスポーターのイソキノリン調節因子 |
| JP2015159316A Pending JP2015205936A (ja) | 2007-11-16 | 2015-08-12 | Ａｔｐ結合カセットトランスポーターのイソキノリン調節因子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014018471A Active JP5885359B2 (ja) | 2007-11-16 | 2014-02-03 | Ａｔｐ結合カセットトランスポーターのイソキノリン調節因子 |
| JP2015159316A Pending JP2015205936A (ja) | 2007-11-16 | 2015-08-12 | Ａｔｐ結合カセットトランスポーターのイソキノリン調節因子 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8507524B2 (enExample) |
| EP (3) | EP2217572B1 (enExample) |
| JP (3) | JP5646338B2 (enExample) |
| CN (2) | CN102743385B (enExample) |
| AU (1) | AU2008322616B2 (enExample) |
| CA (1) | CA2705562C (enExample) |
| CY (1) | CY1115318T1 (enExample) |
| DK (2) | DK2578571T3 (enExample) |
| ES (3) | ES2556080T3 (enExample) |
| HR (2) | HRP20140103T1 (enExample) |
| HU (1) | HUE026334T2 (enExample) |
| NZ (2) | NZ585980A (enExample) |
| PL (2) | PL2217572T3 (enExample) |
| PT (2) | PT2217572E (enExample) |
| SI (2) | SI2217572T1 (enExample) |
| WO (1) | WO2009064959A1 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06002567A (es) | 2003-09-06 | 2006-09-04 | Vertex Pharma | Moduladores de transportadores con casete de union de atp. |
| EP1682127B1 (en) * | 2003-11-14 | 2009-07-29 | Vertex Pharmaceuticals Incorporated | Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters |
| JP4960708B2 (ja) * | 2004-01-30 | 2012-06-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセットトランスポーターのモジュレーター |
| US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| MX341797B (es) | 2004-06-24 | 2016-09-02 | Vertex Pharmaceuticals Incorporated * | Moduladores de transportadores con casete de union con atp. |
| MX2008002019A (es) | 2005-08-11 | 2008-04-16 | Vertex Pharma | Moduladores del regulador de conductancia transmembrana de fibrosis quistica. |
| ES2778846T3 (es) | 2005-11-08 | 2020-08-12 | Vertex Pharma | Moduladores heterocíclicos de transportadores de casete de unión a ATP |
| US7671221B2 (en) * | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| LT1993360T (lt) | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
| AU2006336504C9 (en) * | 2005-12-28 | 2015-05-14 | Vertex Pharmaceuticals Incorporated | 1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis |
| NZ596889A (en) | 2006-04-07 | 2013-06-28 | Vertex Pharma | Use of amide indole derivatives as modulators of ATP-binding cassette transporters |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US7754739B2 (en) * | 2007-05-09 | 2010-07-13 | Vertex Pharmaceuticals Incorporated | Modulators of CFTR |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| CN102863432B (zh) | 2007-05-09 | 2016-09-07 | 沃泰克斯药物股份有限公司 | Cftr调节剂 |
| JP2010528035A (ja) * | 2007-05-25 | 2010-08-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネル調節物質およびその使用 |
| HUE028426T2 (en) | 2007-08-24 | 2016-12-28 | Vertex Pharma | Isothiazolopyridinones for (inter alia) treating cystic fibrosis |
| ES2556080T3 (es) | 2007-11-16 | 2016-01-12 | Vertex Pharmaceuticals Incorporated | Moduladores de isoquinolina de transportadores de casete de unión a ATP |
| US20100036130A1 (en) | 2007-12-07 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
| WO2009076142A2 (en) | 2007-12-07 | 2009-06-18 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxiamido-pyridine benzoic acids |
| KR20150063170A (ko) | 2007-12-07 | 2015-06-08 | 버텍스 파마슈티칼스 인코포레이티드 | 3-(6-(1-(2,2-디플루오로벤조[ｄ][1,3]디옥솔-5-일)사이클로프로판카복스아미도)-3-메틸피리딘-2-일)벤조산의 고체 형태 |
| EA201070699A1 (ru) * | 2007-12-07 | 2011-02-28 | Вертекс Фармасьютикалз Инкорпорейтед | Композиции 3-(6-(1-2,2-дифторбензо[d][1,3]диоксол-5-ил)циклопропанкарбоксамидо)-3-метилпиридин-2-ил)бензойной кислоты |
| CN106432213A (zh) | 2008-02-28 | 2017-02-22 | 沃泰克斯药物股份有限公司 | 作为cftr调节剂的杂芳基衍生物 |
| EP2615085B1 (en) * | 2008-03-31 | 2015-08-26 | Vertex Pharmaceuticals Incorporated | Pyridyl derivatives as CFTR modulators |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| AU2009296271A1 (en) * | 2008-09-29 | 2010-04-01 | Vertex Pharmaceuticals Incorporated | Dosage units of 3-(6-(1-(2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| NZ592685A (en) | 2008-10-23 | 2013-04-26 | Vertex Pharma | Modulators of cystic fibrosis transmembrane conductance regulator |
| MX384179B (es) | 2009-03-20 | 2025-03-14 | Vertex Pharma | Proceso para producir moduladores del regulador de conductancia transmembrana de fibrosis quística. |
| ES2834451T3 (es) | 2009-05-01 | 2021-06-17 | Aerie Pharmaceuticals Inc | Inhibidores de mecanismo doble para el tratamiento de enfermedades |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| CN102933206A (zh) | 2010-04-07 | 2013-02-13 | 弗特克斯药品有限公司 | 3-(6-(1-(2，2-二氟苯并[d][1，3]二氧杂环戊烯-5-基)环丙烷甲酰胺基)-3-甲基吡啶-2-基)苯甲酸的固体形式 |
| BR112012026255A2 (pt) | 2010-04-07 | 2017-03-14 | Vertex Pharma | composições farmacêuticas de ácido 3-(6-(1-(2-,2-difluorbenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il)benzóico e administração das mesmas |
| RU2745977C2 (ru) | 2010-04-22 | 2021-04-05 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| US8563593B2 (en) | 2010-06-08 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
| KR101985044B1 (ko) | 2011-11-08 | 2019-05-31 | 버텍스 파마슈티칼스 인코포레이티드 | Atp-결합 카세트 수송체의 조절제 |
| DK2806859T3 (da) | 2012-01-25 | 2019-08-05 | Vertex Pharma | Formuleringer af 3-(6-(1-(2.2-difluorbenzo[d][1,3]dioxol-5-yl) cyclopropancarboxamido)-3-methylpyridin-2-yl)benzoesyre |
| JP2015511583A (ja) | 2012-02-27 | 2015-04-20 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 薬学的組成物およびその投与 |
| US8674108B2 (en) | 2012-04-20 | 2014-03-18 | Vertex Pharmaceuticals Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| EP2858645A1 (en) | 2012-06-08 | 2015-04-15 | Vertex Pharmaceuticals Incorporated | Pharmaceuticl compositions for the treatment of cftr -mediated disorders |
| AU2013290444B2 (en) | 2012-07-16 | 2018-04-26 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof |
| EP2976080B1 (en) | 2013-03-15 | 2019-12-25 | Aerie Pharmaceuticals, Inc. | Conjugates of isoquinoline compounds and prostaglandins |
| DK3068392T5 (da) | 2013-11-12 | 2021-09-20 | Vertex Pharma | Fremgangsmåde til fremstilling af farmaceutiske sammensætninger til behandlingen af cftr-medierede sygdomme |
| SG10201913575VA (en) | 2014-04-15 | 2020-02-27 | Vertex Pharma | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases |
| GB201415381D0 (en) | 2014-08-29 | 2014-10-15 | Algipharma As | Inhalable powder formulations of alginate oligomers |
| EP3204358B1 (en) | 2014-10-07 | 2018-09-19 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| EP3212189B1 (en) | 2014-10-31 | 2020-09-09 | AbbVie Overseas S.à r.l. | Substituted chromanes and method of use |
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| GB201504878D0 (en) | 2015-03-23 | 2015-05-06 | Algipharma As | Use of alginate oligomers and CFTR modulators in the treatment of conditions associated with CFTR dysfuntion |
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