PL2578571T3 - Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP - Google Patents

Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP

Info

Publication number
PL2578571T3
PL2578571T3 PL12181370T PL12181370T PL2578571T3 PL 2578571 T3 PL2578571 T3 PL 2578571T3 PL 12181370 T PL12181370 T PL 12181370T PL 12181370 T PL12181370 T PL 12181370T PL 2578571 T3 PL2578571 T3 PL 2578571T3
Authority
PL
Poland
Prior art keywords
isoquinoline
atp
modulators
binding cassette
cassette transporters
Prior art date
Application number
PL12181370T
Other languages
English (en)
Polish (pl)
Inventor
Ruah Sara Hadida
Mark Miller
Jinglan Zhou
Brian Bear
Peter D J Grootenhuis
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PL2578571T3 publication Critical patent/PL2578571T3/pl

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
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  • Ophthalmology & Optometry (AREA)
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PL12181370T 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP PL2578571T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98855907P 2007-11-16 2007-11-16
EP20080849242 EP2217572B1 (en) 2007-11-16 2008-11-14 Isoquinoline modulators of atp-binding cassette transporters
EP12181370.3A EP2578571B1 (en) 2007-11-16 2008-11-14 Isoquinoline modulators of ATP-binding cassette transporters

Publications (1)

Publication Number Publication Date
PL2578571T3 true PL2578571T3 (pl) 2016-03-31

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Family Applications (2)

Application Number Title Priority Date Filing Date
PL12181370T PL2578571T3 (pl) 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP
PL08849242T PL2217572T3 (pl) 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL08849242T PL2217572T3 (pl) 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP

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US (4) US8507524B2 (enExample)
EP (3) EP2578571B1 (enExample)
JP (3) JP5646338B2 (enExample)
CN (2) CN102743385B (enExample)
AU (1) AU2008322616B2 (enExample)
CA (1) CA2705562C (enExample)
CY (1) CY1115318T1 (enExample)
DK (2) DK2217572T3 (enExample)
ES (3) ES2445447T3 (enExample)
HR (2) HRP20140103T1 (enExample)
HU (1) HUE026334T2 (enExample)
NZ (2) NZ598941A (enExample)
PL (2) PL2578571T3 (enExample)
PT (2) PT2578571E (enExample)
SI (2) SI2578571T1 (enExample)
WO (1) WO2009064959A1 (enExample)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7973169B2 (en) 2003-09-06 2011-07-05 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
ATE437640T1 (de) * 2003-11-14 2009-08-15 Vertex Pharma Thiazole udn oxazole als modulatoren von atp- bindungs-kassetten-transportern
EP3219709B1 (en) * 2004-01-30 2020-03-18 Vertex Pharmaceuticals Incorporated Intermediate compound of modulators of atp-binding cassette transporters
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
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KR102447581B1 (ko) 2014-04-15 2022-09-28 버텍스 파마슈티칼스 인코포레이티드 낭포성 섬유증 막전도 조절자 매개 질환 치료용 약제학적 조성물
SG10201913603QA (en) 2014-10-06 2020-02-27 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
RU2749213C2 (ru) 2014-10-07 2021-06-07 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе

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