DK2578571T3 - Isoquinoline modulators of ATP binding cassette transporters - Google Patents

Isoquinoline modulators of ATP binding cassette transporters Download PDF

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Publication number
DK2578571T3
DK2578571T3 DK12181370.3T DK12181370T DK2578571T3 DK 2578571 T3 DK2578571 T3 DK 2578571T3 DK 12181370 T DK12181370 T DK 12181370T DK 2578571 T3 DK2578571 T3 DK 2578571T3
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aliphatic
cycloaliphatic
optionally substituted
carbonyl
heterocycloaliphatic
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DK12181370.3T
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Danish (da)
English (en)
Inventor
Ruah Sara Hadida
Mark Miller
Jinglan Zhou
Brian Bear
Peter D J Grootenhuis
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Vertex Pharma
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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DK12181370.3T 2007-11-16 2008-11-14 Isoquinoline modulators of ATP binding cassette transporters DK2578571T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98855907P 2007-11-16 2007-11-16
EP20080849242 EP2217572B1 (en) 2007-11-16 2008-11-14 Isoquinoline modulators of atp-binding cassette transporters

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DK2578571T3 true DK2578571T3 (en) 2015-10-05

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DK12181370.3T DK2578571T3 (en) 2007-11-16 2008-11-14 Isoquinoline modulators of ATP binding cassette transporters
DK08849242T DK2217572T3 (da) 2007-11-16 2008-11-14 Isoquinoliner som modulatorer af ATP-bindingskassettetransportører

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US (4) US8507524B2 (enExample)
EP (3) EP2217572B1 (enExample)
JP (3) JP5646338B2 (enExample)
CN (2) CN102743385B (enExample)
AU (1) AU2008322616B2 (enExample)
CA (1) CA2705562C (enExample)
CY (1) CY1115318T1 (enExample)
DK (2) DK2578571T3 (enExample)
ES (3) ES2556080T3 (enExample)
HR (2) HRP20140103T1 (enExample)
HU (1) HUE026334T2 (enExample)
NZ (2) NZ585980A (enExample)
PL (2) PL2217572T3 (enExample)
PT (2) PT2217572E (enExample)
SI (2) SI2217572T1 (enExample)
WO (1) WO2009064959A1 (enExample)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06002567A (es) 2003-09-06 2006-09-04 Vertex Pharma Moduladores de transportadores con casete de union de atp.
EP1682127B1 (en) * 2003-11-14 2009-07-29 Vertex Pharmaceuticals Incorporated Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters
JP4960708B2 (ja) * 2004-01-30 2012-06-27 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｐ結合カセットトランスポーターのモジュレーター
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
MX341797B (es) 2004-06-24 2016-09-02 Vertex Pharmaceuticals Incorporated * Moduladores de transportadores con casete de union con atp.
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