JP7061076B2 - アイバカフトール類似体を含有するケイ素原子 - Google Patents

アイバカフトール類似体を含有するケイ素原子 Download PDF

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JP7061076B2
JP7061076B2 JP2018552693A JP2018552693A JP7061076B2 JP 7061076 B2 JP7061076 B2 JP 7061076B2 JP 2018552693 A JP2018552693 A JP 2018552693A JP 2018552693 A JP2018552693 A JP 2018552693A JP 7061076 B2 JP7061076 B2 JP 7061076B2
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disease
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tert
cftr
compound
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JP2019513741A (ja
JP2019513741A5 (enExample
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ムノーズ，ベニート
パークス，ダニエル
バストス，セシリア，エム．
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プロテオステイシス セラピューティクス，インコーポレイテッド
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
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    • C07F7/0803—Compounds with Si-C or Si-Si linkages
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  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018552693A 2016-04-07 2017-04-07 アイバカフトール類似体を含有するケイ素原子 Active JP7061076B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662319439P 2016-04-07 2016-04-07
US62/319,439 2016-04-07
PCT/US2017/026579 WO2017177124A1 (en) 2016-04-07 2017-04-07 Silicone atoms containing ivacaftor analogues

Publications (3)

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JP2019513741A JP2019513741A (ja) 2019-05-30
JP2019513741A5 JP2019513741A5 (enExample) 2020-05-14
JP7061076B2 true JP7061076B2 (ja) 2022-04-27

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US (4) US10662207B2 (enExample)
EP (1) EP3440057B1 (enExample)
JP (1) JP7061076B2 (enExample)
KR (1) KR102448404B1 (enExample)
CN (1) CN109563047A (enExample)
AR (1) AR108203A1 (enExample)
AU (1) AU2017248253B2 (enExample)
BR (1) BR112018070747B1 (enExample)
CA (1) CA3019663C (enExample)
IL (1) IL262030B (enExample)
MA (1) MA43775A (enExample)
MX (1) MX386698B (enExample)
NZ (1) NZ746793A (enExample)
SA (1) SA518400164B1 (enExample)
SG (1) SG11201808682XA (enExample)
WO (1) WO2017177124A1 (enExample)

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CN109563047A (zh) * 2016-04-07 2019-04-02 蛋白质平衡治疗股份有限公司 含有硅原子的依伐卡托类似物
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JP7551087B2 (ja) 2018-06-27 2024-09-17 キネタ， インコーポレイテッド プロテアソーム活性増強化合物
CN109663129B (zh) * 2019-02-27 2021-05-11 四川大学华西第二医院 扩张型心肌病治疗药物及其应用
UY38630A (es) 2019-04-03 2020-10-30 Vertex Pharma Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística
TWI867024B (zh) 2019-08-14 2024-12-21 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
US11584761B2 (en) 2019-08-14 2023-02-21 Vertex Pharmaceuticals Incorporated Process of making CFTR modulators
EP4013760A1 (en) 2019-08-14 2022-06-22 Vertex Pharmaceuticals Incorporated Crystalline forms of cftr modulators
AU2021397294A1 (en) 2020-12-10 2023-07-06 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
CN116425642B (zh) * 2023-04-06 2025-06-10 浙江科聚生物医药有限公司 2-甲氧基-4-氟-5-胺基苯酚的制备方法

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