JP2010519304A5 - - Google Patents
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- Publication number
- JP2010519304A5 JP2010519304A5 JP2009550944A JP2009550944A JP2010519304A5 JP 2010519304 A5 JP2010519304 A5 JP 2010519304A5 JP 2009550944 A JP2009550944 A JP 2009550944A JP 2009550944 A JP2009550944 A JP 2009550944A JP 2010519304 A5 JP2010519304 A5 JP 2010519304A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- adamantyl
- heteroaryl
- nhr
- conh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 25
- -1 1-adamantyl Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 8
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 125000006603 (C1-C3) alkylaminosulfonyl group Chemical group 0.000 claims 6
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 6
- 125000004043 oxo group Chemical group O=* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000003670 adamantan-2-yl group Chemical group [H]C1([H])C(C2([H])[H])([H])C([H])([H])C3([H])C([*])([H])C1([H])C([H])([H])C2([H])C3([H])[H] 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 3
- 125000006602 (C1-C3) alkylsulfonylamino group Chemical group 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000004442 acylamino group Chemical group 0.000 claims 3
- 150000001602 bicycloalkyls Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- UVIDCLANAUXYRC-NJJRTNTQSA-N (4r,5s)-3-(1-adamantylmethyl)-4-methyl-5-phenyl-1,3-oxazolidin-2-one Chemical compound C1([C@H]2[C@H](N(C(=O)O2)CC23CC4CC(CC(C4)C2)C3)C)=CC=CC=C1 UVIDCLANAUXYRC-NJJRTNTQSA-N 0.000 claims 1
- VCNMMSZBCCMGNE-MUGCCGGLSA-N (4s)-1-(1-adamantyl)-4-phenylimidazolidin-2-one Chemical compound C1([C@@H]2NC(N(C2)C23CC4CC(CC(C4)C2)C3)=O)=CC=CC=C1 VCNMMSZBCCMGNE-MUGCCGGLSA-N 0.000 claims 1
- SNROXQRDXSTKOQ-BLKUPOTMSA-N (4s)-1-(2-adamantyl)-4-cyclohexylimidazolidin-2-one Chemical compound C1([C@@H]2NC(N(C2)C2C3CC4CC(C3)CC2C4)=O)CCCCC1 SNROXQRDXSTKOQ-BLKUPOTMSA-N 0.000 claims 1
- GDOBAHJVBZQCFD-DUTNFGBUSA-N (4s)-1-(2-adamantyl)-4-propan-2-ylimidazolidin-2-one Chemical compound O=C1N[C@@H](C(C)C)CN1C1C(C2)CC3CC2CC1C3 GDOBAHJVBZQCFD-DUTNFGBUSA-N 0.000 claims 1
- LCMFOHRTPUJGLL-BAPHQMLMSA-N (4s)-1-(2-adamantyl)-4-tert-butyl-3-methylimidazolidin-2-one Chemical compound O=C1N(C)[C@@H](C(C)(C)C)CN1C1C(C2)CC3CC2CC1C3 LCMFOHRTPUJGLL-BAPHQMLMSA-N 0.000 claims 1
- MBSUQRMKUQZSEH-DUTNFGBUSA-N (4s)-1-(2-adamantyl)-4-tert-butylimidazolidin-2-one Chemical compound O=C1N[C@@H](C(C)(C)C)CN1C1C(C2)CC3CC2CC1C3 MBSUQRMKUQZSEH-DUTNFGBUSA-N 0.000 claims 1
- KFLZODUWJZMGLK-XEFPTXDNSA-N (5r)-3-(2-adamantyl)-5-cyclohexyl-1,3-oxazolidin-2-one Chemical compound C1([C@H]2OC(N(C2)C2C3CC4CC(C3)CC2C4)=O)CCCCC1 KFLZODUWJZMGLK-XEFPTXDNSA-N 0.000 claims 1
- FHYIDQYBRFYKCZ-RDVIWEACSA-N (5s)-3-(1-adamantyl)-5-(2-methylpropyl)-1,3-oxazolidin-2-one Chemical compound O=C1O[C@@H](CC(C)C)CN1C1(C2)CC(C3)CC2CC3C1 FHYIDQYBRFYKCZ-RDVIWEACSA-N 0.000 claims 1
- GUSXIVDHTCICPU-XAPRQVHKSA-N (5s)-3-(1-adamantylmethyl)-5-(2-chlorophenyl)-1,3-oxazolidin-2-one Chemical compound ClC1=CC=CC=C1[C@@H]1OC(=O)N(CC23CC4CC(CC(C4)C2)C3)C1 GUSXIVDHTCICPU-XAPRQVHKSA-N 0.000 claims 1
- RALOMNAAAHWZEG-KUNBBXKYSA-N (5s)-3-(1-adamantylmethyl)-5-(2-methylpropyl)-1,3-oxazolidin-2-one Chemical compound O=C1O[C@@H](CC(C)C)CN1CC1(C2)CC(C3)CC2CC3C1 RALOMNAAAHWZEG-KUNBBXKYSA-N 0.000 claims 1
- BJUHZYGOMNIORB-ZVQXUQNISA-N (5s)-3-(1-adamantylmethyl)-5-cyclohexyl-1,3-oxazolidin-2-one Chemical compound C1([C@@H]2OC(N(C2)CC23CC4CC(CC(C4)C2)C3)=O)CCCCC1 BJUHZYGOMNIORB-ZVQXUQNISA-N 0.000 claims 1
- BZZKITLTPWMQQT-ZVQXUQNISA-N (5s)-3-(1-adamantylmethyl)-5-phenyl-1,3-oxazolidin-2-one Chemical compound C1([C@@H]2OC(N(C2)CC23CC4CC(CC(C4)C2)C3)=O)=CC=CC=C1 BZZKITLTPWMQQT-ZVQXUQNISA-N 0.000 claims 1
- ZGXBQWCTLMTHKT-GNFNDJEDSA-N (5s)-3-(1-adamantylmethyl)-5-tert-butyl-1,3-oxazolidin-2-one Chemical compound O=C1O[C@@H](C(C)(C)C)CN1CC1(C2)CC(C3)CC2CC3C1 ZGXBQWCTLMTHKT-GNFNDJEDSA-N 0.000 claims 1
- KTESQRUWMNMPEM-CGAUPDFVSA-N (5s)-3-(2-adamantyl)-5-(2-methylpropyl)-1,3-oxazolidin-2-one Chemical compound O=C1O[C@@H](CC(C)C)CN1C1C(C2)CC3CC2CC1C3 KTESQRUWMNMPEM-CGAUPDFVSA-N 0.000 claims 1
- KFLZODUWJZMGLK-BLKUPOTMSA-N (5s)-3-(2-adamantyl)-5-cyclohexyl-1,3-oxazolidin-2-one Chemical compound C1([C@@H]2OC(N(C2)C2C3CC4CC(C3)CC2C4)=O)CCCCC1 KFLZODUWJZMGLK-BLKUPOTMSA-N 0.000 claims 1
- KODJCCQGIJYXNB-VWGVWWFLSA-N (5s)-3-(2-adamantyl)-5-methyl-5-phenyl-1,3-oxazolidin-2-one Chemical compound C1([C@@]2(OC(=O)N(C3C4CC5CC(C4)CC3C5)C2)C)=CC=CC=C1 KODJCCQGIJYXNB-VWGVWWFLSA-N 0.000 claims 1
- AGPOAQCDQOZCFJ-DUTNFGBUSA-N (5s)-3-(2-adamantyl)-5-tert-butyl-1,3-oxazolidin-2-one Chemical compound O=C1O[C@@H](C(C)(C)C)CN1C1C(C2)CC3CC2CC1C3 AGPOAQCDQOZCFJ-DUTNFGBUSA-N 0.000 claims 1
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 1
- FUFTXPVYVRWGJL-UHFFFAOYSA-N 1-(2-adamantyl)-4-(hydroxymethyl)-4-(2-methylpropyl)imidazolidin-2-one Chemical compound O=C1NC(CC(C)C)(CO)CN1C1C(C2)CC3CC2CC1C3 FUFTXPVYVRWGJL-UHFFFAOYSA-N 0.000 claims 1
- XNTCFFBBTQRRFS-UHFFFAOYSA-N 1-(2-adamantyl)-4-tert-butyl-1,3-diazinan-2-one Chemical compound O=C1NC(C(C)(C)C)CCN1C1C(C2)CC3CC2CC1C3 XNTCFFBBTQRRFS-UHFFFAOYSA-N 0.000 claims 1
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 1
- JLAGPCGJRXZEOV-UHFFFAOYSA-N 3-(2-adamantyl)-5-(3-bromophenyl)-1,3-oxazolidin-2-one Chemical compound BrC1=CC=CC(C2OC(=O)N(C3C4CC5CC(C4)CC3C5)C2)=C1 JLAGPCGJRXZEOV-UHFFFAOYSA-N 0.000 claims 1
- FXZUOSHUUJZNNC-UHFFFAOYSA-N 3-(2-adamantyl)-5-(3-phenylphenyl)-1,3-oxazolidin-2-one Chemical compound C1N(C2C3CC4CC(C3)CC2C4)C(=O)OC1C(C=1)=CC=CC=1C1=CC=CC=C1 FXZUOSHUUJZNNC-UHFFFAOYSA-N 0.000 claims 1
- ILOBCAGBOOYVBZ-UHFFFAOYSA-N 3-(2-adamantyl)-5-(4-bromophenyl)-1,3-oxazolidin-2-one Chemical compound C1=CC(Br)=CC=C1C1OC(=O)N(C2C3CC4CC(C3)CC2C4)C1 ILOBCAGBOOYVBZ-UHFFFAOYSA-N 0.000 claims 1
- 101150065749 Churc1 gene Proteins 0.000 claims 1
- 102100038239 Protein Churchill Human genes 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical class 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000004212 difluorophenyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000005309 thioalkoxy group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90347307P | 2007-02-26 | 2007-02-26 | |
| US60/903,473 | 2007-02-26 | ||
| PCT/US2008/002517 WO2008106128A2 (en) | 2007-02-26 | 2008-02-26 | CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010519304A JP2010519304A (ja) | 2010-06-03 |
| JP2010519304A5 true JP2010519304A5 (OSRAM) | 2012-03-15 |
| JP5486928B2 JP5486928B2 (ja) | 2014-05-07 |
Family
ID=39627776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009550944A Expired - Fee Related JP5486928B2 (ja) | 2007-02-26 | 2008-02-26 | １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックウレアおよびカルバメートインヒビター |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8835426B2 (OSRAM) |
| EP (1) | EP2125750B1 (OSRAM) |
| JP (1) | JP5486928B2 (OSRAM) |
| CA (1) | CA2678577A1 (OSRAM) |
| WO (1) | WO2008106128A2 (OSRAM) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2125750B1 (en) | 2007-02-26 | 2014-05-21 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8329897B2 (en) * | 2007-07-26 | 2012-12-11 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 |
| AR069207A1 (es) * | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| CA2704628C (en) | 2007-11-16 | 2016-11-29 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| JP5490020B2 (ja) | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター |
| WO2009102428A2 (en) * | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-OXAZEPAN-2-ONE AND 1,3-DIAZEPAN-2-ONE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1 |
| US8598160B2 (en) * | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP5538356B2 (ja) * | 2008-03-18 | 2014-07-02 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 |
| US8569292B2 (en) | 2008-05-01 | 2013-10-29 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| US8242111B2 (en) * | 2008-05-01 | 2012-08-14 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| CA2723034A1 (en) * | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| PL2300461T3 (pl) * | 2008-05-01 | 2013-09-30 | Vitae Pharmaceuticals Inc | Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1 |
| CL2009001151A1 (es) | 2008-05-13 | 2010-08-13 | Boehringer Ingelheim Int | Compuestos derivados de acidos carbociclicos aliciclicos de benzomorfanos, procedimiento de preparacion, composicion farmaceutica, utiles para tratar enfermedades influenciadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa, como trastornos metabolicos. |
| JP5379160B2 (ja) * | 2008-07-25 | 2013-12-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
| TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2010010150A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| JP5589003B2 (ja) * | 2009-02-04 | 2014-09-10 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | 脂質障害のような代謝疾患の処置のために有用な［１，３］オキサジン−２−オンの誘導体 |
| EP2393807B1 (en) * | 2009-02-04 | 2013-08-14 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1 |
| GEP20156309B (en) * | 2009-04-30 | 2015-07-10 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| MA33216B1 (fr) | 2009-04-30 | 2012-04-02 | Boehringer Ingelheim Int | Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1 |
| EP2438049B1 (en) * | 2009-06-02 | 2014-05-14 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5656986B2 (ja) | 2009-06-11 | 2015-01-21 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| JP5749263B2 (ja) * | 2009-07-01 | 2015-07-15 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
| US8552212B2 (en) | 2009-11-05 | 2013-10-08 | Boehringer Ingelheim International Gmbh | Chiral phosphorus ligands |
| TWI531571B (zh) | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8648192B2 (en) | 2010-05-26 | 2014-02-11 | Boehringer Ingelheim International Gmbh | 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives |
| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| WO2012059416A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| US8735585B2 (en) | 2011-08-17 | 2014-05-27 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9340549B2 (en) | 2012-03-05 | 2016-05-17 | Amgen Inc. | Oxazolidinone compounds and derivatives thereof |
| CN103360341B (zh) * | 2012-03-30 | 2016-02-17 | 华东理工大学 | 一类叔亮氨酸衍生的手性胺化合物及其制备方法和应用 |
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| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP5538356B2 (ja) | 2008-03-18 | 2014-07-02 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 |
| CA2723034A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8569292B2 (en) | 2008-05-01 | 2013-10-29 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| US8242111B2 (en) | 2008-05-01 | 2012-08-14 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| PL2300461T3 (pl) | 2008-05-01 | 2013-09-30 | Vitae Pharmaceuticals Inc | Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1 |
| CL2009001151A1 (es) | 2008-05-13 | 2010-08-13 | Boehringer Ingelheim Int | Compuestos derivados de acidos carbociclicos aliciclicos de benzomorfanos, procedimiento de preparacion, composicion farmaceutica, utiles para tratar enfermedades influenciadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa, como trastornos metabolicos. |
| EP2303844A1 (en) | 2008-07-23 | 2011-04-06 | BioAlliance Pharma | Styrylquinolines, their process of preparation and their therapeutic uses |
| TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5379160B2 (ja) | 2008-07-25 | 2013-12-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
| EP2318355B1 (en) | 2008-07-25 | 2018-09-12 | Boehringer Ingelheim International GmbH | 1,1'-diadamantyl carboxylic acids, medicaments containing such compounds and their use |
| EP2318403B1 (en) | 2008-08-25 | 2015-12-23 | Boehringer Ingelheim International GmbH | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| TW201022266A (en) | 2008-10-23 | 2010-06-16 | Boehringer Ingelheim Int | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| JP5589003B2 (ja) | 2009-02-04 | 2014-09-10 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | 脂質障害のような代謝疾患の処置のために有用な［１，３］オキサジン−２−オンの誘導体 |
| GEP20156309B (en) | 2009-04-30 | 2015-07-10 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
-
2008
- 2008-02-26 EP EP08726100.4A patent/EP2125750B1/en not_active Not-in-force
- 2008-02-26 US US12/449,752 patent/US8835426B2/en not_active Expired - Fee Related
- 2008-02-26 JP JP2009550944A patent/JP5486928B2/ja not_active Expired - Fee Related
- 2008-02-26 WO PCT/US2008/002517 patent/WO2008106128A2/en not_active Ceased
- 2008-02-26 CA CA002678577A patent/CA2678577A1/en not_active Abandoned
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