JP2010518009A5 - - Google Patents
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- JP2010518009A5 JP2010518009A5 JP2009548334A JP2009548334A JP2010518009A5 JP 2010518009 A5 JP2010518009 A5 JP 2010518009A5 JP 2009548334 A JP2009548334 A JP 2009548334A JP 2009548334 A JP2009548334 A JP 2009548334A JP 2010518009 A5 JP2010518009 A5 JP 2010518009A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- seq
- actriib
- sequence
- pharmaceutical preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 166
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 claims description 166
- 102000004169 proteins and genes Human genes 0.000 claims description 101
- 108090000623 proteins and genes Proteins 0.000 claims description 101
- 150000001413 amino acids Chemical class 0.000 claims description 87
- 108020001507 fusion proteins Proteins 0.000 claims description 75
- 102000037865 fusion proteins Human genes 0.000 claims description 75
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 72
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 42
- 208000035475 disorder Diseases 0.000 claims description 42
- 230000011664 signaling Effects 0.000 claims description 23
- 239000003446 ligand Substances 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 claims description 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 21
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims description 20
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims description 20
- 101000893545 Homo sapiens Growth/differentiation factor 11 Proteins 0.000 claims description 20
- 201000006938 muscular dystrophy Diseases 0.000 claims description 20
- 108010059616 Activins Proteins 0.000 claims description 16
- 102100026818 Inhibin beta E chain Human genes 0.000 claims description 16
- 239000000488 activin Substances 0.000 claims description 16
- 210000003205 muscle Anatomy 0.000 claims description 15
- 108010056852 Myostatin Proteins 0.000 claims description 14
- 210000000577 adipose tissue Anatomy 0.000 claims description 14
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 14
- 238000000423 cell based assay Methods 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 12
- 230000005764 inhibitory process Effects 0.000 claims description 12
- 239000000710 homodimer Substances 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 9
- 229920001184 polypeptide Polymers 0.000 claims description 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 9
- 208000008589 Obesity Diseases 0.000 claims description 8
- 238000003745 diagnosis Methods 0.000 claims description 8
- 239000000539 dimer Substances 0.000 claims description 8
- 208000001022 morbid obesity Diseases 0.000 claims description 8
- 238000011275 oncology therapy Methods 0.000 claims description 8
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 8
- 235000012000 cholesterol Nutrition 0.000 claims description 7
- 230000037257 muscle growth Effects 0.000 claims description 7
- 230000004770 neurodegeneration Effects 0.000 claims description 7
- 208000001076 sarcopenia Diseases 0.000 claims description 7
- 150000003626 triacylglycerols Chemical class 0.000 claims description 7
- 230000004584 weight gain Effects 0.000 claims description 7
- 235000019786 weight gain Nutrition 0.000 claims description 7
- 101000886562 Homo sapiens Growth/differentiation factor 8 Proteins 0.000 claims description 6
- 238000012986 modification Methods 0.000 claims description 6
- 230000004048 modification Effects 0.000 claims description 6
- 210000002966 serum Anatomy 0.000 claims description 6
- 208000029742 colonic neoplasm Diseases 0.000 claims description 5
- 239000004475 Arginine Substances 0.000 claims description 4
- 206010006895 Cachexia Diseases 0.000 claims description 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 208000000059 Dyspnea Diseases 0.000 claims description 4
- 206010013975 Dyspnoeas Diseases 0.000 claims description 4
- 206010020772 Hypertension Diseases 0.000 claims description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 4
- 239000004472 Lysine Substances 0.000 claims description 4
- 206010028289 Muscle atrophy Diseases 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
- 208000006011 Stroke Diseases 0.000 claims description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 4
- 208000012696 congenital leptin deficiency Diseases 0.000 claims description 4
- 208000008570 facioscapulohumeral muscular dystrophy Diseases 0.000 claims description 4
- 208000020694 gallbladder disease Diseases 0.000 claims description 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 4
- 230000020763 muscle atrophy Effects 0.000 claims description 4
- 201000000585 muscular atrophy Diseases 0.000 claims description 4
- 235000020824 obesity Nutrition 0.000 claims description 4
- 201000008482 osteoarthritis Diseases 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 230000019491 signal transduction Effects 0.000 claims description 3
- -1 Q53 Chemical compound 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 38
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89930407P | 2007-02-02 | 2007-02-02 | |
| US60/899,304 | 2007-02-02 | ||
| US92708807P | 2007-05-01 | 2007-05-01 | |
| US60/927,088 | 2007-05-01 | ||
| US93188007P | 2007-05-25 | 2007-05-25 | |
| US60/931,880 | 2007-05-25 | ||
| PCT/US2008/001506 WO2008097541A2 (en) | 2007-02-02 | 2008-02-04 | Variants derived from actriib and uses therefor |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013055112A Division JP5876847B2 (ja) | 2007-02-02 | 2013-03-18 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2014032768A Division JP2014098028A (ja) | 2007-02-02 | 2014-02-24 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518009A JP2010518009A (ja) | 2010-05-27 |
| JP2010518009A5 true JP2010518009A5 (https=) | 2011-03-24 |
| JP5554067B2 JP5554067B2 (ja) | 2014-07-23 |
Family
ID=39682306
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548334A Active JP5554067B2 (ja) | 2007-02-02 | 2008-02-04 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2013055112A Active JP5876847B2 (ja) | 2007-02-02 | 2013-03-18 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2014032768A Withdrawn JP2014098028A (ja) | 2007-02-02 | 2014-02-24 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2016087844A Active JP6317779B2 (ja) | 2007-02-02 | 2016-04-26 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2018067000A Active JP6662939B2 (ja) | 2007-02-02 | 2018-03-30 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2020022122A Withdrawn JP2020072750A (ja) | 2007-02-02 | 2020-02-13 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2021201830A Pending JP2022044589A (ja) | 2007-02-02 | 2021-12-13 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013055112A Active JP5876847B2 (ja) | 2007-02-02 | 2013-03-18 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2014032768A Withdrawn JP2014098028A (ja) | 2007-02-02 | 2014-02-24 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2016087844A Active JP6317779B2 (ja) | 2007-02-02 | 2016-04-26 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2018067000A Active JP6662939B2 (ja) | 2007-02-02 | 2018-03-30 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2020022122A Withdrawn JP2020072750A (ja) | 2007-02-02 | 2020-02-13 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
| JP2021201830A Pending JP2022044589A (ja) | 2007-02-02 | 2021-12-13 | ＡｃｔＲＩＩＢから誘導されたバリアントおよびその使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (6) | US7842663B2 (https=) |
| EP (6) | EP2607379B1 (https=) |
| JP (7) | JP5554067B2 (https=) |
| KR (5) | KR102072897B1 (https=) |
| CN (5) | CN105884880B (https=) |
| AR (1) | AR065169A1 (https=) |
| AU (5) | AU2008214375B2 (https=) |
| BR (1) | BRPI0808164B8 (https=) |
| CA (2) | CA3038197A1 (https=) |
| CY (1) | CY1115489T1 (https=) |
| DK (1) | DK2607379T3 (https=) |
| EA (3) | EA018868B1 (https=) |
| ES (4) | ES2796347T3 (https=) |
| HR (1) | HRP20140731T1 (https=) |
| IL (6) | IL200171A (https=) |
| ME (1) | ME02234B (https=) |
| MX (5) | MX2009008154A (https=) |
| NO (1) | NO3053933T3 (https=) |
| PL (2) | PL2607379T3 (https=) |
| PT (1) | PT2607379E (https=) |
| RS (1) | RS53455B (https=) |
| SI (1) | SI2607379T1 (https=) |
| TW (9) | TWI782836B (https=) |
| WO (1) | WO2008097541A2 (https=) |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6891082B2 (en) * | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| EP1771470B1 (en) | 2004-07-23 | 2013-06-26 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
| AU2006213686A1 (en) | 2005-02-09 | 2006-08-17 | Avi Bio Pharma, Inc. | Antisense composition and method for treating muscle atrophy |
| US8067562B2 (en) | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
| KR20190006086A (ko) | 2005-11-23 | 2019-01-16 | 악셀레론 파마 인코포레이티드 | 액티빈-ａｃｔｒⅱａ 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US8895016B2 (en) * | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
| DK2124999T3 (da) * | 2006-12-18 | 2013-01-14 | Acceleron Pharma Inc | Activin-actrii antagonister og anvendelser til behandling af anæmi |
| EP2111229B1 (en) | 2007-02-01 | 2013-04-10 | Acceleron Pharma, Inc. | Pharmaceutical compositions comprising Activin-ActRIIA antagonists for use in preventing or treating breast cancer metastasis or breast cancer related bone loss |
| TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| ES2756725T3 (es) * | 2007-02-09 | 2020-04-27 | Acceleron Pharma Inc | Composiciones farmacéuticas que comprenden antagonistas de Activina-ActRIIA |
| US8501678B2 (en) | 2007-03-06 | 2013-08-06 | Atara Biotherapeutics, Inc. | Variant activin receptor polypeptides and uses thereof |
| TWI573802B (zh) | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
| EP3243524A1 (en) * | 2007-09-18 | 2017-11-15 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| AU2009262970A1 (en) | 2008-06-26 | 2009-12-30 | Acceleron Pharma Inc. | Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients |
| JP5773868B2 (ja) | 2008-06-26 | 2015-09-02 | アクセルロン ファーマ， インコーポレイテッド | アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| AU2015202035B2 (en) * | 2008-08-14 | 2017-03-23 | Acceleron Pharma Inc. | Use of GDF traps to increase red blood cell levels |
| SMT202300222T1 (it) * | 2008-08-14 | 2023-09-06 | Acceleron Pharma Inc | Trappole di gdf |
| SG10201703067QA (en) * | 2008-11-26 | 2017-05-30 | Amgen Inc | Variants Of Activin IIB Receptor Polypeptides And Uses Thereof |
| US8138142B2 (en) * | 2009-01-13 | 2012-03-20 | Acceleron Pharma Inc. | Methods for increasing adiponectin in a patient in need thereof |
| JP5766179B2 (ja) * | 2009-04-27 | 2015-08-19 | ノバルティス アーゲー | 筋肉増殖を増加させるための組成物および方法 |
| BRPI1010587A2 (pt) * | 2009-06-08 | 2019-04-09 | Acceleron Pharma Inc. | métodos para aumentar adipócitos termogênicos |
| EP2440577A4 (en) * | 2009-06-12 | 2013-01-23 | Acceleron Pharma Inc | SHORTEN ACTRIIB FC FUSION PROTEINS |
| KR20180085825A (ko) * | 2009-08-13 | 2018-07-27 | 악셀레론 파마 인코포레이티드 | 적혈구 수준을 증가시키기 위한 ｇｄｆ 트랩과 에리트로포이에틴 수용체 활성인자의 병용 |
| AU2015203400A1 (en) * | 2009-08-13 | 2015-07-16 | Acceleron Pharma Inc. | Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels |
| BR112012005225B8 (pt) * | 2009-09-09 | 2023-01-10 | Acceleron Pharma Inc | Uso de uma proteína de fusão actriib-fc para o tratamento de um transtorno relacionado ao osso ou associado à perda de músculo por crescimento muscular insuficiente |
| EP3818988A1 (en) * | 2009-11-03 | 2021-05-12 | Acceleron Pharma Inc. | Methods for treating fatty liver disease |
| JP6267425B2 (ja) * | 2009-11-17 | 2018-01-24 | アクセルロン ファーマ， インコーポレイテッド | 筋ジストロフィー治療のためのユートロフィン誘導に関するａｃｔｒｉｉｂタンパク質およびその改変体およびその使用 |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
| CN103298832A (zh) | 2010-11-08 | 2013-09-11 | 阿塞勒隆制药公司 | Actriia结合剂及其用途 |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| HUE040276T2 (hu) * | 2011-07-01 | 2019-02-28 | Novartis Ag | Eljárás metabolikus rendellenességek kezelésére |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| US20130085139A1 (en) | 2011-10-04 | 2013-04-04 | Royal Holloway And Bedford New College | Oligomers |
| BR112014009528B1 (pt) | 2011-10-17 | 2020-12-29 | Acceleron Pharma, Inc. | usos de polipeptídeos actriib para a fabricação de um medicamento para tratar eritropoiese ineficaz |
| US8765385B2 (en) * | 2011-10-27 | 2014-07-01 | Ravindra Kumar | Method of detection of neutralizing anti-actriib antibodies |
| CN104114572A (zh) | 2011-12-16 | 2014-10-22 | 现代治疗公司 | 经修饰的核苷、核苷酸和核酸组合物 |
| HK1203384A1 (en) * | 2011-12-19 | 2015-12-11 | Amgen Inc. | Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof |
| AU2013243948A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9809636B2 (en) | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| GB201206559D0 (en) * | 2012-04-13 | 2012-05-30 | Ucl Business Plc | Polypeptide |
| AU2013334660B2 (en) | 2012-10-24 | 2018-08-09 | Celgene Corporation | Methods for treating anemia |
| CN104968801B (zh) | 2012-10-24 | 2021-06-15 | 细胞基因公司 | 用于治疗贫血症的生物标志物 |
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| SG10201706148WA (en) | 2013-02-01 | 2017-08-30 | Santa Maria Biotherapeutics Inc | Administration of an anti-activin-a compound to a subject |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| DK3037524T3 (da) * | 2013-08-23 | 2020-03-16 | Sumitomo Chemical Co | Fremgangsmåde til at fremstille nethindevæv og nethinderelaterede celler |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
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| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
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| MA41119A (fr) | 2014-12-03 | 2017-10-10 | Acceleron Pharma Inc | Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique |
| MX2017007519A (es) * | 2014-12-08 | 2017-08-22 | Novartis Ag | Antagonistas de miostatina o activina para el tratamiento de sarcopenia. |
| EP3256148A1 (en) | 2015-02-12 | 2017-12-20 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for predicting the responsiveness of a patient affected with malignant hematological disease to chemotherapy treatment and methods of treatment of such disease |
| MA41795A (fr) | 2015-03-18 | 2018-01-23 | Sarepta Therapeutics Inc | Exclusion d'un exon induite par des composés antisens dans la myostatine |
| EA039118B1 (ru) * | 2015-04-01 | 2021-12-07 | Ридженерон Фармасьютикалз, Инк. | Способ лечения прогрессирующей оссифицирующей фибродисплазии |
| CN107849114B (zh) | 2015-04-06 | 2021-08-20 | 阿塞勒隆制药公司 | 单臂i型和ii型受体融合蛋白和其用途 |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| US10227392B2 (en) | 2015-04-06 | 2019-03-12 | Acceleron Pharma Inc. | ALK7:ActRIIB heteromultimers and uses thereof |
| PT3286206T (pt) | 2015-04-22 | 2021-04-01 | Biogen Ma Inc | Novas proteínas híbridas bloqueadoras de ligando actriib para tratar doenças de desgaste muscular |
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