JP2020521478A5 - - Google Patents
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- Publication number
- JP2020521478A5 JP2020521478A5 JP2019565865A JP2019565865A JP2020521478A5 JP 2020521478 A5 JP2020521478 A5 JP 2020521478A5 JP 2019565865 A JP2019565865 A JP 2019565865A JP 2019565865 A JP2019565865 A JP 2019565865A JP 2020521478 A5 JP2020521478 A5 JP 2020521478A5
- Authority
- JP
- Japan
- Prior art keywords
- isvd
- seq
- polypeptide
- lrp5
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 43
- 229920001184 polypeptide Polymers 0.000 claims 36
- 102000004196 processed proteins & peptides Human genes 0.000 claims 36
- 230000027455 binding Effects 0.000 claims 25
- 102000009027 Albumins Human genes 0.000 claims 13
- 108010088751 Albumins Proteins 0.000 claims 13
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 10
- 102000052547 Wnt-1 Human genes 0.000 claims 7
- 108700020987 Wnt-1 Proteins 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 230000035897 transcription Effects 0.000 claims 6
- 238000013518 transcription Methods 0.000 claims 6
- 108060003951 Immunoglobulin Proteins 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 102000018358 immunoglobulin Human genes 0.000 claims 5
- 101001039199 Homo sapiens Low-density lipoprotein receptor-related protein 6 Proteins 0.000 claims 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims 4
- 108091006905 Human Serum Albumin Proteins 0.000 claims 4
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 4
- 239000012581 transferrin Substances 0.000 claims 4
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 3
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102100040704 Low-density lipoprotein receptor-related protein 6 Human genes 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 208000017442 Retinal disease Diseases 0.000 claims 2
- 206010038923 Retinopathy Diseases 0.000 claims 2
- 102000004338 Transferrin Human genes 0.000 claims 2
- 108090000901 Transferrin Proteins 0.000 claims 2
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940022399 cancer vaccine Drugs 0.000 claims 2
- 238000009566 cancer vaccine Methods 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229940121647 egfr inhibitor Drugs 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 102000055436 human LRP6 Human genes 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 230000019491 signal transduction Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 101001043594 Homo sapiens Low-density lipoprotein receptor-related protein 5 Proteins 0.000 claims 1
- 102000007330 LDL Lipoproteins Human genes 0.000 claims 1
- 108010007622 LDL Lipoproteins Proteins 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 101710196169 Receptor-like protein 5 Proteins 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 102000013814 Wnt Human genes 0.000 claims 1
- 108050003627 Wnt Proteins 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 230000003054 hormonal effect Effects 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 102000055426 human LRP5 Human genes 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000000116 mitigating effect Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17173782 | 2017-05-31 | ||
| EP17173782.8 | 2017-05-31 | ||
| PCT/EP2018/064295 WO2018220080A1 (en) | 2017-05-31 | 2018-05-30 | Polypeptides antagonizing wnt signaling in tumor cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020521478A JP2020521478A (ja) | 2020-07-27 |
| JP2020521478A5 true JP2020521478A5 (https=) | 2021-07-26 |
| JP7216024B2 JP7216024B2 (ja) | 2023-01-31 |
Family
ID=59021278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565865A Active JP7216024B2 (ja) | 2017-05-31 | 2018-05-30 | 腫瘍細胞におけるＷｎｔシグナル伝達と拮抗するポリペプチド |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US11033636B2 (https=) |
| EP (1) | EP3630816B1 (https=) |
| JP (1) | JP7216024B2 (https=) |
| KR (1) | KR102717656B1 (https=) |
| CN (1) | CN110637030B (https=) |
| AR (1) | AR111840A1 (https=) |
| AU (1) | AU2018276409B2 (https=) |
| BR (1) | BR112019022729A2 (https=) |
| CA (1) | CA3060401A1 (https=) |
| CL (1) | CL2019003419A1 (https=) |
| CO (1) | CO2019012329A2 (https=) |
| EA (1) | EA201992808A1 (https=) |
| ES (1) | ES2979194T3 (https=) |
| HU (1) | HUE067691T2 (https=) |
| IL (1) | IL270854B2 (https=) |
| MA (1) | MA48760A (https=) |
| MX (1) | MX2019014331A (https=) |
| MY (1) | MY200744A (https=) |
| NZ (1) | NZ758031A (https=) |
| PE (1) | PE20200610A1 (https=) |
| PH (1) | PH12019502602A1 (https=) |
| PL (1) | PL3630816T3 (https=) |
| TW (1) | TWI887192B (https=) |
| UA (1) | UA125761C2 (https=) |
| WO (1) | WO2018220080A1 (https=) |
| ZA (1) | ZA201906610B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3630816T3 (pl) * | 2017-05-31 | 2024-08-05 | Boehringer Ingelheim International Gmbh | Polipeptydy antagonizujące sygnalizację wnt w komórkach nowotworowych |
| AU2018316166A1 (en) | 2017-08-07 | 2020-02-06 | The Regents Of The University Of California | Platform for generating safe cell therapeutics |
| EP3732201A4 (en) | 2017-12-19 | 2022-04-20 | Surrozen Operating, Inc. | WNT SURROGATES AND THEIR USES |
| CN111655729B (zh) | 2017-12-19 | 2023-10-20 | 瑟罗泽恩奥普瑞汀公司 | 抗卷曲蛋白抗体和使用方法 |
| CN111699003B (zh) | 2017-12-19 | 2024-05-03 | 瑟罗泽恩奥普瑞汀公司 | 抗lrp5/6抗体和使用方法 |
| WO2020080941A1 (en) * | 2018-10-16 | 2020-04-23 | Umc Utrecht Holding B.V. | Anti- low-density lipoprotein receptor-related protein 5/6 antibodies |
| JP7663501B2 (ja) * | 2019-02-11 | 2025-04-16 | スロゼン オペレーティング， インコーポレイテッド | 眼障害におけるｗｎｔシグナル伝達の調節 |
| TW202104258A (zh) * | 2019-03-29 | 2021-02-01 | 德商百靈佳殷格翰國際股份有限公司 | 抗癌組合療法 |
| KR20220078568A (ko) * | 2019-08-14 | 2022-06-10 | 모드맵 테라퓨틱스 인코포레이티드 | Lrp5 단백질에 결합하는 항체 및 사용 방법 |
| WO2023250402A2 (en) * | 2022-06-22 | 2023-12-28 | Antlera Therapeutics Inc. | Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof |
| KR102920873B1 (ko) * | 2021-07-13 | 2026-02-02 | 인제대학교 산학협력단 | NEURL 유전자, 이를 포함하는 발현벡터 또는 NEURL 단백질을 유효성분으로 포함하는 β-카테닌 과발현으로 인한 암질환 예방 또는 치료용 약학조성물 |
| WO2023019137A1 (en) * | 2021-08-10 | 2023-02-16 | Heat Biologics, Inc. | Generation and characterization of novel tim-4 binding agents |
| CN114702588B (zh) * | 2022-04-27 | 2022-11-22 | 博际生物医药科技(杭州)有限公司 | 抗Nectin-4抗体和双特异性抗体 |
| CN120424217B (zh) * | 2025-04-30 | 2026-03-06 | 立凌生物制药(苏州)有限公司 | 靶向b细胞抗原和t细胞抗原的多特异性抗体及其应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU701578B2 (en) | 1992-08-21 | 1999-02-04 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| WO1998046743A1 (en) | 1997-04-15 | 1998-10-22 | The Wellcome Trust Limited As Trustee To The Wellcome Trust | Novel ldl-receptor |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| EP2206720A1 (en) | 2000-04-12 | 2010-07-14 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| IL158750A0 (en) | 2001-05-17 | 2004-05-12 | Genome Therapeutics Corp | Reagents and methods for modulating dkk-mediated interactions |
| DK1399484T3 (da) | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
| AU2002364587A1 (en) | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| ES2263984T3 (es) * | 2002-06-28 | 2006-12-16 | Domantis Limited | Ligandos doble-especificos con una vida media serica aumentada. |
| WO2004041867A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Camelidae antibodies against imminoglobulin e and use thereof for the treatment of allergic disorders |
| US8461155B2 (en) | 2003-09-22 | 2013-06-11 | University Of Connecticut | Sclerostin and the inhibition of WNT signaling and bone formation |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| WO2006122787A1 (en) | 2005-05-18 | 2006-11-23 | Ablynx Nv | Serum albumin binding proteins |
| US20090220488A1 (en) * | 2005-08-31 | 2009-09-03 | Humphrey Gardner | Evaluating and treating scleroderma |
| EP2057191A1 (en) | 2006-08-18 | 2009-05-13 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
| CN101646689A (zh) | 2006-09-08 | 2010-02-10 | 埃博灵克斯股份有限公司 | 具有长半衰期的血清清蛋白结合蛋白 |
| CA2671581A1 (en) | 2006-12-05 | 2008-06-12 | Ablynx N.V. | Peptides capable of binding to serum proteins |
| CN101965362A (zh) | 2008-03-05 | 2011-02-02 | 埃博灵克斯股份有限公司 | 新型抗原结合二聚体-复合物及其制备方法和应用 |
| EP2268668A1 (en) | 2008-04-17 | 2011-01-05 | Ablynx N.V. | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
| US8716243B2 (en) | 2008-05-28 | 2014-05-06 | St. Jude Childen's Research Hospital | Methods of effecting Wnt signaling through Dkk structural analysis |
| CA2777527C (en) | 2009-12-23 | 2020-06-23 | Esbatech, An Alcon Biomedical Research Unit Llc | Method for decreasing immunogenicity |
| CN102781959A (zh) | 2010-02-05 | 2012-11-14 | 埃博灵克斯股份有限公司 | 能够结合血清白蛋白的肽和包含所述肽的化合物、构建体和多肽 |
| UY33253A (es) | 2010-03-03 | 2011-09-30 | Boehringer Ingelheim Int | Polipéptidos de unión a a-beta |
| AR080795A1 (es) * | 2010-03-24 | 2012-05-09 | Genentech Inc | Anticuerpos anti-lrp6 (proteina relacionada con el receptor ldl tipo 6) |
| EP4234698A3 (en) * | 2010-05-06 | 2023-11-08 | Novartis AG | Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (lrp6) antibodies |
| KR20130066631A (ko) | 2010-05-06 | 2013-06-20 | 노파르티스 아게 | 치료적 저밀도 지단백질-관련 단백질 ６ （ｌｒｐ６） 다가 항체에 대한 조성물 및 사용 방법 |
| JP2014506568A (ja) | 2011-01-28 | 2014-03-17 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | Ｗｎｔ組成物およびその使用方法 |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| US8790650B2 (en) | 2011-04-28 | 2014-07-29 | Vanderbilt University | Methods of using an antibody to inhibit WNT-mediated cardiac remodeling |
| DK2723769T4 (da) | 2011-06-23 | 2022-09-05 | Ablynx Nv | Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner |
| SG2014010482A (en) | 2011-08-17 | 2014-04-28 | Glaxo Group Ltd | Modified proteins and peptides |
| CN104039830A (zh) | 2011-11-04 | 2014-09-10 | 诺华股份有限公司 | 低密度脂蛋白相关蛋白6(lrp6)-半寿期延长物构建体 |
| EP2804629A1 (en) * | 2012-01-18 | 2014-11-26 | Genentech, Inc. | Anti-lrp5 antibodies and methods of use |
| CN120535622A (zh) | 2015-11-18 | 2025-08-26 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合剂 |
| KR102802241B1 (ko) * | 2015-12-04 | 2025-05-07 | 베링거 인겔하임 인터내셔날 게엠베하 | 종양 세포에서 wnt 신호 전달을 길항하는 바이파라토픽 폴리펩타이드 |
| PL3630816T3 (pl) * | 2017-05-31 | 2024-08-05 | Boehringer Ingelheim International Gmbh | Polipeptydy antagonizujące sygnalizację wnt w komórkach nowotworowych |
| TW202104258A (zh) * | 2019-03-29 | 2021-02-01 | 德商百靈佳殷格翰國際股份有限公司 | 抗癌組合療法 |
-
2018
- 2018-05-30 PL PL18729376.6T patent/PL3630816T3/pl unknown
- 2018-05-30 UA UAA201911920A patent/UA125761C2/uk unknown
- 2018-05-30 HU HUE18729376A patent/HUE067691T2/hu unknown
- 2018-05-30 MY MYPI2019006657A patent/MY200744A/en unknown
- 2018-05-30 EA EA201992808A patent/EA201992808A1/ru unknown
- 2018-05-30 PE PE2019002493A patent/PE20200610A1/es unknown
- 2018-05-30 WO PCT/EP2018/064295 patent/WO2018220080A1/en not_active Ceased
- 2018-05-30 ES ES18729376T patent/ES2979194T3/es active Active
- 2018-05-30 CN CN201880033136.9A patent/CN110637030B/zh active Active
- 2018-05-30 KR KR1020197033590A patent/KR102717656B1/ko active Active
- 2018-05-30 TW TW107118382A patent/TWI887192B/zh active
- 2018-05-30 JP JP2019565865A patent/JP7216024B2/ja active Active
- 2018-05-30 US US15/992,345 patent/US11033636B2/en active Active
- 2018-05-30 MX MX2019014331A patent/MX2019014331A/es unknown
- 2018-05-30 AU AU2018276409A patent/AU2018276409B2/en active Active
- 2018-05-30 MA MA048760A patent/MA48760A/fr unknown
- 2018-05-30 AR ARP180101427A patent/AR111840A1/es unknown
- 2018-05-30 EP EP18729376.6A patent/EP3630816B1/en active Active
- 2018-05-30 BR BR112019022729A patent/BR112019022729A2/pt unknown
- 2018-05-30 NZ NZ758031A patent/NZ758031A/en unknown
- 2018-05-30 CA CA3060401A patent/CA3060401A1/en active Pending
-
2019
- 2019-10-08 ZA ZA2019/06610A patent/ZA201906610B/en unknown
- 2019-10-31 CO CONC2019/0012329A patent/CO2019012329A2/es unknown
- 2019-11-20 PH PH12019502602A patent/PH12019502602A1/en unknown
- 2019-11-24 IL IL270854A patent/IL270854B2/en unknown
- 2019-11-25 CL CL2019003419A patent/CL2019003419A1/es unknown
-
2021
- 2021-05-10 US US17/316,042 patent/US12285493B2/en active Active
-
2025
- 2025-03-20 US US19/085,495 patent/US20250345448A1/en active Pending
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