DK3037524T3 - Fremgangsmåde til at fremstille nethindevæv og nethinderelaterede celler - Google Patents

Fremgangsmåde til at fremstille nethindevæv og nethinderelaterede celler Download PDF

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Publication number
DK3037524T3
DK3037524T3 DK14838289.8T DK14838289T DK3037524T3 DK 3037524 T3 DK3037524 T3 DK 3037524T3 DK 14838289 T DK14838289 T DK 14838289T DK 3037524 T3 DK3037524 T3 DK 3037524T3
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procedures
procedure
tables
manufacturing
manufacturing procedural
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DK14838289.8T
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Chikafumi Ozone
Yoshiki Sasai
Tokushige Nakano
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Sumitomo Chemical Co
Riken
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
    • C—CHEMISTRY; METALLURGY
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/44—Thiols, e.g. mercaptoethanol
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/19—Growth and differentiation factors [GDF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
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  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
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  • Urology & Nephrology (AREA)
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  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK14838289.8T 2013-08-23 2014-08-22 Fremgangsmåde til at fremstille nethindevæv og nethinderelaterede celler DK3037524T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013173285 2013-08-23
PCT/JP2014/072065 WO2015025967A1 (ja) 2013-08-23 2014-08-22 網膜組織及び網膜関連細胞の製造方法

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DK3037524T3 true DK3037524T3 (da) 2020-03-16

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US (3) US10501724B2 (da)
EP (2) EP3656853B1 (da)
JP (4) JP6580989B2 (da)
KR (1) KR102278978B1 (da)
CN (1) CN105683366B (da)
AU (1) AU2014309730B2 (da)
CA (1) CA2922079C (da)
DK (1) DK3037524T3 (da)
ES (2) ES2776707T3 (da)
SG (1) SG11201601294PA (da)
WO (1) WO2015025967A1 (da)

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KR102297584B1 (ko) 2013-11-11 2021-09-03 스미또모 가가꾸 가부시끼가이샤 망막 색소 표피 세포의 제조 방법
WO2016063986A1 (ja) 2014-10-24 2016-04-28 大日本住友製薬株式会社 網膜組織の製造方法
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AU2017254264C1 (en) 2016-04-22 2023-10-05 Riken Method for producing retinal tissue
CN109996873A (zh) 2016-11-25 2019-07-09 国立研究开发法人理化学研究所 移植用细胞群及其制造方法
CN110945115A (zh) * 2017-07-20 2020-03-31 国立研究开发法人理化学研究所 神经组织的保存方法
US20200208103A1 (en) 2017-07-20 2020-07-02 Riken Method for maturation of retinal tissue containing continuous epithelium
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CA3075877A1 (en) 2017-09-14 2019-03-21 Riken Method for producing retinal tissues
EP3683304A4 (en) 2017-09-14 2021-06-09 Riken PROCESS FOR AMPLIFYING CONE PHOTOReceptors or STICK PHOTOReceptors USING A DORSALIZATION SIGNAL TRANSMITTER OR VENTRALIZATION SIGNAL TRANSMITTER
JP7384671B2 (ja) * 2017-11-24 2023-11-21 住友化学株式会社 神経系細胞又は神経組織と非神経上皮組織とを含む細胞塊の製造方法及びその細胞塊
WO2020138430A1 (ja) 2018-12-28 2020-07-02 国立研究開発法人理化学研究所 網膜系細胞又は網膜組織の障害を伴う疾患の治療薬
CN113557311A (zh) 2019-03-13 2021-10-26 大日本住友制药株式会社 移植用神经视网膜的品质评价方法及移植用神经视网膜片
AU2020260894A1 (en) 2019-04-26 2021-11-18 Riken Composite including neural retina, retinal pigment epithelial cells, and hydrogel, and method for producing same
GB2584664B (en) * 2019-06-10 2023-05-24 Newcells Biotech Ltd Improved retinal organoids and methods of making the same
CN116157512A (zh) 2020-09-11 2023-05-23 国立研究开发法人理化学研究所 包含含神经视网膜的细胞聚集体和基质的复合体及其制造方法
US20230310614A1 (en) 2020-09-11 2023-10-05 Sumitomo Pharma Co., Ltd. Medium for Tissue for Transplantation
TW202330906A (zh) 2021-11-19 2023-08-01 國立研究開發法人理化學研究所 片狀視網膜組織之製造方法
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JP6546089B2 (ja) 2013-08-06 2019-07-17 国立研究開発法人理化学研究所 前眼部組織の製造方法

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AU2014309730A1 (en) 2016-04-14
EP3037524A1 (en) 2016-06-29
CN105683366A (zh) 2016-06-15
EP3037524B1 (en) 2019-12-11
JP2021118729A (ja) 2021-08-12
EP3037524A4 (en) 2017-05-03
JP6885550B2 (ja) 2021-06-16
US20200102535A1 (en) 2020-04-02
CN105683366B (zh) 2020-11-06
CA2922079C (en) 2022-07-05
US20160251616A1 (en) 2016-09-01
AU2014309730B2 (en) 2020-11-19
EP3037524B8 (en) 2020-03-04
WO2015025967A1 (ja) 2015-02-26
US11473056B2 (en) 2022-10-18
JP6580989B2 (ja) 2019-09-25
EP3656853A1 (en) 2020-05-27
ES2776707T3 (es) 2020-07-31
SG11201601294PA (en) 2016-03-30
US20220364054A1 (en) 2022-11-17
KR102278978B1 (ko) 2021-07-19
CA2922079A1 (en) 2015-02-26
JPWO2015025967A1 (ja) 2017-03-02
JP7435984B2 (ja) 2024-02-21
ES2943670T3 (es) 2023-06-15
US10501724B2 (en) 2019-12-10
EP3656853B1 (en) 2023-02-15
JP7120585B2 (ja) 2022-08-17
JP2020000248A (ja) 2020-01-09
KR20160045145A (ko) 2016-04-26
JP2022141924A (ja) 2022-09-29

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