JP2010515698A5 - - Google Patents

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JP2010515698A5
JP2010515698A5 JP2009545143A JP2009545143A JP2010515698A5 JP 2010515698 A5 JP2010515698 A5 JP 2010515698A5 JP 2009545143 A JP2009545143 A JP 2009545143A JP 2009545143 A JP2009545143 A JP 2009545143A JP 2010515698 A5 JP2010515698 A5 JP 2010515698A5
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formula
compound
biphenyl
salt
nitrogen protecting
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JP2009545143A
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JP2010515698A (ja
JP5715339B2 (ja
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Priority claimed from PCT/EP2008/000142 external-priority patent/WO2008083967A2/en
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JP2009545143A 2007-01-12 2008-01-10 5−ビフェニル−4−アミノ−2−メチルペンタン酸の製造方法 Active JP5715339B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07100451 2007-01-12
EP07100451.9 2007-01-12
PCT/EP2008/000142 WO2008083967A2 (en) 2007-01-12 2008-01-10 Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid

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JP2010515698A JP2010515698A (ja) 2010-05-13
JP2010515698A5 true JP2010515698A5 (enExample) 2011-03-03
JP5715339B2 JP5715339B2 (ja) 2015-05-07

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JP2009545143A Active JP5715339B2 (ja) 2007-01-12 2008-01-10 5−ビフェニル−4−アミノ−2−メチルペンタン酸の製造方法

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US (4) US8115016B2 (enExample)
EP (1) EP2121578B1 (enExample)
JP (1) JP5715339B2 (enExample)
KR (2) KR101580067B1 (enExample)
CN (1) CN101631765B (enExample)
AR (1) AR064842A1 (enExample)
AU (2) AU2008204546B2 (enExample)
BR (1) BRPI0806700A8 (enExample)
CA (1) CA2674291C (enExample)
CL (1) CL2008000077A1 (enExample)
CO (1) CO6251311A2 (enExample)
CY (1) CY1118225T1 (enExample)
DK (1) DK2121578T3 (enExample)
EC (1) ECSP099508A (enExample)
ES (1) ES2602566T3 (enExample)
GT (1) GT200900195A (enExample)
HR (1) HRP20161484T1 (enExample)
HU (1) HUE030695T2 (enExample)
IL (1) IL199492A (enExample)
JO (1) JO3142B1 (enExample)
LT (1) LT2121578T (enExample)
MA (1) MA31284B1 (enExample)
MX (1) MX2009007474A (enExample)
MY (2) MY153432A (enExample)
NZ (1) NZ577910A (enExample)
PE (2) PE20081563A1 (enExample)
PH (1) PH12012502091A1 (enExample)
PL (1) PL2121578T3 (enExample)
PT (1) PT2121578T (enExample)
RU (1) RU2530900C2 (enExample)
SG (1) SG185318A1 (enExample)
SI (1) SI2121578T1 (enExample)
TN (1) TN2009000296A1 (enExample)
TW (1) TWI413638B (enExample)
WO (1) WO2008083967A2 (enExample)
ZA (1) ZA200904311B (enExample)

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CN104230865B (zh) * 2013-06-13 2018-01-09 上海翰森生物医药科技有限公司 联芳基取代的4‑氨基丁酸衍生物及其制备方法和用途
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CN104557600B (zh) * 2015-01-26 2016-05-04 苏州明锐医药科技有限公司 沙库比曲的制备方法
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LT3259255T (lt) 2015-02-19 2021-04-26 Theravance Biopharma R&D Ip, Llc (2r,4r)-5-(5`-chlor-2`-fluorbifenil-4-il)-2-hidroksi-4-[(5-metiloksazol-2-karbonil)amino]pentano rūgštis
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CN104926707B (zh) * 2015-05-12 2017-10-27 江苏福瑞生物医药有限公司 一种药物中间体的合成方法
CN104829514B (zh) * 2015-05-12 2017-10-03 江苏福瑞生物医药有限公司 一种药物中间体的合成方法
CN104860894B (zh) * 2015-06-10 2017-05-17 北京博全健医药科技有限公司 一种抗心衰药lcz696的制备方法
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US11786498B2 (en) * 2015-07-02 2023-10-17 Novartis Ag Sacubitril calcium salts
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CN105061263B (zh) * 2015-08-11 2017-03-15 苏州楚凯药业有限公司 一种nep抑制剂中间体的制备方法
CN105168205A (zh) * 2015-08-18 2015-12-23 泰力特医药(湖北)有限公司 一种血管紧张素ii受体和脑啡肽酶受体双重抑制剂lcz696的制备方法
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WO2017051326A1 (en) 2015-09-23 2017-03-30 Novartis Ag New processes and intermediates useful in synthesis of nep inhibitors
CN105348209B (zh) 2015-12-09 2017-12-26 浙江天宇药业股份有限公司 一种抗心衰药lcz696的制备方法
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CN106977415B (zh) * 2016-01-15 2021-03-26 广东东阳光药业有限公司 一种沙库必曲的中间体及其制备方法
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WO2017148357A1 (zh) * 2016-02-29 2017-09-08 广东东阳光药业有限公司 一种沙库必曲的中间体及其制备方法
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CN107602399B (zh) * 2016-07-11 2020-09-25 江西东邦药业有限公司 一种脑啡肽酶抑制剂中间体的制备方法
JP6945619B2 (ja) * 2016-08-17 2021-10-06 ノバルティス アーゲー Nep阻害剤合成のための新規な方法および中間体
CN106496055A (zh) * 2016-10-09 2017-03-15 杭州科巢生物科技有限公司 一种抗心衰新药的关键组分沙库比曲的新合成方法
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CN107311909A (zh) * 2017-06-22 2017-11-03 东南大学 一种lcz696杂质对照品的制备方法
CN109206419B (zh) * 2017-06-29 2023-07-14 上海迪赛诺化学制药有限公司 沙库比曲中间体及其制备方法和应用
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CN110407733A (zh) * 2018-04-26 2019-11-05 鲁南制药集团股份有限公司 一种沙库巴曲杂质化合物
CN110551151A (zh) * 2018-05-30 2019-12-10 微宏动力系统(湖州)有限公司 一种磷酸酯或亚磷酸酯的制备方法、电解液及二次电池
CN108727213B (zh) * 2018-06-29 2021-06-08 中国科学院上海有机化学研究所 一种沙库必曲的制备方法
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CN109400504A (zh) * 2018-12-11 2019-03-01 重庆三圣实业股份有限公司 Lcz696中间体非对映异构体的分离纯化方法
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CN109912486B (zh) * 2019-04-25 2022-09-27 东北制药集团股份有限公司 一种联苯甲基内酰胺化合物的制备方法
CN110878039A (zh) * 2019-12-18 2020-03-13 株洲千金药业股份有限公司 一种沙库巴曲缬沙坦钠杂质的制备方法
JP7064527B2 (ja) * 2020-05-01 2022-05-10 ノバルティス アーゲー サクビトリルカルシウム塩
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