|
MY151993A
(en)
*
|
2007-01-12 |
2014-07-31 |
Novartis Ag |
Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
|
|
PE20091364A1
(es)
*
|
2008-01-17 |
2009-10-13 |
Novartis Ag |
Proceso para la preparacion de inhibidores de nep
|
|
AU2012202949B2
(en)
*
|
2008-01-17 |
2015-01-22 |
Novartis Ag |
Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
|
|
ES2582395T3
(es)
|
2009-05-28 |
2016-09-12 |
Novartis Ag |
Derivados aminobutíricos sustituidos como inhibidores de neprilisina
|
|
MX2011012628A
(es)
|
2009-05-28 |
2011-12-14 |
Novartis Ag |
Derivados amino-propionicos sustituidos como inhibidores de neprilisina.
|
|
JO2967B1
(en)
|
2009-11-20 |
2016-03-15 |
نوفارتس ايه جي |
Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
|
|
AU2011207020B2
(en)
*
|
2010-01-22 |
2014-04-17 |
Novartis Ag |
Intermediates of neutral endopeptidase inhibitors and preparation method thereof
|
|
KR20130106374A
(ko)
*
|
2010-08-23 |
2013-09-27 |
노파르티스 아게 |
Nep 억제제의 제조에 유용한 중간체의 신규한 제조 방법
|
|
EP2609075B1
(en)
|
2010-08-23 |
2016-03-16 |
Novartis AG |
Process for the preparation of intermediates for the manufacture of nep inhibitors
|
|
US8993631B2
(en)
|
2010-11-16 |
2015-03-31 |
Novartis Ag |
Method of treating contrast-induced nephropathy
|
|
US8877815B2
(en)
*
|
2010-11-16 |
2014-11-04 |
Novartis Ag |
Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
|
|
US8673974B2
(en)
*
|
2010-11-16 |
2014-03-18 |
Novartis Ag |
Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
|
|
AU2011343903B2
(en)
|
2010-12-15 |
2016-06-30 |
Theravance Biopharma R&D Ip, Llc |
Neprilysin inhibitors
|
|
DK2651896T3
(en)
|
2010-12-15 |
2015-10-05 |
Theravance Biopharma R & D Ip Llc |
Neprilysininhibitorer
|
|
JP5959065B2
(ja)
|
2011-02-17 |
2016-08-02 |
セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー |
ネプリライシン阻害剤としての置換アミノ酪酸誘導体
|
|
JP5959066B2
(ja)
|
2011-02-17 |
2016-08-02 |
セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー |
ネプリライシン阻害剤としての置換アミノ酪酸誘導体
|
|
US8513244B2
(en)
|
2011-05-31 |
2013-08-20 |
Theravance, Inc. |
Neprilysin inhibitors
|
|
ES2699773T3
(es)
|
2011-05-31 |
2019-02-12 |
Theravance Biopharma R&D Ip Llc |
Inhibidores de neprilisina
|
|
CN103748070B
(zh)
|
2011-05-31 |
2015-06-24 |
施万生物制药研发Ip有限责任公司 |
脑啡肽酶抑制剂
|
|
TWI560172B
(en)
*
|
2011-11-02 |
2016-12-01 |
Theravance Biopharma R&D Ip Llc |
Neprilysin inhibitors
|
|
TWI562986B
(en)
|
2012-02-15 |
2016-12-21 |
Theravance Biopharma R&D Ip Llc |
Process for preparing 4-amino-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-pentanoic acid compounds
|
|
WO2013181332A1
(en)
|
2012-05-31 |
2013-12-05 |
Theravance, Inc. |
Nitric oxide donor neprilysin inhibitors
|
|
JP6162229B2
(ja)
|
2012-06-08 |
2017-07-12 |
セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー |
ネプリライシン阻害剤
|
|
PT2864292T
(pt)
|
2012-06-08 |
2017-07-10 |
Theravance Biopharma R&D Ip Llc |
Inibidores de neprisilina
|
|
SG11201500845UA
(en)
|
2012-08-08 |
2015-03-30 |
Theravance Biopharma R&D Ip Llc |
Neprilysin inhibitors
|
|
JP6295277B2
(ja)
|
2013-02-14 |
2018-03-14 |
ノバルティス アーゲー |
Nep(中性エンドペプチダーゼ)阻害剤としての置換ビスフェニルブタン酸ホスホン酸誘導体
|
|
WO2014126972A1
(en)
|
2013-02-14 |
2014-08-21 |
Novartis Ag |
Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
|
|
HUE034210T2
(hu)
|
2013-03-05 |
2018-02-28 |
Theravance Biopharma R&D Ip Llc |
Neprilizininhibitorok
|
|
CN104230865B
(zh)
*
|
2013-06-13 |
2018-01-09 |
上海翰森生物医药科技有限公司 |
联芳基取代的4‑氨基丁酸衍生物及其制备方法和用途
|
|
WO2015116786A1
(en)
|
2014-01-30 |
2015-08-06 |
Theravance Biopharma R&D Ip, Llc |
Neprilysin inhibitors
|
|
US9585882B2
(en)
|
2014-01-30 |
2017-03-07 |
Theravance Biopharma R&D Ip, Llc |
Neprilysin inhibitors
|
|
PL3218351T3
(pl)
|
2014-11-14 |
2019-12-31 |
Zentiva K.S. |
Sposób wytwarzania, wyodrębniania i oczyszczania farmaceutycznie dopuszczalnych postaci AHU-377
|
|
WO2016086798A1
(zh)
*
|
2014-12-03 |
2016-06-09 |
上海翰森生物医药科技有限公司 |
Nep抑制剂结晶型游离酸、钙盐多晶型及其制备方法和应用
|
|
CN104557600B
(zh)
*
|
2015-01-26 |
2016-05-04 |
苏州明锐医药科技有限公司 |
沙库比曲的制备方法
|
|
MY187899A
(en)
|
2015-02-11 |
2021-10-27 |
Theravance Biopharma R&D Ip Llc |
(2s,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor
|
|
TW201632493A
(zh)
|
2015-02-13 |
2016-09-16 |
諾華公司 |
新穎方法
|
|
AU2016220348B2
(en)
|
2015-02-19 |
2019-10-17 |
Theravance Biopharma R&D Ip, Llc |
(2R,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid
|
|
WO2016135751A1
(en)
|
2015-02-25 |
2016-09-01 |
Mylan Laboratories Limited |
Novel process for the preparation of sacubitril and its intermediates
|
|
CN106187808A
(zh)
*
|
2015-05-08 |
2016-12-07 |
苏州鹏旭医药科技有限公司 |
Ahu-377的制备方法、ahu-377中间体及ahu-377中间体的制备方法
|
|
CN104926707B
(zh)
*
|
2015-05-12 |
2017-10-27 |
江苏福瑞生物医药有限公司 |
一种药物中间体的合成方法
|
|
CN104829514B
(zh)
*
|
2015-05-12 |
2017-10-03 |
江苏福瑞生物医药有限公司 |
一种药物中间体的合成方法
|
|
CN104860894B
(zh)
*
|
2015-06-10 |
2017-05-17 |
北京博全健医药科技有限公司 |
一种抗心衰药lcz696的制备方法
|
|
WO2016203500A2
(en)
*
|
2015-06-19 |
2016-12-22 |
Actavis Group Ptc Ehf. |
Preparation of sacubitril or salt thereof and novel intermediates in the preparation of sacubitril
|
|
HUE052222T2
(hu)
*
|
2015-07-02 |
2021-04-28 |
Novartis Ag |
Sacubitril kalciumsók
|
|
WO2017006254A1
(en)
|
2015-07-08 |
2017-01-12 |
Novartis Ag |
Drug combination comprising an angiotensin ii receptor antagonist, a neutral endopeptidase inhibitor and a mineralcorticoid receptor antagonist
|
|
CN105061263B
(zh)
*
|
2015-08-11 |
2017-03-15 |
苏州楚凯药业有限公司 |
一种nep抑制剂中间体的制备方法
|
|
CN105168205A
(zh)
*
|
2015-08-18 |
2015-12-23 |
泰力特医药(湖北)有限公司 |
一种血管紧张素ii受体和脑啡肽酶受体双重抑制剂lcz696的制备方法
|
|
WO2017033128A1
(en)
|
2015-08-25 |
2017-03-02 |
Novartis Ag |
Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
|
|
CN105130869B
(zh)
*
|
2015-09-07 |
2017-12-26 |
曾伟 |
一种Entresto中间体(S)‑5‑(联苯‑4‑羰基)吡咯烷‑2‑酮的合成方法
|
|
WO2017051326A1
(en)
|
2015-09-23 |
2017-03-30 |
Novartis Ag |
New processes and intermediates useful in synthesis of nep inhibitors
|
|
CN105523964B
(zh)
*
|
2015-12-09 |
2017-05-24 |
苏州楚凯药业有限公司 |
一种抗心衰药物中间体的制备方法
|
|
CN105348209B
(zh)
|
2015-12-09 |
2017-12-26 |
浙江天宇药业股份有限公司 |
一种抗心衰药lcz696的制备方法
|
|
RU2769445C2
(ru)
|
2015-12-10 |
2022-03-31 |
Новартис Аг |
Новый способ и новые промежуточные соединения
|
|
EP3386945A1
(en)
|
2015-12-11 |
2018-10-17 |
Zentiva, K.S. |
Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method
|
|
CN106977415B
(zh)
*
|
2016-01-15 |
2021-03-26 |
广东东阳光药业有限公司 |
一种沙库必曲的中间体及其制备方法
|
|
CN105566194A
(zh)
*
|
2016-02-01 |
2016-05-11 |
张伯引 |
一种Sacubitril中间体的制备方法
|
|
EP3424899B1
(en)
*
|
2016-02-29 |
2022-05-11 |
Sunshine Lake Pharma Co., Ltd. |
Sacubitril intermediate and preparation method thereof
|
|
SG11201807591VA
(en)
|
2016-03-08 |
2018-10-30 |
Theravance Biopharma R&D Ip Llc |
Crystalline(2s,4r)-5-(5'-chloro-2'-fluoro-[1,1'-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof
|
|
WO2017191620A1
(en)
*
|
2016-05-06 |
2017-11-09 |
Sun Pharmaceutical Industries Limited |
A crystalline form of a salt of sacubitril and a process of its preparation
|
|
CN105924355B
(zh)
*
|
2016-05-11 |
2018-08-17 |
浙江宏元药业有限公司 |
沙库比曲中间体及沙库比曲中间体和沙库比曲的制备方法
|
|
CN109415308B
(zh)
*
|
2016-07-05 |
2022-09-06 |
诺华股份有限公司 |
用于早期沙卡布曲中间体的新方法
|
|
CN107602399B
(zh)
*
|
2016-07-11 |
2020-09-25 |
江西东邦药业有限公司 |
一种脑啡肽酶抑制剂中间体的制备方法
|
|
EP3500549B1
(en)
|
2016-08-17 |
2020-12-16 |
Novartis AG |
New processes and intermediates for nep inhibitor synthesis
|
|
CN106496055A
(zh)
*
|
2016-10-09 |
2017-03-15 |
杭州科巢生物科技有限公司 |
一种抗心衰新药的关键组分沙库比曲的新合成方法
|
|
WO2018069833A1
(en)
*
|
2016-10-10 |
2018-04-19 |
Laurus Labs Limited |
Stable amorphous form of sacubitril valsartan trisodium complex and processes for preparation thereof
|
|
CN110088079A
(zh)
|
2016-12-23 |
2019-08-02 |
诺华股份有限公司 |
用于早期沙卡布曲中间体的新方法
|
|
CN107311909A
(zh)
*
|
2017-06-22 |
2017-11-03 |
东南大学 |
一种lcz696杂质对照品的制备方法
|
|
CN109206419B
(zh)
*
|
2017-06-29 |
2023-07-14 |
上海迪赛诺化学制药有限公司 |
沙库比曲中间体及其制备方法和应用
|
|
RU2020122121A
(ru)
*
|
2017-12-05 |
2022-01-10 |
Басф Се |
Соли органических сульфокислот со сложными эфирами аминокислот и способ их получения
|
|
UY38072A
(es)
|
2018-02-07 |
2019-10-01 |
Novartis Ag |
Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
|
|
CN110407733A
(zh)
*
|
2018-04-26 |
2019-11-05 |
鲁南制药集团股份有限公司 |
一种沙库巴曲杂质化合物
|
|
CN110551151A
(zh)
*
|
2018-05-30 |
2019-12-10 |
微宏动力系统(湖州)有限公司 |
一种磷酸酯或亚磷酸酯的制备方法、电解液及二次电池
|
|
CN108727213B
(zh)
*
|
2018-06-29 |
2021-06-08 |
中国科学院上海有机化学研究所 |
一种沙库必曲的制备方法
|
|
WO2020039394A1
(en)
|
2018-08-24 |
2020-02-27 |
Novartis Ag |
New drug combinations
|
|
CN109456212A
(zh)
*
|
2018-12-03 |
2019-03-12 |
康化(上海)新药研发有限公司 |
一种沙库比曲中间体的合成方法
|
|
CN109400504A
(zh)
*
|
2018-12-11 |
2019-03-01 |
重庆三圣实业股份有限公司 |
Lcz696中间体非对映异构体的分离纯化方法
|
|
CN113286780B
(zh)
*
|
2019-01-08 |
2024-08-27 |
巴斯夫欧洲公司 |
制备氨基酸酯的有机硫酸盐的方法
|
|
CN109912486B
(zh)
*
|
2019-04-25 |
2022-09-27 |
东北制药集团股份有限公司 |
一种联苯甲基内酰胺化合物的制备方法
|
|
CN110878039A
(zh)
*
|
2019-12-18 |
2020-03-13 |
株洲千金药业股份有限公司 |
一种沙库巴曲缬沙坦钠杂质的制备方法
|
|
JP7064527B2
(ja)
*
|
2020-05-01 |
2022-05-10 |
ノバルティス アーゲー |
サクビトリルカルシウム塩
|
|
US11897834B2
(en)
|
2020-07-09 |
2024-02-13 |
Advansix Resins & Chemicals Llc |
Branched amino acid surfactants
|
|
EP4179056A2
(en)
|
2020-07-13 |
2023-05-17 |
AdvanSix Resins & Chemicals LLC |
Branched amino acid surfactants for electronics products
|
|
WO2022015674A2
(en)
|
2020-07-13 |
2022-01-20 |
Advansix Resins & Chemicals Llc |
Branched amino acid surfactants for inks, paints, and adhesives
|
|
AU2021308180B2
(en)
|
2020-07-13 |
2024-06-13 |
Advansix Resins & Chemicals Llc |
Branched amino acid surfactants for cleaning products
|
|
JP7682991B2
(ja)
|
2020-07-13 |
2025-05-26 |
アドバンシックス・レジンズ・アンド・ケミカルズ・リミテッド・ライアビリティ・カンパニー |
油およびガス生産用分岐アミノ酸界面活性剤
|
|
WO2022015675A1
(en)
|
2020-07-13 |
2022-01-20 |
Advansix Resins & Chemicals Llc |
Branched amino acid surfactants for use in healthcare products
|
|
EP4178681A1
(en)
|
2020-07-13 |
2023-05-17 |
AdvanSix Resins & Chemicals LLC |
Branched amino acid surfactants for personal care and cosmetic products
|
|
CN115677521B
(zh)
*
|
2022-11-16 |
2024-02-02 |
迪嘉药业集团股份有限公司 |
一种高纯度沙库巴曲钙的制备方法
|
|
CN117447341B
(zh)
*
|
2023-09-06 |
2025-11-18 |
杭州国瑞生物科技有限公司 |
一种沙库巴曲缬沙坦钠中间体的精制方法
|
|
CN117756622A
(zh)
*
|
2023-12-21 |
2024-03-26 |
安徽皓元药业有限公司 |
一种沙库巴曲关键中间体的制备方法
|