CN101631765B - 用于制备5-联苯基-4-氨基-2-甲基戊酸的方法 - Google Patents
用于制备5-联苯基-4-氨基-2-甲基戊酸的方法 Download PDFInfo
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- CN101631765B CN101631765B CN200880008018.9A CN200880008018A CN101631765B CN 101631765 B CN101631765 B CN 101631765B CN 200880008018 A CN200880008018 A CN 200880008018A CN 101631765 B CN101631765 B CN 101631765B
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- 0 *N(C(CC1)C(c(cc2)ccc2-c2ccccc2)=O)C1=O Chemical compound *N(C(CC1)C(c(cc2)ccc2-c2ccccc2)=O)C1=O 0.000 description 17
- PYNXFZCZUAOOQC-OQHSHRKDSA-N CCOC([C@H](C)CC(Cc(cc1)ccc1-c1ccccc1)NC(CCC(O)=O)=O)=O Chemical compound CCOC([C@H](C)CC(Cc(cc1)ccc1-c1ccccc1)NC(CCC(O)=O)=O)=O PYNXFZCZUAOOQC-OQHSHRKDSA-N 0.000 description 1
- YNELJETWNMPEEH-QRIPLOBPSA-N C[C@H](CC(Cc(cc1)ccc1-c1ccccc1)NC(OC(C)(C)C)=O)C(O)=O Chemical compound C[C@H](CC(Cc(cc1)ccc1-c1ccccc1)NC(OC(C)(C)C)=O)C(O)=O YNELJETWNMPEEH-QRIPLOBPSA-N 0.000 description 1
- QFSVQKHMDZTJDY-AUSIDOKSSA-N C[C@H](C[C@@H](CCc(cc1)ccc1-c1ccccc1)N1CN2CCCC2)C1=O Chemical compound C[C@H](C[C@@H](CCc(cc1)ccc1-c1ccccc1)N1CN2CCCC2)C1=O QFSVQKHMDZTJDY-AUSIDOKSSA-N 0.000 description 1
- WQQLDAFJPWYZCC-DYVFJYSZSA-N C[C@H](C[C@@H](Cc(cc1)ccc1-c1ccccc1)N)C(O)=O Chemical compound C[C@H](C[C@@H](Cc(cc1)ccc1-c1ccccc1)N)C(O)=O WQQLDAFJPWYZCC-DYVFJYSZSA-N 0.000 description 1
- WPDJMBAXQKFEOI-ZETCQYMHSA-N O=C([C@H](CC1)NC1=O)N1CCOCC1 Chemical compound O=C([C@H](CC1)NC1=O)N1CCOCC1 WPDJMBAXQKFEOI-ZETCQYMHSA-N 0.000 description 1
- YFXRBWUXDNJWKM-HNNXBMFYSA-N O=C([C@H](CC1)NC1=O)c(cc1)ccc1-c1ccccc1 Chemical compound O=C([C@H](CC1)NC1=O)c(cc1)ccc1-c1ccccc1 YFXRBWUXDNJWKM-HNNXBMFYSA-N 0.000 description 1
- SOBIWLIICMUXJK-INIZCTEOSA-N O=C1N[C@H](Cc(cc2)ccc2-c2ccccc2)CC1 Chemical compound O=C1N[C@H](Cc(cc2)ccc2-c2ccccc2)CC1 SOBIWLIICMUXJK-INIZCTEOSA-N 0.000 description 1
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07100451.9 | 2007-01-12 | ||
| EP07100451 | 2007-01-12 | ||
| PCT/EP2008/000142 WO2008083967A2 (en) | 2007-01-12 | 2008-01-10 | Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid |
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| Publication Number | Publication Date |
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| CN101631765A CN101631765A (zh) | 2010-01-20 |
| CN101631765B true CN101631765B (zh) | 2014-10-01 |
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| CN200880008018.9A Active CN101631765B (zh) | 2007-01-12 | 2008-01-10 | 用于制备5-联苯基-4-氨基-2-甲基戊酸的方法 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107980038A (zh) * | 2015-07-02 | 2018-05-01 | 诺华股份有限公司 | 沙库巴曲钙盐 |
| CN110878039A (zh) * | 2019-12-18 | 2020-03-13 | 株洲千金药业股份有限公司 | 一种沙库巴曲缬沙坦钠杂质的制备方法 |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG185318A1 (en) * | 2007-01-12 | 2012-11-29 | Novartis Ag | Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid |
| AU2012202949B2 (en) * | 2008-01-17 | 2015-01-22 | Novartis Ag | Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives |
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| CN109456212A (zh) * | 2018-12-03 | 2019-03-12 | 康化(上海)新药研发有限公司 | 一种沙库比曲中间体的合成方法 |
| CN109400504A (zh) * | 2018-12-11 | 2019-03-01 | 重庆三圣实业股份有限公司 | Lcz696中间体非对映异构体的分离纯化方法 |
| US11739052B2 (en) | 2019-01-08 | 2023-08-29 | Basf Se | Process for the preparation of organosulfate salts of amino acids esters |
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| JP7064527B2 (ja) * | 2020-05-01 | 2022-05-10 | ノバルティス アーゲー | サクビトリルカルシウム塩 |
| JP2023534641A (ja) | 2020-07-09 | 2023-08-10 | アドバンシックス・レジンズ・アンド・ケミカルズ・リミテッド・ライアビリティ・カンパニー | 分岐鎖状アミノ酸界面活性剤 |
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| WO2022015675A1 (en) | 2020-07-13 | 2022-01-20 | Advansix Resins & Chemicals Llc | Branched amino acid surfactants for use in healthcare products |
| MX2023000568A (es) | 2020-07-13 | 2023-02-13 | Advansix Resins & Chemicals Llc | Tensioactivos de aminoacidos ramificados para la produccion de gas y petroleo. |
| CN115677521B (zh) * | 2022-11-16 | 2024-02-02 | 迪嘉药业集团股份有限公司 | 一种高纯度沙库巴曲钙的制备方法 |
| CN117447341B (zh) * | 2023-09-06 | 2025-11-18 | 杭州国瑞生物科技有限公司 | 一种沙库巴曲缬沙坦钠中间体的精制方法 |
| CN117756622A (zh) * | 2023-12-21 | 2024-03-26 | 安徽皓元药业有限公司 | 一种沙库巴曲关键中间体的制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5217996A (en) * | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
| US5250522A (en) * | 1992-10-09 | 1993-10-05 | Ciba-Geigy Corporation | Phosphono/biaryl substituted amino acid derivatives |
| CN1216522A (zh) * | 1996-02-19 | 1999-05-12 | 日本烟草产业株式会社 | 糖尿病治疗剂 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5015793B2 (enExample) | 1972-06-07 | 1975-06-07 | ||
| DE3164237D1 (en) | 1980-12-23 | 1984-07-19 | Air Ind | Thermo-electrical plants |
| FR2597100A1 (fr) | 1986-01-21 | 1987-10-16 | Nippon Shinyaku Co Ltd | Derives du pyroglutamide |
| PH24872A (en) | 1986-08-25 | 1990-12-26 | Schering Corp | (5r,6s,8r)-6-(-1-hydroxyethyl)-2-(3r-pyrrolidin-2-one-3-yl)thiopenem-3-carboxylic acid |
| JPH07103101B2 (ja) | 1989-07-24 | 1995-11-08 | キッセイ薬品工業株式会社 | ピログルタミン酸誘導体 |
| IL97219A (en) | 1990-02-19 | 1995-12-08 | Ciba Geigy Ag | Biphenyl substituted aliphatic amino compounds process for their preparation and pharmaceutical compositions containing them |
| US5273990A (en) | 1992-09-03 | 1993-12-28 | Ciba-Geigy Corporation | Phosphono substituted tetrazole derivatives |
| DE69324106T2 (de) | 1992-11-17 | 1999-12-09 | Sankyo Co., Ltd. | Krystallines Carbapenemderivat |
| ZA938438B (en) * | 1992-11-17 | 1994-06-20 | Sankyo Co | Crystalline carbapenem derivative |
| US5550119A (en) | 1995-03-02 | 1996-08-27 | Ciba-Geigy Corporation | Phosphono substituted tetrazole derivatives as ECE inhibitors |
| US6420415B1 (en) * | 1998-09-21 | 2002-07-16 | Takeda Chemical Industries, Ltd. | Thiol compounds, their production and use |
| ES2290429T3 (es) | 2002-01-17 | 2008-02-16 | Novartis Ag | Composiciones farmaceuticas que comprenden valsartan e inhibidores de nep. |
| ATE473216T1 (de) | 2002-03-29 | 2010-07-15 | Senju Pharma Co | Hydroxymorpholinonderivat und dessen medizinische verwendung |
| US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| CN100577673C (zh) | 2004-05-07 | 2010-01-06 | 优美科两合公司 | 用于均相、对映选择性氢化催化剂的二茂铁基配体 |
| GB0418046D0 (en) | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Eantioselective process |
| MY146830A (en) | 2005-02-11 | 2012-09-28 | Novartis Ag | Combination of organic compounds |
| EP1903027A1 (en) | 2006-09-13 | 2008-03-26 | Novartis AG | Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors |
| SG185318A1 (en) * | 2007-01-12 | 2012-11-29 | Novartis Ag | Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid |
-
2008
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5217996A (en) * | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
| US5250522A (en) * | 1992-10-09 | 1993-10-05 | Ciba-Geigy Corporation | Phosphono/biaryl substituted amino acid derivatives |
| CN1216522A (zh) * | 1996-02-19 | 1999-05-12 | 日本烟草产业株式会社 | 糖尿病治疗剂 |
Non-Patent Citations (1)
| Title |
|---|
| Dicarboxylic Acid Dipeptide Neutral Endopeptidase Inhibitors;Gary M. Ksander等;《J. Med. Chem.》;19951231;第38卷(第10期);1689-1700 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107980038A (zh) * | 2015-07-02 | 2018-05-01 | 诺华股份有限公司 | 沙库巴曲钙盐 |
| CN107980038B (zh) * | 2015-07-02 | 2021-04-27 | 诺华股份有限公司 | 沙库巴曲钙盐 |
| CN110878039A (zh) * | 2019-12-18 | 2020-03-13 | 株洲千金药业股份有限公司 | 一种沙库巴曲缬沙坦钠杂质的制备方法 |
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