MX2009007474A - Proceso para la preparacion de acido 5-bifenil-4-amino-2-metil pentanoico. - Google Patents

Proceso para la preparacion de acido 5-bifenil-4-amino-2-metil pentanoico.

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Publication number
MX2009007474A
MX2009007474A MX2009007474A MX2009007474A MX2009007474A MX 2009007474 A MX2009007474 A MX 2009007474A MX 2009007474 A MX2009007474 A MX 2009007474A MX 2009007474 A MX2009007474 A MX 2009007474A MX 2009007474 A MX2009007474 A MX 2009007474A
Authority
MX
Mexico
Prior art keywords
preparation
new process
phenylphenylmethyl
nep
oxopropyl
Prior art date
Application number
MX2009007474A
Other languages
English (en)
Inventor
Gottfried Sedelmeier
Bernhard Wietfeld
Bernhard Riss
David Hook
Thomas Ruch
Markus Baenziger
Matthias Napp
Steven Hawker
Lech Ciszewski
Liladhar Murlidhar Waykole
Original Assignee
Novartis Ag
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38124137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009007474(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2009007474A publication Critical patent/MX2009007474A/es

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
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    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
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    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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Abstract

La presente invención se refiere a pirrolidin-2-onas de acuerdo con la fórmula (1), o sales de las mismas: (ver fórmula (1)) en donde R1 es hidrógeno o un grupo protector de nitrógeno, métodos para su preparación, y su uso en la preparación de inhibidores de endopeptidasa neutra, en particular en la preparación del etil-éster del ácido N-(3-carboxil-1-oxo-propil)-(4S)-(p-fenil-fen il-metil)-4-amino-(2R)-metil-butanoico, o una sal del mismo.
MX2009007474A 2007-01-12 2008-01-10 Proceso para la preparacion de acido 5-bifenil-4-amino-2-metil pentanoico. MX2009007474A (es)

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RU2530900C2 (ru) 2014-10-20
US20140249320A1 (en) 2014-09-04
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JP5715339B2 (ja) 2015-05-07
NZ577910A (en) 2012-04-27
CY1118225T1 (el) 2017-06-28
CA2674291C (en) 2015-11-24
IL199492A (en) 2015-06-30
ZA200904311B (en) 2010-04-28
US8716495B2 (en) 2014-05-06
SI2121578T1 (sl) 2016-12-30
PE20121615A1 (es) 2012-12-02
US9206116B2 (en) 2015-12-08
AU2008204546A1 (en) 2008-07-17
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CN101631765A (zh) 2010-01-20
GT200900195A (es) 2011-11-03
AU2012203155B2 (en) 2014-03-20

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