PL3218351T3 - Sposób wytwarzania, wyodrębniania i oczyszczania farmaceutycznie dopuszczalnych postaci AHU-377 - Google Patents

Sposób wytwarzania, wyodrębniania i oczyszczania farmaceutycznie dopuszczalnych postaci AHU-377

Info

Publication number
PL3218351T3
PL3218351T3 PL15808087T PL15808087T PL3218351T3 PL 3218351 T3 PL3218351 T3 PL 3218351T3 PL 15808087 T PL15808087 T PL 15808087T PL 15808087 T PL15808087 T PL 15808087T PL 3218351 T3 PL3218351 T3 PL 3218351T3
Authority
PL
Poland
Prior art keywords
ahu
isolation
purification
preparation
pharmaceutically applicable
Prior art date
Application number
PL15808087T
Other languages
English (en)
Inventor
Ales Halama
Pavel ZVATORA
Ondrej Dammer
Jan Stach
Michal Zapadlo
Lukas KREJCIK
Michal Voslar
Original Assignee
Zentiva K.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CZ2014-792A external-priority patent/CZ2014792A3/cs
Priority claimed from CZ2015-758A external-priority patent/CZ2015758A3/cs
Application filed by Zentiva K.S. filed Critical Zentiva K.S.
Publication of PL3218351T3 publication Critical patent/PL3218351T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/06—Monoamines containing only n- or iso-propyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/07—Monoamines containing one, two or three alkyl groups, each having the same number of carbon atoms in excess of three
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL15808087T 2014-11-14 2015-11-11 Sposób wytwarzania, wyodrębniania i oczyszczania farmaceutycznie dopuszczalnych postaci AHU-377 PL3218351T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CZ2014-792A CZ2014792A3 (cs) 2014-11-14 2014-11-14 Způsob přípravy, izolace a čištění farmaceuticky využitelných forem AHU-377
CZ2015-758A CZ2015758A3 (cs) 2015-10-27 2015-10-27 Pevné formy vápenaté soli ethyl esteru (2R, 4S)-5-(bifenyl-4-yl)-4-[(3-karboxypropionyl)amino]-2-methylpentanové kyseliny, způsob jejich přípravy a použití
PCT/CZ2015/000136 WO2016074651A1 (en) 2014-11-14 2015-11-11 A method for the preparation, isolation and purification of pharmaceutically applicable forms of ahu-377
EP15808087.9A EP3218351B1 (en) 2014-11-14 2015-11-11 A method for the preparation, isolation and purification of pharmaceutically applicable forms of ahu-377

Publications (1)

Publication Number Publication Date
PL3218351T3 true PL3218351T3 (pl) 2019-12-31

Family

ID=54848362

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15808087T PL3218351T3 (pl) 2014-11-14 2015-11-11 Sposób wytwarzania, wyodrębniania i oczyszczania farmaceutycznie dopuszczalnych postaci AHU-377

Country Status (8)

Country Link
EP (1) EP3218351B1 (pl)
DK (1) DK3218351T3 (pl)
ES (1) ES2745157T3 (pl)
HU (1) HUE046278T2 (pl)
LT (1) LT3218351T (pl)
PL (1) PL3218351T3 (pl)
PT (1) PT3218351T (pl)
WO (1) WO2016074651A1 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE052222T2 (hu) 2015-07-02 2021-04-28 Novartis Ag Sacubitril kalciumsók
EP3386945A1 (en) * 2015-12-11 2018-10-17 Zentiva, K.S. Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method
WO2018040065A1 (zh) * 2016-09-02 2018-03-08 诺瑞特国际药业股份有限公司 缬沙坦二钠盐的晶型
EP3511317A4 (en) * 2016-09-07 2020-04-15 Noratech Pharmaceuticals, Inc. New crystalline form of sacubitril sodium salt
CN106496055A (zh) * 2016-10-09 2017-03-15 杭州科巢生物科技有限公司 一种抗心衰新药的关键组分沙库比曲的新合成方法
WO2018069833A1 (en) * 2016-10-10 2018-04-19 Laurus Labs Limited Stable amorphous form of sacubitril valsartan trisodium complex and processes for preparation thereof
JP7022747B2 (ja) * 2016-10-28 2022-02-18 バイオコン・リミテッド アモルファスサクビトリルバルサルタン三ナトリウムおよびその調製のためのプロセス
CN107188817A (zh) * 2017-05-22 2017-09-22 杭州瑞法康科技有限公司 一种高纯度沙库比曲半钙盐一水合物的新晶型及其制备方法
CN107602410A (zh) * 2017-09-13 2018-01-19 浙江三门恒康制药有限公司 沙库比曲钠盐的晶型ii及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217996A (en) 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
CA2472399C (en) 2002-01-17 2012-02-21 Novartis Ag Pharmaceutical compositions comprising valsartan and nep inhibitors
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
EP1903027A1 (en) 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
MY151993A (en) 2007-01-12 2014-07-31 Novartis Ag Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
PE20091364A1 (es) 2008-01-17 2009-10-13 Novartis Ag Proceso para la preparacion de inhibidores de nep
AU2011207020B2 (en) 2010-01-22 2014-04-17 Novartis Ag Intermediates of neutral endopeptidase inhibitors and preparation method thereof
EP2609075B1 (en) 2010-08-23 2016-03-16 Novartis AG Process for the preparation of intermediates for the manufacture of nep inhibitors
KR20130106374A (ko) 2010-08-23 2013-09-27 노파르티스 아게 Ｎｅｐ 억제제의 제조에 유용한 중간체의 신규한 제조 방법
AR092278A1 (es) 2012-08-31 2015-04-08 Novartis Ag Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados
CN105168205A (zh) * 2015-08-18 2015-12-23 泰力特医药（湖北）有限公司 一种血管紧张素ii受体和脑啡肽酶受体双重抑制剂lcz696的制备方法

Also Published As

Publication number Publication date
WO2016074651A1 (en) 2016-05-19
EP3218351A1 (en) 2017-09-20
LT3218351T (lt) 2019-09-25
DK3218351T3 (da) 2019-09-16
ES2745157T3 (es) 2020-02-27
PT3218351T (pt) 2019-09-26
EP3218351B1 (en) 2019-06-19
HUE046278T2 (hu) 2020-02-28

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