JP2006503588A5 - - Google Patents
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- Publication number
- JP2006503588A5 JP2006503588A5 JP2004569752A JP2004569752A JP2006503588A5 JP 2006503588 A5 JP2006503588 A5 JP 2006503588A5 JP 2004569752 A JP2004569752 A JP 2004569752A JP 2004569752 A JP2004569752 A JP 2004569752A JP 2006503588 A5 JP2006503588 A5 JP 2006503588A5
- Authority
- JP
- Japan
- Prior art keywords
- diabetes
- type
- therapeutic agent
- agent according
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40697702P | 2002-08-30 | 2002-08-30 | |
| US60/406,977 | 2002-08-30 | ||
| US10/378,094 US7176278B2 (en) | 2001-08-30 | 2003-03-04 | Modified transferrin fusion proteins |
| US10/378,094 | 2003-03-04 | ||
| PCT/US2003/026818 WO2004020405A2 (en) | 2002-08-30 | 2003-08-28 | Modified transferrin fusion proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006503588A JP2006503588A (ja) | 2006-02-02 |
| JP2006503588A5 true JP2006503588A5 (enExample) | 2006-10-19 |
| JP4873860B2 JP4873860B2 (ja) | 2012-02-08 |
Family
ID=31978395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004569752A Expired - Fee Related JP4873860B2 (ja) | 2002-08-30 | 2003-08-28 | 改変トランスフェリン融合タンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060130158A1 (enExample) |
| EP (1) | EP1545595B1 (enExample) |
| JP (1) | JP4873860B2 (enExample) |
| CN (3) | CN102268094A (enExample) |
| AT (1) | ATE473011T1 (enExample) |
| AU (2) | AU2003262886A1 (enExample) |
| DE (1) | DE60333306D1 (enExample) |
| ES (1) | ES2347144T3 (enExample) |
| WO (1) | WO2004020454A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070031440A1 (en) * | 2001-08-30 | 2007-02-08 | Prior Christopher P | Modified transferin-antibody fusion proteins |
| US8129504B2 (en) | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
| CN1628126A (zh) * | 2001-08-30 | 2005-06-15 | 比奥雷克西斯药物公司 | 经修饰的运铁蛋白融合蛋白 |
| US7176278B2 (en) * | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| US20030226155A1 (en) * | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP2007512001A (ja) * | 2003-08-28 | 2007-05-17 | バイオレクシス ファーマシューティカル コーポレイション | Epoミメティックペプチドおよび融合タンパク質 |
| US20060205037A1 (en) * | 2003-08-28 | 2006-09-14 | Homayoun Sadeghi | Modified transferrin fusion proteins |
| EA200700391A1 (ru) * | 2004-08-03 | 2007-10-26 | Байорексис Текнолоджи, Инк. | Комбинированное лечение с применением слитых белков трансферрина, содержащих glp-1 |
| US20090275481A1 (en) * | 2005-06-17 | 2009-11-05 | Pfizer, Inc. | Anchored Transferrin Fusion Protein Libraries |
| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
| EP2463295A1 (en) * | 2006-05-22 | 2012-06-13 | The Regents of The University of California | Compositions and methods for the delivery of oxygen |
| CN101088502B (zh) * | 2006-06-16 | 2012-11-21 | 中国科学院化学研究所 | 一种含有转铁蛋白和槲皮素的结合物的混合溶液及其用途 |
| CA2657277C (en) | 2006-07-13 | 2015-11-24 | Upperton Limited | Process for preparing particles of proteinaceous material |
| DK2046826T3 (da) * | 2006-07-24 | 2011-10-24 | Biorexis Pharmaceutical Corp | Exendin-fusionsproteiner |
| CN101578373A (zh) * | 2006-09-06 | 2009-11-11 | 费斯生物制药公司 | 融合肽治疗组合物 |
| EP2114999A2 (en) | 2006-12-12 | 2009-11-11 | Biorexis Pharmaceutical Corporation | Transferrin fusion protein libraries |
| CN105727261A (zh) | 2008-06-27 | 2016-07-06 | 杜克大学 | 包含弹性蛋白样肽的治疗剂 |
| US9034341B2 (en) * | 2009-04-20 | 2015-05-19 | Transtech Pharma, Llc | Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions |
| AU2010306940A1 (en) | 2009-10-12 | 2012-06-07 | Smith, Larry | Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro |
| US9644197B2 (en) * | 2010-06-04 | 2017-05-09 | Sk Chemicals Co., Ltd. | Fusion protein having factor VII activity |
| CN103443125B (zh) | 2010-11-30 | 2019-05-03 | 霍夫曼-拉罗奇有限公司 | 低亲和力血脑屏障受体抗体及其用途 |
| US9603897B2 (en) | 2012-03-12 | 2017-03-28 | Massachusetts Institute Of Technology | Methods for treating tissue damage associated with ischemia with apolipoprotein D |
| HK1212448A1 (en) | 2012-09-07 | 2016-06-10 | The Governors Of The University Of Alberta | Methods and compositions for diagnosis of inflammatory liver disease |
| SG11201509566RA (en) * | 2013-05-20 | 2015-12-30 | Genentech Inc | Anti-transferrin receptor antibodies and methods of use |
| WO2015006337A2 (en) * | 2013-07-08 | 2015-01-15 | Nanjingjinsirui Science & Technology Biology Corporation | Compositions and methods for increasing protein half-life in a serum |
| WO2015023649A2 (en) * | 2013-08-12 | 2015-02-19 | 3M Innovative Properties Company | Peptides for enhancing transdermal delivery |
| KR102058864B1 (ko) | 2013-12-16 | 2019-12-24 | 주식회사 티움바이오 | 인자 vii의 융합 단백질을 포함하는 안정성이 개선된 약학적 조성물 |
| PL3092251T3 (pl) * | 2014-01-06 | 2021-08-02 | F. Hoffmann-La Roche Ag | Jednowartościowe moduły transportera wahadłowego przez barierę krew-mózg |
| JP2015224327A (ja) * | 2014-05-29 | 2015-12-14 | 花王株式会社 | 繊維製品用洗浄剤組成物 |
| KR102618312B1 (ko) * | 2015-03-17 | 2023-12-28 | 메모리얼 슬로안 케터링 캔서 센터 | 항muc16 항체 및 그의 용도 |
| HK1247933A1 (en) | 2015-06-24 | 2018-10-05 | Jcr Pharmaceuticals Co., Ltd. | Fusion protein containing bdnf |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| MX2018003822A (es) | 2015-10-02 | 2018-06-22 | Hoffmann La Roche | Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso. |
| CN110167585B (zh) * | 2016-09-02 | 2024-03-08 | 美国卫生与公众服务部 | 稳定化的第2组流感血凝素茎区三聚体及其用途 |
| TWI833178B (zh) | 2016-12-26 | 2024-02-21 | 日商Jcr製藥股份有限公司 | 通過血腦障壁之新穎抗人類運鐵蛋白受體抗體 |
| TWI791006B (zh) * | 2016-12-26 | 2023-02-01 | 日商Jcr製藥股份有限公司 | 包含bdnf之融合蛋白質 |
| RS63818B1 (sr) * | 2017-02-17 | 2023-01-31 | Denali Therapeutics Inc | Konstruisani polipeptidi za vezivanje za receptor transferina |
| CN106967171B (zh) * | 2017-02-23 | 2021-04-27 | 郑州大学 | 一种全人源重组CD40L单抗Fab片段及其制备方法 |
| CN107010616B (zh) * | 2017-04-13 | 2019-04-02 | 浙江理工大学 | 一种具有靶向传递功能的纳米药物载体的制备方法 |
| WO2019055841A1 (en) * | 2017-09-14 | 2019-03-21 | Denali Therapeutics Inc. | ANTI-TREM2 ANTIBODIES AND METHODS OF USE |
| BR112020005271A2 (pt) * | 2017-10-02 | 2020-09-15 | Denali Therapeutics Inc. | proteína, polipeptídeo, polinucleotídeo, vetor, célula hospedeira, método para produção de um polipeptídeo, métodos de tratamento de um distúrbio, de diminuição do acúmulo, de monitoramento, de transporte de um agente e de tratamento de um lsd e composição farmacêutica |
| AU2017435322A1 (en) * | 2017-10-11 | 2020-04-30 | Nanjing Legend Biotech Co., Ltd. | Compositions and methods for increasing protein half-life in a serum |
| BR112020013921A2 (pt) * | 2018-01-10 | 2020-12-01 | Denali Therapeutics Inc. | polipeptídeos de ligação ao receptor de transferrina e usos destes |
| CN112312922B (zh) * | 2018-06-21 | 2025-04-11 | 诺和诺德股份有限公司 | 用于治疗肥胖症的新型化合物 |
| CN109180819A (zh) * | 2018-09-14 | 2019-01-11 | 苏州康宇生物科技有限公司 | 一种胰岛素衍生物的制备方法 |
| US20220002752A1 (en) * | 2018-11-13 | 2022-01-06 | Denovo Biopharma Llc | Recombinant vectors comprising genes for binding domains and secretable peptides |
| WO2021081485A1 (en) * | 2019-10-25 | 2021-04-29 | Northwestern University | Cell-free extract preparation protocol for enrichment of membrane vesicles and increased glycoprotein yields |
| CN111948388B (zh) * | 2020-08-18 | 2022-03-22 | 山东农业大学 | 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用 |
| CN112661862B (zh) * | 2020-12-25 | 2023-03-31 | 深圳大学 | 一种融合蛋白及其制备方法和应用 |
| CN113267631A (zh) * | 2021-05-17 | 2021-08-17 | 江苏普若维生物技术有限责任公司 | 一种检测TNF-α的电化学试剂盒制备方法 |
| WO2023142109A1 (zh) * | 2022-01-30 | 2023-08-03 | 领诺(上海)医药科技有限公司 | 一种长效重组人生长激素及其应用 |
| KR20250114322A (ko) * | 2022-12-02 | 2025-07-29 | 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 | 항-tfr1 항체 및 이의 용도 |
| CN118931931B (zh) * | 2024-07-23 | 2025-02-21 | 中国农业科学院北京畜牧兽医研究所 | 一种产气荚膜梭菌epsilon毒素-铁蛋白纳米颗粒抗原的制备方法 |
| CN122080239B (zh) * | 2026-04-22 | 2026-07-17 | 华中农业大学 | 一种动态共价交联双蛋白及其制备方法和应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4289689A (en) * | 1980-03-14 | 1981-09-15 | Hoffmann-La Roche Inc. | Preparation of homogeneous human fibroblast interferon |
| WO1982002715A1 (fr) * | 1981-02-04 | 1982-08-19 | Sugano Haruo | Gene d'interferon (beta)humain |
| US4816449A (en) * | 1984-08-09 | 1989-03-28 | Immunetech Pharmaceuticals | Immunotherapeutic anti-inflammatory peptide agents |
| US5026651A (en) * | 1985-04-25 | 1991-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of human transferrin |
| US5262177A (en) * | 1986-02-07 | 1993-11-16 | Oncogen | Recombinant viruses encoding the human melanoma-associated antigen |
| US5260203A (en) * | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US5091513A (en) * | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| GB8901778D0 (en) | 1989-01-27 | 1989-03-15 | Univ Court Of The University O | Manipulatory technique |
| US5571691A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
| US5977307A (en) * | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
| US5672683A (en) * | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
| US6066469A (en) * | 1990-03-08 | 2000-05-23 | Ferro Dynamics, Inc. | Cloning, expression, and uses of human lactoferrin |
| US5723286A (en) * | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5986067A (en) | 1991-02-08 | 1999-11-16 | The University Of Vermont And State Agricultural College | Recombinant transferrins, transferrin half-molecules and mutants thereof |
| US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| CA2110404A1 (en) * | 1991-05-31 | 1992-12-10 | Christina Teng | Human lactoferrin |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| ZA932568B (en) * | 1992-04-24 | 1993-11-12 | Baylor College Midecine A Non | Production of recombinant human lactoferrin |
| EP0599303A3 (en) * | 1992-11-27 | 1998-07-29 | Takeda Chemical Industries, Ltd. | Peptide conjugate |
| WO1994023744A1 (en) | 1993-04-16 | 1994-10-27 | The Wistar Institute Of Anatomy And Biology | Recombinant cytomegalovirus vaccine |
| US5455933A (en) * | 1993-07-14 | 1995-10-03 | Dell Usa, L.P. | Circuit and method for remote diagnosis of personal computers |
| US5843882A (en) * | 1995-04-27 | 1998-12-01 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral proteins and peptides |
| US5817789A (en) * | 1995-06-06 | 1998-10-06 | Transkaryotic Therapies, Inc. | Chimeric proteins for use in transport of a selected substance into cells |
| US5849293A (en) * | 1996-01-11 | 1998-12-15 | Cornell Research Foundation, Inc. | Use of human transferrin in controlling insulin levels |
| US7235627B2 (en) * | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) * | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| FR2762843B1 (fr) * | 1997-04-30 | 1999-12-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US6258782B1 (en) * | 1998-05-20 | 2001-07-10 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| PT1180121E (pt) * | 1999-05-17 | 2004-03-31 | Conjuchem Inc | Peptidos insulinotropicos de longa duracao |
| US6380362B1 (en) * | 1999-12-23 | 2002-04-30 | Genesis Research & Development Corporation Ltd. | Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use |
| US6420346B1 (en) * | 2000-02-07 | 2002-07-16 | Rappaport Family Institute For Research In The Medical Sciences | Polynucleotides encoding MIP-1α, MCP-1, MIP-1β, Rantes and TNF-α, and methods for treating rheumatoid arthritis |
| SI1724284T1 (sl) * | 2000-12-07 | 2009-12-31 | Lilly Co Eli | Glp-1 fuzijski proteini |
| JP2002247847A (ja) * | 2001-02-20 | 2002-08-30 | Internatl Business Mach Corp <Ibm> | Acアダプタ、電源供給装置、電気機器、および電源供給装置の制御方法 |
| US20030226155A1 (en) * | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
| US7176278B2 (en) * | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| CN1628126A (zh) * | 2001-08-30 | 2005-06-15 | 比奥雷克西斯药物公司 | 经修饰的运铁蛋白融合蛋白 |
| US20060105387A1 (en) * | 2002-08-30 | 2006-05-18 | Prior Christopher P | Transferrin fusion proteins libraries |
| EP1407985B1 (en) * | 2002-10-11 | 2005-12-28 | Habasit AG | Conveyor belt module with high friction surface |
| US20060205037A1 (en) * | 2003-08-28 | 2006-09-14 | Homayoun Sadeghi | Modified transferrin fusion proteins |
-
2003
- 2003-08-28 CN CN201110175090A patent/CN102268094A/zh active Pending
- 2003-08-28 CN CNA038247453A patent/CN1694895A/zh active Pending
- 2003-08-28 EP EP03791808A patent/EP1545595B1/en not_active Expired - Lifetime
- 2003-08-28 ES ES03791808T patent/ES2347144T3/es not_active Expired - Lifetime
- 2003-08-28 AU AU2003262886A patent/AU2003262886A1/en not_active Abandoned
- 2003-08-28 WO PCT/US2003/026742 patent/WO2004020454A2/en not_active Ceased
- 2003-08-28 CN CNA038247399A patent/CN1713920A/zh active Pending
- 2003-08-28 DE DE60333306T patent/DE60333306D1/de not_active Expired - Lifetime
- 2003-08-28 AT AT03791808T patent/ATE473011T1/de not_active IP Right Cessation
- 2003-08-28 JP JP2004569752A patent/JP4873860B2/ja not_active Expired - Fee Related
- 2003-08-28 US US10/515,324 patent/US20060130158A1/en not_active Abandoned
-
2009
- 2009-07-21 AU AU2009202932A patent/AU2009202932B2/en not_active Ceased
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