JP2006503588A5 - - Google Patents
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- Publication number
- JP2006503588A5 JP2006503588A5 JP2004569752A JP2004569752A JP2006503588A5 JP 2006503588 A5 JP2006503588 A5 JP 2006503588A5 JP 2004569752 A JP2004569752 A JP 2004569752A JP 2004569752 A JP2004569752 A JP 2004569752A JP 2006503588 A5 JP2006503588 A5 JP 2006503588A5
- Authority
- JP
- Japan
- Prior art keywords
- diabetes
- type
- therapeutic agent
- agent according
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40697702P | 2002-08-30 | 2002-08-30 | |
| US60/406,977 | 2002-08-30 | ||
| US10/378,094 | 2003-03-04 | ||
| US10/378,094 US7176278B2 (en) | 2001-08-30 | 2003-03-04 | Modified transferrin fusion proteins |
| PCT/US2003/026818 WO2004020405A2 (en) | 2002-08-30 | 2003-08-28 | Modified transferrin fusion proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006503588A JP2006503588A (ja) | 2006-02-02 |
| JP2006503588A5 true JP2006503588A5 (enExample) | 2006-10-19 |
| JP4873860B2 JP4873860B2 (ja) | 2012-02-08 |
Family
ID=31978395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004569752A Expired - Fee Related JP4873860B2 (ja) | 2002-08-30 | 2003-08-28 | 改変トランスフェリン融合タンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060130158A1 (enExample) |
| EP (1) | EP1545595B1 (enExample) |
| JP (1) | JP4873860B2 (enExample) |
| CN (3) | CN1694895A (enExample) |
| AT (1) | ATE473011T1 (enExample) |
| AU (2) | AU2003262886A1 (enExample) |
| DE (1) | DE60333306D1 (enExample) |
| ES (1) | ES2347144T3 (enExample) |
| WO (1) | WO2004020454A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030226155A1 (en) * | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
| IL160289A0 (en) * | 2001-08-30 | 2004-07-25 | Biorexis Pharmaceutical Corp | Modified transferrin fusion proteins |
| US8129504B2 (en) | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
| US20070031440A1 (en) * | 2001-08-30 | 2007-02-08 | Prior Christopher P | Modified transferin-antibody fusion proteins |
| US7176278B2 (en) * | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20060205037A1 (en) * | 2003-08-28 | 2006-09-14 | Homayoun Sadeghi | Modified transferrin fusion proteins |
| WO2005021579A2 (en) * | 2003-08-28 | 2005-03-10 | Biorexis Pharmaceutical Corporation | Epo mimetic peptides and fusion proteins |
| JP2008509153A (ja) * | 2004-08-03 | 2008-03-27 | バイオレクシス ファーマシューティカル コーポレイション | Glp−1を含むトランスフェリン融合タンパク質用いた併用療法 |
| JP2008546392A (ja) * | 2005-06-17 | 2008-12-25 | バイオレクシス ファーマシューティカル コーポレーション | 固定されたトランスフェリン融合タンパク質ライブラリー |
| US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| CA2653080C (en) * | 2006-05-22 | 2019-02-12 | The Regents Of The University Of California | Compositions and methods for the delivery of oxygen |
| CN101088502B (zh) * | 2006-06-16 | 2012-11-21 | 中国科学院化学研究所 | 一种含有转铁蛋白和槲皮素的结合物的混合溶液及其用途 |
| CA2657277C (en) | 2006-07-13 | 2015-11-24 | Upperton Limited | Process for preparing particles of proteinaceous material |
| ATE524493T1 (de) | 2006-07-24 | 2011-09-15 | Biorexis Pharmaceutical Corp | Exendin-fusionsproteine |
| MX2009002547A (es) * | 2006-09-06 | 2009-06-19 | Phasebio Pharmaceuticals Inc | Composiciones terapeuticas de peptido de fusion. |
| KR20090098880A (ko) | 2006-12-12 | 2009-09-17 | 바이오렉시스 파마슈티칼 코포레이션 | 트랜스페린 융합 단백질 라이브러리 |
| EP2307038A4 (en) | 2008-06-27 | 2013-03-27 | Univ Duke | ELASTIC PEPTIDES COMPREHENSIVE THERAPEUTIC AGENTS |
| KR20110139292A (ko) * | 2009-04-20 | 2011-12-28 | 화이자 인코포레이티드 | 단백질 글리코실화의 제어 및 그와 관련된 조성물 및 방법 |
| US20130079382A1 (en) | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| CA2801223C (en) * | 2010-06-04 | 2019-12-03 | Sk Chemicals Co., Ltd. | Fusion protein having factor vii activity |
| EP3208282A1 (en) | 2010-11-30 | 2017-08-23 | F. Hoffmann-La Roche AG | Low affinity anti transferrin receptor and their use to transfer therapeutic scfv across the blood brain barrier |
| WO2013138338A2 (en) | 2012-03-12 | 2013-09-19 | Massachusetts Institute Of Technology | Methods for treating tissue damage associated with ischemia with apoliporotein d |
| CN104797933A (zh) | 2012-09-07 | 2015-07-22 | 阿尔伯达大学董事会 | 用于诊断发炎性肝病的方法和组合物 |
| AR096364A1 (es) * | 2013-05-20 | 2015-12-23 | Genentech Inc | Anticuerpos receptores de antitransferina y métodos de uso |
| JP6449272B2 (ja) * | 2013-07-08 | 2019-01-09 | ナンジン レジェンド バイオテック カンパニー,リミテッドNanjing Legend Biotech Co.,Ltd. | タンパク質の血清半減期を増加する組成物及び方法 |
| EP3033056B1 (en) * | 2013-08-12 | 2020-01-15 | 3M Innovative Properties Company | Peptides for enhancing transdermal delivery |
| KR102058864B1 (ko) | 2013-12-16 | 2019-12-24 | 주식회사 티움바이오 | 인자 vii의 융합 단백질을 포함하는 안정성이 개선된 약학적 조성물 |
| EP3851452A1 (en) * | 2014-01-06 | 2021-07-21 | F. Hoffmann-La Roche AG | Monovalent blood brain barrier shuttle modules |
| JP2015224327A (ja) * | 2014-05-29 | 2015-12-14 | 花王株式会社 | 繊維製品用洗浄剤組成物 |
| US11066480B2 (en) * | 2015-03-17 | 2021-07-20 | Memorial Sloan Kettering Cancer Center | Anti-MUC16 antibodies and uses thereof |
| KR20180020279A (ko) | 2015-06-24 | 2018-02-27 | 제이씨알 파마 가부시키가이샤 | Bdnf를 포함하는 융합 단백질 |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| KR20250052494A (ko) | 2015-10-02 | 2025-04-18 | 에프. 호프만-라 로슈 아게 | 이중특이성 항-인간 cd20/인간 트랜스페린 수용체 항체 및 사용 방법 |
| IL303650B2 (en) * | 2016-09-02 | 2025-02-01 | Us Health | Stable group 2 trimers from the stem region of influenza hemagglutinin and their uses |
| CA3052936A1 (en) * | 2016-12-26 | 2018-07-05 | Jcr Pharmaceuticals Co., Ltd. | Fusion protein of bdnf and anti-transferrin receptor antibody |
| KR102420850B1 (ko) | 2016-12-26 | 2022-07-15 | 제이씨알 파마 가부시키가이샤 | 혈액뇌관문을 통과하는 신규한 항인간 트랜스페린 수용체 항체 |
| SI3583120T1 (sl) * | 2017-02-17 | 2023-02-28 | Denali Therapeutics Inc. | Inženirani polipeptidi, ki vezujejo transferinske receptorje |
| CN106967171B (zh) * | 2017-02-23 | 2021-04-27 | 郑州大学 | 一种全人源重组CD40L单抗Fab片段及其制备方法 |
| CN107010616B (zh) * | 2017-04-13 | 2019-04-02 | 浙江理工大学 | 一种具有靶向传递功能的纳米药物载体的制备方法 |
| US20200277373A1 (en) * | 2017-09-14 | 2020-09-03 | Denali Therapeutics Inc. | Anti-trem2 antibodies and methods of use thereof |
| CR20200129A (es) * | 2017-10-02 | 2020-08-22 | Denali Therapeutics Inc | Proteínas de fusión que comprenden enzimas de terapia de reemplazo de enzimas |
| WO2019074498A1 (en) * | 2017-10-11 | 2019-04-18 | Nanjing Legend Biotech Co., Ltd. | COMPOSITIONS AND METHODS FOR INCREASING THE HALF-LIFE OF A PROTEIN IN A SERUM |
| AU2019207735A1 (en) * | 2018-01-10 | 2020-07-23 | Denali Therapeutics Inc. | Transferrin receptor-binding polypeptides and uses thereof |
| EP3810186B1 (en) | 2018-06-21 | 2022-09-28 | Novo Nordisk A/S | Novel compounds for treatment of obesity |
| CN109180819A (zh) * | 2018-09-14 | 2019-01-11 | 苏州康宇生物科技有限公司 | 一种胰岛素衍生物的制备方法 |
| JP2022507268A (ja) * | 2018-11-13 | 2022-01-18 | デノボ バイオファーマ エルエルシー | 結合ドメインおよび分泌可能なペプチドの遺伝子を含む組換えベクター |
| CA3155758A1 (en) * | 2019-10-25 | 2021-04-29 | Michael C. Jewett | Cell-free extract preparation protocol for enrichment of membrane vesicles and increased glycoprotein yields |
| CN111948388B (zh) * | 2020-08-18 | 2022-03-22 | 山东农业大学 | 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用 |
| CN112661862B (zh) * | 2020-12-25 | 2023-03-31 | 深圳大学 | 一种融合蛋白及其制备方法和应用 |
| CN113267631A (zh) * | 2021-05-17 | 2021-08-17 | 江苏普若维生物技术有限责任公司 | 一种检测TNF-α的电化学试剂盒制备方法 |
| WO2023142109A1 (zh) * | 2022-01-30 | 2023-08-03 | 领诺(上海)医药科技有限公司 | 一种长效重组人生长激素及其应用 |
| EP4626923A1 (en) * | 2022-12-02 | 2025-10-08 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-tfr1 antibodies and uses thereof |
| CN118931931B (zh) * | 2024-07-23 | 2025-02-21 | 中国农业科学院北京畜牧兽医研究所 | 一种产气荚膜梭菌epsilon毒素-铁蛋白纳米颗粒抗原的制备方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4289689A (en) * | 1980-03-14 | 1981-09-15 | Hoffmann-La Roche Inc. | Preparation of homogeneous human fibroblast interferon |
| WO1982002715A1 (fr) * | 1981-02-04 | 1982-08-19 | Sugano Haruo | Gene d'interferon (beta)humain |
| US4816449A (en) * | 1984-08-09 | 1989-03-28 | Immunetech Pharmaceuticals | Immunotherapeutic anti-inflammatory peptide agents |
| US5026651A (en) * | 1985-04-25 | 1991-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of human transferrin |
| US5262177A (en) * | 1986-02-07 | 1993-11-16 | Oncogen | Recombinant viruses encoding the human melanoma-associated antigen |
| US5260203A (en) * | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US5091513A (en) * | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| GB8901778D0 (en) | 1989-01-27 | 1989-03-15 | Univ Court Of The University O | Manipulatory technique |
| US5571691A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
| US5672683A (en) * | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
| US5977307A (en) * | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
| US6066469A (en) * | 1990-03-08 | 2000-05-23 | Ferro Dynamics, Inc. | Cloning, expression, and uses of human lactoferrin |
| US5723286A (en) * | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5986067A (en) * | 1991-02-08 | 1999-11-16 | The University Of Vermont And State Agricultural College | Recombinant transferrins, transferrin half-molecules and mutants thereof |
| US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| EP0603187A4 (en) * | 1991-05-31 | 1995-08-30 | Us Health | Human lactoferrin. |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| ZA932568B (en) * | 1992-04-24 | 1993-11-12 | Baylor College Midecine A Non | Production of recombinant human lactoferrin |
| EP0599303A3 (en) * | 1992-11-27 | 1998-07-29 | Takeda Chemical Industries, Ltd. | Peptide conjugate |
| EP0708658A4 (en) | 1993-04-16 | 1997-05-21 | Wistar Inst | RECOMBINANT CYTOMEGALOVIRUS VACCINE |
| US5455933A (en) * | 1993-07-14 | 1995-10-03 | Dell Usa, L.P. | Circuit and method for remote diagnosis of personal computers |
| US5843882A (en) * | 1995-04-27 | 1998-12-01 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral proteins and peptides |
| US5817789A (en) * | 1995-06-06 | 1998-10-06 | Transkaryotic Therapies, Inc. | Chimeric proteins for use in transport of a selected substance into cells |
| US5849293A (en) * | 1996-01-11 | 1998-12-15 | Cornell Research Foundation, Inc. | Use of human transferrin in controlling insulin levels |
| US7235627B2 (en) * | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) * | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| FR2762843B1 (fr) * | 1997-04-30 | 1999-12-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US6258782B1 (en) * | 1998-05-20 | 2001-07-10 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| SI1180121T1 (en) * | 1999-05-17 | 2004-04-30 | Conjuchem, Inc. | Long lasting insulinotropic peptides |
| US6380362B1 (en) * | 1999-12-23 | 2002-04-30 | Genesis Research & Development Corporation Ltd. | Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use |
| US6420346B1 (en) * | 2000-02-07 | 2002-07-16 | Rappaport Family Institute For Research In The Medical Sciences | Polynucleotides encoding MIP-1α, MCP-1, MIP-1β, Rantes and TNF-α, and methods for treating rheumatoid arthritis |
| HU230603B1 (hu) * | 2000-12-07 | 2017-03-28 | Eli Lilly And Company | GLP1 fúziós fehérjék |
| JP2002247847A (ja) * | 2001-02-20 | 2002-08-30 | Internatl Business Mach Corp <Ibm> | Acアダプタ、電源供給装置、電気機器、および電源供給装置の制御方法 |
| IL160289A0 (en) * | 2001-08-30 | 2004-07-25 | Biorexis Pharmaceutical Corp | Modified transferrin fusion proteins |
| US20030226155A1 (en) * | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
| US7176278B2 (en) * | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| US20060105387A1 (en) * | 2002-08-30 | 2006-05-18 | Prior Christopher P | Transferrin fusion proteins libraries |
| ES2253655T3 (es) * | 2002-10-11 | 2006-06-01 | Habasit Ag | Modulos de cinta transportadora con superficie de alta friccion. |
| US20060205037A1 (en) * | 2003-08-28 | 2006-09-14 | Homayoun Sadeghi | Modified transferrin fusion proteins |
-
2003
- 2003-08-28 CN CNA038247453A patent/CN1694895A/zh active Pending
- 2003-08-28 AT AT03791808T patent/ATE473011T1/de not_active IP Right Cessation
- 2003-08-28 DE DE60333306T patent/DE60333306D1/de not_active Expired - Lifetime
- 2003-08-28 JP JP2004569752A patent/JP4873860B2/ja not_active Expired - Fee Related
- 2003-08-28 ES ES03791808T patent/ES2347144T3/es not_active Expired - Lifetime
- 2003-08-28 CN CNA038247399A patent/CN1713920A/zh active Pending
- 2003-08-28 EP EP03791808A patent/EP1545595B1/en not_active Expired - Lifetime
- 2003-08-28 AU AU2003262886A patent/AU2003262886A1/en not_active Abandoned
- 2003-08-28 US US10/515,324 patent/US20060130158A1/en not_active Abandoned
- 2003-08-28 WO PCT/US2003/026742 patent/WO2004020454A2/en not_active Ceased
- 2003-08-28 CN CN201110175090A patent/CN102268094A/zh active Pending
-
2009
- 2009-07-21 AU AU2009202932A patent/AU2009202932B2/en not_active Ceased
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