JP2006503588A5 - - Google Patents
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- Publication number
- JP2006503588A5 JP2006503588A5 JP2004569752A JP2004569752A JP2006503588A5 JP 2006503588 A5 JP2006503588 A5 JP 2006503588A5 JP 2004569752 A JP2004569752 A JP 2004569752A JP 2004569752 A JP2004569752 A JP 2004569752A JP 2006503588 A5 JP2006503588 A5 JP 2006503588A5
- Authority
- JP
- Japan
- Prior art keywords
- diabetes
- type
- therapeutic agent
- agent according
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40697702P | 2002-08-30 | 2002-08-30 | |
| US60/406,977 | 2002-08-30 | ||
| US10/378,094 US7176278B2 (en) | 2001-08-30 | 2003-03-04 | Modified transferrin fusion proteins |
| US10/378,094 | 2003-03-04 | ||
| PCT/US2003/026818 WO2004020405A2 (en) | 2002-08-30 | 2003-08-28 | Modified transferrin fusion proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006503588A JP2006503588A (ja) | 2006-02-02 |
| JP2006503588A5 true JP2006503588A5 (enExample) | 2006-10-19 |
| JP4873860B2 JP4873860B2 (ja) | 2012-02-08 |
Family
ID=31978395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004569752A Expired - Fee Related JP4873860B2 (ja) | 2002-08-30 | 2003-08-28 | 改変トランスフェリン融合タンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060130158A1 (enExample) |
| EP (1) | EP1545595B1 (enExample) |
| JP (1) | JP4873860B2 (enExample) |
| CN (3) | CN1713920A (enExample) |
| AT (1) | ATE473011T1 (enExample) |
| AU (2) | AU2003262886A1 (enExample) |
| DE (1) | DE60333306D1 (enExample) |
| ES (1) | ES2347144T3 (enExample) |
| WO (1) | WO2004020454A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8129504B2 (en) | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
| US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| US20070031440A1 (en) * | 2001-08-30 | 2007-02-08 | Prior Christopher P | Modified transferin-antibody fusion proteins |
| US20030226155A1 (en) * | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
| AU2002323501C1 (en) * | 2001-08-30 | 2010-04-29 | Biorexis Technology, Inc | Modified transferrin fusion proteins |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20060205037A1 (en) * | 2003-08-28 | 2006-09-14 | Homayoun Sadeghi | Modified transferrin fusion proteins |
| JP2007512001A (ja) * | 2003-08-28 | 2007-05-17 | バイオレクシス ファーマシューティカル コーポレイション | Epoミメティックペプチドおよび融合タンパク質 |
| AU2005271403A1 (en) * | 2004-08-03 | 2006-02-16 | Biorexis Pharmaceutical Corporation | Combination therapy using transferrin fusion proteins comprising GLP-1 |
| US20090275481A1 (en) * | 2005-06-17 | 2009-11-05 | Pfizer, Inc. | Anchored Transferrin Fusion Protein Libraries |
| US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| AU2007268052B2 (en) * | 2006-05-22 | 2013-07-04 | The Regents Of The University Of California | Compositions and methods for the delivery of oxygen |
| CN101088502B (zh) * | 2006-06-16 | 2012-11-21 | 中国科学院化学研究所 | 一种含有转铁蛋白和槲皮素的结合物的混合溶液及其用途 |
| WO2008007146A1 (en) | 2006-07-13 | 2008-01-17 | Upperton Limited | Process for preparing particles of proteinaceous material |
| ES2371495T3 (es) * | 2006-07-24 | 2012-01-03 | Biorexis Pharmaceutical Corporation | Proteínas de fusión de exendina. |
| CN103230598A (zh) * | 2006-09-06 | 2013-08-07 | 费斯生物制药公司 | 融合肽治疗组合物 |
| ES2535358T3 (es) | 2006-12-12 | 2015-05-08 | Biorexis Pharmaceutical Corporation | Bibliotecas de proteínas de fusión de transferrina |
| CA2953975C (en) | 2008-06-27 | 2019-11-26 | Duke University | Therapeutic agents comprising elastin-like peptides |
| RU2011142230A (ru) * | 2009-04-20 | 2013-05-27 | Пфайзер Инк. | Контроль гликозилирования белка и композиции и способы, касающиеся этого |
| US20130079382A1 (en) | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| CA2801223C (en) * | 2010-06-04 | 2019-12-03 | Sk Chemicals Co., Ltd. | Fusion protein having factor vii activity |
| CN110251668A (zh) | 2010-11-30 | 2019-09-20 | 霍夫曼-拉罗奇有限公司 | 低亲和力血脑屏障受体抗体及其用途 |
| WO2013138338A2 (en) | 2012-03-12 | 2013-09-19 | Massachusetts Institute Of Technology | Methods for treating tissue damage associated with ischemia with apoliporotein d |
| HK1212448A1 (en) | 2012-09-07 | 2016-06-10 | The Governors Of The University Of Alberta | Methods and compositions for diagnosis of inflammatory liver disease |
| EP4324480A3 (en) * | 2013-05-20 | 2024-05-08 | F. Hoffmann-La Roche AG | Anti-transferrin receptor antibodies and methods of use |
| CN105555310B (zh) * | 2013-07-08 | 2019-07-23 | 南京传奇生物科技有限公司 | 一种提高蛋白血清半衰期的组合物和方法 |
| US9642895B2 (en) * | 2013-08-12 | 2017-05-09 | 3M Innovative Properties Company | Peptides for enhancing transdermal delivery |
| KR102058864B1 (ko) * | 2013-12-16 | 2019-12-24 | 주식회사 티움바이오 | 인자 vii의 융합 단백질을 포함하는 안정성이 개선된 약학적 조성물 |
| EP3092251B1 (en) * | 2014-01-06 | 2021-01-20 | F. Hoffmann-La Roche AG | Monovalent blood brain barrier shuttle modules |
| JP2015224327A (ja) * | 2014-05-29 | 2015-12-14 | 花王株式会社 | 繊維製品用洗浄剤組成物 |
| SG11201707538XA (en) * | 2015-03-17 | 2017-10-30 | Memorial Sloan Kettering Cancer Center | Anti-muc16 antibodies and uses thereof |
| AU2016283344B2 (en) | 2015-06-24 | 2022-08-04 | Jcr Pharmaceuticals Co., Ltd. | Fusion protein containing BDNF |
| NZ741067A (en) * | 2015-10-02 | 2023-07-28 | Hoffmann La Roche | Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| AU2017321883B2 (en) | 2016-09-02 | 2022-07-07 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof |
| CN110100000B (zh) * | 2016-12-26 | 2023-06-20 | Jcr制药股份有限公司 | 含有bdnf的融合蛋白 |
| EA201991577A1 (ru) | 2016-12-26 | 2019-12-30 | Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. | Новые антитела против рецептора трансферрина человека, способные преодолевать гематоэнцефалический барьер |
| SG11201907427YA (en) * | 2017-02-17 | 2019-09-27 | Denali Therapeutics Inc | Engineered transferrin receptor binding polypeptides |
| CN106967171B (zh) * | 2017-02-23 | 2021-04-27 | 郑州大学 | 一种全人源重组CD40L单抗Fab片段及其制备方法 |
| CN107010616B (zh) * | 2017-04-13 | 2019-04-02 | 浙江理工大学 | 一种具有靶向传递功能的纳米药物载体的制备方法 |
| CA3075285A1 (en) * | 2017-09-14 | 2019-03-21 | Denali Therapeutics Inc. | Anti-trem2 antibodies and methods of use thereof |
| JP2021500857A (ja) * | 2017-10-02 | 2021-01-14 | デナリ セラピューティクス インコーポレイテッドDenali Therapeutics Inc. | 酵素補充療法用酵素を含む融合タンパク質 |
| CN111526887B (zh) * | 2017-10-11 | 2023-12-01 | 南京传奇生物科技有限公司 | 用于使血清中的蛋白质半衰期增加的组合物和方法 |
| AR114077A1 (es) * | 2018-01-10 | 2020-07-15 | Denali Therapeutics Inc | Polipéptidos de unión al receptor de transferrina y usos de los mismos |
| JP7589049B2 (ja) * | 2018-06-21 | 2024-11-25 | ノヴォ ノルディスク アー/エス | 肥満を治療するための新規化合物 |
| CN109180819A (zh) * | 2018-09-14 | 2019-01-11 | 苏州康宇生物科技有限公司 | 一种胰岛素衍生物的制备方法 |
| JP2022507268A (ja) * | 2018-11-13 | 2022-01-18 | デノボ バイオファーマ エルエルシー | 結合ドメインおよび分泌可能なペプチドの遺伝子を含む組換えベクター |
| CA3155758A1 (en) * | 2019-10-25 | 2021-04-29 | Michael C. Jewett | Cell-free extract preparation protocol for enrichment of membrane vesicles and increased glycoprotein yields |
| CN111948388B (zh) * | 2020-08-18 | 2022-03-22 | 山东农业大学 | 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用 |
| CN112661862B (zh) * | 2020-12-25 | 2023-03-31 | 深圳大学 | 一种融合蛋白及其制备方法和应用 |
| CN113267631A (zh) * | 2021-05-17 | 2021-08-17 | 江苏普若维生物技术有限责任公司 | 一种检测TNF-α的电化学试剂盒制备方法 |
| WO2023142109A1 (zh) * | 2022-01-30 | 2023-08-03 | 领诺(上海)医药科技有限公司 | 一种长效重组人生长激素及其应用 |
| WO2024114687A1 (en) * | 2022-12-02 | 2024-06-06 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-tfr1 antibodies and uses thereof |
| CN118931931B (zh) * | 2024-07-23 | 2025-02-21 | 中国农业科学院北京畜牧兽医研究所 | 一种产气荚膜梭菌epsilon毒素-铁蛋白纳米颗粒抗原的制备方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4289689A (en) * | 1980-03-14 | 1981-09-15 | Hoffmann-La Roche Inc. | Preparation of homogeneous human fibroblast interferon |
| EP0070906B1 (en) * | 1981-02-04 | 1986-10-15 | Juridical Foundation Japanese Foundation For Cancer Research | Human interferon-beta gene |
| US4816449A (en) * | 1984-08-09 | 1989-03-28 | Immunetech Pharmaceuticals | Immunotherapeutic anti-inflammatory peptide agents |
| US5026651A (en) * | 1985-04-25 | 1991-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of human transferrin |
| US5262177A (en) * | 1986-02-07 | 1993-11-16 | Oncogen | Recombinant viruses encoding the human melanoma-associated antigen |
| US5260203A (en) * | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US5091513A (en) * | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| GB8901778D0 (en) | 1989-01-27 | 1989-03-15 | Univ Court Of The University O | Manipulatory technique |
| US5571691A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
| US5672683A (en) * | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
| US5977307A (en) * | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
| US6066469A (en) * | 1990-03-08 | 2000-05-23 | Ferro Dynamics, Inc. | Cloning, expression, and uses of human lactoferrin |
| US5723286A (en) * | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5986067A (en) * | 1991-02-08 | 1999-11-16 | The University Of Vermont And State Agricultural College | Recombinant transferrins, transferrin half-molecules and mutants thereof |
| US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| EP0603187A4 (en) * | 1991-05-31 | 1995-08-30 | Us Health | Human lactoferrin. |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| ZA932568B (en) * | 1992-04-24 | 1993-11-12 | Baylor College Midecine A Non | Production of recombinant human lactoferrin |
| EP0599303A3 (en) * | 1992-11-27 | 1998-07-29 | Takeda Chemical Industries, Ltd. | Peptide conjugate |
| WO1994023744A1 (en) | 1993-04-16 | 1994-10-27 | The Wistar Institute Of Anatomy And Biology | Recombinant cytomegalovirus vaccine |
| US5455933A (en) * | 1993-07-14 | 1995-10-03 | Dell Usa, L.P. | Circuit and method for remote diagnosis of personal computers |
| US5843882A (en) * | 1995-04-27 | 1998-12-01 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral proteins and peptides |
| US5817789A (en) * | 1995-06-06 | 1998-10-06 | Transkaryotic Therapies, Inc. | Chimeric proteins for use in transport of a selected substance into cells |
| US5849293A (en) * | 1996-01-11 | 1998-12-15 | Cornell Research Foundation, Inc. | Use of human transferrin in controlling insulin levels |
| US7235627B2 (en) * | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) * | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| FR2762843B1 (fr) * | 1997-04-30 | 1999-12-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US6258782B1 (en) * | 1998-05-20 | 2001-07-10 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| JP4115671B2 (ja) * | 1999-05-17 | 2008-07-09 | コンジュケム バイオテクノロジーズ インコーポレイテッド | 長期間持続するインシュリン向性ペプチド |
| US6380362B1 (en) * | 1999-12-23 | 2002-04-30 | Genesis Research & Development Corporation Ltd. | Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use |
| US6420346B1 (en) * | 2000-02-07 | 2002-07-16 | Rappaport Family Institute For Research In The Medical Sciences | Polynucleotides encoding MIP-1α, MCP-1, MIP-1β, Rantes and TNF-α, and methods for treating rheumatoid arthritis |
| DK1724284T3 (da) * | 2000-12-07 | 2009-11-02 | Lilly Co Eli | GLP-1 fusionsproteiner |
| JP2002247847A (ja) * | 2001-02-20 | 2002-08-30 | Internatl Business Mach Corp <Ibm> | Acアダプタ、電源供給装置、電気機器、および電源供給装置の制御方法 |
| US7176278B2 (en) * | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| AU2002323501C1 (en) * | 2001-08-30 | 2010-04-29 | Biorexis Technology, Inc | Modified transferrin fusion proteins |
| US20030226155A1 (en) * | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
| US20060105387A1 (en) * | 2002-08-30 | 2006-05-18 | Prior Christopher P | Transferrin fusion proteins libraries |
| ATE314289T1 (de) * | 2002-10-11 | 2006-01-15 | Habasit Ag | Förderbandmodul mit einer reibungsoberfäche |
| US20060205037A1 (en) * | 2003-08-28 | 2006-09-14 | Homayoun Sadeghi | Modified transferrin fusion proteins |
-
2003
- 2003-08-28 DE DE60333306T patent/DE60333306D1/de not_active Expired - Lifetime
- 2003-08-28 JP JP2004569752A patent/JP4873860B2/ja not_active Expired - Fee Related
- 2003-08-28 CN CNA038247399A patent/CN1713920A/zh active Pending
- 2003-08-28 AU AU2003262886A patent/AU2003262886A1/en not_active Abandoned
- 2003-08-28 ES ES03791808T patent/ES2347144T3/es not_active Expired - Lifetime
- 2003-08-28 WO PCT/US2003/026742 patent/WO2004020454A2/en not_active Ceased
- 2003-08-28 CN CN201110175090A patent/CN102268094A/zh active Pending
- 2003-08-28 US US10/515,324 patent/US20060130158A1/en not_active Abandoned
- 2003-08-28 CN CNA038247453A patent/CN1694895A/zh active Pending
- 2003-08-28 EP EP03791808A patent/EP1545595B1/en not_active Expired - Lifetime
- 2003-08-28 AT AT03791808T patent/ATE473011T1/de not_active IP Right Cessation
-
2009
- 2009-07-21 AU AU2009202932A patent/AU2009202932B2/en not_active Ceased
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