JP2011236247A5 - - Google Patents
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- Publication number
- JP2011236247A5 JP2011236247A5 JP2011175796A JP2011175796A JP2011236247A5 JP 2011236247 A5 JP2011236247 A5 JP 2011236247A5 JP 2011175796 A JP2011175796 A JP 2011175796A JP 2011175796 A JP2011175796 A JP 2011175796A JP 2011236247 A5 JP2011236247 A5 JP 2011236247A5
- Authority
- JP
- Japan
- Prior art keywords
- pseudohalogen
- hnr
- pseudomycin
- hygromycin
- chen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002577 pseudohalo group Chemical group 0.000 description 2
- YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53364903P | 2003-12-30 | 2003-12-30 | |
| US60/533,649 | 2003-12-30 | ||
| US60663704P | 2004-08-13 | 2004-08-13 | |
| US60/606,637 | 2004-08-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547532A Division JP4927563B2 (ja) | 2003-12-30 | 2004-12-30 | アシルオキシアルキルカルバメートプロドラッグ及び中間体の合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011236247A JP2011236247A (ja) | 2011-11-24 |
| JP2011236247A5 true JP2011236247A5 (enExample) | 2014-02-13 |
| JP5670842B2 JP5670842B2 (ja) | 2015-02-18 |
Family
ID=34753006
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547532A Expired - Lifetime JP4927563B2 (ja) | 2003-12-30 | 2004-12-30 | アシルオキシアルキルカルバメートプロドラッグ及び中間体の合成 |
| JP2011175796A Expired - Fee Related JP5670842B2 (ja) | 2003-12-30 | 2011-08-11 | アシルオキシアルキルカルバメートプロドラッグの合成 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547532A Expired - Lifetime JP4927563B2 (ja) | 2003-12-30 | 2004-12-30 | アシルオキシアルキルカルバメートプロドラッグ及び中間体の合成 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7227028B2 (enExample) |
| EP (2) | EP2371815A1 (enExample) |
| JP (2) | JP4927563B2 (enExample) |
| CN (1) | CN102702065A (enExample) |
| CA (1) | CA2551859C (enExample) |
| DK (1) | DK1716115T3 (enExample) |
| ES (1) | ES2405329T3 (enExample) |
| IL (2) | IL176341A (enExample) |
| WO (1) | WO2005066122A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) * | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7025745B2 (en) * | 2002-10-07 | 2006-04-11 | Advanced Cardiovascular Systems, Inc. | Method of making a catheter balloon using a tapered mandrel |
| WO2005010011A2 (en) * | 2003-07-15 | 2005-02-03 | Xenoport, Inc. | Methods of synthesis of acyloxyalkyl compounds |
| AU2004267100B2 (en) * | 2003-08-20 | 2010-10-07 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| CA2537837A1 (en) * | 2003-09-11 | 2005-03-24 | Xenoport, Inc. | Treating and/or preventing urinary incontinence using prodrugs of gaba analogs |
| CA2541752C (en) * | 2003-10-14 | 2012-01-03 | Xenoport, Inc. | Crystalline form of gamma-aminobutyric acid analog |
| CA2551859C (en) | 2003-12-30 | 2011-10-04 | Xenoport, Inc. | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
| EP1809619A1 (en) * | 2004-10-21 | 2007-07-25 | Transtech Pharma, Inc. | Bissulfonamide compounds as agonists of galr1, compositions, and methods of use |
| US7494985B2 (en) | 2004-11-03 | 2009-02-24 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use |
| EP1811986B1 (en) | 2004-11-04 | 2014-03-26 | XenoPort, Inc. | Gabapentin prodrug sustained release oral dosage forms |
| EP1919859B1 (en) * | 2005-06-20 | 2010-06-02 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of tranexamic acid and use |
| WO2007085933A2 (en) * | 2006-01-25 | 2007-08-02 | Glenmark Pharmaceuticals Limited | Process for the preparation of n-[1-(s)-ethoxycarbonyl-1-butyl]-(s)-alanine-dmt complex and its use in the preparation of perindopril |
| TW200820963A (en) | 2006-07-28 | 2008-05-16 | Xenoport Inc | Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use |
| WO2008033572A1 (en) | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| CA2674610C (en) * | 2007-01-11 | 2013-06-18 | Xenoport, Inc. | Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment |
| US20090118365A1 (en) * | 2007-11-06 | 2009-05-07 | Xenoport, Inc | Use of Prodrugs of GABA B Agonists for Treating Neuropathic and Musculoskeletal Pain |
| WO2009094563A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use |
| WO2009094577A2 (en) * | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| CA2710538A1 (en) * | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Crystalline form of a (3s)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use |
| WO2009096985A1 (en) * | 2008-02-01 | 2009-08-06 | Xenoport, Inc. | Sustained release particulate oral dosage forms of (r)-baclofen prodrugs and methods of treatment |
| US20100137442A2 (en) * | 2008-02-01 | 2010-06-03 | Xenoport, Inc. | Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment |
| SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| WO2010008886A2 (en) * | 2008-06-24 | 2010-01-21 | Teva Pharmaceutical Industries Ltd. | Processes for preparing prodrugs of gabapentin and intermediates thereof |
| KR20110028320A (ko) * | 2008-07-02 | 2011-03-17 | 테바 파마슈티컬 인더스트리즈 리미티드 | 가바펜틴 에나카르빌 염 및 이의 제조 방법 |
| WO2010017498A1 (en) * | 2008-08-07 | 2010-02-11 | Xenoport, Inc. | Methods of synthesizing n-hydroxysuccinimidyl carbonates |
| WO2010017504A1 (en) * | 2008-08-07 | 2010-02-11 | Xenoport, Inc. | Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs |
| WO2010063002A2 (en) * | 2008-11-26 | 2010-06-03 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation and purification of gabapentin enacarbil |
| WO2010075520A1 (en) | 2008-12-23 | 2010-07-01 | Teva Pharmaceutical Industries Ltd. | Preparation of gabapentin enacarbil intermediate |
| US10071068B2 (en) * | 2009-03-03 | 2018-09-11 | Xenoport, Inc. | Sustained release oral dosage forms of an R-baclofen prodrug |
| CN102341098A (zh) * | 2009-03-06 | 2012-02-01 | 什诺波特有限公司 | 具有高负荷的加巴喷丁前药的口服剂型 |
| EP2419401A2 (en) * | 2009-04-17 | 2012-02-22 | XenoPort, Inc. | GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAb RECEPTOR LIGANDS |
| WO2011012723A1 (en) | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Injectable sustained release compositions comprising a pramipexole prodrug |
| US20120191039A1 (en) | 2009-07-31 | 2012-07-26 | Ascendis Pharma A/S | Carrier linked pramipexole prodrugs |
| WO2011028234A1 (en) * | 2009-09-04 | 2011-03-10 | Xenoport, Inc. | Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid |
| US20110130454A1 (en) * | 2009-11-24 | 2011-06-02 | Xenoport, Inc. | Prodrugs of gamma-amino acid, alpha-2-delta ligands, pharmaceutical compositions and uses thereof |
| US20110124705A1 (en) * | 2009-11-24 | 2011-05-26 | Xenoport, Inc. | Prodrugs of alpha-2-delta ligands, pharmaceutical compositions and uses thereof |
| WO2011091164A1 (en) | 2010-01-22 | 2011-07-28 | Xenoport, Inc. | Oral dosage forms having a high loading of a tranexamic acid prodrug |
| WO2011109403A1 (en) | 2010-03-01 | 2011-09-09 | Xenoport, Inc. | Use of (3r)-4-{[(1s)-2-methyl-1- (2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl) butanoic acid for treating urinary incontinence |
| EP2937334B1 (en) * | 2010-03-10 | 2017-04-19 | Promentis Pharmaceuticals, Inc. | Propionic acids, propionic acid esters, and related compounds |
| SG10201502026XA (en) | 2010-03-18 | 2015-05-28 | Daiichi Sankyo Co Ltd | Cycloalkyl-substituted imidazole derivative |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| EP2705842A1 (en) | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| RS53227B (sr) | 2011-03-01 | 2014-08-29 | Pharnext | Terapija neuroloških poremećaja kombinacijom baklofena i akamprosata |
| UA115968C2 (uk) | 2011-03-01 | 2018-01-25 | Фарнекст | Нові композиції для лікування неврологічних захворювань |
| US8580850B2 (en) | 2011-08-11 | 2013-11-12 | Xenoport, Inc. | Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use |
| WO2013026777A1 (en) * | 2011-08-24 | 2013-02-28 | Solvay Sa | Fluoroalkyl s-(fluoro)alkyl thiocarbonates, a method for the preparation of fluoroalkyl s-(fluoro)alkyl thiocarbonates, and their use |
| SG11201500309VA (en) | 2012-07-18 | 2015-02-27 | Pharnext | Baclofen and acamprosate based therapy of macular degeneration disorders |
| EP2705843A1 (en) | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating epilepsy and related disorders through reduction of epileptogenesis |
| EP2705841A1 (en) | 2012-09-05 | 2014-03-12 | Pharnext | Combinations of nootropic agents for treating cognitive dysfunctions |
| EP2961730A2 (en) | 2013-02-26 | 2016-01-06 | XenoPort, Inc. | Method of making 1-(acyloxy)-alkyl carbamate compounds |
| KR102336426B1 (ko) | 2013-11-05 | 2021-12-08 | 아스트라제네카 아베 | Nmda 길항제 전구약물 |
| EP3102195B1 (en) | 2014-02-03 | 2021-10-06 | Quadriga Biosciences, Inc. | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents |
| EP3102194A1 (en) | 2014-02-03 | 2016-12-14 | Quadriga Biosciences, Inc. | Beta-substituted gamma-amino acids and analogs as chemotherapeutic agents |
| EP3104850A1 (en) | 2014-02-11 | 2016-12-21 | Pharnext | Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders |
| ES3072651T3 (en) | 2014-10-17 | 2026-07-03 | Univ Illinois | Scalable synthesis of reduced toxicity derivative of amphotericin b |
| JPWO2016208709A1 (ja) | 2015-06-26 | 2018-04-19 | 第一三共株式会社 | 1−(アシルオキシ)アルキルカルバメート誘導体の新規な製造方法 |
| AR105592A1 (es) | 2015-08-03 | 2017-10-18 | Quadriga Biosciences Inc | b-AMINOÁCIDOS b-SUSTITUIDOS Y ANÁLOGOS COMO AGENTES QUIMIOTERAPÉUTICOS Y USOS DE LOS MISMOS |
| EP3339291A1 (en) | 2016-12-22 | 2018-06-27 | Vita Api | Proteasome inhibiting ss-lactam prodrugs useful for the treatment of cancer and neurodegenerative disorders |
| US10736876B2 (en) | 2017-04-24 | 2020-08-11 | Pharnext | Idalopirdine-based combinatorial therapies of Alzheimer's disease |
| CN108976147B (zh) * | 2017-05-31 | 2021-02-12 | 首都医科大学 | 氨基正己酰氨基甲环酰氨基正己酰碱性氨基酸,其合成,活性和应用 |
| CN111902138A (zh) | 2018-01-29 | 2020-11-06 | 法奈克斯公司 | 在乙酰胆碱酯酶抑制剂治疗失去反应的患者中对阿兹海默氏病的基于巴氯芬和阿坎酸的治疗 |
| IL309210A (en) * | 2021-06-09 | 2024-02-01 | Atai Therapeutics Inc | Parent drugs and conjugates of dimethyltryptamine |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0079872B1 (en) | 1981-11-17 | 1985-03-20 | KabiVitrum AB | Antifibrinolytically active compounds |
| US4426391A (en) | 1982-09-15 | 1984-01-17 | Merck & Co., Inc. | [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa |
| US4760057A (en) | 1983-06-23 | 1988-07-26 | Merck & Co., Inc. | (Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs |
| US4916230A (en) * | 1984-07-02 | 1990-04-10 | Merck & Co., Inc. | Process for preparing novel N-(acyloxy-alkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs |
| JP2629375B2 (ja) * | 1989-09-14 | 1997-07-09 | 日立化成工業株式会社 | アミノ基が保護されたドーパ又はドーパ誘導体の製造法 |
| US5098999A (en) | 1989-08-23 | 1992-03-24 | Hitachi Chemical Company | Amino-protected dopa derivative and production thereof |
| DE69023844T2 (de) | 1989-09-06 | 1996-06-20 | Merck & Co Inc | Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren. |
| GB9001405D0 (en) * | 1990-01-22 | 1990-03-21 | Leo Pharm Prod Ltd | New intermediates,their production and use |
| SE9200858L (sv) * | 1992-03-20 | 1993-09-21 | Kabi Pharmacia Ab | Metod för framställning av pellets med fördröjd frisättning |
| SE9300013L (sv) | 1992-12-30 | 1994-07-01 | Kabi Pharmacia Ab | Nytt förfarande och mellanprodukter för framställning av pro- läkemedel |
| IL111584A0 (en) * | 1993-11-18 | 1995-01-24 | Merck & Co Inc | Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them |
| US5684018A (en) * | 1994-12-13 | 1997-11-04 | Merck & Co., Inc. | Acyloxyisopropyl carbamates as prodrugs for amine drugs |
| JPH10148903A (ja) * | 1996-11-20 | 1998-06-02 | Konica Corp | 耐圧性の改良されたハロゲン化銀写真感光材料 |
| JP3526243B2 (ja) | 1999-07-09 | 2004-05-10 | 松下電器産業株式会社 | 基地局装置及び回線品質劣化防止方法 |
| JP2003505396A (ja) * | 1999-07-15 | 2003-02-12 | イーライ・リリー・アンド・カンパニー | プソイドマイシンプロドラッグ |
| GB2365425A (en) * | 2000-08-01 | 2002-02-20 | Parke Davis & Co Ltd | Alkyl amino acid derivatives useful as pharmaceutical agents |
| AU2002310409C1 (en) * | 2001-06-11 | 2008-04-17 | Xenoport, Inc. | Orally administered dosage forms of GABA analog prodrugs having reduced toxicity |
| AU2004267100B2 (en) * | 2003-08-20 | 2010-10-07 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US7265140B2 (en) * | 2003-09-23 | 2007-09-04 | Pfizer Inc | Acyloxymethylcarbamate prodrugs of oxazolidinones |
| CA2551859C (en) | 2003-12-30 | 2011-10-04 | Xenoport, Inc. | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
| US7494985B2 (en) | 2004-11-03 | 2009-02-24 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use |
| US7566738B2 (en) | 2004-11-03 | 2009-07-28 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use |
-
2004
- 2004-12-30 CA CA2551859A patent/CA2551859C/en not_active Expired - Lifetime
- 2004-12-30 DK DK04815821.6T patent/DK1716115T3/da active
- 2004-12-30 JP JP2006547532A patent/JP4927563B2/ja not_active Expired - Lifetime
- 2004-12-30 WO PCT/US2004/043823 patent/WO2005066122A2/en not_active Ceased
- 2004-12-30 EP EP11001106A patent/EP2371815A1/en not_active Ceased
- 2004-12-30 ES ES04815821T patent/ES2405329T3/es not_active Expired - Lifetime
- 2004-12-30 EP EP04815821A patent/EP1716115B1/en not_active Expired - Lifetime
- 2004-12-30 US US11/026,491 patent/US7227028B2/en not_active Expired - Lifetime
- 2004-12-30 CN CN2012101837531A patent/CN102702065A/zh active Pending
-
2006
- 2006-06-15 IL IL176341A patent/IL176341A/en active IP Right Grant
-
2007
- 2007-05-25 US US11/754,232 patent/US7511158B2/en not_active Expired - Lifetime
-
2009
- 2009-02-20 US US12/390,000 patent/US8003809B2/en not_active Expired - Lifetime
- 2009-09-08 IL IL200821A patent/IL200821A/en active IP Right Grant
-
2011
- 2011-08-11 JP JP2011175796A patent/JP5670842B2/ja not_active Expired - Fee Related
- 2011-08-11 US US13/208,176 patent/US8378137B2/en not_active Expired - Fee Related
-
2013
- 2013-01-15 US US13/742,134 patent/US9353057B2/en not_active Expired - Fee Related
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