JP2011236247A5 - - Google Patents

Download PDF

Info

Publication number
JP2011236247A5
JP2011236247A5 JP2011175796A JP2011175796A JP2011236247A5 JP 2011236247 A5 JP2011236247 A5 JP 2011236247A5 JP 2011175796 A JP2011175796 A JP 2011175796A JP 2011175796 A JP2011175796 A JP 2011175796A JP 2011236247 A5 JP2011236247 A5 JP 2011236247A5
Authority
JP
Japan
Prior art keywords
pseudohalogen
hnr
pseudomycin
hygromycin
chen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011175796A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011236247A (ja
JP5670842B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2011236247A publication Critical patent/JP2011236247A/ja
Publication of JP2011236247A5 publication Critical patent/JP2011236247A5/ja
Application granted granted Critical
Publication of JP5670842B2 publication Critical patent/JP5670842B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2011175796A 2003-12-30 2011-08-11 アシルオキシアルキルカルバメートプロドラッグの合成 Expired - Fee Related JP5670842B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53364903P 2003-12-30 2003-12-30
US60/533,649 2003-12-30
US60663704P 2004-08-13 2004-08-13
US60/606,637 2004-08-13

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006547532A Division JP4927563B2 (ja) 2003-12-30 2004-12-30 アシルオキシアルキルカルバメートプロドラッグ及び中間体の合成

Publications (3)

Publication Number Publication Date
JP2011236247A JP2011236247A (ja) 2011-11-24
JP2011236247A5 true JP2011236247A5 (enExample) 2014-02-13
JP5670842B2 JP5670842B2 (ja) 2015-02-18

Family

ID=34753006

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006547532A Expired - Lifetime JP4927563B2 (ja) 2003-12-30 2004-12-30 アシルオキシアルキルカルバメートプロドラッグ及び中間体の合成
JP2011175796A Expired - Fee Related JP5670842B2 (ja) 2003-12-30 2011-08-11 アシルオキシアルキルカルバメートプロドラッグの合成

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2006547532A Expired - Lifetime JP4927563B2 (ja) 2003-12-30 2004-12-30 アシルオキシアルキルカルバメートプロドラッグ及び中間体の合成

Country Status (9)

Country Link
US (5) US7227028B2 (enExample)
EP (2) EP1716115B1 (enExample)
JP (2) JP4927563B2 (enExample)
CN (1) CN102702065A (enExample)
CA (1) CA2551859C (enExample)
DK (1) DK1716115T3 (enExample)
ES (1) ES2405329T3 (enExample)
IL (2) IL176341A (enExample)
WO (1) WO2005066122A2 (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7025745B2 (en) * 2002-10-07 2006-04-11 Advanced Cardiovascular Systems, Inc. Method of making a catheter balloon using a tapered mandrel
WO2005010011A2 (en) * 2003-07-15 2005-02-03 Xenoport, Inc. Methods of synthesis of acyloxyalkyl compounds
BRPI0413756A (pt) * 2003-08-20 2006-10-31 Xenoport Inc composto, métodos para tratar ou evitar espasticidade ou um sintoma de espasticidade, doença de refluxo gastro-esofágico, vìcio em droga, vìcio em ou abuso de álcool, ou vìcio em ou abuso de nicotina, e tosse ou êmese em um paciente, e, composição farmacêutica
MXPA06002731A (es) * 2003-09-11 2006-06-05 Xenoport Inc Tratamiento y/o prevencion de incontinencia urinaria utilizando profarmacos de analogos de gaba.
BRPI0415288B8 (pt) * 2003-10-14 2021-05-25 Xenoport Inc composição farmacêutica compreendendo o ácido 1-{[(a- isobutanoiloxietoxi) carbonil] aminometil}- 1-ciclo- hexano acético cristalino
JP4927563B2 (ja) 2003-12-30 2012-05-09 ゼノポート，インコーポレイティド アシルオキシアルキルカルバメートプロドラッグ及び中間体の合成
AU2005299771A1 (en) * 2004-10-21 2006-05-04 High Point Pharmaceuticals, Llc Bissulfonamide compounds as agonists of GalR1, compositions, and methods of use
WO2006050472A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
MX2007005306A (es) 2004-11-04 2007-06-11 Xenoport Inc Formas de dosis oral de liberacion sostenida de la prodroga gabapentina.
US7351740B2 (en) * 2005-06-20 2008-04-01 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
WO2007085933A2 (en) * 2006-01-25 2007-08-02 Glenmark Pharmaceuticals Limited Process for the preparation of n-[1-(s)-ethoxycarbonyl-1-butyl]-(s)-alanine-dmt complex and its use in the preparation of perindopril
WO2008013860A2 (en) * 2006-07-28 2008-01-31 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of alpha-amino acids, methods of synthesis and use
WO2008033572A1 (en) 2006-09-15 2008-03-20 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
EP2117517B1 (en) * 2007-01-11 2011-06-01 XenoPort, Inc. Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment
WO2009061934A1 (en) * 2007-11-06 2009-05-14 Xenoport, Inc. Use of prodrugs of gaba b agonists for treating neuropathic and musculoskeletal pain
US7872046B2 (en) * 2008-01-25 2011-01-18 Xenoport, Inc. Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
TWI380812B (zh) * 2008-01-25 2013-01-01 Xenoport Inc （３ｓ）-胺甲基-５-甲基己酸前藥之晶形及使用方法
WO2009094577A2 (en) * 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
US20100137442A2 (en) * 2008-02-01 2010-06-03 Xenoport, Inc. Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment
WO2009096985A1 (en) * 2008-02-01 2009-08-06 Xenoport, Inc. Sustained release particulate oral dosage forms of (r)-baclofen prodrugs and methods of treatment
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
WO2010008886A2 (en) * 2008-06-24 2010-01-21 Teva Pharmaceutical Industries Ltd. Processes for preparing prodrugs of gabapentin and intermediates thereof
CN102137840A (zh) * 2008-07-02 2011-07-27 特瓦制药工业有限公司 加巴喷丁酯盐及其制备方法
US8299291B2 (en) * 2008-08-07 2012-10-30 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
WO2010017498A1 (en) * 2008-08-07 2010-02-11 Xenoport, Inc. Methods of synthesizing n-hydroxysuccinimidyl carbonates
WO2010063002A2 (en) * 2008-11-26 2010-06-03 Teva Pharmaceutical Industries Ltd. Processes for the preparation and purification of gabapentin enacarbil
WO2010075520A1 (en) 2008-12-23 2010-07-01 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin enacarbil intermediate
JP2012519212A (ja) 2009-03-03 2012-08-23 ゼノポート，インコーポレイティド Ｒ−バクロフェンプロドラッグの持効性放出経口投与形
NZ594952A (en) 2009-03-06 2013-10-25 Xenoport Inc Oral dosage forms having a high loading of a gabapentin prodrug
US8344028B2 (en) * 2009-04-17 2013-01-01 Xenoport, Inc. Gamma-amino-butyric acid derivatives as GABAB receptor ligands
WO2011012723A1 (en) 2009-07-31 2011-02-03 Ascendis Pharma As Injectable sustained release compositions comprising a pramipexole prodrug
US20120191039A1 (en) 2009-07-31 2012-07-26 Ascendis Pharma A/S Carrier linked pramipexole prodrugs
WO2011028234A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
US20110130454A1 (en) * 2009-11-24 2011-06-02 Xenoport, Inc. Prodrugs of gamma-amino acid, alpha-2-delta ligands, pharmaceutical compositions and uses thereof
US20110124705A1 (en) * 2009-11-24 2011-05-26 Xenoport, Inc. Prodrugs of alpha-2-delta ligands, pharmaceutical compositions and uses thereof
WO2011091164A1 (en) 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug
US8377956B2 (en) * 2010-03-01 2013-02-19 Xenoport, Inc. Use of (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl) butanoic acid for treating urinary incontinence
JP5978136B2 (ja) * 2010-03-10 2016-08-24 プロメンテイス・フアーマシユーテイカルズ・インコーポレイテツド プロピオン酸、プロピオン酸エステルおよび関連化合物
LT2548871T (lt) 2010-03-18 2017-09-25 Daiichi Sankyo Company, Limited Cikloalkilpakeistieji imidazolo dariniai
EP2796132B1 (en) 2011-03-01 2018-05-02 Pharnext Baclofen and acamprosate based therapy of neurological disorders
EP2705842A1 (en) 2012-09-05 2014-03-12 Pharnext Therapeutic approaches for treating parkinson's disease
UA115968C2 (uk) 2011-03-01 2018-01-25 Фарнекст Нові композиції для лікування неврологічних захворювань
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
US8580850B2 (en) 2011-08-11 2013-11-12 Xenoport, Inc. Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use
WO2013026777A1 (en) * 2011-08-24 2013-02-28 Solvay Sa Fluoroalkyl s-(fluoro)alkyl thiocarbonates, a method for the preparation of fluoroalkyl s-(fluoro)alkyl thiocarbonates, and their use
KR20150058159A (ko) 2012-07-18 2015-05-28 파넥스트 바클로펜 및 아캄프로세이트 기반 황반 변성 장애의 치료
EP2705843A1 (en) 2012-09-05 2014-03-12 Pharnext Therapeutic approaches for treating epilepsy and related disorders through reduction of epileptogenesis
EP2705841A1 (en) 2012-09-05 2014-03-12 Pharnext Combinations of nootropic agents for treating cognitive dysfunctions
HK1219268A1 (zh) 2013-02-26 2017-03-31 Xenoport, Inc. 1-(酰氧基)-烷基氨基甲酸酯化合物的制造方法
RS58991B1 (sr) 2013-11-05 2019-08-30 Astrazeneca Ab Prolekovi nmda antagonista
BR112016017997A2 (pt) 2014-02-03 2017-08-08 Quadriga Biosciences Inc Beta aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos
WO2015117146A1 (en) 2014-02-03 2015-08-06 Quadriga Biosciences, Inc. Beta-substituted gamma-amino acids and analogs as chemotherapeutic agents
AU2015217796B2 (en) 2014-02-11 2020-04-30 Pharnext Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders
US10087206B2 (en) 2014-10-17 2018-10-02 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B
US10308612B2 (en) 2015-06-26 2019-06-04 Daiichi Sankyo Company, Limited Method for producing 1-(acyloxy)alkyl carbamate derivative
EP3331851A1 (en) 2015-08-03 2018-06-13 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof
EP3339291A1 (en) 2016-12-22 2018-06-27 Vita Api Proteasome inhibiting ss-lactam prodrugs useful for the treatment of cancer and neurodegenerative disorders
EP3615017A1 (en) 2017-04-24 2020-03-04 Pharnext Idalopirdine-based combinatorial therapies of alzheimer's disease
CN108976147B (zh) * 2017-05-31 2021-02-12 首都医科大学 氨基正己酰氨基甲环酰氨基正己酰碱性氨基酸，其合成，活性和应用
WO2019145523A1 (en) 2018-01-29 2019-08-01 Pharnext Baclofen and acamprosate based therapy of alzheimer's disease in patients having lost responsiveness to acetylcholinesterase inhibitor therapy

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0079872B1 (en) 1981-11-17 1985-03-20 KabiVitrum AB Antifibrinolytically active compounds
US4426391A (en) 1982-09-15 1984-01-17 Merck & Co., Inc. [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa
US4760057A (en) * 1983-06-23 1988-07-26 Merck & Co., Inc. (Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs
US4916230A (en) * 1984-07-02 1990-04-10 Merck & Co., Inc. Process for preparing novel N-(acyloxy-alkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs
US5098999A (en) 1989-08-23 1992-03-24 Hitachi Chemical Company Amino-protected dopa derivative and production thereof
JP2629375B2 (ja) * 1989-09-14 1997-07-09 日立化成工業株式会社 アミノ基が保護されたドーパ又はドーパ誘導体の製造法
EP0416689B1 (en) 1989-09-06 1995-11-29 Merck & Co. Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
GB9001405D0 (en) * 1990-01-22 1990-03-21 Leo Pharm Prod Ltd New intermediates,their production and use
SE9200858L (sv) 1992-03-20 1993-09-21 Kabi Pharmacia Ab Metod för framställning av pellets med fördröjd frisättning
SE9300013L (sv) 1992-12-30 1994-07-01 Kabi Pharmacia Ab Nytt förfarande och mellanprodukter för framställning av pro- läkemedel
IL111584A0 (en) * 1993-11-18 1995-01-24 Merck & Co Inc Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
US5684018A (en) * 1994-12-13 1997-11-04 Merck & Co., Inc. Acyloxyisopropyl carbamates as prodrugs for amine drugs
JPH10148903A (ja) * 1996-11-20 1998-06-02 Konica Corp 耐圧性の改良されたハロゲン化銀写真感光材料
JP3526243B2 (ja) 1999-07-09 2004-05-10 松下電器産業株式会社 基地局装置及び回線品質劣化防止方法
MXPA02000315A (es) * 1999-07-15 2002-06-21 Lilly Co Eli Profarmacos de pseudomicina.
GB2365425A (en) * 2000-08-01 2002-02-20 Parke Davis & Co Ltd Alkyl amino acid derivatives useful as pharmaceutical agents
AU2002345664C1 (en) * 2001-06-11 2008-03-06 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
BRPI0413756A (pt) 2003-08-20 2006-10-31 Xenoport Inc composto, métodos para tratar ou evitar espasticidade ou um sintoma de espasticidade, doença de refluxo gastro-esofágico, vìcio em droga, vìcio em ou abuso de álcool, ou vìcio em ou abuso de nicotina, e tosse ou êmese em um paciente, e, composição farmacêutica
US7265140B2 (en) * 2003-09-23 2007-09-04 Pfizer Inc Acyloxymethylcarbamate prodrugs of oxazolidinones
JP4927563B2 (ja) 2003-12-30 2012-05-09 ゼノポート，インコーポレイティド アシルオキシアルキルカルバメートプロドラッグ及び中間体の合成
WO2006050472A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
WO2006050471A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use

Similar Documents

Publication Publication Date Title
JP2011236247A5 (enExample)
JP2010538767A5 (enExample)
DK3309139T3 (da) Process for the preparation of 2,3,3,3-trifluoropropene
PL1993985T3 (pl) Sposób wytwarzania 1,2-propanodiolu
JP2013500200A5 (enExample)
FR2916364B1 (fr) Procede de preparation de pre-composites a base de nanotubes notamment de carbone
WO2010014883A3 (en) Azacitidine process and polymorphs
JP2010219032A5 (enExample)
JP2012502876A5 (enExample)
JP2015532645A5 (enExample)
WO2011088027A8 (en) Compounds and methods
WO2009123704A3 (en) Process for preparing bis(thiohydrazide amides)
ZA201105102B (en) Process for the synthesis of l-fucosyl di-or oligosaccharides and novel 2,3,4 tribenzyl-fucosyl derivatives intermediates thereof
WO2010014566A3 (en) Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
JP2009544651A5 (enExample)
JP2010509477A5 (enExample)
EP2146574A4 (en) METHOD FOR PRODUCING HIGH-PURITY D - (-) - N, N-DIETHYL-2 - (- NAPHTHOXY) PROPIONAMIDE
WO2009073147A3 (en) Process for preparing bis(thiohydrazide amides)
JP2009055850A5 (enExample)
IT1392558B1 (it) Procedimento per la produzione di boro elementare, opzionalmente drogato
EP2184104A4 (en) Catalyst for the production of hydrogen at low temperature, process for production of the catalyst, and process for production of hydrogen
JP2012250569A5 (enExample)
ZA201004118B (en) Process for the production of 1,2-propanediol
JP2011057638A5 (enExample)
WO2012068429A3 (en) Production and purification of acetic acid with optionally generation of steam from heat of the reaction