JP2009120624A5 - - Google Patents
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- Publication number
- JP2009120624A5 JP2009120624A5 JP2009058477A JP2009058477A JP2009120624A5 JP 2009120624 A5 JP2009120624 A5 JP 2009120624A5 JP 2009058477 A JP2009058477 A JP 2009058477A JP 2009058477 A JP2009058477 A JP 2009058477A JP 2009120624 A5 JP2009120624 A5 JP 2009120624A5
- Authority
- JP
- Japan
- Prior art keywords
- suspension
- calcium
- atorvastatin hemi
- carried out
- process according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 5
- FQCKMBLVYCEXJB-MNSAWQCASA-L atorvastatin calcium Chemical group [Ca+2].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1.C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 FQCKMBLVYCEXJB-MNSAWQCASA-L 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25007200P | 2000-11-30 | 2000-11-30 | |
| US26789701P | 2001-02-09 | 2001-02-09 | |
| US28187201P | 2001-04-05 | 2001-04-05 | |
| US31214401P | 2001-08-13 | 2001-08-13 | |
| US32652901P | 2001-10-01 | 2001-10-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002545702A Division JP2004514694A (ja) | 2000-11-30 | 2001-11-29 | アトルバスタチンヘミカルシウムの新規結晶形態およびその調製方法ならびに他の形態の新規調製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009120624A JP2009120624A (ja) | 2009-06-04 |
| JP2009120624A5 true JP2009120624A5 (enExample) | 2010-03-04 |
Family
ID=27540285
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002545702A Pending JP2004514694A (ja) | 2000-11-30 | 2001-11-29 | アトルバスタチンヘミカルシウムの新規結晶形態およびその調製方法ならびに他の形態の新規調製方法 |
| JP2009058477A Pending JP2009120624A (ja) | 2000-11-30 | 2009-03-11 | アトルバスタチンヘミカルシウムの新規結晶形態およびその調製方法ならびに他の形態の新規調製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002545702A Pending JP2004514694A (ja) | 2000-11-30 | 2001-11-29 | アトルバスタチンヘミカルシウムの新規結晶形態およびその調製方法ならびに他の形態の新規調製方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (15) | US20020183378A1 (enExample) |
| EP (5) | EP1363621A4 (enExample) |
| JP (2) | JP2004514694A (enExample) |
| KR (1) | KR100765871B1 (enExample) |
| CN (1) | CN1489463A (enExample) |
| AU (1) | AU2002217927A1 (enExample) |
| BG (1) | BG107856A (enExample) |
| BR (1) | BR0115892A (enExample) |
| CA (3) | CA2625277A1 (enExample) |
| CZ (1) | CZ20031766A3 (enExample) |
| DE (1) | DE01998348T1 (enExample) |
| ES (2) | ES2437157T3 (enExample) |
| HR (2) | HRP20030523A2 (enExample) |
| HU (1) | HUP0600538A3 (enExample) |
| IL (2) | IL156055A0 (enExample) |
| IS (1) | IS6829A (enExample) |
| MX (1) | MXPA03004844A (enExample) |
| NO (1) | NO20032425L (enExample) |
| PL (1) | PL363228A1 (enExample) |
| SK (1) | SK8062003A3 (enExample) |
| TR (1) | TR200400815T3 (enExample) |
| WO (1) | WO2002043732A1 (enExample) |
| YU (1) | YU42803A (enExample) |
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| US7411075B1 (en) | 2000-11-16 | 2008-08-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic form of atorvastatin calcium |
| IL155734A0 (en) * | 2000-11-03 | 2003-11-23 | Teve Pharmaceutical Ind Ltd | Atorvastatin hemi-calcium form vii |
| KR100877165B1 (ko) * | 2000-11-16 | 2009-01-07 | 테바 파마슈티컬 인더스트리즈 리미티드 | 수산화 칼슘을 이용한[Ｒ(Ｒ*,Ｒ*)]-2-(4-플루오로페닐)-β,δ-디하이드록시-5-(1-메틸에틸)-3-페닐-4-[(페닐아미노)카보닐]-1Ｈ-피롤-1-헵탄산 에스테르의 가수분해 |
| US7501450B2 (en) | 2000-11-30 | 2009-03-10 | Teva Pharaceutical Industries Ltd. | Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
| IL156055A0 (en) | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
| ATE420070T1 (de) * | 2000-12-27 | 2009-01-15 | Teva Pharma | Kristalline formen von atorvastatin |
| CZ20033478A3 (cs) | 2001-06-29 | 2004-10-13 | Warner@Lambertácompanyállc | Krystalické formy vápenaté soli }@�B [R@}RgŹRgB]@}@fluorofenylB@betaŹ@delta@dihydroxy@Q@}�@methylethylB@fenyl[}fenylaminoBkarbonyl]@�H@pyrrol@�@heptanové kyseliny }atorvastatinB |
| HRP20040077A2 (en) * | 2001-07-30 | 2004-06-30 | Reddys Lab Ltd Dr | Crystalline forms vi and vii of atorvastatin-calcium |
| US7074818B2 (en) | 2001-07-30 | 2006-07-11 | Dr. Reddy's Laboratories Limited | Crystalline forms VI and VII of Atorvastatin calcium |
| HUP0500616A3 (en) * | 2001-08-16 | 2011-07-28 | Teva Pharma | Processes for preparing calcium salt forms of statins |
| CZ296967B6 (cs) * | 2002-02-01 | 2006-08-16 | Zentiva, A.S. | Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) |
| DE03713610T1 (de) * | 2002-02-15 | 2005-10-20 | Teva Pharma | Neue kristallformen von atorvastatin-hemicalcium und verfahren zu deren herstellung, sowie neue verfahren zur herstellung der formen i, viii und ix von atorvastatin-hemicalcium |
| IL163594A0 (en) * | 2002-02-19 | 2005-12-18 | Teva Pharma | Processes for desolvating solvates of atorvastatinhemi-calcium and atorvastatin hemi-calcium essentially free of organic solvent |
| WO2003099785A1 (en) * | 2002-05-28 | 2003-12-04 | Cadila Healthcare Limited | Process for the preparation of amorphous atorvastatin calcium |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| WO2004022053A1 (en) * | 2002-09-03 | 2004-03-18 | Morepen Laboratories Limited | Atorvastatin calcium form vi or hydrates thereof |
| EP1572643A2 (en) * | 2002-11-28 | 2005-09-14 | Teva Pharmaceutical Industries Ltd. | Crystalline form f of atorvastatin hemi-calcium salt |
| EP1424324A1 (en) * | 2002-11-28 | 2004-06-02 | Teva Pharmaceutical Industries Limited | Crystalline form F of Atorvastatin hemi-calcium salt |
| BRPI0410840A (pt) * | 2003-05-30 | 2006-07-04 | Ranbaxy Lab Ltd | derivados substituìdos de pirrol, composição farmacêutica contendo os mesmos e processo para sua preparação |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| US7790197B2 (en) | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
| US20050271717A1 (en) | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
| US7655692B2 (en) | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
| UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
| CA2456430A1 (en) * | 2004-01-28 | 2005-07-28 | Brantford Chemicals Inc. | Improved process for the preparation of amorphous atorvastatin calcium |
| CN1942439B (zh) | 2004-03-17 | 2011-12-21 | 兰贝克赛实验室有限公司 | 无定形形式的阿托伐他汀钙的制备方法 |
| US7875731B2 (en) | 2004-05-05 | 2011-01-25 | Pfizer Inc. | Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)Carbonyl]-1H-pyrrole-1-heptanoic acid |
| EP1773769A1 (en) * | 2004-05-24 | 2007-04-18 | Warner-Lambert Company LLC | Salt forms of atorvastatin |
| RU2412191C2 (ru) * | 2004-07-16 | 2011-02-20 | Лек Фармасьютиклз Д.Д. | Продукты окислительной деструкции кальций аторвастатина |
| MX2007000765A (es) | 2004-07-20 | 2007-03-28 | Warner Lambert Co | Formas cristalinas de sal de calcio del acido (r-(r*, r*))-2- (4-fluorofenil)- beta,gama- dihidroxi-5- (1-metiletil)-3 -fenil-4-((fenilamino) (carbonil)-1ih -pirrol-1- heptanoico (2:1). |
| JP2007505944A (ja) * | 2004-07-22 | 2007-03-15 | テバ ファーマシューティカル インダストリーズ リミティド | アトルバスタチンヘミカルシウム及びその調製の方法 |
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| CA2582449A1 (en) * | 2004-09-30 | 2006-04-13 | Dr. Reddy's Laboratories Ltd. | Amorphous atorvastatin calcium |
| JP2007515430A (ja) * | 2004-10-18 | 2007-06-14 | テバ ファーマシューティカル インダストリーズ リミティド | アルコール及びケトン、及び／又はエステルの混合物である有機溶媒に塩を溶解し、そして溶媒を除去することにより非晶質アトルバスタチンへミ−カルシウムの調製方法 |
| MX2007004722A (es) | 2004-10-28 | 2007-06-15 | Warner Lambert Co | Procedimiento para formar atorvastatina amorfa. |
| WO2006048894A1 (en) * | 2004-11-05 | 2006-05-11 | Morepen Laboratories Limited | Novel crystalline forms of atorvastatin calcium and processes for preparing them. |
| US20090208539A1 (en) * | 2004-11-22 | 2009-08-20 | Adel Penhasi | Stable atorvastatin formulations |
| SI1698630T1 (sl) * | 2005-03-03 | 2015-01-30 | Alfa Wassermann S.P.A. | Nove polimorfne oblike rifaksimina, postopki za njihovo pripravo in njihova uporaba v medicinskih pripravkih |
| RU2409563C2 (ru) * | 2005-04-08 | 2011-01-20 | Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг | Новая полиморфная форма кристаллической гемикальциевой соли аторвастатина |
| US20070032665A1 (en) * | 2005-08-04 | 2007-02-08 | Srinivasulu Gudipati | Preparation of atorvastatin calcium form i |
| ES2270722B1 (es) * | 2005-09-15 | 2008-03-01 | Ercros Industrial, S.A. | Procedimiento para la obtencion de atorvastatina calcica amorfa. |
| US20090216029A1 (en) * | 2005-09-16 | 2009-08-27 | Yatendra Kumar | Process for the production of atorvastatin calcium in amorphous form |
| CA2547216A1 (en) | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Process for annealing amorphous atorvastatin |
| EP1948599A1 (en) | 2005-11-08 | 2008-07-30 | Ranbaxy Laboratories Limited | Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
| EP1808162A1 (en) | 2005-11-21 | 2007-07-18 | Teva Pharmaceutical Industries Ltd. | Atorvastatin pharmaceutical formulation |
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| WO2008039894A2 (en) * | 2006-09-27 | 2008-04-03 | Dr. Reddy's Labortories, Ltd. | Atorvastatin pharmaceutical compositions |
| US20100113802A1 (en) * | 2006-11-02 | 2010-05-06 | Cadila Pharmaceuticals Limited | Process for preparing amorphous atorvastatin hemi calcium salt and its itermediate |
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| WO2008093650A1 (ja) * | 2007-01-31 | 2008-08-07 | Toyama Chemical Co., Ltd. | ピペラシリンナトリウムの新規な結晶 |
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| WO2008129562A2 (en) * | 2007-04-20 | 2008-10-30 | Morepen Laboratories Limited | An improved process for the preparation of stable amorphous atorvastatin hemi calcium and their salts thereof |
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| EP2075246A1 (en) | 2007-12-27 | 2009-07-01 | M. J. Institute of Research | A process for preparation of amorphous form of atorvastatin hemi-calcium salt |
| CN101538237B (zh) * | 2008-05-30 | 2011-04-06 | 天津和美生物技术有限公司 | 阿伐他汀半钙盐丁酮共结晶物、其制备和作为HMG-CoA酶抑制剂的应用 |
| JP2011528231A (ja) | 2008-07-17 | 2011-11-17 | デラヴァル ホールディング エービー | 食品および飲料の製造および取扱い設備の洗浄方法 |
| US9334266B2 (en) | 2009-09-04 | 2016-05-10 | The University Of Toledo | Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby |
| US11473032B2 (en) | 2010-02-02 | 2022-10-18 | Fuchs Petrolub Se | Constant velocity joint having a boot |
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| CN102766136A (zh) * | 2012-08-07 | 2012-11-07 | 浙江宏元药业有限公司 | 一种制备阿托伐他汀钙中间体的方法 |
| TWI846166B (zh) | 2013-11-15 | 2024-06-21 | 美商阿克比治療有限公司 | {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式，其組合物及用途 |
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